 N-Acetylmuramoyl-L-alanine Amidase
"N-Acetylmuramoyl-L-alanine Amidase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An autolytic enzyme bound to the surface of bacterial cell walls. It catalyzes the hydrolysis of the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell wall glycopeptides, particularly peptidoglycan. EC 3.5.1.28.
| Descriptor ID |
D009238
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| MeSH Number(s) |
D08.811.277.087.030
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| Concept/Terms |
N-Acetylmuramoyl-L-alanine Amidase- N-Acetylmuramoyl-L-alanine Amidase
- Amidase, N-Acetylmuramoyl-L-alanine
- N Acetylmuramoyl L alanine Amidase
- Mucopeptide Amidohydrolase
- Amidohydrolase, Mucopeptide
- Peptidoglycan Hydrolase
- Hydrolase, Peptidoglycan
- LE-Enzyme
- LE Enzyme
- Murein Hydrolase
- Hydrolase, Murein
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Below are MeSH descriptors whose meaning is more general than "N-Acetylmuramoyl-L-alanine Amidase".
Below are MeSH descriptors whose meaning is more specific than "N-Acetylmuramoyl-L-alanine Amidase".
This graph shows the total number of publications written about "N-Acetylmuramoyl-L-alanine Amidase" by people in this website by year, and whether "N-Acetylmuramoyl-L-alanine Amidase" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 | | 2004 | 1 | 0 | 1 | | 2007 | 1 | 0 | 1 | | 2009 | 1 | 1 | 2 | | 2016 | 1 | 0 | 1 | | 2017 | 1 | 0 | 1 | | 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "N-Acetylmuramoyl-L-alanine Amidase" by people in Profiles.
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Sobieraj AM, Huemer M, Zinsli LV, Meile S, Keller AP, R?hrig C, Eichenseher F, Shen Y, Zinkernagel AS, Loessner MJ, Schmelcher M. Engineering of Long-Circulating Peptidoglycan Hydrolases Enables Efficient Treatment of Systemic Staphylococcus aureus Infection. mBio. 2020 09 22; 11(5).
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Verbree CT, D?twyler SM, Meile S, Eichenseher F, Donovan DM, Loessner MJ, Schmelcher M. Identification of Peptidoglycan Hydrolase Constructs with Synergistic Staphylolytic Activity in Cow's Milk. Appl Environ Microbiol. 2017 04 01; 83(7).
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Becker SC, Roach DR, Chauhan VS, Shen Y, Foster-Frey J, Powell AM, Bauchan G, Lease RA, Mohammadi H, Harty WJ, Simmons C, Schmelcher M, Camp M, Dong S, Baker JR, Sheen TR, Doran KS, Pritchard DG, Almeida RA, Nelson DC, Marriott I, Lee JC, Donovan DM. Triple-acting Lytic Enzyme Treatment of Drug-Resistant and Intracellular Staphylococcus aureus. Sci Rep. 2016 04 28; 6:25063.
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Hwang J, Kim HS. Cell Wall Recycling-Linked Coregulation of AmpC and PenB ?-Lactamases through ampD Mutations in Burkholderia cenocepacia. Antimicrob Agents Chemother. 2015 Dec; 59(12):7602-10.
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Lauderdale KJ, Boles BR, Cheung AL, Horswill AR. Interconnections between Sigma B, agr, and proteolytic activity in Staphylococcus aureus biofilm maturation. Infect Immun. 2009 Apr; 77(4):1623-35.
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Humann J, Lenz LL. Bacterial peptidoglycan degrading enzymes and their impact on host muropeptide detection. J Innate Immun. 2009; 1(2):88-97.
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Humann J, Bjordahl R, Andreasen K, Lenz LL. Expression of the p60 autolysin enhances NK cell activation and is required for listeria monocytogenes expansion in IFN-gamma-responsive mice. J Immunol. 2007 Feb 15; 178(4):2407-14.
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Deng LL, Humphries DE, Arbeit RD, Carlton LE, Smole SC, Carroll JD. Identification of a novel peptidoglycan hydrolase CwlM in Mycobacterium tuberculosis. Biochim Biophys Acta. 2005 Feb 14; 1747(1):57-66.
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Lenz LL, Mohammadi S, Geissler A, Portnoy DA. SecA2-dependent secretion of autolytic enzymes promotes Listeria monocytogenes pathogenesis. Proc Natl Acad Sci U S A. 2003 Oct 14; 100(21):12432-7.
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