Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
Keywords
Last Name
Institution
Menu

Contact Us
If you have any questions or feedback please contact us.

James Crapo

TitlePrincipal Investigator
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED
Phone303/398-1436

    Collapse Research 
    Collapse research activities and funding
    75N92023D00     Jun 1, 2023 - Jun 30, 2034
    NIH
    NHLBI TRANS-OMICS FOR PRECISION MEDICINE (TOPMED) FOR THE CENTRALIZED OMICS RESOURCE (CORE) - TASK AREAS 2, 3, AND 4 - 2024 TASK ORDER
    Role: Co-Principal Investigator
    R44CA195749     (CRAPO, JAMES D)Sep 18, 2015 - May 31, 2023
    NIH
    BMX-001 as a Therapeutic Agent for Treatment of High-Grade Gliomas
    Role: Principal Investigator
    R13HL102943     (CRAPO, JAMES D)Feb 1, 2010 - Jan 31, 2011
    NIH
    Building Consensus on Qualitative Chest CT-based Subphenotypes for COPD
    Role: Principal Investigator
    U01HL089897     (CRAPO, JAMES D)Sep 27, 2007 - Jul 31, 2022
    NIH
    (1 of 2) Genetic Epidemiology of COPD
    Role: Principal Investigator
    R01HL089897     (CRAPO, JAMES D)Jul 1, 2007 - Aug 31, 2017
    NIH
    (1 of 2) Genetic Epidemiology of COPD
    Role: Principal Investigator
    S07RR018132     (JOHNSTON, RICHARD B.)Sep 1, 2002 - Aug 31, 2005
    NIH
    IRB Assessment and Education Project
    Role: Co-Principal Investigator
    U01HL063397     (CRAPO, JAMES D)Aug 1, 1999 - Aug 31, 2007
    NIH
    Treatment of BPD Using Mimetics of Superoxide Dismutase
    Role: Principal Investigator
    K30RR022279     (CRAPO, JAMES D)Jun 1, 1999 - May 31, 2010
    NIH
    Advanced Training for Clinical Investigators
    Role: Principal Investigator
    K30HL004111     (CRAPO, JAMES D)Jun 1, 1999 - May 31, 2005
    NIH
    ADVANCED TRAINING FOR CLINICAL INVESTIGATORS
    Role: Principal Investigator
    R13HL045391     (CRAPO, JAMES D)May 1, 1990 - Apr 30, 1991
    NIH
    WORLD CONFERENCE ON LUNG HEALTH
    Role: Principal Investigator
    R01HL042609     (CRAPO, JAMES D)May 1, 1989 - Apr 30, 1998
    NIH
    EC-SOD IN AIRWAY AND PULMONARY VASCULAR BIOLOGY
    Role: Principal Investigator
    R01HL037721     (CRAPO, JAMES D)Sep 30, 1986 - Mar 31, 1989
    NIH
    HYPO- AND HYPERBARIC RESEARCH SUPPORT FACILITIES
    Role: Principal Investigator
    S10RR002699     (CRAPO, JAMES D)Feb 1, 1986 - Jan 31, 1987
    NIH
    ELECTRON MICROSCOPE
    Role: Principal Investigator
    C06HL035525     (CRAPO, JAMES D)Sep 30, 1985 - Sep 29, 1987
    NIH
    NHLBI SHARED RESEARCH FACILITY
    Role: Principal Investigator
    P01HL031992     (CRAPO, JAMES D)May 1, 1984 - Mar 31, 2007
    NIH
    ACUTE LUNG INJURY-MECHANISMS AND THERAPY
    Role: Principal Investigator
    T32HL007538     (PIANTADOSI, CLAUDE A)Jul 1, 1982 - Jun 30, 2021
    NIH
    Interdisciplinary Training Program in Lung Disease
    Role: Co-Principal Investigator
    T32ES007031     (DI GIULIO, RICHARD)Jul 1, 1978 - Jun 30, 2008
    NIH
    Integrated Toxicology Program
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Higbee DH, Lirio A, Hamilton F, Granell R, Wyss AB, London SJ, Bartz TM, Gharib SA, Cho MH, Wan E, Silverman E, Crapo JD, Lominchar JVT, Hansen T, Grarup N, Dantoft T, K?rhus L, Linneberg A, O'Connor GT, Dupuis J, Xu H, De Vries MM, Hu X, Rich SS, Barr RG, Manichaikul A, Wijnant SRA, Brusselle GG, Lahousse L, Li X, Hern?ndez Cordero AI, Obeidat M, Sin DD, Harris SE, Redmond P, Taylor AM, Cox SR, Williams AT, Shrine N, John C, Guyatt AL, Hall IP, Davey Smith G, Tobin MD, Dodd JW. Genome-wide association study of preserved ratio impaired spirometry (PRISm). Eur Respir J. 2024 01; 63(1). PMID: 38097206.
