 PrPC Proteins
"PrPC Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Normal cellular isoform of PRION PROTEINS encoded by a chromosomal gene and found in normal and scrapie-infected brain tissue, and other normal tissue. PrPC are protease-sensitive proteins whose function is unknown. Posttranslational modification of PrPC into PrPSC leads to infectivity.
| Descriptor ID |
D018621
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| MeSH Number(s) |
D12.776.785.340.500
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| Concept/Terms |
PrPC Proteins- PrPC Proteins
- PrP-sen
- PrP sen
- Cp 33-35
- Scrapie Amyloid Precursor Protein
- Cp33-35, Scrapie
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Below are MeSH descriptors whose meaning is more general than "PrPC Proteins".
Below are MeSH descriptors whose meaning is more specific than "PrPC Proteins".
This graph shows the total number of publications written about "PrPC Proteins" by people in this website by year, and whether "PrPC Proteins" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 1 | 1 | | 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "PrPC Proteins" by people in Profiles.
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McNulty EE, Nalls AV, Xun R, Denkers ND, Hoover EA, Mathiason CK. In vitro detection of haematogenous prions in white-tailed deer orally dosed with low concentrations of chronic wasting disease. J Gen Virol. 2020 03; 101(3):347-361.
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Bender H, Noyes N, Annis JL, Hitpas A, Mollnow L, Croak K, Kane S, Wagner K, Dow S, Zabel M. PrPC knockdown by liposome-siRNA-peptide complexes (LSPCs) prolongs survival and normal behavior of prion-infected mice immunotolerant to treatment. PLoS One. 2019; 14(7):e0219995.
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Bosque P. Molecular types of Creutzfeldt-Jakob disease: the strange diversity of prions. Neurology. 2005 Nov 22; 65(10):1520-1.
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Goldfarb LG, Haltia M, Brown P, Nieto A, Kovanen J, McCombie WR, Trapp S, Gajdusek DC. New mutation in scrapie amyloid precursor gene (at codon 178) in Finnish Creutzfeldt-Jakob kindred. Lancet. 1991 Feb 16; 337(8738):425.
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