 Cyclic Nucleotide Phosphodiesterases, Type 3
"Cyclic Nucleotide Phosphodiesterases, Type 3" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A cyclic nucleotide phosphodiesterase subfamily that is inhibited by the binding of CYCLIC GMP to an allosteric domain found on the enzyme and through phosphorylation by regulatory kinases such as PROTEIN KINASE A and PROTEIN KINASE B. The two members of this family are referred to as type 3A, and type 3B, and are each product of a distinct gene. In addition multiple enzyme variants of each subtype can be produced due to multiple alternative mRNA splicing.
| Descriptor ID |
D054684
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| MeSH Number(s) |
D08.811.277.352.640.150.300 D12.644.360.008.300 D12.776.476.008.300
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| Concept/Terms |
Cyclic Nucleotide Phosphodiesterases, Type 3- Cyclic Nucleotide Phosphodiesterases, Type 3
- cGMP-Inhibited Cyclic Nucleotide Phosphodiesterase
- cGMP Inhibited Cyclic Nucleotide Phosphodiesterase
- Cyclic Nucleotide Phosphodiesterase PDE3 Family
- Phosphodiesterase III
- cGMP-Inhibited Phosphodiesterase
- Phosphodiesterase, cGMP-Inhibited
- cGMP Inhibited Phosphodiesterase
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Below are MeSH descriptors whose meaning is more general than "Cyclic Nucleotide Phosphodiesterases, Type 3".
Below are MeSH descriptors whose meaning is more specific than "Cyclic Nucleotide Phosphodiesterases, Type 3".
This graph shows the total number of publications written about "Cyclic Nucleotide Phosphodiesterases, Type 3" by people in this website by year, and whether "Cyclic Nucleotide Phosphodiesterases, Type 3" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
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| 1996 | 0 | 1 | 1 | | 2006 | 0 | 1 | 1 | | 2015 | 1 | 0 | 1 | | 2019 | 0 | 1 | 1 | | 2023 | 1 | 0 | 1 |
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Below are the most recent publications written about "Cyclic Nucleotide Phosphodiesterases, Type 3" by people in Profiles.
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Skogestad J, Albert I, Hougen K, Lothe GB, Lunde M, Eken OS, Veras I, Huynh NTT, B?rstad M, Marshall S, Shen X, Louch WE, Robinson EL, Cleveland JC, Ambardekar AV, Schwisow JA, Jonas E, Calejo AI, Morth JP, Task?n K, Melleby AO, Lunde PK, Sjaastad I, Carlson CR, Aronsen JM. Disruption of Phosphodiesterase 3A Binding to SERCA2 Increases SERCA2 Activity and Reduces Mortality in Mice With Chronic Heart Failure. Circulation. 2023 04 18; 147(16):1221-1236.
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Sucharov CC, Nakano SJ, Slavov D, Schwisow JA, Rodriguez E, Nunley K, Medway A, Stafford N, Nelson P, McKinsey TA, Movsesian M, Minobe W, Carroll IA, Taylor MRG, Bristow MR. A PDE3A Promoter Polymorphism Regulates cAMP-Induced Transcriptional Activity in Failing Human Myocardium. J Am Coll Cardiol. 2019 03 19; 73(10):1173-1184.
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Ye H, Wang X, Sussman CR, Hopp K, Irazabal MV, Bakeberg JL, LaRiviere WB, Manganiello VC, Vorhees CV, Zhao H, Harris PC, van Deursen J, Ward CJ, Torres VE. Modulation of Polycystic Kidney Disease Severity by Phosphodiesterase 1 and 3 Subfamilies. J Am Soc Nephrol. 2016 05; 27(5):1312-20.
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Oikawa M, Wu M, Lim S, Knight WE, Miller CL, Cai Y, Lu Y, Blaxall BC, Takeishi Y, Abe J, Yan C. Cyclic nucleotide phosphodiesterase 3A1 protects the heart against ischemia-reperfusion injury. J Mol Cell Cardiol. 2013 Nov; 64:11-9.
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Willoughby D, Wong W, Schaack J, Scott JD, Cooper DM. An anchored PKA and PDE4 complex regulates subplasmalemmal cAMP dynamics. EMBO J. 2006 May 17; 25(10):2051-61.
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Kuhlenb?umer G, Berger K, Huge A, Lange E, Kessler C, John U, Funke H, Nabavi DG, St?gbauer F, Ringelstein EB, Stoll M. Evaluation of single nucleotide polymorphisms in the phosphodiesterase 4D gene (PDE4D) and their association with ischaemic stroke in a large German cohort. J Neurol Neurosurg Psychiatry. 2006 Apr; 77(4):521-4.
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Focaccio A, Peeters G, Movsesian M, Roden R, Eki Y, Krall J, Bristow MR. Mechanism of action of OPC-8490 in human ventricular myocardium. Circulation. 1996 Feb 15; 93(4):817-25.
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