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Michael T Falta

TitleAsst Professor-Research
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED
Phone303/724-7191

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Littlefield KM, Watson RO, Schneider JM, Neff CP, Yamada E, Zhang M, Campbell TB, Falta MT, Jolley SE, Fontenot AP, Palmer BE. SARS-CoV-2-specific T cells associate with inflammation and reduced lung function in pulmonary post-acute sequalae of SARS-CoV-2. PLoS Pathog. 2022 05; 18(5):e1010359. PMID: 35617421.
      View in: PubMed
    2. McKee AS, Atif SM, Falta MT, Fontenot AP. Innate and Adaptive Immunity in Noninfectious Granulomatous Lung Disease. J Immunol. 2022 04 15; 208(8):1835-1843. PMID: 35418504.
      View in: PubMed
    3. Greaves SA, Ravindran A, Santos RG, Chen L, Falta MT, Wang Y, Mitchell AM, Atif SM, Mack DG, Tinega AN, Maier LA, Dai S, Pinilla C, Grunewald J, Fontenot AP. CD4+ T cells in the lungs of acute sarcoidosis patients recognize an Aspergillus nidulans epitope. J Exp Med. 2021 10 04; 218(10). PMID: 34410304.
      View in: PubMed
    4. Falta MT, Crawford JC, Tinega AN, Landry LG, Crawford F, Mack DG, Martin AK, Atif SM, Li L, Santos RG, Nakayama M, Kappler JW, Maier LA, Thomas PG, Pinilla C, Fontenot AP. Beryllium-specific CD4+ T cells induced by chemokine neoantigens perpetuate inflammation. J Clin Invest. 2021 05 03; 131(9). PMID: 33630763.
      View in: PubMed
    5. Mitchell AM, Kaiser Y, Falta MT, Munson DJ, Landry LG, Eklund A, Nakayama M, Slansky JE, Grunewald J, Fontenot AP. Shared a? TCR Usage in Lungs of Sarcoidosis Patients with L?fgren's Syndrome. J Immunol. 2017 10 01; 199(7):2279-2290. PMID: 28827283.
      View in: PubMed
    6. Munson DJ, Egelston CA, Chiotti KE, Parra ZE, Bruno TC, Moore BL, Nakano TA, Simons DL, Jimenez G, Yim JH, Rozanov DV, Falta MT, Fontenot AP, Reynolds PR, Leach SM, Borges VF, Kappler JW, Spellman PT, Lee PP, Slansky JE. Identification of shared TCR sequences from T cells in human breast cancer using emulsion RT-PCR. Proc Natl Acad Sci U S A. 2016 07 19; 113(29):8272-7. PMID: 27307436.
      View in: PubMed
    7. Fontenot AP, Falta MT, Kappler JW, Dai S, McKee AS. Beryllium-Induced Hypersensitivity: Genetic Susceptibility and Neoantigen Generation. J Immunol. 2016 Jan 01; 196(1):22-7. PMID: 26685315.
      View in: PubMed
    8. Falta MT, Tinega AN, Mack DG, Bowerman NA, Crawford F, Kappler JW, Pinilla C, Fontenot AP. Metal-specific CD4+ T-cell responses induced by beryllium exposure in HLA-DP2 transgenic mice. Mucosal Immunol. 2016 Jan; 9(1):218-28. PMID: 26129650.
      View in: PubMed
    9. Clayton GM, Wang Y, Crawford F, Novikov A, Wimberly BT, Kieft JS, Falta MT, Bowerman NA, Marrack P, Fontenot AP, Dai S, Kappler JW. Structural basis of chronic beryllium disease: linking allergic hypersensitivity and autoimmunity. Cell. 2014 Jul 03; 158(1):132-42. PMID: 24995984.
      View in: PubMed
    10. Mack DG, Falta MT, McKee AS, Martin AK, Simonian PL, Crawford F, Gordon T, Mercer RR, Hoover MD, Marrack P, Kappler JW, Tuder RM, Fontenot AP. Regulatory T cells modulate granulomatous inflammation in an HLA-DP2 transgenic murine model of beryllium-induced disease. Proc Natl Acad Sci U S A. 2014 Jun 10; 111(23):8553-8. PMID: 24912188.
      View in: PubMed
    11. Bowerman NA, Falta MT, Mack DG, Wehrmann F, Crawford F, Mroz MM, Maier LA, Kappler JW, Fontenot AP. Identification of multiple public TCR repertoires in chronic beryllium disease. J Immunol. 2014 May 15; 192(10):4571-80. PMID: 24719461.
      View in: PubMed
    12. Dai S, Falta MT, Bowerman NA, McKee AS, Fontenot AP. T cell recognition of beryllium. Curr Opin Immunol. 2013 Dec; 25(6):775-80. PMID: 23978481.
      View in: PubMed
    13. Falta MT, Pinilla C, Mack DG, Tinega AN, Crawford F, Giulianotti M, Santos R, Clayton GM, Wang Y, Zhang X, Maier LA, Marrack P, Kappler JW, Fontenot AP. Identification of beryllium-dependent peptides recognized by CD4+ T cells in chronic beryllium disease. J Exp Med. 2013 Jul 01; 210(7):1403-18. PMID: 23797096.
