 Alarmins
"Alarmins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A structurally diverse group of endogenous molecules that are multifunctional, having physiological functions inside the cell, but when released from dying cells or from cells under stress or certain immune cells, they function to activate INNATE IMMUNITY. Uncontrolled and excessive release of alarmins may contribute to INFLAMMATION; CARCINOGENESIS, and NEOPLASM METASTASIS. Alarmins are also critical for heart and nerve tissue homeostasis.
| Descriptor ID |
D000067531
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| MeSH Number(s) |
D23.035
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| Concept/Terms |
Alarmins- Alarmins
- Damage-Associated Molecular Pattern Molecules
- Damage Associated Molecular Pattern Molecules
- Danger-Associated Molecular Pattern Molecules
- Danger Associated Molecular Pattern Molecules
- Alarmin Proteins
- Alarmin
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Below are MeSH descriptors whose meaning is more general than "Alarmins".
Below are MeSH descriptors whose meaning is more specific than "Alarmins".
This graph shows the total number of publications written about "Alarmins" by people in this website by year, and whether "Alarmins" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2015 | 2 | 1 | 3 | | 2016 | 0 | 1 | 1 | | 2017 | 3 | 0 | 3 | | 2018 | 1 | 2 | 3 | | 2019 | 1 | 1 | 2 | | 2021 | 0 | 1 | 1 | | 2022 | 0 | 1 | 1 | | 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "Alarmins" by people in Profiles.
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Poole JA, England BR, Sayles H, Johnson TM, Duryee MJ, Hunter CD, Baker JF, Kerr GS, Kunkel G, Cannon GW, Sauer BC, Wysham KD, Joseph AM, Wallace BI, Thiele GM, Mikuls TR. Serum alarmins and the risk of incident interstitial lung disease in rheumatoid arthritis. Rheumatology (Oxford). 2024 07 01; 63(7):1998-2005.
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Song NJ, Allen C, Vilgelm AE, Riesenberg BP, Weller KP, Reynolds K, Chakravarthy KB, Kumar A, Khatiwada A, Sun Z, Ma A, Chang Y, Yusuf M, Li A, Zeng C, Evans JP, Bucci D, Gunasena M, Xu M, Liyanage NPM, Bolyard C, Velegraki M, Liu SL, Ma Q, Devenport M, Liu Y, Zheng P, Malvestutto CD, Chung D, Li Z. Treatment with soluble CD24 attenuates COVID-19-associated systemic immunopathology. J Hematol Oncol. 2022 01 10; 15(1):5.
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Shotland AM, Fontenot AP, McKee AS. Pulmonary Macrophage Cell Death in Lung Health and Disease. Am J Respir Cell Mol Biol. 2021 05; 64(5):547-556.
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Ramaswamy A, Brodsky NN, Sumida TS, Comi M, Asashima H, Hoehn KB, Li N, Liu Y, Shah A, Ravindra NG, Bishai J, Khan A, Lau W, Sellers B, Bansal N, Guerrerio P, Unterman A, Habet V, Rice AJ, Catanzaro J, Chandnani H, Lopez M, Kaminski N, Dela Cruz CS, Tsang JS, Wang Z, Yan X, Kleinstein SH, van Dijk D, Pierce RW, Hafler DA, Lucas CL. Immune dysregulation and autoreactivity correlate with disease severity in SARS-CoV-2-associated multisystem inflammatory syndrome in children. Immunity. 2021 05 11; 54(5):1083-1095.e7.
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Amer LD, Saleh LS, Walker C, Thomas S, Janssen WJ, Alper S, Bryant SJ. Inflammation via myeloid differentiation primary response gene 88 signaling mediates the fibrotic response to implantable synthetic poly(ethylene glycol) hydrogels. Acta Biomater. 2019 12; 100:105-117.
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Carter DW, Prudovsky I, Kacer D, Soul T, Kumpel C, Pyburn K, Palmeri M, Kramer R, Rappold J. Tranexamic acid suppresses the release of mitochondrial DAMPs and reduces lung inflammation in a murine burn model. J Trauma Acute Care Surg. 2019 04; 86(4):617-624.
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Voronov E, Dinarello CA, Apte RN. Interleukin-1a as an intracellular alarmin in cancer biology. Semin Immunol. 2018 08; 38:3-14.
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Walker MM, Crute BW, Cambier JC, Getahun A. B Cell-Intrinsic STING Signaling Triggers Cell Activation, Synergizes with B Cell Receptor Signals, and Promotes Antibody Responses. J Immunol. 2018 11 01; 201(9):2641-2653.
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Frank MG, Fonken LK, Dolzani SD, Annis JL, Siebler PH, Schmidt D, Watkins LR, Maier SF, Lowry CA. Immunization with Mycobacterium vaccae induces an anti-inflammatory milieu in the CNS: Attenuation of stress-induced microglial priming, alarmins and anxiety-like behavior. Brain Behav Immun. 2018 10; 73:352-363.
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Grace PM, Strand KA, Galer EL, Rice KC, Maier SF, Watkins LR. Protraction of neuropathic pain by morphine is mediated by spinal damage associated molecular patterns (DAMPs) in male rats. Brain Behav Immun. 2018 08; 72:45-50.
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