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Xiao-Jing Wang

TitleAffiliate
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-Pathology

    Collapse Research 
    Collapse research activities and funding
    SB1DE024659     (YOUNG, CHRISTIAN)Sep 21, 2023 - Aug 31, 2025
    NIH
    IND-enabling toxicology studies to reach IND approval for a proprietary biologic to treat oral mucositis in cancer patients
    Role: Co-Principal Investigator
    P50CA261605     (JIMENO, ANTONIO ;WANG, XIAO-JING)Sep 1, 2021 - Aug 31, 2026
    NIH
    Colorado Head and Neck Cancer SPORE
    Role: Co-Principal Investigator
    R44AR078669     (YOUNG, CHRISTIAN)Sep 24, 2020 - Aug 31, 2022
    NIH
    Proprietary drug to treat radiodermatitis
    Role: Co-Principal Investigator
    R01DE028420     (WANG, JING HONG;WANG, XIAO-JING)Jan 1, 2019 - Dec 31, 2023
    NIH
    Mechanisms of Dual Inhibition of TGFbeta/PD-L1 in HNSCC
    Role: Principal Investigator
    R01DE027329     (WANG, JING HONG ;WANG, XIAO-JING)Aug 9, 2018 - Jul 31, 2023
    NIH
    Elucidating Mechanism of Immune Evasion in Head and Neck Cancers
    Role: Principal Investigator
    I01BX003232     (WANG, XIAO-JING)Oct 1, 2016 - Jun 30, 2025
    NIH
    Mechanisms and Therapeutic Targets of SCC Metastasis
    Role: Principal Investigator
    R44DE024659     (YOUNG, CHRISTIAN)Sep 15, 2014 - Aug 31, 2021
    NIH
    Topical proprietary biologic to treat oral mucositis
    Role: Co-Principal Investigator
    R43DE024659     (TURNER, BRIAN CURTIS)Sep 15, 2014 - Feb 28, 2017
    NIH
    Smad7 use in oral mucositis treatment
    Role: Co-Principal Investigator
    R44DE028718     (YOUNG, CHRISTIAN)Sep 1, 2014 - Aug 31, 2021
    NIH
    Proprietary biologic treatment to heal skin wounds
    Role: Co-Principal Investigator
    R41AR067106     (WANG, XIAO-JING)Sep 1, 2014 - Aug 31, 2016
    NIH
    Testing Smad7-based biologics for treating chronic wounds
    Role: Principal Investigator
    R01DE024371     (WANG, XIAO-JING)Aug 1, 2014 - Jul 31, 2019
    NIH
    Identifying oral cancer stem cell properties affected by the microenvironment
    Role: Principal Investigator
    T32CA174648     (KARAM, SANA)Apr 1, 2013 - Jun 30, 2024
    NIH
    Training in Translational Research of Lung, Head and Neck Cancer
    Role: Principal Investigator
    R01AR061792     (WANG, XIAO-JING)Jul 18, 2011 - Jun 30, 2017
    NIH
    Effects of Altering TGF Beta Signaling on Wound Healing
    Role: Principal Investigator
    RC1DE020649     (WANG, XIAO-JING)Sep 17, 2009 - Aug 31, 2011
    NIH
    Identification of normal and cancer stem cells and their niche in oral mucosa
    Role: Principal Investigator
    R01GM070966     (WANG, XIAO-JING)Apr 1, 2004 - Mar 31, 2009
    NIH
    Effects of altering TGF beta signaling on wound healing
    Role: Principal Investigator
    R01DE015953     (WANG, XIAO-JING)Mar 1, 2004 - Jan 31, 2016
    NIH
    Role of TGFbeta signaling in HNSCC progression
    Role: Principal Investigator
    R01CA087849     (WANG, XIAO-JING)Jul 1, 2000 - Jul 31, 2013
    NIH
    Role of Smads in the epidermis and skin carcinogenesis
    Role: Principal Investigator
    R01CA079998     (WANG, XIAO-JING)Jan 1, 1999 - Apr 30, 2011
    NIH
    Role of TGF beta Signaling in skin carcinogenesis
    Role: Principal Investigator
    R41ES007597     (WANG, XIAO-JING)Sep 30, 1995 - Sep 29, 1996
    NIH
    CARCINOGENICITY ASSAY USING TRANSGENIC KERATINOCYTES
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Malkoski SP, Haeger SM, Cleaver TG, Rodriguez KJ, Li H, Lu SL, Feser WJ, Bar?n AE, Merrick D, Lighthall JG, Ijichi H, Franklin W, Wang XJ. Loss of transforming growth factor beta type II receptor increases aggressive tumor behavior and reduces survival in lung adenocarcinoma and squamous cell carcinoma. Clin Cancer Res. 2012 Apr 15; 18(8):2173-83. PMID: 22399565.
