 Smad7 Protein
"Smad7 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An inhibitory smad protein that associates with TRANSFORMING GROWTH FACTOR BETA RECEPTORS and BONE MORPHOGENETIC PROTEIN RECEPTORS. It negatively regulates SIGNAL TRANSDUCTION PATHWAYS by inhibiting PHOSPHORYLATION of RECEPTOR-REGULATED SMAD PROTEINS.
| Descriptor ID |
D051906
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| MeSH Number(s) |
D12.644.360.024.334.200.700 D12.776.157.057.170.249.700 D12.776.476.024.428.249.700
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Smad7 Protein".
Below are MeSH descriptors whose meaning is more specific than "Smad7 Protein".
This graph shows the total number of publications written about "Smad7 Protein" by people in this website by year, and whether "Smad7 Protein" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 1 | 0 | 1 | | 2006 | 1 | 0 | 1 | | 2007 | 0 | 1 | 1 | | 2010 | 1 | 0 | 1 | | 2011 | 2 | 0 | 2 | | 2013 | 2 | 0 | 2 | | 2014 | 1 | 0 | 1 | | 2018 | 2 | 0 | 2 | | 2020 | 1 | 0 | 1 | | 2021 | 0 | 1 | 1 | | 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Smad7 Protein" by people in Profiles.
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Ke Y, Li BZ, Nguyen K, Wang D, Wang S, Young CD, Wang XJ. IL-22RA2 Is a SMAD7 Target Mediating the Alleviation of Dermatitis and Psoriatic Phenotypes in Mice. J Invest Dermatol. 2023 11; 143(11):2243-2254.e10.
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Boss MK, Ke Y, Bian L, Harrison LG, Lee BI, Prebble A, Martin T, Trageser E, Hall S, Wang DD, Wang S, Chow L, Holwerda B, Raben D, Regan D, Karam SD, Dow S, Young CD, Wang XJ. Therapeutic Intervention Using a Smad7-Based Tat Protein to Treat Radiation-Induced Oral Mucositis. Int J Radiat Oncol Biol Phys. 2022 03 01; 112(3):759-770.
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Hupy ML, Pedler MG, Shieh B, Wang D, Wang XJ, Petrash JM. Suppression of epithelial to mesenchymal transition markers in mouse lens by a Smad7-based recombinant protein. Chem Biol Interact. 2021 Aug 01; 344:109495.
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Tufa DM, Shank T, Yingst AM, Trahan GD, Shim S, Lake J, Woods R, Jones K, Verneris MR. Prolactin Acts on Myeloid Progenitors to Modulate SMAD7 Expression and Enhance Hematopoietic Stem Cell Differentiation into the NK Cell Lineage. Sci Rep. 2020 04 14; 10(1):6335.
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Li F, Bian L, Iriyama S, Jian Z, Fan B, Luo J, Wang DD, Young CD, Han G, Wang XJ. Smad7 Ameliorates TGF-?-Mediated Skin Inflammation and Associated Wound Healing Defects but Not Susceptibility to Experimental Skin Carcinogenesis. J Invest Dermatol. 2019 04; 139(4):940-950.
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Luo J, Bian L, Blevins MA, Wang D, Liang C, Du D, Wu F, Holwerda B, Zhao R, Raben D, Zhou H, Young CD, Wang XJ. Smad7 Promotes Healing of Radiotherapy-Induced Oral Mucositis without Compromising Oral Cancer Therapy in a Xenograft Mouse Model. Clin Cancer Res. 2019 01 15; 25(2):808-818.
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Xiao X, Gaffar I, Guo P, Wiersch J, Fischbach S, Peirish L, Song Z, El-Gohary Y, Prasadan K, Shiota C, Gittes GK. M2 macrophages promote beta-cell proliferation by up-regulation of SMAD7. Proc Natl Acad Sci U S A. 2014 Apr 01; 111(13):E1211-20.
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El-Gohary Y, Tulachan S, Guo P, Welsh C, Wiersch J, Prasadan K, Paredes J, Shiota C, Xiao X, Wada Y, Diaz M, Gittes G. Smad signaling pathways regulate pancreatic endocrine development. Dev Biol. 2013 Jun 15; 378(2):83-93.
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Jiang X, Castelao JE, Vandenberg D, Carracedo A, Redondo CM, Conti DV, Paredes Cotor? JP, Potter JD, Newcomb PA, Passarelli MN, Jenkins MA, Hopper JL, Gallinger S, Le Marchand L, Mart?nez ME, Ahnen DJ, Baron JA, Lindor NM, Haile RW, Gago-Dominguez M. Genetic variations in SMAD7 are associated with colorectal cancer risk in the colon cancer family registry. PLoS One. 2013; 8(4):e60464.
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Han G, Bian L, Li F, Cotrim A, Wang D, Lu J, Deng Y, Bird G, Sowers A, Mitchell JB, Gutkind JS, Zhao R, Raben D, ten Dijke P, Refaeli Y, Zhang Q, Wang XJ. Preventive and therapeutic effects of Smad7 on radiation-induced oral mucositis. Nat Med. 2013 Apr; 19(4):421-8.
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