 Amyloid Precursor Protein Secretases
"Amyloid Precursor Protein Secretases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Endopeptidases that are specific for AMYLOID PROTEIN PRECURSOR. Three secretase subtypes referred to as alpha, beta, and gamma have been identified based upon the region of amyloid protein precursor they cleave.
| Descriptor ID |
D053829
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| MeSH Number(s) |
D08.811.277.656.300.032
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Amyloid Precursor Protein Secretases".
Below are MeSH descriptors whose meaning is more specific than "Amyloid Precursor Protein Secretases".
This graph shows the total number of publications written about "Amyloid Precursor Protein Secretases" by people in this website by year, and whether "Amyloid Precursor Protein Secretases" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 2 | 2 | | 2004 | 0 | 3 | 3 | | 2005 | 0 | 2 | 2 | | 2006 | 1 | 2 | 3 | | 2007 | 1 | 1 | 2 | | 2008 | 3 | 0 | 3 | | 2009 | 1 | 0 | 1 | | 2010 | 4 | 0 | 4 | | 2011 | 0 | 1 | 1 | | 2012 | 2 | 2 | 4 | | 2013 | 2 | 2 | 4 | | 2014 | 4 | 0 | 4 | | 2015 | 0 | 2 | 2 | | 2016 | 0 | 1 | 1 | | 2017 | 4 | 0 | 4 | | 2018 | 1 | 0 | 1 | | 2019 | 0 | 1 | 1 | | 2021 | 1 | 0 | 1 | | 2022 | 1 | 1 | 2 | | 2023 | 0 | 4 | 4 | | 2024 | 1 | 0 | 1 | | 2025 | 2 | 0 | 2 |
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Below are the most recent publications written about "Amyloid Precursor Protein Secretases" by people in Profiles.
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Pfundstein G, Keable R, Hu S, Al-Hadi M, Baker M, Schachner M, Leshchyns'ka I, Sytnyk V. NCAM2 promotes targeting of APP from the cell surface to BACE1-containing recycling endosomes. Prog Neurobiol. 2025 Aug; 251:102807.
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Chafe SC, Zhai K, Aghaei N, Miletic P, Huang Z, Brown KR, Mobilio D, Young D, Suk Y, Grewal S, McKenna D, Alizada Z, Kieliszek AM, Lam FC, Escudero L, Huang Q, Huebner A, Lu J, Ang P, Anand A, Custers S, Apel E, Slassi S, Brakel B, Kim J, Liu JKC, Bassey-Archibong BI, Abdo R, Shargall Y, Lu JQ, Cutz JC, Zhang Q, Li SS, Venugopal C, Hynds RE, Dufour A, Moffat J, Swanton C, Bao S, Singh SK. A genome-wide in vivo CRISPR activation screen identifies BACE1 as a therapeutic vulnerability of lung cancer brain metastasis. Sci Transl Med. 2025 Jul 02; 17(805):eadu2459.
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Brinkley DM, Smith KC, Fink EC, Kwen W, Yoo NH, West Z, Sullivan NL, Farthing AS, Hale VA, Goutte C. Notch signaling without the APH-2/nicastrin subunit of gamma secretase in Caenorhabditis elegans germline stem cells. Genetics. 2024 Jul 08; 227(3).
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Sah S, Keable R, Pfundstein G, Clemens KJ, Begg D, Schachner M, Leshchyns'ka I, Sytnyk V. Deficiency in the neural cell adhesion molecule 2 (NCAM2) reduces axonal levels of beta-site amyloid precursor protein cleaving enzyme 1 (BACE1), affects axonal organization in the hippocampus, and leads to behavioral deficits. Cereb Cortex. 2023 09 09; 33(18):10047-10065.
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Vladar EK, Kunimoto K, Rojas-Hernandez LS, Spano JM, Sellers ZM, Joo NS, Cooney RA, Axelrod JD, Milla CE. Notch signaling inactivation by small molecule ?-secretase inhibitors restores the multiciliated cell population in the airway epithelium. Am J Physiol Lung Cell Mol Physiol. 2023 06 01; 324(6):L771-L782.
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Gounder M, Ratan R, Alcindor T, Schöffski P, van der Graaf WT, Wilky BA, Riedel RF, Lim A, Smith LM, Moody S, Attia S, Chawla S, D'Amato G, Federman N, Merriam P, Van Tine BA, Vincenzi B, Benson C, Bui NQ, Chugh R, Tinoco G, Charlson J, Dileo P, Hartner L, Lapeire L, Mazzeo F, Palmerini E, Reichardt P, Stacchiotti S, Bailey HH, Burgess MA, Cote GM, Davis LE, Deshpande H, Gelderblom H, Grignani G, Loggers E, Philip T, Pressey JG, Kummar S, Kasper B. Nirogacestat, a ?-Secretase Inhibitor for Desmoid Tumors. N Engl J Med. 2023 03 09; 388(10):898-912.
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Basak JM, Falk M, Mitchell DN, Coakley KA, Quillinan N, Orfila JE, Herson PS. Targeting BACE1-mediated production of amyloid beta improves hippocampal synaptic function in an experimental model of ischemic stroke. J Cereb Blood Flow Metab. 2023 11; 43(2_suppl):66-77.
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Tyagi A, Musa M, Labeikovsky W, Pugazhenthi S. Sirt3 deficiency induced down regulation of insulin degrading enzyme in comorbid Alzheimer's disease with metabolic syndrome. Sci Rep. 2022 11 17; 12(1):19808.
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Keable R, Hu S, Pfundstein G, Kozlova I, Su F, Du X, Yang H, Gunnersen J, Schachner M, Leshchyns'ka I, Sytnyk V. The BACE1-generated C-terminal fragment of the neural cell adhesion molecule 2 (NCAM2) promotes BACE1 targeting to Rab11-positive endosomes. Cell Mol Life Sci. 2022 Oct 17; 79(11):555.
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Mueller AC, Piper M, Goodspeed A, Bhuvane S, Williams JS, Bhatia S, Phan AV, Van Court B, Zolman KL, Peña B, Oweida AJ, Zakem S, Meguid C, Knitz MW, Darragh L, Bickett TE, Gadwa J, Mestroni L, Taylor MRG, Jordan KR, Dempsey P, Lucia MS, McCarter MD, Del Chiaro M, Messersmith WA, Schulick RD, Goodman KA, Gough MJ, Greene CS, Costello JC, Neto AG, Lagares D, Hansen KC, Van Bokhoven A, Karam SD. Induction of ADAM10 by Radiation Therapy Drives Fibrosis, Resistance, and Epithelial-to-Mesenchyal Transition in Pancreatic Cancer. Cancer Res. 2021 06 15; 81(12):3255-3269.
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