 Sodium Channel Blockers
"Sodium Channel Blockers" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A class of drugs that act by inhibition of sodium influx through cell membranes. Blockade of sodium channels slows the rate and amplitude of initial rapid depolarization, reduces cell excitability, and reduces conduction velocity.
| Descriptor ID |
D026941
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| MeSH Number(s) |
D27.505.519.562.750 D27.505.954.411.720
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| Concept/Terms |
Sodium Channel Blockers- Sodium Channel Blockers
- Sodium Channel Inhibitors
- Channel Inhibitors, Sodium
- Inhibitors, Sodium Channel
- Channel Blockers, Sodium
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Below are MeSH descriptors whose meaning is more general than "Sodium Channel Blockers".
Below are MeSH descriptors whose meaning is more specific than "Sodium Channel Blockers".
This graph shows the total number of publications written about "Sodium Channel Blockers" by people in this website by year, and whether "Sodium Channel Blockers" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 | | 2001 | 0 | 1 | 1 | | 2005 | 0 | 1 | 1 | | 2006 | 0 | 1 | 1 | | 2008 | 1 | 0 | 1 | | 2009 | 0 | 1 | 1 | | 2010 | 0 | 1 | 1 | | 2012 | 0 | 2 | 2 | | 2014 | 0 | 2 | 2 | | 2015 | 1 | 0 | 1 | | 2016 | 0 | 2 | 2 | | 2017 | 1 | 0 | 1 | | 2020 | 1 | 0 | 1 | | 2021 | 1 | 1 | 2 |
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Below are the most recent publications written about "Sodium Channel Blockers" by people in Profiles.
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Isom LL, Knupp KG. Dravet Syndrome: Novel Approaches for the Most Common Genetic Epilepsy. Neurotherapeutics. 2021 07; 18(3):1524-1534.
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Aledo-Serrano ?, G?mez-Iglesias P, Toledano R, Garcia-Pe?as JJ, Garcia-Morales I, Anciones C, Soto-Insuga V, Benke TA, Del Pino I, Gil-Nagel A. Sodium channel blockers for the treatment of epilepsy in CDKL5 deficiency disorder: Findings from a multicenter cohort. Epilepsy Behav. 2021 05; 118:107946.
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Meredith FL, Rennie KJ. Persistent and resurgent Na+ currents in vestibular calyx afferents. J Neurophysiol. 2020 08 01; 124(2):510-524.
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Coppini R, Mazzoni L, Ferrantini C, Gentile F, Pioner JM, Laurino A, Santini L, Bargelli V, Rotellini M, Bartolucci G, Crocini C, Sacconi L, Tesi C, Belardinelli L, Tardiff J, Mugelli A, Olivotto I, Cerbai E, Poggesi C. Ranolazine Prevents Phenotype Development in a Mouse Model of Hypertrophic Cardiomyopathy. Circ Heart Fail. 2017 03; 10(3).
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Ishiwata T, Oshimoto A, Saito T, Kotani Y, Nomoto S, Aihara Y, Hasegawa H, Greenwood BN. Possible mechanisms of hypothermia after inhibition of the median or dorsal raphe nucleus of freely moving rats. Neuroreport. 2016 Dec 07; 27(17):1287-1292.
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Tabakoff B, Ren W, Vanderlinden L, Snell LD, Matheson CJ, Wang ZJ, Levinson R, Smothers CT, Woodward JJ, Honse Y, Lovinger D, Rush AM, Sather WA, Gustafson DL, Hoffman PL. A novel substituted aminoquinoline selectively targets voltage-sensitive sodium channel isoforms and NMDA receptor subtypes and alleviates chronic inflammatory and neuropathic pain. Eur J Pharmacol. 2016 Aug 05; 784:1-14.
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Pettus J, McNabb B, Eckel RH, Skyler JS, Dhalla A, Guan S, Jochelson P, Belardinelli L, Henry RH. Effect of ranolazine on glycaemic control in patients with type 2 diabetes treated with either glimepiride or metformin. Diabetes Obes Metab. 2016 May; 18(5):463-74.
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Wang ZJ, Tabakoff B, Levinson SR, Heinbockel T. Inhibition of Nav1.7 channels by methyl eugenol as a mechanism underlying its antinociceptive and anesthetic actions. Acta Pharmacol Sin. 2015 Jul; 36(7):791-9.
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Chua-Tuan JL, Cao D, Iwanicki JL, Hoyte CO. Cardiac sodium channel blockade after an intentional ingestion of lacosamide, cyclobenzaprine, and levetiracetam: Case report. Clin Toxicol (Phila). 2015 Jul; 53(6):565-8.
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Bortz DM, J?rgensen CV, Mikkelsen JD, Bruno JP. Transient inactivation of the ventral hippocampus in neonatal rats impairs the mesolimbic regulation of prefrontal glutamate release in?adulthood. Neuropharmacology. 2014 Sep; 84:19-30.
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