 Freeze Substitution
"Freeze Substitution" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A modification of the freeze-drying method in which the ice within the frozen tissue is replaced by alcohol or other solvent at a very low temperature.
| Descriptor ID |
D017110
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| MeSH Number(s) |
E01.370.225.500.620.760.160.260.270 E01.370.225.750.600.760.160.260.270 E02.792.156.260.270 E05.200.500.620.760.160.260.270 E05.200.750.600.760.160.260.270 E05.760.156.260.270
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Freeze Substitution".
Below are MeSH descriptors whose meaning is more specific than "Freeze Substitution".
This graph shows the total number of publications written about "Freeze Substitution" by people in this website by year, and whether "Freeze Substitution" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 | | 2010 | 0 | 1 | 1 | | 2012 | 1 | 0 | 1 | | 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Freeze Substitution" by people in Profiles.
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Basta T, Morgan GP, O'Toole ET, Rao NR, Savas JN, Stowell MHB. Electron Tomographic Methods for Studying Organelles of the Murine Chemical Synapse. Methods Mol Biol. 2022; 2473:129-139.
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O'Toole ET, Giddings TH, Winey M. Building Cell Structures in Three Dimensions: Electron Tomography Methods for Budding Yeast. Cold Spring Harb Protoc. 2017 03 01; 2017(3).
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O'Toole ET, Giddings TH, Winey M. Cryopreparation and Electron Tomography of Yeast Cells. Cold Spring Harb Protoc. 2017 03 01; 2017(3).
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Winey M, Stemm-Wolf AJ, Giddings TH, Pearson CG. Cytological analysis of Tetrahymena thermophila. Methods Cell Biol. 2012; 109:357-78.
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Giddings TH, Meehl JB, Pearson CG, Winey M. Electron tomography and immuno-labeling of Tetrahymena thermophila basal bodies. Methods Cell Biol. 2010; 96:117-41.
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O'Toole ET. Chlamydomonas cryopreparation methods for the 3-D analysis of cellular organelles. Methods Cell Biol. 2010; 96:71-91.
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O'Toole E, M?ller-Reichert T. Electron tomography of microtubule end-morphologies in C. elegans embryos. Methods Mol Biol. 2009; 545:135-44.
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M?ller-Reichert T, Srayko M, Hyman A, O'Toole ET, McDonald K. Correlative light and electron microscopy of early Caenorhabditis elegans embryos in mitosis. Methods Cell Biol. 2007; 79:101-19.
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Ladinsky MS, Mastronarde DN, McIntosh JR, Howell KE, Staehelin LA. Golgi structure in three dimensions: functional insights from the normal rat kidney cell. J Cell Biol. 1999 Mar 22; 144(6):1135-49.
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