 Elongation Factor 2 Kinase
"Elongation Factor 2 Kinase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A monomeric calcium-calmodulin-dependent protein kinase subtype that specifically phosphorylates PEPTIDE ELONGATION FACTOR 2. The enzyme lacks a phosphorylatable activation domain that can respond to CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE KINASE, however it is regulated by phosphorylation by PROTEIN KINASE A and through intramolecular autophosphorylation.
| Descriptor ID |
D054736
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| MeSH Number(s) |
D08.811.913.696.620.682.700.125.425 D12.644.360.100.425 D12.776.476.100.425
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| Concept/Terms |
Elongation Factor 2 Kinase- Elongation Factor 2 Kinase
- Protein Kinase CPK3
- Kinase CPK3, Protein
- Calcium-Calmodulin-Dependent Protein Kinase Type 3
- Calcium Calmodulin Dependent Protein Kinase Type 3
- Eukaryotic Elongation Factor-2 Kinase
- Eukaryotic Elongation Factor 2 Kinase
- CAM Kinase III
- Cam PK III
- E-2 Kinase
- E 2 Kinase
- eEF-2-Specific Ca and Calmodulin-Dependent Protein Kinase III
- eEF 2 Specific Ca and Calmodulin Dependent Protein Kinase III
- Calmodulin-Dependent Protein Kinase III
- Calmodulin Dependent Protein Kinase III
- EF-2 Kinase
- EF 2 Kinase
- Kinase, EF-2
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Below are MeSH descriptors whose meaning is more general than "Elongation Factor 2 Kinase".
Below are MeSH descriptors whose meaning is more specific than "Elongation Factor 2 Kinase".
This graph shows the total number of publications written about "Elongation Factor 2 Kinase" by people in this website by year, and whether "Elongation Factor 2 Kinase" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 0 | 1 | 1 | | 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Elongation Factor 2 Kinase" by people in Profiles.
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Nabais Sá MJ, Olson AN, Yoon G, Nimmo GAM, Gomez CM, Willemsen MA, Millan F, Schneider A, Pfundt R, de Brouwer APM, Dinman JD, de Vries BBA. De Novo variants in EEF2 cause a neurodevelopmental disorder with benign external hydrocephalus. Hum Mol Genet. 2021 02 25; 29(24):3892-3899.
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Pires Da Silva J, Monceaux K, Guilbert A, Gressette M, Piquereau J, Novotova M, Ventura-Clapier R, Garnier A, Lemaire C. SIRT1 Protects the Heart from ER Stress-Induced Injury by Promoting eEF2K/eEF2-Dependent Autophagy. Cells. 2020 02 12; 9(2).
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Tavares CD, O'Brien JP, Abramczyk O, Devkota AK, Shores KS, Ferguson SB, Kaoud TS, Warthaka M, Marshall KD, Keller KM, Zhang Y, Brodbelt JS, Ozpolat B, Dalby KN. Calcium/calmodulin stimulates the autophosphorylation of elongation factor 2 kinase on Thr-348 and Ser-500 to regulate its activity and calcium dependence. Biochemistry. 2012 Mar 20; 51(11):2232-45.
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Devkota AK, Tavares CD, Warthaka M, Abramczyk O, Marshall KD, Kaoud TS, Gorgulu K, Ozpolat B, Dalby KN. Investigating the kinetic mechanism of inhibition of elongation factor 2 kinase by NH125: evidence of a common in vitro artifact. Biochemistry. 2012 Mar 13; 51(10):2100-12.
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Orellana RA, Wilson FA, Gazzaneo MC, Suryawan A, Davis TA, Nguyen HV. Sepsis and development impede muscle protein synthesis in neonatal pigs by different ribosomal mechanisms. Pediatr Res. 2011 Jun; 69(6):473-8.
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Perraud AL, Zhao X, Ryazanov AG, Schmitz C. The channel-kinase TRPM7 regulates phosphorylation of the translational factor eEF2 via eEF2-k. Cell Signal. 2011 Mar; 23(3):586-93.
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