 Myosin-Light-Chain Kinase
"Myosin-Light-Chain Kinase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that phosphorylates myosin light chains in the presence of ATP to yield myosin-light chain phosphate and ADP, and requires calcium and CALMODULIN. The 20-kDa light chain is phosphorylated more rapidly than any other acceptor, but light chains from other myosins and myosin itself can act as acceptors. The enzyme plays a central role in the regulation of smooth muscle contraction.
| Descriptor ID |
D009219
|
| MeSH Number(s) |
D08.811.913.696.620.682.700.125.500 D12.644.360.100.500 D12.776.476.100.500
|
| Concept/Terms |
Myosin-Light-Chain Kinase- Myosin-Light-Chain Kinase
- Kinase, Myosin-Light-Chain
- Myosin Light Chain Kinase
- Myosin Regulatory Light-Chain Kinase
- Myosin Regulatory Light Chain Kinase
- Myosin Kinase
- Kinase, Myosin
- Myosin LCK
- LCK, Myosin
|
Below are MeSH descriptors whose meaning is more general than "Myosin-Light-Chain Kinase".
Below are MeSH descriptors whose meaning is more specific than "Myosin-Light-Chain Kinase".
This graph shows the total number of publications written about "Myosin-Light-Chain Kinase" by people in this website by year, and whether "Myosin-Light-Chain Kinase" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 2 | 0 | 2 | | 2006 | 1 | 0 | 1 | | 2007 | 1 | 0 | 1 | | 2012 | 1 | 2 | 3 | | 2013 | 0 | 1 | 1 | | 2014 | 0 | 1 | 1 | | 2019 | 0 | 1 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Myosin-Light-Chain Kinase" by people in Profiles.
-
Iguchi N, D?nmez MI, Carrasco A, Wilcox DT, Pineda RH, Malykhina AP, Cost NG. Doxorubicin induces detrusor smooth muscle impairments through myosin dysregulation, leading to a risk of lower urinary tract dysfunction. Am J Physiol Renal Physiol. 2019 07 01; 317(1):F197-F206.
-
Lynn H, Sun X, Ayshiev D, Siegler JH, Rizzo AN, Karnes JH, Gonzales Garay M, Wang T, Casanova N, Camp SM, Ellis NA, Garcia JGN. Single nucleotide polymorphisms in the MYLKP1 pseudogene are associated with increased colon cancer risk in African Americans. PLoS One. 2018; 13(8):e0200916.
-
Karabina A, Kazmierczak K, Szczesna-Cordary D, Moore JR. Myosin regulatory light chain phosphorylation enhances cardiac ?-myosin in vitro motility under load. Arch Biochem Biophys. 2015 Aug 15; 580:14-21.
-
Chen MM, Zahs A, Brown MM, Ramirez L, Turner JR, Choudhry MA, Kovacs EJ. An alteration of the gut-liver axis drives pulmonary inflammation after intoxication and burn injury in mice. Am J Physiol Gastrointest Liver Physiol. 2014 Oct 01; 307(7):G711-8.
-
Belvitch P, Adyshev D, Elangovan VR, Brown ME, Naureckas C, Rizzo AN, Siegler JH, Garcia JG, Dudek SM. Proline-rich region of non-muscle myosin light chain kinase modulates kinase activity and endothelial cytoskeletal dynamics. Microvasc Res. 2014 Sep; 95:94-102.
-
Schnatwinkel C, Niswander L. Multiparametric image analysis of lung-branching morphogenesis. Dev Dyn. 2013 Jun; 242(6):622-37.
-
Warren SA, Briggs LE, Zeng H, Chuang J, Chang EI, Terada R, Li M, Swanson MS, Lecker SH, Willis MS, Spinale FG, Maupin-Furlowe J, McMullen JR, Moss RL, Kasahara H. Myosin light chain phosphorylation is critical for adaptation to cardiac stress. Circulation. 2012 Nov 27; 126(22):2575-88.
-
Zahs A, Bird MD, Ramirez L, Turner JR, Choudhry MA, Kovacs EJ. Inhibition of long myosin light-chain kinase activation alleviates intestinal damage after binge ethanol exposure and burn injury. Am J Physiol Gastrointest Liver Physiol. 2012 Sep 15; 303(6):G705-12.
-
Ziemba BP, Knight JD, Falke JJ. Assembly of membrane-bound protein complexes: detection and analysis by single molecule diffusion. Biochemistry. 2012 Feb 28; 51(8):1638-47.
-
Inoue T, Pecen P, Maddala R, Skiba NP, Pattabiraman PP, Epstein DL, Rao PV. Characterization of cytoskeleton-enriched protein fraction of the trabecular meshwork and ciliary muscle cells. Invest Ophthalmol Vis Sci. 2010 Dec; 51(12):6461-71.
|
People  People who have written about this concept. _
Similar Concepts
People who have written about this concept.
_
Top Journals
Top journals in which articles about this concept have been published.
|