 Metabolic Detoxication, Phase I
"Metabolic Detoxication, Phase I" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Functionalization of exogenous substances to prepare them for conjugation in PHASE II DETOXIFICATION. Phase I enzymes include CYTOCHROME P450 enzymes and some OXIDOREDUCTASES. Excess induction of phase I over phase II detoxification leads to higher levels of FREE RADICALS that can induce CANCER and other cell damage. Induction or antagonism of phase I detoxication is the basis of a number of DRUG INTERACTIONS.
| Descriptor ID |
D050216
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| MeSH Number(s) |
G03.171.450.500 G03.787.225.450.500 G07.690.725.225.450.500
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| Concept/Terms |
Metabolic Detoxication, Phase I- Metabolic Detoxication, Phase I
- Metabolic Detoxication, Oxidative
- Detoxication, Oxidative Metabolic
- Detoxications, Oxidative Metabolic
- Metabolic Detoxications, Oxidative
- Oxidative Metabolic Detoxication
- Oxidative Metabolic Detoxications
- Phase I Detoxification
- Detoxification, Phase I
- Detoxifications, Phase I
- Metabolic Detoxification, Phase I
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Below are MeSH descriptors whose meaning is more general than "Metabolic Detoxication, Phase I".
Below are MeSH descriptors whose meaning is more specific than "Metabolic Detoxication, Phase I".
This graph shows the total number of publications written about "Metabolic Detoxication, Phase I" by people in this website by year, and whether "Metabolic Detoxication, Phase I" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2010 | 0 | 2 | 2 | | 2016 | 0 | 1 | 1 |
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Below are the most recent publications written about "Metabolic Detoxication, Phase I" by people in Profiles.
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Ladage ML, King SD, Burks DJ, Quan DL, Garcia AM, Azad RK, Padilla PA. Glucose or Altered Ceramide Biosynthesis Mediate Oxygen Deprivation Sensitivity Through Novel Pathways Revealed by Transcriptome Analysis in Caenorhabditis elegans. G3 (Bethesda). 2016 10 13; 6(10):3149-3160.
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Wempe MF, Anderson PL. Atazanavir metabolism according to CYP3A5 status: an in vitro-in vivo assessment. Drug Metab Dispos. 2011 Mar; 39(3):522-7.
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Backos DS, Fritz KS, Roede JR, Petersen DR, Franklin CC. Posttranslational modification and regulation of glutamate-cysteine ligase by the a,?-unsaturated aldehyde 4-hydroxy-2-nonenal. Free Radic Biol Med. 2011 Jan 01; 50(1):14-26.
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