 Sodium-Coupled Vitamin C Transporters
"Sodium-Coupled Vitamin C Transporters" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Membrane transport proteins that actively co-transport ASCORBIC ACID and sodium ions across the CELL MEMBRANE. Dietary absorption of VITAMIN C is highly dependent upon this class of transporters and a subset of SODIUM GLUCOSE TRANSPORTERS which transport the oxidized form of vitamin C, DEHYDROASCORBIC ACID.
| Descriptor ID |
D060347
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| MeSH Number(s) |
D12.776.157.530.450.074.500.687.500 D12.776.157.530.450.625.405 D12.776.157.530.937.688 D12.776.543.585.450.074.500.812.500 D12.776.543.585.450.625.531 D12.776.543.585.937.813
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| Concept/Terms |
Sodium-Coupled Vitamin C Transporters- Sodium-Coupled Vitamin C Transporters
- Sodium Coupled Vitamin C Transporters
- Sodium-Dependent Vitamin C Transporter
- Sodium Dependent Vitamin C Transporter
Sodium-Dependent Vitamin C Transporter 1- Sodium-Dependent Vitamin C Transporter 1
- Sodium Dependent Vitamin C Transporter 1
- SVCT 1, Ascorbic Acid Transporter
- SLC23A1 Transporter
- Transporter, SLC23A1
- Solute Carrier Family 23 (Nucleobase Transporters), Member 1
Sodium-Dependent Vitamin C Transporter 2- Sodium-Dependent Vitamin C Transporter 2
- Sodium Dependent Vitamin C Transporter 2
- Solute Carrier Family 23 (Nucleobase Transporters), Member 2
- SVCT 2, Ascorbic Acid Transporter
- SLC23A2 Transporter
- Transporter, SLC23A2
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Below are MeSH descriptors whose meaning is more general than "Sodium-Coupled Vitamin C Transporters".
Below are MeSH descriptors whose meaning is more specific than "Sodium-Coupled Vitamin C Transporters".
This graph shows the total number of publications written about "Sodium-Coupled Vitamin C Transporters" by people in this website by year, and whether "Sodium-Coupled Vitamin C Transporters" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
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| 2002 | 0 | 2 | 2 | | 2004 | 0 | 2 | 2 | | 2005 | 0 | 1 | 1 | | 2008 | 0 | 1 | 1 | | 2009 | 0 | 1 | 1 | | 2010 | 0 | 1 | 1 | | 2016 | 1 | 0 | 1 |
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Below are the most recent publications written about "Sodium-Coupled Vitamin C Transporters" by people in Profiles.
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Eck PK, Corpe C, Levine MA. Temporo-spacial microanatomical distribution of the murine sodium-dependent ascorbic acid transporters Slc23a1 and Slc23a2 in the kidney throughout development. Biochem Cell Biol. 2017 06; 95(3):421-427.
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Corpe CP, Tu H, Eck P, Wang J, Faulhaber-Walter R, Schnermann J, Margolis S, Padayatty S, Sun H, Wang Y, Nussbaum RL, Espey MG, Levine M. Vitamin C transporter Slc23a1 links renal reabsorption, vitamin C tissue accumulation, and perinatal survival in mice. J Clin Invest. 2010 Apr; 120(4):1069-83.
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Levine M, Espey MG, Chen Q. Losing and finding a way at C: new promise for pharmacologic ascorbate in cancer treatment. Free Radic Biol Med. 2009 Jul 01; 47(1):27-9.
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Erichsen HC, Peters U, Eck P, Welch R, Schoen RE, Yeager M, Levine M, Hayes RB, Chanock S. Genetic variation in sodium-dependent vitamin C transporters SLC23A1 and SLC23A2 and risk of advanced colorectal adenoma. Nutr Cancer. 2008; 60(5):652-9.
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Erichsen HC, Engel SA, Eck PK, Welch R, Yeager M, Levine M, Siega-Riz AM, Olshan AF, Chanock SJ. Genetic variation in the sodium-dependent vitamin C transporters, SLC23A1, and SLC23A2 and risk for preterm delivery. Am J Epidemiol. 2006 Feb 01; 163(3):245-54.
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Corpe CP, Lee JH, Kwon O, Eck P, Narayanan J, Kirk KL, Levine M. 6-Bromo-6-deoxy-L-ascorbic acid: an ascorbate analog specific for Na+-dependent vitamin C transporter but not glucose transporter pathways. J Biol Chem. 2005 Feb 18; 280(7):5211-20.
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Eck P, Erichsen HC, Taylor JG, Yeager M, Hughes AL, Levine M, Chanock S. Comparison of the genomic structure and variation in the two human sodium-dependent vitamin C transporters, SLC23A1 and SLC23A2. Hum Genet. 2004 Sep; 115(4):285-94.
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Sotiriou S, Gispert S, Cheng J, Wang Y, Chen A, Hoogstraten-Miller S, Miller GF, Kwon O, Levine M, Guttentag SH, Nussbaum RL. Ascorbic-acid transporter Slc23a1 is essential for vitamin C transport into the brain and for perinatal survival. Nat Med. 2002 May; 8(5):514-7.
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Song J, Kwon O, Chen S, Daruwala R, Eck P, Park JB, Levine M. Flavonoid inhibition of sodium-dependent vitamin C transporter 1 (SVCT1) and glucose transporter isoform 2 (GLUT2), intestinal transporters for vitamin C and Glucose. J Biol Chem. 2002 May 03; 277(18):15252-60.
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