 Cyclic Nucleotide Phosphodiesterases, Type 1
"Cyclic Nucleotide Phosphodiesterases, Type 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A CALCIUM and CALMODULIN-dependent cyclic nucleotide phosphodiesterase subfamily. The three members of this family are referred to as type 1A, type 1B, and type 1C and are each product of a distinct gene. In addition, multiple enzyme variants of each subtype can be produced due to multiple alternative mRNA splicing. Although the type 1 enzymes are classified as 3',5'-cyclic-AMP phosphodiesterases (EC 3.1.4.17), some members of this class have additional specificity for CYCLIC GMP.
| Descriptor ID |
D054677
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| MeSH Number(s) |
D08.811.277.352.640.150.100 D08.811.277.352.640.155.100 D12.644.360.008.100 D12.644.360.009.100 D12.776.476.008.100 D12.776.476.009.100
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| Concept/Terms |
Cyclic Nucleotide Phosphodiesterases, Type 1- Cyclic Nucleotide Phosphodiesterases, Type 1
- Calmodulin-Dependent cGMP Phosphodiesterase
- Calmodulin Dependent cGMP Phosphodiesterase
- Phosphodiesterase, Calmodulin-Dependent cGMP
- cGMP Phosphodiesterase, Calmodulin-Dependent
- Calcium-Calmodulin-Dependent Phosphodiesterase
- Calcium Calmodulin Dependent Phosphodiesterase
- Phosphodiesterase, Calcium-Calmodulin-Dependent
- Ca(2+)-CaM-Stimulated PDE
- Calcium-Calmodulin-Stimulated Cyclic AMP Phosphodiesterase
- Calcium Calmodulin Stimulated Cyclic AMP Phosphodiesterase
- Calmodulin-Dependent Phosphodiesterase
- Calmodulin Dependent Phosphodiesterase
- PDE1 Phosphodiesterases
- Phosphodiesterases, PDE1
- Cyclic Nucleotide Phosphodiesterase PDE1 Family
- Ca++ Calmodulin Dependent Cyclic AMP Phosphodiesterase
- Calmodulin Phosphodiesterase
- Ca-CaM-Phosphodiesterase
- Ca CaM Phosphodiesterase
- Cyclic Nucleotide Phosphodiesterases, Type I
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Below are MeSH descriptors whose meaning is more general than "Cyclic Nucleotide Phosphodiesterases, Type 1".
- Chemicals and Drugs [D]
- Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
- Hydrolases [D08.811.277]
- Esterases [D08.811.277.352]
- Phosphoric Diester Hydrolases [D08.811.277.352.640]
- 3',5'-Cyclic-AMP Phosphodiesterases [D08.811.277.352.640.150]
- Cyclic Nucleotide Phosphodiesterases, Type 1 [D08.811.277.352.640.150.100]
- 3',5'-Cyclic-GMP Phosphodiesterases [D08.811.277.352.640.155]
- Cyclic Nucleotide Phosphodiesterases, Type 1 [D08.811.277.352.640.155.100]
- Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
- Intracellular Signaling Peptides and Proteins [D12.644.360]
- 3',5'-Cyclic-AMP Phosphodiesterases [D12.644.360.008]
- Cyclic Nucleotide Phosphodiesterases, Type 1 [D12.644.360.008.100]
- 3',5'-Cyclic-GMP Phosphodiesterases [D12.644.360.009]
- Cyclic Nucleotide Phosphodiesterases, Type 1 [D12.644.360.009.100]
- Proteins [D12.776]
- Intracellular Signaling Peptides and Proteins [D12.776.476]
- 3',5'-Cyclic-AMP Phosphodiesterases [D12.776.476.008]
- Cyclic Nucleotide Phosphodiesterases, Type 1 [D12.776.476.008.100]
- 3',5'-Cyclic-GMP Phosphodiesterases [D12.776.476.009]
- Cyclic Nucleotide Phosphodiesterases, Type 1 [D12.776.476.009.100]
Below are MeSH descriptors whose meaning is more specific than "Cyclic Nucleotide Phosphodiesterases, Type 1".
This graph shows the total number of publications written about "Cyclic Nucleotide Phosphodiesterases, Type 1" by people in this website by year, and whether "Cyclic Nucleotide Phosphodiesterases, Type 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
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| 2008 | 0 | 1 | 1 | | 2015 | 1 | 0 | 1 | | 2016 | 1 | 0 | 1 |
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Below are the most recent publications written about "Cyclic Nucleotide Phosphodiesterases, Type 1" by people in Profiles.
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Zhang Y, Knight W, Chen S, Mohan A, Yan C. Multiprotein Complex With TRPC (Transient Receptor Potential-Canonical) Channel, PDE1C (Phosphodiesterase 1C), and A2R (Adenosine A2 Receptor) Plays a Critical Role in Regulating Cardiomyocyte cAMP and Survival. Circulation. 2018 10 30; 138(18):1988-2002.
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Antunes G, Roque AC, Simoes de Souza FM. Modelling intracellular competition for calcium: kinetic and thermodynamic control of different molecular modes of signal decoding. Sci Rep. 2016 Apr 01; 6:23730.
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Ye H, Wang X, Sussman CR, Hopp K, Irazabal MV, Bakeberg JL, LaRiviere WB, Manganiello VC, Vorhees CV, Zhao H, Harris PC, van Deursen J, Ward CJ, Torres VE. Modulation of Polycystic Kidney Disease Severity by Phosphodiesterase 1 and 3 Subfamilies. J Am Soc Nephrol. 2016 05; 27(5):1312-20.
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Movsesian M, Stehlik J, Vandeput F, Bristow MR. Phosphodiesterase inhibition in heart failure. Heart Fail Rev. 2009 Dec; 14(4):255-63.
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