 Mice, Inbred CFTR
"Mice, Inbred CFTR" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A strain of mice widely studied as a model for cystic fibrosis. These mice are generated from embryonic stem cells in which the CFTR (cystic fibrosis transmembrane conductance regulator) gene is inactivated by gene targeting. As a result, all mice have one copy of this altered gene in all their tissues. Mice homozygous for the disrupted gene exhibit many features common to young cystic fibrosis patients, including failure to thrive, meconium ileus, and alteration of mucous and serous glands.
| Descriptor ID |
D018181
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| MeSH Number(s) |
B01.050.050.199.520.520.445 B01.050.150.900.649.313.992.635.505.500.400.445
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| Concept/Terms |
Mice, Inbred CFTR- Mice, Inbred CFTR
- CFTR Mice, Inbred
- Inbred CFTR Mice
- Mouse, Inbred CFTR
- CFTR Mouse, Inbred
- Inbred CFTR Mouse
- Mice, CFTR
- CFTR Mice
- Mouse, CFTR
- CFTR Mouse
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Below are MeSH descriptors whose meaning is more general than "Mice, Inbred CFTR".
Below are MeSH descriptors whose meaning is more specific than "Mice, Inbred CFTR".
This graph shows the total number of publications written about "Mice, Inbred CFTR" by people in this website by year, and whether "Mice, Inbred CFTR" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 | | 2006 | 0 | 1 | 1 | | 2007 | 0 | 1 | 1 | | 2008 | 0 | 1 | 1 | | 2012 | 0 | 1 | 1 |
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Below are the most recent publications written about "Mice, Inbred CFTR" by people in Profiles.
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Gould NS, Min E, Martin RJ, Day BJ. CFTR is the primary known apical glutathione transporter involved in cigarette smoke-induced adaptive responses in the lung. Free Radic Biol Med. 2012 Apr 01; 52(7):1201-6.
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Gould NS, Gauthier S, Kariya CT, Min E, Huang J, Brian DJ. Hypertonic saline increases lung epithelial lining fluid glutathione and thiocyanate: two protective CFTR-dependent thiols against oxidative injury. Respir Res. 2010 Aug 27; 11:119.
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Liang L, MacDonald K, Schwiebert EM, Zeitlin PL, Guggino WB. Spiperone, identified through compound screening, activates calcium-dependent chloride secretion in the airway. Am J Physiol Cell Physiol. 2009 Jan; 296(1):C131-41.
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Kariya C, Leitner H, Min E, van Heeckeren C, van Heeckeren A, Day BJ. A role for CFTR in the elevation of glutathione levels in the lung by oral glutathione administration. Am J Physiol Lung Cell Mol Physiol. 2007 Jun; 292(6):L1590-7.
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Velsor LW, Kariya C, Kachadourian R, Day BJ. Mitochondrial oxidative stress in the lungs of cystic fibrosis transmembrane conductance regulator protein mutant mice. Am J Respir Cell Mol Biol. 2006 Nov; 35(5):579-86.
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Day BJ, van Heeckeren AM, Min E, Velsor LW. Role for cystic fibrosis transmembrane conductance regulator protein in a glutathione response to bronchopulmonary pseudomonas infection. Infect Immun. 2004 Apr; 72(4):2045-51.
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