 Estrogen Receptor alpha
"Estrogen Receptor alpha" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
One of the ESTROGEN RECEPTORS that has marked affinity for ESTRADIOL. Its expression and function differs from, and in some ways opposes, ESTROGEN RECEPTOR BETA.
| Descriptor ID |
D047628
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| MeSH Number(s) |
D12.776.826.750.350.174
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| Concept/Terms |
Estrogen Receptor alpha- Estrogen Receptor alpha
- Estradiol Receptor alpha
- Receptor alpha, Estradiol
- alpha, Estradiol Receptor
- Receptor alpha, Estrogen
- ERalpha
- Estrogen Receptors alpha
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Below are MeSH descriptors whose meaning is more general than "Estrogen Receptor alpha".
Below are MeSH descriptors whose meaning is more specific than "Estrogen Receptor alpha".
This graph shows the total number of publications written about "Estrogen Receptor alpha" by people in this website by year, and whether "Estrogen Receptor alpha" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 | | 2001 | 0 | 1 | 1 | | 2002 | 0 | 1 | 1 | | 2003 | 0 | 1 | 1 | | 2004 | 0 | 2 | 2 | | 2005 | 1 | 0 | 1 | | 2006 | 2 | 1 | 3 | | 2007 | 1 | 0 | 1 | | 2008 | 3 | 0 | 3 | | 2009 | 7 | 2 | 9 | | 2010 | 6 | 2 | 8 | | 2011 | 1 | 0 | 1 | | 2012 | 3 | 3 | 6 | | 2013 | 3 | 2 | 5 | | 2014 | 3 | 2 | 5 | | 2015 | 2 | 0 | 2 | | 2016 | 5 | 1 | 6 | | 2017 | 4 | 2 | 6 | | 2018 | 1 | 3 | 4 | | 2019 | 3 | 3 | 6 | | 2020 | 4 | 3 | 7 | | 2021 | 3 | 2 | 5 | | 2022 | 5 | 0 | 5 | | 2023 | 0 | 2 | 2 | | 2024 | 2 | 1 | 3 | | 2025 | 1 | 0 | 1 |
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Below are the most recent publications written about "Estrogen Receptor alpha" by people in Profiles.
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Liang J, Yao X, Aouad P, Wang BE, Crocker L, Chaudhuri S, Liang Y, Darmanis S, Giltnane J, Moore HM, Aimi J, Chang CW, Gates MR, Eng-Wong J, Hafner M, Metcalfe C. ERa dysfunction caused by ESR1 mutations and therapeutic pressure promotes lineage plasticity in ER+ breast cancer. Nat Cancer. 2025 Feb; 6(2):357-371.
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Hemphill WO, Steiner HR, Kominsky JR, Wuttke DS, Cech TR. Transcription factors ERa and Sox2 have differing multiphasic DNA- and RNA-binding mechanisms. RNA. 2024 07 16; 30(8):1089-1105.
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Hamilton E, Oliveira M, Turner N, Garc?a-Corbacho J, Hernando C, Ciruelos EM, Kabos P, Ruiz-Borrego M, Armstrong A, Patel MR, Vaklavas C, Twelves C, Boni V, Incorvati J, Brier T, Gibbons L, Klinowska T, Lindemann JPO, Morrow CJ, Sykes A, Baird RD. A phase I dose escalation and expansion trial of the next-generation oral SERD camizestrant in women with ER-positive, HER2-negative advanced breast cancer: SERENA-1 monotherapy results. Ann Oncol. 2024 Aug; 35(8):707-717.
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Severyn NT, Esparza P, Gao H, Mickler EA, Albrecht ME, Fisher AJ, Yakubov B, Cook TG, Slaven JE, Walts AD, Tepper RS, Lahm T. Effect of estrogen receptor a on cardiopulmonary adaptation to chronic developmental hypoxia in a rat model. Am J Physiol Lung Cell Mol Physiol. 2024 Jun 01; 326(6):L786-L795.
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Li Z, Li T, Yates ME, Wu Y, Ferber A, Chen L, Brown DD, Carroll JS, Sikora MJ, Tseng GC, Oesterreich S, Lee AV. The EstroGene Database Reveals Diverse Temporal, Context-Dependent, and Bidirectional Estrogen Receptor Regulomes in Breast Cancer. Cancer Res. 2023 08 15; 83(16):2656-2674.
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Orlicky DJ, Smith EE, Bok R, Guess MK, Rascoff LG, Arruda JS, Hutchinson-Colas JA, Johnson J, Connell KA. Estrogen and Androgen Receptor Status in Uterosacral Ligaments of Women with Pelvic Organ Prolapse Stratified by the Pelvic Organ Prolapse Histology Quantification System. Reprod Sci. 2023 12; 30(12):3495-3506.
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Steiner HR, Lammer NC, Batey RT, Wuttke DS. An Extended DNA Binding Domain of the Estrogen Receptor Alpha Directly Interacts with RNAs in Vitro. Biochemistry. 2022 11 15; 61(22):2490-2494.
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Liang J, Ingalla ER, Yao X, Wang BE, Tai L, Giltnane J, Liang Y, Daemen A, Moore HM, Aimi J, Chang CW, Gates MR, Eng-Wong J, Tam L, Bacarro N, Roose-Girma M, Bellet M, Hafner M, Metcalfe C. Giredestrant reverses progesterone hypersensitivity driven by estrogen receptor mutations in breast cancer. Sci Transl Med. 2022 Sep 21; 14(663):eabo5959.
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Lennard Richard ML, Wirth JR, Khatiwada A, Chung D, Gilkeson GS, Cunningham MA. Conditional knockout of oestrogen receptor alpha in CD11c+ cells impacts female survival and inflammatory cytokine profile in murine lupus. Immunology. 2022 11; 167(3):354-367.
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Li Z, McGinn O, Wu Y, Bahreini A, Priedigkeit NM, Ding K, Onkar S, Lampenfeld C, Sartorius CA, Miller L, Rosenzweig M, Cohen O, Wagle N, Richer JK, Muller WJ, Buluwela L, Ali S, Bruno TC, Vignali DAA, Fang Y, Zhu L, Tseng GC, Gertz J, Atkinson JM, Lee AV, Oesterreich S. ESR1 mutant breast cancers show elevated basal cytokeratins and immune activation. Nat Commun. 2022 04 19; 13(1):2011.
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