      View in: PubMed
    14. Menezes CA, Sullivan AK, Falta MT, Mack DG, Freed BM, Rocha MO, Gollob KJ, Fontenot AP, Dutra WO. Highly conserved CDR3 region in circulating CD4(+)V?5(+) T cells may be associated with cytotoxic activity in Chagas disease. Clin Exp Immunol. 2012 Aug; 169(2):109-18. PMID: 22774985.
      View in: PubMed
    15. Martin AK, Mack DG, Falta MT, Mroz MM, Newman LS, Maier LA, Fontenot AP. Beryllium-specific CD4+ T cells in blood as a biomarker of disease progression. J Allergy Clin Immunol. 2011 Nov; 128(5):1100-6.e1-5. PMID: 21943943.
      View in: PubMed
    16. Bowerman NA, Falta MT, Mack DG, Kappler JW, Fontenot AP. Mutagenesis of beryllium-specific TCRs suggests an unusual binding topology for antigen recognition. J Immunol. 2011 Oct 01; 187(7):3694-703. PMID: 21873524.
      View in: PubMed
    17. Goldstein JI, Kominsky DJ, Jacobson N, Bowers B, Regalia K, Austin GL, Yousefi M, Falta MT, Fontenot AP, Gerich ME, Golden-Mason L, Colgan SP. Defective leukocyte GM-CSF receptor (CD116) expression and function in inflammatory bowel disease. Gastroenterology. 2011 Jul; 141(1):208-16. PMID: 21557945.
      View in: PubMed
    18. Falta MT, Bowerman NA, Dai S, Kappler JW, Fontenot AP. Linking genetic susceptibility and T cell activation in beryllium-induced disease. Proc Am Thorac Soc. 2010 May; 7(2):126-9. PMID: 20427584.
      View in: PubMed
    19. Dai S, Murphy GA, Crawford F, Mack DG, Falta MT, Marrack P, Kappler JW, Fontenot AP. Crystal structure of HLA-DP2 and implications for chronic beryllium disease. Proc Natl Acad Sci U S A. 2010 Apr 20; 107(16):7425-30. PMID: 20356827.
      View in: PubMed
    20. Mack DG, Lanham AM, Falta MT, Palmer BE, Maier LA, Fontenot AP. Deficient and dysfunctional regulatory T cells in the lungs of chronic beryllium disease subjects. Am J Respir Crit Care Med. 2010 Jun 01; 181(11):1241-9. PMID: 20299529.
      View in: PubMed
    21. Mack CL, Falta MT, Sullivan AK, Karrer F, Sokol RJ, Freed BM, Fontenot AP. Oligoclonal expansions of CD4+ and CD8+ T-cells in the target organ of patients with biliary atresia. Gastroenterology. 2007 Jul; 133(1):278-87. PMID: 17631149.
      View in: PubMed
    22. J?rgensen TN, Thurman J, Izui S, Falta MT, Metzger TE, Flannery SA, Kappler J, Marrack P, Kotzin BL. Genetic susceptibility to polyI:C-induced IFNalpha/beta-dependent accelerated disease in lupus-prone mice. Genes Immun. 2006 Oct; 7(7):555-67. PMID: 16900204.
      View in: PubMed
    23. Sullivan AK, Simonian PL, Falta MT, Cosgrove GP, Brown KK, Kotzin BL, Voelkel NF, Fontenot AP. Activated oligoclonal CD4+ T cells in the lungs of patients with severe emphysema. Proc Am Thorac Soc. 2006 Aug; 3(6):486. PMID: 16921120.
      View in: PubMed
    24. Bill JR, Mack DG, Falta MT, Maier LA, Sullivan AK, Joslin FG, Martin AK, Freed BM, Kotzin BL, Fontenot AP. Beryllium presentation to CD4+ T cells is dependent on a single amino acid residue of the MHC class II beta-chain. J Immunol. 2005 Nov 15; 175(10):7029-37. PMID: 16272364.
      View in: PubMed
    25. Sullivan AK, Simonian PL, Falta MT, Mitchell JD, Cosgrove GP, Brown KK, Kotzin BL, Voelkel NF, Fontenot AP. Oligoclonal CD4+ T cells in the lungs of patients with severe emphysema. Am J Respir Crit Care Med. 2005 Sep 01; 172(5):590-6. PMID: 15937291.
      View in: PubMed
    26. Falta MT, Fontenot AP, Rosloniec EF, Crawford F, Roark CL, Bill J, Marrack P, Kappler J, Kotzin BL. Class II major histocompatibility complex-peptide tetramer staining in relation to functional avidity and T cell receptor diversity in the mouse CD4(+) T cell response to a rheumatoid arthritis-associated antigen. Arthritis Rheum. 2005 Jun; 52(6):1885-96. PMID: 15934080.
      View in: PubMed
    27. Bennett SR, Falta MT, Bill J, Kotzin BL. Antigen-specific T cells in rheumatoid arthritis. Curr Rheumatol Rep. 2003 Aug; 5(4):255-63. PMID: 14531952.
