 Elongation Factor 2 Kinase
"Elongation Factor 2 Kinase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A monomeric calcium-calmodulin-dependent protein kinase subtype that specifically phosphorylates PEPTIDE ELONGATION FACTOR 2. The enzyme lacks a phosphorylatable activation domain that can respond to CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE KINASE, however it is regulated by phosphorylation by PROTEIN KINASE A and through intramolecular autophosphorylation.
| Descriptor ID |
D054736
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| MeSH Number(s) |
D08.811.913.696.620.682.700.125.425 D12.644.360.100.425 D12.776.476.100.425
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| Concept/Terms |
Elongation Factor 2 Kinase- Elongation Factor 2 Kinase
- Protein Kinase CPK3
- Kinase CPK3, Protein
- Calcium-Calmodulin-Dependent Protein Kinase Type 3
- Calcium Calmodulin Dependent Protein Kinase Type 3
- Eukaryotic Elongation Factor-2 Kinase
- Eukaryotic Elongation Factor 2 Kinase
- CAM Kinase III
- Cam PK III
- E-2 Kinase
- E 2 Kinase
- eEF-2-Specific Ca and Calmodulin-Dependent Protein Kinase III
- eEF 2 Specific Ca and Calmodulin Dependent Protein Kinase III
- Calmodulin-Dependent Protein Kinase III
- Calmodulin Dependent Protein Kinase III
- EF-2 Kinase
- EF 2 Kinase
- Kinase, EF-2
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Below are MeSH descriptors whose meaning is more general than "Elongation Factor 2 Kinase".
Below are MeSH descriptors whose meaning is more specific than "Elongation Factor 2 Kinase".
This graph shows the total number of publications written about "Elongation Factor 2 Kinase" by people in this website by year, and whether "Elongation Factor 2 Kinase" was a major or minor topic of these publications.
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Below are the most recent publications written about "Elongation Factor 2 Kinase" by people in Profiles.
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Pires Da Silva J, Monceaux K, Guilbert A, Gressette M, Piquereau J, Novotova M, Ventura-Clapier R, Garnier A, Lemaire C. SIRT1 Protects the Heart from ER Stress-Induced Injury by Promoting eEF2K/eEF2-Dependent Autophagy. Cells. 2020 02 12; 9(2).
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Tavares CD, O'Brien JP, Abramczyk O, Devkota AK, Shores KS, Ferguson SB, Kaoud TS, Warthaka M, Marshall KD, Keller KM, Zhang Y, Brodbelt JS, Ozpolat B, Dalby KN. Calcium/calmodulin stimulates the autophosphorylation of elongation factor 2 kinase on Thr-348 and Ser-500 to regulate its activity and calcium dependence. Biochemistry. 2012 Mar 20; 51(11):2232-45.
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Devkota AK, Tavares CD, Warthaka M, Abramczyk O, Marshall KD, Kaoud TS, Gorgulu K, Ozpolat B, Dalby KN. Investigating the kinetic mechanism of inhibition of elongation factor 2 kinase by NH125: evidence of a common in vitro artifact. Biochemistry. 2012 Mar 13; 51(10):2100-12.
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Perraud AL, Zhao X, Ryazanov AG, Schmitz C. The channel-kinase TRPM7 regulates phosphorylation of the translational factor eEF2 via eEF2-k. Cell Signal. 2011 Mar; 23(3):586-93.
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