      View in: PubMed
    2. Vegas S?nchez-Ferrero G, D?az AA, Ash SY, Baraghoshi D, Strand M, Crapo JD, Silverman EK, Humphries SM, Washko GR, Lynch DA, San Jos? Est?par R. Quantification of Emphysema Progression at CT Using Simultaneous Volume, Noise, and Bias Lung Density Correction. Radiology. 2024 01; 310(1):e231632. PMID: 38165244.
      View in: PubMed
    3. Regan EA, Lowe ME, Make BJ, Curtis JL, Chen QG, Crooks JL, Wilson C, Oates GR, Gregg RW, Baldomero AK, Bhatt SP, Diaz AA, Benos PV, O'Brien JK, Young KA, Kinney GL, Conrad DJ, Lowe KE, DeMeo DL, Non A, Cho MH, Kallet J, Foreman MG, Westney GE, Hoth K, MacIntyre NR, Hanania NA, Wolfe A, Amaza H, Han M, Beaty TH, Hansel NN, McCormack MC, Balasubramanian A, Crapo JD, Silverman EK, Casaburi R, Wise RA. Early Evidence of Chronic Obstructive Pulmonary Disease Obscured by Race-Specific Prediction Equations. Am J Respir Crit Care Med. 2024 01 01; 209(1):59-69. PMID: 37611073.
      View in: PubMed
    4. Crapo JD, Gupta A, Lynch DA, Turner AM, Mroz RM, Janssens W, Ludwig-Sengpiel A, Koegler H, Eleftheraki A, Risse F, Diefenbach C. Baseline characteristics from a 3-year longitudinal study to phenotype subjects with COPD: the FOOTPRINTS study. Respir Res. 2023 Nov 17; 24(1):290. PMID: 37978492.
      View in: PubMed
    5. Baraghoshi D, Strand M, Humphries SM, San Jos? Est?par R, Vegas Sanchez-Ferrero G, Charbonnier JP, Latisenko R, Silverman EK, Crapo JD, Lynch DA. Erratum for: Quantitative CT Evaluation of Emphysema Progression over 10 Years in the COPDGene Study. Radiology. 2023 Nov; 309(2):e239028. PMID: 38015087.
      View in: PubMed
    6. Silverman EK, Kim AY, Make BJ, Regan EA, Morrow JD, Hersh CP, O'Brien J, Crapo JD, Hansel NN, Criner G, Flenaugh EL, Conrad D, Casaburi R, Bowler RP, Hanania NA, Barr RG, Bhatt SP, Sciurba FC, Anzueto A, Han MK, McEvoy CE, Comellas AP, DeMeo DL, Rosiello R, Curtis JL, Uchida T, Wilson C, O'Rourke PP. Returning incidentally discovered Hepatitis C RNA-seq results to COPDGene study participants. NPJ Genom Med. 2023 Oct 31; 8(1):36. PMID: 37903807.
      View in: PubMed
    7. Li X, Duan W, Du L, Chu D, Wang P, Yang Z, Qu X, Yang Z, Batinic-Haberle I, Spasojevic I, Warner DS, Crapo JD, Treggiari MM, Sheng H. Intracarotid Infusion of Redox-Active Manganese Porphyrin, MnTnBuOE-2-PyP5+, following Reperfusion Improves Long-Term, 28-Day Post-Stroke Outcomes in Rats. Antioxidants (Basel). 2023 Oct 13; 12(10). PMID: 37891940.
