 Transforming Growth Factor alpha
"Transforming Growth Factor alpha" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An EPIDERMAL GROWTH FACTOR related protein that is found in a variety of tissues including EPITHELIUM, and maternal DECIDUA. It is synthesized as a transmembrane protein which can be cleaved to release a soluble active form which binds to the EGF RECEPTOR.
| Descriptor ID |
D016211
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| MeSH Number(s) |
D12.644.276.382.750 D12.644.276.963.360 D12.776.467.382.750 D12.776.467.960.360 D23.529.382.750 D23.529.960.360
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| Concept/Terms |
Transforming Growth Factor alpha- Transforming Growth Factor alpha
- TGF-alpha
- TGFalpha
- Epidermal Growth Factor-Related Transforming Growth Factor
- Epidermal Growth Factor Related Transforming Growth Factor
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Below are MeSH descriptors whose meaning is more general than "Transforming Growth Factor alpha".
Below are MeSH descriptors whose meaning is more specific than "Transforming Growth Factor alpha".
This graph shows the total number of publications written about "Transforming Growth Factor alpha" by people in this website by year, and whether "Transforming Growth Factor alpha" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 5 | 2 | 7 | | 1995 | 4 | 0 | 4 | | 1996 | 3 | 1 | 4 | | 1997 | 0 | 1 | 1 | | 1999 | 1 | 2 | 3 | | 2000 | 2 | 1 | 3 | | 2002 | 1 | 0 | 1 | | 2003 | 2 | 0 | 2 | | 2005 | 1 | 0 | 1 | | 2006 | 0 | 2 | 2 | | 2007 | 1 | 0 | 1 | | 2008 | 1 | 1 | 2 | | 2009 | 1 | 0 | 1 | | 2010 | 2 | 1 | 3 | | 2013 | 0 | 1 | 1 | | 2015 | 0 | 1 | 1 | | 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "Transforming Growth Factor alpha" by people in Profiles.
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Bunker EN, Wheeler GE, Chapnick DA, Liu X. Suppression of a-catenin and adherens junctions enhances epithelial cell proliferation and motility via TACE-mediated TGF-a autocrine/paracrine signaling. Mol Biol Cell. 2021 02 15; 32(4):348-361.
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Ito Y, Correll K, Zemans RL, Leslie CC, Murphy RC, Mason RJ. Influenza induces IL-8 and GM-CSF secretion by human alveolar epithelial cells through HGF/c-Met and TGF-a/EGFR signaling. Am J Physiol Lung Cell Mol Physiol. 2015 Jun 01; 308(11):L1178-88.
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Chapnick DA, Bunker E, Liu X. A biosensor for the activity of the "sheddase" TACE (ADAM17) reveals novel and cell type-specific mechanisms of TACE activation. Sci Signal. 2015 Feb 24; 8(365):rs1.
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Yan F, Liu L, Dempsey PJ, Tsai YH, Raines EW, Wilson CL, Cao H, Cao Z, Liu L, Polk DB. A Lactobacillus rhamnosus GG-derived soluble protein, p40, stimulates ligand release from intestinal epithelial cells to transactivate epidermal growth factor receptor. J Biol Chem. 2013 Oct 18; 288(42):30742-30751.
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Xu Q, Zhang X, Yue J, Liu C, Cao C, Zhong H, Ma Q. Human TGFalpha-derived peptide TGFalphaL3 fused with superantigen for immunotherapy of EGFR-expressing tumours. BMC Biotechnol. 2010 Dec 22; 10:91.
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Cheng X, Jin J, Hu L, Shen D, Dong XP, Samie MA, Knoff J, Eisinger B, Liu ML, Huang SM, Caterina MJ, Dempsey P, Michael LE, Dlugosz AA, Andrews NC, Clapham DE, Xu H. TRP channel regulates EGFR signaling in hair morphogenesis and skin barrier formation. Cell. 2010 Apr 16; 141(2):331-43.
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Yin Q, Jia H, Zhang Y, Liu C, Ma Q, Zhang B, Zhong H, Xu Q. [Design and activity analysis of chimeric epidermal growth factor fusion vaccine E5T-mSEA]. Sheng Wu Gong Cheng Xue Bao. 2010 Mar; 26(3):357-62.
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Auerbach SR, Manlhiot C, Reddy S, Kinnear C, Richmond ME, Gruber D, McCrindle BW, Deng L, Chen JM, Addonizio LJ, Chung WK, Mital S. Recipient genotype is a predictor of allograft cytokine expression and outcomes after pediatric cardiac transplantation. J Am Coll Cardiol. 2009 May 19; 53(20):1909-17.
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Merchant NB, Voskresensky I, Rogers CM, Lafleur B, Dempsey PJ, Graves-Deal R, Revetta F, Foutch AC, Rothenberg ML, Washington MK, Coffey RJ. TACE/ADAM-17: a component of the epidermal growth factor receptor axis and a promising therapeutic target in colorectal cancer. Clin Cancer Res. 2008 Feb 15; 14(4):1182-91.
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Tyagi A, Sharma Y, Agarwal C, Agarwal R. Silibinin impairs constitutively active TGFalpha-EGFR autocrine loop in advanced human prostate carcinoma cells. Pharm Res. 2008 Sep; 25(9):2143-50.
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