 Inactivation, Metabolic
"Inactivation, Metabolic" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Reduction of pharmacologic activity or toxicity of a drug or other foreign substance by a living system, usually by enzymatic action. It includes those metabolic transformations that make the substance more soluble for faster renal excretion.
| Descriptor ID |
D008658
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| MeSH Number(s) |
G03.171.450 G03.787.225.450 G07.690.725.225.450
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| Concept/Terms |
Metabolic Detoxication, Drug- Metabolic Detoxication, Drug
- Detoxication, Drug Metabolic
- Drug Metabolic Detoxication
- Drug Detoxication, Metabolic
- Detoxication, Metabolic Drug
- Metabolic Drug Detoxication
- Metabolic Detoxification, Drug
- Detoxification, Drug Metabolic
- Drug Metabolic Detoxification
- Detoxification, Drug, Metabolic
- Detoxication, Drug, Metabolic
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Below are MeSH descriptors whose meaning is more general than "Inactivation, Metabolic".
Below are MeSH descriptors whose meaning is more specific than "Inactivation, Metabolic".
This graph shows the total number of publications written about "Inactivation, Metabolic" by people in this website by year, and whether "Inactivation, Metabolic" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 2 | 2 | | 2011 | 0 | 1 | 1 | | 2014 | 0 | 1 | 1 | | 2015 | 0 | 2 | 2 | | 2018 | 0 | 1 | 1 | | 2020 | 1 | 1 | 2 |
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Below are the most recent publications written about "Inactivation, Metabolic" by people in Profiles.
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Lkhagvadorj K, Zeng Z, Meyer KF, Verweij LP, Kooistra W, Reinders-Luinge M, Dijkhuizen HW, de Graaf IAM, Pl?sch T, Hylkema MN. Postnatal Smoke Exposure Further Increases the Hepatic Nicotine Metabolism in Prenatally Smoke Exposed Male Offspring and Is Linked with Aberrant Cyp2a5 Methylation. Int J Mol Sci. 2020 Dec 26; 22(1).
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Driscoll JP, Sadlowski CM, Shah NR, Feula A. Metabolism and Bioactivation: It's Time to Expect the Unexpected. J Med Chem. 2020 06 25; 63(12):6303-6314.
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Gao RY, Wang M, Liu Q, Feng D, Wen Y, Xia Y, Colgan SP, Eltzschig HK, Ju C. Hypoxia-Inducible Factor-2a Reprograms Liver Macrophages to Protect Against Acute Liver Injury Through the Production of Interleukin-6. Hepatology. 2020 06; 71(6):2105-2117.
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Bhatt DK, Basit A, Zhang H, Gaedigk A, Lee SB, Claw KG, Mehrotra A, Chaudhry AS, Pearce RE, Gaedigk R, Broeckel U, Thornton TA, Nickerson DA, Schuetz EG, Amory JK, Leeder JS, Prasad B. Hepatic Abundance and Activity of Androgen- and Drug-Metabolizing Enzyme UGT2B17 Are Associated with Genotype, Age, and Sex. Drug Metab Dispos. 2018 06; 46(6):888-896.
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Abidi MZ, D'Souza A, Kuppalli K, Ledeboer N, Hari P. CYP2C19*17 genetic polymorphism--an uncommon cause of voriconazole treatment failure. Diagn Microbiol Infect Dis. 2015 Sep; 83(1):46-8.
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McMahon BJ, Kwaan HC. The new or non-vitamin K antagonist oral anticoagulants: what have we learned since their debut. Semin Thromb Hemost. 2015 Mar; 41(2):188-94.
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Bhandari RK, Oda RP, Petrikovics I, Thompson DE, Brenner M, Mahon SB, Bebarta VS, Rockwood GA, Logue BA. Cyanide toxicokinetics: the behavior of cyanide, thiocyanate and 2-amino-2-thiazoline-4-carboxylic acid in multiple animal models. J Anal Toxicol. 2014 May; 38(4):218-25.
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Wu R, Tong C, Wang Z, Mauger D, Tantisira K, Szefler SJ, Chinchilli VM, Israel E. A conceptual framework for pharmacodynamic genome-wide association studies in pharmacogenomics. Drug Discov Today. 2011 Oct; 16(19-20):884-90.
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Booth RE, Campbell BK, Mikulich-Gilbertson SK, Tillotson CJ, Choi D, Robinson J, Calsyn DA, Mandler RN, Jenkins LM, Thompson LL, Dempsey CL, Liepman MR, McCarty D. Reducing HIV-related risk behaviors among injection drug users in residential detoxification. AIDS Behav. 2011 Jan; 15(1):30-44.
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Campbell BK, Fuller BE, Lee ES, Tillotson C, Woelfel T, Jenkins L, Robinson J, Booth RE, McCarty D. Facilitating outpatient treatment entry following detoxification for injection drug use: a multisite test of three interventions. Psychol Addict Behav. 2009 Jun; 23(2):260-70.
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