      View in: PubMed
    8. Castaldi PJ, Xu Z, Young KA, Hokanson JE, Lynch DA, Humphries SM, Ross JC, Cho MH, Hersh CP, Crapo JD, Strand M, Silverman EK. Heterogeneity and Progression of Chronic Obstructive Pulmonary Disease: Emphysema-Predominant and Non-Emphysema-Predominant Disease. Am J Epidemiol. 2023 10 10; 192(10):1647-1658. PMID: 37160347.
      View in: PubMed
    9. Kremsky I, Ali S, Stanbouly S, Holley J, Justinen S, Pecaut M, Crapo J, Mao X. Spaceflight-Induced Gene Expression Profiles in the Mouse Brain Are Attenuated by Treatment with the Antioxidant BuOE. Int J Mol Sci. 2023 Sep 01; 24(17). PMID: 37686374.
      View in: PubMed
    10. Labaki WW, Gu T, Murray S, Curtis JL, Wells JM, Bhatt SP, Bon J, Diaz AA, Hersh CP, Wan ES, Kim V, Beaty TH, Hokanson JE, Bowler RP, Arenberg DA, Kazerooni EA, Martinez FJ, Silverman EK, Crapo JD, Make BJ, Regan EA, Han MK. Causes of and Clinical Features Associated with Death in Tobacco Cigarette Users by Lung Function Impairment. Am J Respir Crit Care Med. 2023 08 15; 208(4):451-460. PMID: 37159910.
      View in: PubMed
    11. Ngo D, Pratte KA, Flexeder C, Petersen H, Dang H, Ma Y, Keyes MJ, Gao Y, Deng S, Peterson BD, Farrell LA, Bhambhani VM, Palacios C, Quadir J, Gillenwater L, Xu H, Emson C, Gieger C, Suhre K, Graumann J, Jain D, Conomos MP, Tracy RP, Guo X, Liu Y, Johnson WC, Cornell E, Durda P, Taylor KD, Papanicolaou GJ, Rich SS, Rotter JI, Rennard SI, Curtis JL, Woodruff PG, Comellas AP, Silverman EK, Crapo JD, Larson MG, Vasan RS, Wang TJ, Correa A, Sims M, Wilson JG, Gerszten RE, O'Connor GT, Barr RG, Couper D, Dupuis J, Manichaikul A, O'Neal WK, Tesfaigzi Y, Schulz H, Bowler RP. Systemic Markers of Lung Function and Forced Expiratory Volume in 1 Second Decline across Diverse Cohorts. Ann Am Thorac Soc. 2023 08; 20(8):1124-1135. PMID: 37351609.
      View in: PubMed
    12. Huffman JE, Nicolas J, Hahn J, Heath AS, Raffield LM, Yanek LR, Brody JA, Thibord F, Almasy L, Bartz TM, Bielak LF, Bowler RP, Carrasquilla GD, Chasman DI, Chen MH, Emmert DB, Ghanbari M, Haessle J, Hottenga JJ, Kleber ME, Le NQ, Lee J, Lewis JP, Li-Gao R, Luan J, Malmberg A, Mangino M, Marioni RE, Martinez-Perez A, Pankratz N, Polasek O, Richmond A, Rodriguez BA, Rotter JI, Steri M, Suchon P, Trompet S, Weiss S, Zare M, Auer P, Cho MH, Christofidou P, Davies G, de Geus E, Deleuze JF, Delgado GE, Ekunwe L, Faraday N, G?gele M, Greinacher A, He G, Howard T, Joshi PK, Kilpel?inen TO, Lahti J, Linneberg A, Naitza S, Noordam R, Pa?ls-Verg?s F, Rich SS, Rosendaal FR, Rudan I, Ryan KA, Souto JC, van Rooij FJ, Wang H, Zhao W, Becker LC, Beswick A, Brown MR, Cade BE, Campbell H, Cho K, Crapo JD, Curran JE, de Maat MP, Doyle M, Elliott P, Floyd JS, Fuchsberger C, Grarup N, Guo X, Harris SE, Hou L, Kolcic I, Kooperberg C, Menni C, Nauck M, O'Connell JR, Orr? V, Psaty BM, R?ikk?nen K, Smith JA, Soria JM, Stott DJ, van Hylckama Vlieg A, Watkins H, Willemsen G, Wilson P, Ben-Shlomo Y, Blangero J, Boomsma D, Cox SR, Dehghan A, Eriksson JG, Fiorillo E, Fornage M, Hansen T, Hayward C, Ikram MA, Jukema JW, Kardia SL, Lange LA, M?rz W, Mathias RA, Mitchell BD, Mook-Kanamori DO, Morange PE, Pedersen O, Pramstaller PP, Redline S, Reiner A, Ridker PM, Silverman EK, Spector TD, V?lker U, Wareham N, Wilson JF, Yao J, Tr?gou?t DA, Johnson AD, Wolberg AS, de Vries PS, Sabater-Lleal M, Morrison AC, Smith NL. Whole genome analysis of plasma fibrinogen reveals population-differentiated genetic regulators with putative liver roles. medRxiv. 2023 Jun 12. PMID: 37398003.