      View in: PubMed
    2. Malkoski SP, Wang XJ. Two sides of the story? Smad4 loss in pancreatic cancer versus head-and-neck cancer. FEBS Lett. 2012 Jul 04; 586(14):1984-92. PMID: 22321641.
      View in: PubMed
    3. Han G, Li F, Singh TP, Wolf P, Wang XJ. The pro-inflammatory role of TGF?1: a paradox? Int J Biol Sci. 2012; 8(2):228-35. PMID: 22253566.
      View in: PubMed
    4. Han G, Wang XJ. Roles of TGF? signaling Smads in squamous cell carcinoma. Cell Biosci. 2011 Dec 28; 1:41. PMID: 22204491.
      View in: PubMed
    5. Minor J, Wang X, Zhang F, Song J, Jimeno A, Wang XJ, Lu X, Gross N, Kulesz-Martin M, Wang D, Lu SL. Methylation of microRNA-9 is a specific and sensitive biomarker for oral and oropharyngeal squamous cell carcinomas. Oral Oncol. 2012 Jan; 48(1):73-8. PMID: 22133638.
      View in: PubMed
    6. Han G, Li F, Ten Dijke P, Wang XJ. Temporal smad7 transgene induction in mouse epidermis accelerates skin wound healing. Am J Pathol. 2011 Oct; 179(4):1768-79. PMID: 21944279.
      View in: PubMed
    7. Deng Y, Deng H, Liu J, Han G, Malkoski S, Liu B, Zhao R, Wang XJ, Zhang Q. Transcriptional down-regulation of Brca1 and E-cadherin by CtBP1 in breast cancer. Mol Carcinog. 2012 Jun; 51(6):500-7. PMID: 21681822.
      View in: PubMed
    8. Deng Y, Liu J, Han G, Lu SL, Wang SY, Malkoski S, Tan AC, Deng C, Wang XJ, Zhang Q. Redox-dependent Brca1 transcriptional regulation by an NADH-sensor CtBP1. Oncogene. 2010 Dec 16; 29(50):6603-8. PMID: 20818429.
      View in: PubMed
    9. Malkoski SP, Cleaver TG, Lu SL, Lighthall JG, Wang XJ. Keratin promoter based gene manipulation in the murine conducting airway. Int J Biol Sci. 2010 Jan 20; 6(1):68-79. PMID: 20140084.
      View in: PubMed
    10. Han G, Williams CA, Salter K, Garl PJ, Li AG, Wang XJ. A role for TGFbeta signaling in the pathogenesis of psoriasis. J Invest Dermatol. 2010 Feb; 130(2):371-7. PMID: 19710682.
      View in: PubMed
    11. Hoot KE, Lighthall J, Han G, Lu SL, Li A, Ju W, Kulesz-Martin M, Bottinger E, Wang XJ. Keratinocyte-specific Smad2 ablation results in increased epithelial-mesenchymal transition during skin cancer formation and progression. J Clin Invest. 2008 Aug; 118(8):2722-32. PMID: 18618014.
      View in: PubMed
    12. Owens P, Bazzi H, Engelking E, Han G, Christiano AM, Wang XJ. Smad4-dependent desmoglein-4 expression contributes to hair follicle integrity. Dev Biol. 2008 Oct 01; 322(1):156-66. PMID: 18692037.
      View in: PubMed
    13. Han G, Li AG, Liang YY, Owens P, He W, Lu S, Yoshimatsu Y, Wang D, Ten Dijke P, Lin X, Wang XJ. Smad7-induced beta-catenin degradation alters epidermal appendage development. Dev Cell. 2006 Sep; 11(3):301-12. PMID: 16950122.
      View in: PubMed
    14. Lu SL, Herrington H, Reh D, Weber S, Bornstein S, Wang D, Li AG, Tang CF, Siddiqui Y, Nord J, Andersen P, Corless CL, Wang XJ. Loss of transforming growth factor-beta type II receptor promotes metastatic head-and-neck squamous cell carcinoma. Genes Dev. 2006 May 15; 20(10):1331-42. PMID: 16702406.
      View in: PubMed
    15. Han G, Lu SL, Li AG, He W, Corless CL, Kulesz-Martin M, Wang XJ. Distinct mechanisms of TGF-beta1-mediated epithelial-to-mesenchymal transition and metastasis during skin carcinogenesis. J Clin Invest. 2005 Jul; 115(7):1714-23. PMID: 15937546.
      View in: PubMed
    16. Li AG, Wang D, Feng XH, Wang XJ. Latent TGFbeta1 overexpression in keratinocytes results in a severe psoriasis-like skin disorder. EMBO J. 2004 Apr 21; 23(8):1770-81. PMID: 15057277.
      View in: PubMed
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