 Levodopa
"Levodopa" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can be taken orally and crosses the blood-brain barrier. It is rapidly taken up by dopaminergic neurons and converted to DOPAMINE. It is used for the treatment of PARKINSONIAN DISORDERS and is usually given with agents that inhibit its conversion to dopamine outside of the central nervous system.
| Descriptor ID |
D007980
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| MeSH Number(s) |
D02.092.311.200.480 D12.125.072.050.685.400.500 D12.125.072.050.875.130.500
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| Concept/Terms |
Levodopa- Levodopa
- L-Dopa
- L Dopa
- 3-Hydroxy-L-tyrosine
- 3 Hydroxy L tyrosine
- L-3,4-Dihydroxyphenylalanine
- L 3,4 Dihydroxyphenylalanine
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Below are MeSH descriptors whose meaning is more general than "Levodopa".
Below are MeSH descriptors whose meaning is more specific than "Levodopa".
This graph shows the total number of publications written about "Levodopa" by people in this website by year, and whether "Levodopa" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 1 | 2 | | 2000 | 1 | 0 | 1 | | 2002 | 0 | 1 | 1 | | 2003 | 0 | 1 | 1 | | 2004 | 1 | 1 | 2 | | 2005 | 1 | 0 | 1 | | 2006 | 0 | 1 | 1 | | 2007 | 1 | 0 | 1 | | 2011 | 1 | 0 | 1 | | 2012 | 1 | 1 | 2 | | 2013 | 1 | 0 | 1 | | 2014 | 1 | 0 | 1 | | 2016 | 0 | 1 | 1 | | 2017 | 1 | 1 | 2 | | 2018 | 0 | 1 | 1 | | 2022 | 0 | 1 | 1 | | 2024 | 2 | 0 | 2 |
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Below are the most recent publications written about "Levodopa" by people in Profiles.
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Nielsen BE, Ford CP. Reduced striatal M4-cholinergic signaling following dopamine loss contributes to parkinsonian and l-DOPA-induced dyskinetic behaviors. Sci Adv. 2024 Nov 22; 10(47):eadp6301.
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Ryan MB, Girasole AE, Flores AJ, Twedell EL, McGregor MM, Brakaj R, Paletzki RF, Hnasko TS, Gerfen CR, Nelson AB. Excessive firing of dyskinesia-associated striatal direct pathway neurons is gated by dopamine and excitatory synaptic input. Cell Rep. 2024 08 27; 43(8):114483.
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Khawaldeh S, Tinkhauser G, Torrecillos F, He S, Foltynie T, Limousin P, Zrinzo L, Oswal A, Quinn AJ, Vidaurre D, Tan H, Litvak V, K?hn A, Woolrich M, Brown P. Balance between competing spectral states in subthalamic nucleus is linked to motor impairment in Parkinson's disease. Brain. 2022 03 29; 145(1):237-250.
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Lloyd JT, Yee AG, Kalligappa PK, Jabed A, Cheung PY, Todd KL, Karunasinghe RN, Vlajkovic SM, Freestone PS, Lipski J. Dopamine Dysregulation and Altered Responses to Drugs Affecting Dopaminergic Transmission in a New Dopamine Transporter Knockout (DAT-KO) Rat Model. Neuroscience. 2022 05 21; 491:43-64.
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Sharma A, Vidaurre D, Vesper J, Schnitzler A, Florin E. Differential dopaminergic modulation of spontaneous cortico-subthalamic activity in Parkinson's disease. Elife. 2021 06 04; 10.
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Kim MK, Aung MH, Mees L, Olson DE, Pozdeyev N, Iuvone PM, Thule PM, Pardue MT. Dopamine Deficiency Mediates Early Rod-Driven Inner Retinal Dysfunction in Diabetic Mice. Invest Ophthalmol Vis Sci. 2018 01 01; 59(1):572-581.
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Phillips A, Hoyte FCL, Leung DYM. Dystonia as an unusual presentation of systemic mastocytosis: Possible link between histamine release and movement disorders. J Allergy Clin Immunol Pract. 2018 Jan - Feb; 6(1):269-271.e1.
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Mohl B, Berman BD, Shelton E, Tanabe J. Levodopa response differs in Parkinson's motor subtypes: A task-based effective connectivity study. J Comp Neurol. 2017 Jun 15; 525(9):2192-2201.
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Berman BD, Smucny J, Wylie KP, Shelton E, Kronberg E, Leehey M, Tregellas JR. Levodopa modulates small-world architecture of functional brain networks in Parkinson's disease. Mov Disord. 2016 11; 31(11):1676-1684.
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Seeberger LC, Hauser RA. Carbidopa levodopa enteral suspension. Expert Opin Pharmacother. 2015; 16(18):2807-17.
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