      View in: PubMed
    13. Regan EA, Lowe ME, Make BJ, Curtis JL, Chen QG, Cho MH, Crooks JL, Lowe KE, Wilson C, O'Brien JK, Oates GR, Baldomero AK, Kinney GL, Young KA, Diaz AA, Bhatt SP, McCormack MC, Hansel NN, Kim V, Richmond NE, Westney GE, Foreman MG, Conrad DJ, DeMeo DL, Hoth KF, Amaza H, Balasubramanian A, Kallet J, Watts S, Hanania NA, Hokanson J, Beaty TH, Crapo JD, Silverman EK, Casaburi R, Wise R. Use of the Spirometric "Fixed-Ratio" Underdiagnoses COPD in African-Americans in a Longitudinal Cohort Study. J Gen Intern Med. 2023 10; 38(13):2988-2997. PMID: 37072532.
      View in: PubMed
    14. Mao X, Stanbouly S, Holley J, Pecaut M, Crapo J. Evidence of Spaceflight-Induced Adverse Effects on Photoreceptors and Retinal Function in the Mouse Eye. Int J Mol Sci. 2023 Apr 17; 24(8). PMID: 37108526.
      View in: PubMed
    15. Baraghoshi D, Strand M, Humphries SM, San Jos? Est?par R, Vegas Sanchez-Ferrero G, Charbonnier JP, Latisenko R, Silverman EK, Crapo JD, Lynch DA. Quantitative CT Evaluation of Emphysema Progression over 10 Years in the COPDGene Study. Radiology. 2023 05; 307(4):e222786. PMID: 37039685.
      View in: PubMed
    16. Hayden LP, Hobbs BD, Busch R, Cho MH, Liu M, Lopes-Ramos CM, Lomas DA, Bakke P, Gulsvik A, Silverman EK, Crapo JD, Beaty TH, Laird NM, Lange C, DeMeo DL. X chromosome associations with chronic obstructive pulmonary disease and related phenotypes: an X chromosome-wide association study. Respir Res. 2023 Feb 01; 24(1):38. PMID: 36726148.
      View in: PubMed
    17. Tran TV, Kinney GL, Comellas A, Hoth KF, Baldomero AK, Mamary AJ, Curtis JL, Hanania N, Casaburi R, Young KA, Kim V, Make B, Wan ES, Diaz AA, Hokanson J, Crapo JD, Silverman EK, Bhatt SP, Regan E, Fortis S. Prevalence of abnormal spirometry in individuals with a smoking history and no known obstructive lung disease. Respir Med. 2023 03; 208:107126. PMID: 36717002.
      View in: PubMed
    18. Verstraete K, Das N, Gyselinck I, Topalovic M, Troosters T, Crapo JD, Silverman EK, Make BJ, Regan EA, Jensen R, De Vos M, Janssens W. Principal component analysis of flow-volume curves in COPDGene to link spirometry with phenotypes of COPD. Respir Res. 2023 Jan 19; 24(1):20. PMID: 36658542.
      View in: PubMed
    19. Morris AH, Horvat C, Stagg B, Grainger DW, Lanspa M, Orme J, Clemmer TP, Weaver LK, Thomas FO, Grissom CK, Hirshberg E, East TD, Wallace CJ, Young MP, Sittig DF, Suchyta M, Pearl JE, Pesenti A, Bombino M, Beck E, Sward KA, Weir C, Phansalkar S, