Immunoreceptor Tyrosine-Based Activation Motif
"Immunoreceptor Tyrosine-Based Activation Motif" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A conserved AMINO ACID SEQUENCE located in the intracellular domains of a family of transmembrane proteins involved in various IMMUNE RESPONSES. The CONSENSUS SEQUENCE of this motif is YXXL(or I)X(6-8)YXXL(or I) (where X denotes any amino acid). When phosphorylated ITAM motifs provide docking sites for PROTEIN TYROSINE KINASES of the Syk family thus forming signaling complexes which lead to activation of immune responses.
| Descriptor ID |
D061625
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| MeSH Number(s) |
G02.111.570.820.709.275.500.440
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| Concept/Terms |
Immunoreceptor Tyrosine-Based Activation Motif- Immunoreceptor Tyrosine-Based Activation Motif
- Immunoreceptor Tyrosine Based Activation Motif
- Immuno-Receptor Tyrosine-Based Activation Motif
- Immuno Receptor Tyrosine Based Activation Motif
- Immune Receptor Tyrosine-Based Activation Motif
- Immune Receptor Tyrosine Based Activation Motif
|
Below are MeSH descriptors whose meaning is more general than "Immunoreceptor Tyrosine-Based Activation Motif".
Below are MeSH descriptors whose meaning is more specific than "Immunoreceptor Tyrosine-Based Activation Motif".
This graph shows the total number of publications written about "Immunoreceptor Tyrosine-Based Activation Motif" by people in this website by year, and whether "Immunoreceptor Tyrosine-Based Activation Motif" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2013 | 1 | 0 | 1 |
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Below are the most recent publications written about "Immunoreceptor Tyrosine-Based Activation Motif" by people in Profiles.
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Guy CS, Vignali KM, Temirov J, Bettini ML, Overacre AE, Smeltzer M, Zhang H, Huppa JB, Tsai YH, Lobry C, Xie J, Dempsey PJ, Crawford HC, Aifantis I, Davis MM, Vignali DA. Distinct TCR signaling pathways drive proliferation and cytokine production in T cells. Nat Immunol. 2013 Mar; 14(3):262-70.