 Zinc Transporter 8
"Zinc Transporter 8" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A zinc efflux transporter highly expressed by ISLET CELLS of the pancreas. It functions in the accumulation of zinc in intracellular vesicles and may be involved in INSULIN maturation and storage processes. Variations in the SLC30A8 gene are associated with susceptibility to DIABETES MELLITUS, TYPE 2.
| Descriptor ID |
D000075703
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| MeSH Number(s) |
D12.776.157.530.450.250.940 D12.776.157.530.937.952 D12.776.543.585.450.250.945 D12.776.543.585.937.975
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| Concept/Terms |
Zinc Transporter 8- Zinc Transporter 8
- ZnT-8 Protein
- ZnT 8 Protein
- Slc30A8 Protein
- Solute Carrier Family 30 Member 8 Protein
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Below are MeSH descriptors whose meaning is more general than "Zinc Transporter 8".
Below are MeSH descriptors whose meaning is more specific than "Zinc Transporter 8".
This graph shows the total number of publications written about "Zinc Transporter 8" by people in this website by year, and whether "Zinc Transporter 8" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 0 | 1 | 1 | | 2008 | 0 | 5 | 5 | | 2009 | 0 | 3 | 3 | | 2010 | 0 | 3 | 3 | | 2011 | 0 | 6 | 6 | | 2012 | 0 | 3 | 3 | | 2013 | 0 | 3 | 3 | | 2014 | 0 | 2 | 2 | | 2015 | 0 | 3 | 3 | | 2016 | 0 | 1 | 1 | | 2017 | 0 | 3 | 3 | | 2018 | 1 | 0 | 1 | | 2019 | 1 | 0 | 1 | | 2020 | 0 | 1 | 1 | | 2021 | 3 | 0 | 3 | | 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Zinc Transporter 8" by people in Profiles.
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Kim YK, Walters JA, Moss ND, Wells KL, Sheridan R, Miranda JG, Benninger RKP, Pyle LL, O'Brien RM, Sussel L, Davidson HW. Zinc transporter 8 haploinsufficiency protects against beta cell dysfunction in type 1 diabetes by increasing mitochondrial respiration. Mol Metab. 2022 12; 66:101632.
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Jia X, He L, Miao D, Waugh K, Rasmussen CG, Dong F, Steck AK, Rewers M, Yu L. High-affinity ZnT8 Autoantibodies by Electrochemiluminescence Assay Improve Risk Prediction for Type 1 Diabetes. J Clin Endocrinol Metab. 2021 11 19; 106(12):3455-3463.
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Bediaga NG, Li-Wai-Suen CSN, Haller MJ, Gitelman SE, Evans-Molina C, Gottlieb PA, Hippich M, Ziegler AG, Lernmark A, DiMeglio LA, Wherrett DK, Colman PG, Harrison LC, Wentworth JM. Simplifying prediction of disease progression in pre-symptomatic type 1 diabetes using a single blood sample. Diabetologia. 2021 11; 64(11):2432-2444.
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Gu Y, Merriman C, Guo Z, Jia X, Wenzlau J, Li H, Li H, Rewers M, Yu L, Fu D. Novel autoantibodies to the ?-cell surface epitopes of ZnT8 in patients progressing to type-1 diabetes. J Autoimmun. 2021 08; 122:102677.
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Vehik K, Bonifacio E, Lernmark ?, Yu L, Williams A, Schatz D, Rewers M, She JX, Toppari J, Hagopian W, Akolkar B, Ziegler AG, Krischer JP. Hierarchical Order of Distinct Autoantibody Spreading and Progression to Type 1 Diabetes in the TEDDY Study. Diabetes Care. 2020 09; 43(9):2066-2073.
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Bosma KJ, Syring KE, Oeser JK, Lee JD, Benninger RKP, Pamenter ME, O'Brien RM. Evidence that Evolution of the Diabetes Susceptibility Gene SLC30A8 that Encodes the Zinc Transporter ZnT8 Drives Variations in Pancreatic Islet Zinc Content in Multiple Species. J Mol Evol. 2019 07; 87(4-6):147-151.
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Long AE, Wilson IV, Becker DJ, Libman IM, Arena VC, Wong FS, Steck AK, Rewers MJ, Yu L, Achenbach P, Casas R, Ludvigsson J, Williams AJK, Gillespie KM. Characteristics of slow progression to diabetes in multiple islet autoantibody-positive individuals from five longitudinal cohorts: the SNAIL study. Diabetologia. 2018 06; 61(6):1484-1490.
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Yu L, Zhao Z, Steck AK. T1D Autoantibodies: room for improvement? Curr Opin Endocrinol Diabetes Obes. 2017 Aug; 24(4):285-291.
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Steck AK, Xu P, Geyer S, Redondo MJ, Antinozzi P, Wentworth JM, Sosenko J, Onengut-Gumuscu S, Chen WM, Rich SS, Pugliese A. Can Non-HLA Single Nucleotide Polymorphisms Help Stratify Risk in TrialNet Relatives at Risk for Type 1 Diabetes? J Clin Endocrinol Metab. 2017 08 01; 102(8):2873-2880.
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Bosi E, Boulware DC, Becker DJ, Buckner JH, Geyer S, Gottlieb PA, Henderson C, Kinderman A, Sosenko JM, Steck AK, Bingley PJ. Impact of Age and Antibody Type on Progression From Single to Multiple Autoantibodies in Type 1 Diabetes Relatives. J Clin Endocrinol Metab. 2017 08 01; 102(8):2881-2886.
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