 Asparaginase
"Asparaginase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A hydrolase enzyme that converts L-asparagine and water to L-aspartate and NH3. EC 3.5.1.1.
| Descriptor ID |
D001215
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| MeSH Number(s) |
D08.811.277.087.116
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| Concept/Terms |
Asparaginase- Asparaginase
- Asparagine Deaminase
- Deaminase, Asparagine
- Colaspase
- Asparaginase II
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Below are MeSH descriptors whose meaning is more general than "Asparaginase".
Below are MeSH descriptors whose meaning is more specific than "Asparaginase".
This graph shows the total number of publications written about "Asparaginase" by people in this website by year, and whether "Asparaginase" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 2 | 1 | 3 | | 2000 | 1 | 0 | 1 | | 2001 | 1 | 1 | 2 | | 2006 | 0 | 1 | 1 | | 2010 | 1 | 0 | 1 | | 2014 | 1 | 1 | 2 | | 2015 | 1 | 0 | 1 | | 2016 | 1 | 3 | 4 | | 2017 | 1 | 1 | 2 | | 2018 | 0 | 1 | 1 | | 2020 | 3 | 1 | 4 | | 2021 | 0 | 1 | 1 | | 2024 | 1 | 1 | 2 | | 2025 | 1 | 0 | 1 | | 2026 | 1 | 1 | 2 |
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Below are the most recent publications written about "Asparaginase" by people in Profiles.
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Locatelli F, Karakukcu M, Huynh V, González-Martínez B, Lins MM, Lu MY, Sulis ML, Pauly M, Morris C, Braunlin M, Talpes M, Gore L. Carfilzomib plus induction chemotherapy for children with relapsed or refractory acute lymphoblastic leukemia. Blood Adv. 2026 Oct 13; 10(19):6567-6577.
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Ali A, Elsey G, Fulginiti K, Kanani-Bradley Z, Kubaney HR, Kurtin S, Nguyen T, Turchina J, Wagner CB. Navigating Asparaginase Treatment for Patients With Acute Lymphoblastic Leukemia: US Consensus Panel Recommendations on the Role of Multidisciplinary Care. Am J Hematol. 2026 Nov; 101(11):2713-2725.
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Murphy LA, Bradley ZK, Elozory AN, Gao D, Faulk KE. Universal Premedication Does Not Impact Transition to Short-acting Asparaginase or Incidence of Hypersensitivity to Pegylated Asparaginase: A Single-institution Experience. J Pediatr Hematol Oncol. 2025 07 01; 47(5):e181-e186.
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Parker AS, Burton JH, Curran KM, Wolf-Ringwall A, Thamm DH. Early progression during or after cyclophosphamide, doxorubicin, vincristine, and prednisone chemotherapy indicates poor outcome with rescue protocols in dogs with multicentric lymphoma. J Vet Intern Med. 2024 Jul-Aug; 38(4):2282-2292.
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Gilje EA, Cho C. Multiple reactions during desensitization and predicting decreased efficacy of pegaspargase chemotherapy. Ann Allergy Asthma Immunol. 2024 08; 133(2):219-220.
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Rush C, Faulk KE, Bradley ZK, Turner A, Krumins M, Greenhawt M. The safety of SARS-CoV-2 vaccines in persons with a known history of pegaspargase allergy: A single institution experience. J Allergy Clin Immunol Pract. 2022 02; 10(2):630-632.
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George G, Rezazadeh A, Zook F, Pearl N, McCoy C, Carlson K, Runaas L, Abedin S, Guru Murthy GS, Michaelis LC, Atallah E, Baumann-Kreuziger L. Reducing venous thrombosis with antithrombin supplementation in patients undergoing treatment for ALL with Peg-asparaginase-A real world study. Leuk Res. 2020 07; 94:106368.
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Gupta S, Wang C, Raetz EA, Schore R, Salzer WL, Larsen EC, Maloney KW, Mattano LA, Carroll WL, Winick NJ, Hunger SP, Loh ML, Devidas M. Impact of Asparaginase Discontinuation on Outcome in Childhood Acute Lymphoblastic Leukemia: A Report From the Children's Oncology Group. J Clin Oncol. 2020 06 10; 38(17):1897-1905.
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Cawley JR, Wright ZM, Meleo K, Post GS, Clifford CA, Vickery KR, Vail DM, Bergman PJ, Thamm DH. Concurrent use of rabacfosadine and L-asparaginase for relapsed or refractory multicentric lymphoma in dogs. J Vet Intern Med. 2020 Mar; 34(2):882-889.
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Burke MJ, Kostadinov R, Sposto R, Gore L, Kelley SM, Rabik C, Trepel JB, Lee MJ, Yuno A, Lee S, Bhojwani D, Jeha S, Chang BH, Sulis ML, Hermiston ML, Gaynon P, Huynh V, Verma A, Gardner R, Heym KM, Dennis RM, Ziegler DS, Laetsch TW, Oesterheld JE, Dubois SG, Pollard JA, Glade-Bender J, Cooper TM, Kaplan JA, Farooqi MS, Yoo B, Guest E, Wayne AS, Brown PA. Decitabine and Vorinostat with Chemotherapy in Relapsed Pediatric Acute Lymphoblastic Leukemia: A TACL Pilot Study. Clin Cancer Res. 2020 05 15; 26(10):2297-2307.
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