 Procollagen-Proline Dioxygenase
"Procollagen-Proline Dioxygenase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A mixed-function oxygenase that catalyzes the hydroxylation of a prolyl-glycyl containing peptide, usually in PROTOCOLLAGEN, to a hydroxyprolylglycyl-containing-peptide. The enzyme utilizes molecular OXYGEN with a concomitant oxidative decarboxylation of 2-oxoglutarate to SUCCINATE. The enzyme occurs as a tetramer of two alpha and two beta subunits. The beta subunit of procollagen-proline dioxygenase is identical to the enzyme PROTEIN DISULFIDE-ISOMERASES.
| Descriptor ID |
D011393
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| MeSH Number(s) |
D08.811.682.690.416.617.750 D08.811.682.690.708.694.750
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| Concept/Terms |
Procollagen-Proline Dioxygenase- Procollagen-Proline Dioxygenase
- Dioxygenase, Procollagen-Proline
- Procollagen Proline Dioxygenase
- Protocollagen Prolyl Hydroxylase
- Hydroxylase, Protocollagen Prolyl
- Prolyl Hydroxylase, Protocollagen
- Procollagen Prolyl 4-Hydroxylase
- 4-Hydroxylase, Procollagen Prolyl
- Procollagen Prolyl 4 Hydroxylase
- Prolyl 4-Hydroxylase, Procollagen
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Below are MeSH descriptors whose meaning is more general than "Procollagen-Proline Dioxygenase".
Below are MeSH descriptors whose meaning is more specific than "Procollagen-Proline Dioxygenase".
This graph shows the total number of publications written about "Procollagen-Proline Dioxygenase" by people in this website by year, and whether "Procollagen-Proline Dioxygenase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 1 | 0 | 1 | | 2005 | 0 | 1 | 1 | | 2007 | 0 | 3 | 3 | | 2008 | 1 | 0 | 1 | | 2010 | 0 | 1 | 1 | | 2011 | 1 | 4 | 5 | | 2018 | 0 | 1 | 1 |
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Below are the most recent publications written about "Procollagen-Proline Dioxygenase" by people in Profiles.
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Frump AL, Selej M, Wood JA, Albrecht M, Yakubov B, Petrache I, Lahm T. Hypoxia Upregulates Estrogen Receptor ? in Pulmonary Artery Endothelial Cells in a HIF-1a-Dependent Manner. Am J Respir Cell Mol Biol. 2018 07; 59(1):114-126.
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Manalo DJ, Baek JH, Buehler PW, Struble E, Abraham B, Alayash AI. Inactivation of prolyl hydroxylase domain (PHD) protein by epigallocatechin (EGCG) stabilizes hypoxia-inducible factor (HIF-1a) and induces hepcidin (Hamp) in rat kidney. Biochem Biophys Res Commun. 2011 Dec 16; 416(3-4):421-6.
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Colgan SP, Eltzschig HK. Adenosine and hypoxia-inducible factor signaling in intestinal injury and recovery. Annu Rev Physiol. 2012; 74:153-75.
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Koeppen M, Eckle T, Eltzschig HK. The hypoxia-inflammation link and potential drug targets. Curr Opin Anaesthesiol. 2011 Aug; 24(4):363-9.
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Glover LE, Colgan SP. Hypoxia and metabolic factors that influence inflammatory bowel disease pathogenesis. Gastroenterology. 2011 May; 140(6):1748-55.
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Baek JH, Reiter CE, Manalo DJ, Buehler PW, Hider RC, Alayash AI. Induction of hypoxia inducible factor (HIF-1a) in rat kidneys by iron chelation with the hydroxypyridinone, CP94. Biochim Biophys Acta. 2011 Apr-Jun; 1809(4-6):262-8.
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van der Wel H, Johnson JM, Xu Y, Karunaratne CV, Wilson KD, Vohra Y, Boons GJ, Taylor CM, Bendiak B, West CM. Requirements for Skp1 processing by cytosolic prolyl 4(trans)-hydroxylase and a-N-acetylglucosaminyltransferase enzymes involved in O2 signaling in dictyostelium. Biochemistry. 2011 Mar 15; 50(10):1700-13.
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Glover LE, Irizarry K, Scully M, Campbell EL, Bowers BE, Aherne CM, Kominsky DJ, MacManus CF, Colgan SP. IFN-? attenuates hypoxia-inducible factor (HIF) activity in intestinal epithelial cells through transcriptional repression of HIF-1?. J Immunol. 2011 Feb 01; 186(3):1790-8.
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Bigham A, Bauchet M, Pinto D, Mao X, Akey JM, Mei R, Scherer SW, Julian CG, Wilson MJ, L?pez Herr?ez D, Brutsaert T, Parra EJ, Moore LG, Shriver MD. Identifying signatures of natural selection in Tibetan and Andean populations using dense genome scan data. PLoS Genet. 2010 Sep 09; 6(9):e1001116.
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Eltzschig HK, Eckle T, Grenz A. PHD2 mutation and congenital erythrocytosis with paraganglioma. N Engl J Med. 2009 Mar 26; 360(13):1361-2; author reply 1362.
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