      View in: PubMed
    28. Pitera JW, Falta M, van Gunsteren WF. Dielectric properties of proteins from simulation: the effects of solvent, ligands, pH, and temperature. Biophys J. 2001 Jun; 80(6):2546-55. PMID: 11371433.
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    29. Falta MT, Atkinson MA, Allegretta M, Vacek PM, Albertini RJ. Azathioprine associated T-cell mutations in insulin-dependent diabetes mellitus. Scand J Immunol. 2000 Jun; 51(6):626-33. PMID: 10849375.
      View in: PubMed
    30. Chamberlain WD, Falta MT, Kotzin BL. Functional subsets within clonally expanded CD8(+) memory T cells in elderly humans. Clin Immunol. 2000 Mar; 94(3):160-72. PMID: 10692235.
      View in: PubMed
    31. Kotzin BL, Falta MT, Crawford F, Rosloniec EF, Bill J, Marrack P, Kappler J. Use of soluble peptide-DR4 tetramers to detect synovial T cells specific for cartilage antigens in patients with rheumatoid arthritis. Proc Natl Acad Sci U S A. 2000 Jan 04; 97(1):291-6. PMID: 10618411.
      View in: PubMed
    32. Fontenot AP, Falta MT, Freed BM, Newman LS, Kotzin BL. Identification of pathogenic T cells in patients with beryllium-induced lung disease. J Immunol. 1999 Jul 15; 163(2):1019-26. PMID: 10395700.
      View in: PubMed
    33. Falta MT, Magin GK, Allegretta M, Steinman L, Atkinson MA, Brostoff SW, Albertini RJ. Selection of hprt mutant T cells as surrogates for dividing cells reveals a restricted T cell receptor BV repertoire in insulin-dependent diabetes mellitus. Clin Immunol. 1999 Mar; 90(3):340-51. PMID: 10075863.
      View in: PubMed
    34. Striebich CC, Falta MT, Wang Y, Bill J, Kotzin BL. Selective accumulation of related CD4+ T cell clones in the synovial fluid of patients with rheumatoid arthritis. J Immunol. 1998 Oct 15; 161(8):4428-36. PMID: 9780222.
      View in: PubMed
    35. O'Neill JP, Nicklas JA, Hunter TC, Batson OB, Allegretta M, Falta MT, Branda RF, Albertini RJ. The effect of T-lymphocyte 'clonality' on the calculated hprt mutation frequency occurring in vivo in humans. Mutat Res. 1994 Oct-Dec; 313(2-3):215-25. PMID: 7523907.
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    36. Jacobson-Kram D, Albertini RJ, Branda RF, Falta MT, Iype PT, Kolodner K, Liou SH, McDiarmid MA, Morris M, Nicklas JA, et al. Measurement of chromosomal aberrations, sister chromatid exchange, hprt mutations, and DNA adducts in peripheral lymphocytes of human populations at increased risk for cancer. Environ Health Perspect. 1993 Oct; 101 Suppl 3:121-5. PMID: 8143603.
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    37. Branda RF, Sullivan LM, O'Neill JP, Falta MT, Nicklas JA, Hirsch B, Vacek PM, Albertini RJ. Measurement of HPRT mutant frequencies in T-lymphocytes from healthy human populations. Mutat Res. 1993 Feb; 285(2):267-79. PMID: 7678900.
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    38. Nicklas JA, O'Neill JP, Hunter TC, Falta MT, Lippert MJ, Jacobson-Kram D, Williams JR, Albertini RJ. In vivo ionizing irradiations produce deletions in the hprt gene of human T-lymphocytes. Mutat Res. 1991 Sep-Oct; 250(1-2):383-96. PMID: 1944353.
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    39. Nicklas JA, Falta MT, Hunter TC, O'Neill JP, Jacobson-Kram D, Williams JR, Albertini RJ. Molecular analysis of in vivo hprt mutations in human T lymphocytes. V. Effects of total body irradiation secondary to radioimmunoglobulin therapy (RIT) Mutagenesis. 1990 Sep; 5(5):461-8. PMID: 2175831.
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    40. Skopek TR, Recio L, Simpson D, Dallaire L, Melancon SB, Ogier H, O'Neill JP, Falta MT, Nicklas JA, Albertini RJ. Molecular analyses of a Lesch-Nyhan syndrome mutation (hprtMontreal) by use of T-lymphocyte cultures. Hum Genet. 1990 Jun; 85(1):111-6. PMID: 2358296.
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    41. McGinniss MJ, Falta MT, Sullivan LM, Albertini RJ. In vivo hprt mutant frequencies in T-cells of normal human newborns. Mutat Res. 1990 Feb; 240(2):117-26. PMID: 2300072.
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    42. O'Neill JP, Sullivan LM, Booker JK, Pornelos BS, Falta MT, Greene CJ, Albertini RJ. Longitudinal study of the in vivo hprt mutant frequency in human T-lymphocytes as determined by a cell cloning assay. Environ Mol Mutagen. 1989; 13(4):289-93. PMID: 2786809.
      View in: PubMed
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