 Nicotinamide Phosphoribosyltransferase
"Nicotinamide Phosphoribosyltransferase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the formation of nicotinamide mononucleotide (NMN) from nicotinamide and 5-phosphoribosyl-1-pyrophosphate, the rate-limiting step in the biosynthesis of the NAD coenzyme. It is also known as a growth factor for early B-LYMPHOCYTES, or an ADIPOKINE with insulin-mimetic effects (visfatin).
| Descriptor ID |
D054409
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| MeSH Number(s) |
D08.811.913.400.725.575
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| Concept/Terms |
Nicotinamide Phosphoribosyltransferase- Nicotinamide Phosphoribosyltransferase
- Phosphoribosyltransferase, Nicotinamide
- NAMPT Protein
- Pre-B-Cell Colony-Enhancing Factor
- Colony-Enhancing Factor, Pre-B-Cell
- Pre B Cell Colony Enhancing Factor
- Visfatin
- NAmPRTase
- NMN Pyrophosphorylase
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Below are MeSH descriptors whose meaning is more general than "Nicotinamide Phosphoribosyltransferase".
Below are MeSH descriptors whose meaning is more specific than "Nicotinamide Phosphoribosyltransferase".
This graph shows the total number of publications written about "Nicotinamide Phosphoribosyltransferase" by people in this website by year, and whether "Nicotinamide Phosphoribosyltransferase" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 | | 2005 | 0 | 1 | 1 | | 2006 | 0 | 1 | 1 | | 2018 | 0 | 1 | 1 | | 2021 | 1 | 0 | 1 | | 2024 | 1 | 0 | 1 | | 2026 | 2 | 1 | 3 |
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Below are the most recent publications written about "Nicotinamide Phosphoribosyltransferase" by people in Profiles.
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Kim A, Bhardwaj P, Rehman S, Zhao SJ, Lucas KN, Noronha KJ, Bhatt D, Friedman S, Morotti R, Sundaram RK, Dela Cruz FS, Feinberg TY, Ramakrishnan S, Xue W, Barkauskas DA, Hall D, Shern JF, Sun W, Barr FG, Yi JS, Spurrier J, Yu A, Brenner C, Heer CD, Heske CM, Vasquez JC. NAPRT Expression and Epigenetic Regulation in Pediatric Rhabdomyosarcoma as a Potential Biomarker for NAMPT Inhibition. Mol Cancer Ther. 2026 Oct 02; 25(10):1771-1784.
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Patel SB, Moskop DR, Moreira S, Gipson S, Anderson CC, Crook A, McCabe M, Stephenson D, Terry HE, Kent A, Young TN, Krug AE, Thomas CI, Price C, Ransom M, Miller R, Vujovic A, Minhajuddin M, Althoff MJ, Saviola AJ, Stevens BM, Welner RS, Andrianova EL, Gudkov AV, Darehshouri A, Reisz JA, Nemkov T, D'Alessandro A, Gillen AE, Pollyea DA, Jordan CT, Pietras EM. The Nicotinamide Salvage Pathway Is a Metabolic Vulnerability of High-Risk MDS Stem Cells. Blood Cancer Discov. 2026 Sep 03; 7(5):796-812.
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Razak A, Mahipal A, Diamond JR, Ribas A, Berlin JD, Azmi AS, Mark T, Walker CJ, Chai Y, Kashyap T, Gudi G, Naing A. First-in-Human Phase I Study of KPT-9274, a First-in-Class Dual Inhibitor of PAK4 and NAMPT, in Patients with Advanced Solid Malignancies. Target Oncol. 2026 Mar; 21(2):187-198.
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Scuoppo C, Cai B, Ofori K, Scholze H, Kumar R, D'Alessandro A, Basso K, Pasqualucci L, Dalla-Favera R. Repurposing NAMPT Inhibitors for Germinal Center B Cell-Like Diffuse Large B-Cell Lymphoma. Blood Cancer Discov. 2024 Nov 01; 5(6):417-427.
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Subedi A, Liu Q, Ayyathan DM, Sharon D, Cathelin S, Hosseini M, Xu C, Voisin V, Bader GD, D'Alessandro A, Lechman ER, Dick JE, Minden MD, Wang JCY, Chan SM. Nicotinamide phosphoribosyltransferase inhibitors selectively induce apoptosis of AML stem cells by disrupting lipid homeostasis. Cell Stem Cell. 2021 10 07; 28(10):1851-1867.e8.
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Chmielewski JP, Bowlby SC, Wheeler FB, Shi L, Sui G, Davis AL, Howard TD, D'Agostino RB, Miller LD, Sirintrapun SJ, Cramer SD, Kridel SJ. CD38 Inhibits Prostate Cancer Metabolism and Proliferation by Reducing Cellular NAD+ Pools. Mol Cancer Res. 2018 11; 16(11):1687-1700.
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Nomura K, Tatsumi S, Miyagawa A, Shiozaki Y, Sasaki S, Kaneko I, Ito M, Kido S, Segawa H, Sano M, Fukuwatari T, Shibata K, Miyamoto K. Hepatectomy-related hypophosphatemia: a novel phosphaturic factor in the liver-kidney axis. J Am Soc Nephrol. 2014 Apr; 25(4):761-72.
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Rudwill F, Blanc S, Gauquelin-Koch G, Choukèr A, Heer M, Simon C, Bergouignan A. Effects of different levels of physical inactivity on plasma visfatin in healthy normal-weight men. Appl Physiol Nutr Metab. 2013 Jun; 38(6):689-93.
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Varma V, Yao-Borengasser A, Rasouli N, Bodles AM, Phanavanh B, Lee MJ, Starks T, Kern LM, Spencer HJ, McGehee RE, Fried SK, Kern PA. Human visfatin expression: relationship to insulin sensitivity, intramyocellular lipids, and inflammation. J Clin Endocrinol Metab. 2007 Feb; 92(2):666-72.
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Nonas SA, Finigan JH, Gao L, Garcia JG. Functional genomic insights into acute lung injury: role of ventilators and mechanical stress. Proc Am Thorac Soc. 2005; 2(3):188-94.
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