 Troponin C
"Troponin C" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A TROPONIN complex subunit that binds calcium and help regulate calcium-dependent muscle contraction. There are two troponin C subtypes: troponin C1 and C2. Troponin C1 is skeletal and cardiac type whereas troponin C2 is skeletal type. Troponin C1 is a BIOMARKER for damaged or injured CARDIAC MYOCYTES and mutations in troponin C1 gene are associated with FAMILIAL HYPERTROPHIC CARDIOMYOPATHY.
| Descriptor ID |
D019209
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| MeSH Number(s) |
D05.500.945.900 D05.750.078.730.825.900 D12.776.157.125.900 D12.776.210.500.910.900 D12.776.220.525.825.900
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Troponin C".
Below are MeSH descriptors whose meaning is more specific than "Troponin C".
This graph shows the total number of publications written about "Troponin C" by people in this website by year, and whether "Troponin C" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 1 | 0 | 1 | | 2006 | 0 | 1 | 1 | | 2008 | 0 | 2 | 2 | | 2016 | 1 | 0 | 1 |
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Below are the most recent publications written about "Troponin C" by people in Profiles.
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Hwee DT, Cheng AJ, Hartman JJ, Hinken AC, Lee K, Durham N, Russell AJ, Malik FI, Westerblad H, Jasper JR. The Ca2+ sensitizer CK-2066260 increases myofibrillar Ca2+ sensitivity and submaximal force selectively in fast skeletal muscle. J Physiol. 2017 03 01; 595(5):1657-1670.
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Behunin SM, Lopez-Pier MA, Mayfield RM, Danilo CA, Lipovka Y, Birch C, Lehman S, Tardiff JC, Gregorio CC, Konhilas JP. Liver Kinase B1 complex acts as a novel modifier of myofilament function and localizes to the Z-disk in cardiac myocytes. Arch Biochem Biophys. 2016 07 01; 601:32-41.
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Russell AJ, Hartman JJ, Hinken AC, Muci AR, Kawas R, Driscoll L, Godinez G, Lee KH, Marquez D, Browne WF, Chen MM, Clarke D, Collibee SE, Garard M, Hansen R, Jia Z, Lu PP, Rodriguez H, Saikali KG, Schaletzky J, Vijayakumar V, Albertus DL, Claflin DR, Morgans DJ, Morgan BP, Malik FI. Activation of fast skeletal muscle troponin as a potential therapeutic approach for treating neuromuscular diseases. Nat Med. 2012 Feb 19; 18(3):452-5.
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Bonaca MP, Morrow DA. Defining a role for novel biomarkers in acute coronary syndromes. Clin Chem. 2008 Sep; 54(9):1424-31.
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Jeyasingham MD, Artigues A, Nadeau OW, Carlson GM. Structural evidence for co-evolution of the regulation of contraction and energy production in skeletal muscle. J Mol Biol. 2008 Mar 28; 377(3):623-9.
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Christenson RH, Duh SH, Apple FS, Bodor GS, Bunk DM, Panteghini M, Welch MJ, Wu AH, Kahn SE. Toward standardization of cardiac troponin I measurements part II: assessing commutability of candidate reference materials and harmonization of cardiac troponin I assays. Clin Chem. 2006 Sep; 52(9):1685-92.
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Belin RJ, Sumandea MP, Kobayashi T, Walker LA, Rundell VL, Urboniene D, Yuzhakova M, Ruch SH, Geenen DL, Solaro RJ, de Tombe PP. Left ventricular myofilament dysfunction in rat experimental hypertrophy and congestive heart failure. Am J Physiol Heart Circ Physiol. 2006 Nov; 291(5):H2344-53.
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Tripet B, De Crescenzo G, Grothe S, O'Connor-McCourt M, Hodges RS. Kinetic analysis of the interactions between troponin C (TnC) and troponin I (TnI) binding peptides: evidence for separate binding sites for the 'structural' N-terminus and the 'regulatory' C-terminus of TnI on TnC. J Mol Recognit. 2003 Jan-Feb; 16(1):37-53.
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Hazard AL, Kohout SC, Stricker NL, Putkey JA, Falke JJ. The kinetic cycle of cardiac troponin C: calcium binding and dissociation at site II trigger slow conformational rearrangements. Protein Sci. 1998 Nov; 7(11):2451-9.
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McKay RT, Tripet BP, Hodges RS, Sykes BD. Interaction of the second binding region of troponin I with the regulatory domain of skeletal muscle troponin C as determined by NMR spectroscopy. J Biol Chem. 1997 Nov 07; 272(45):28494-500.
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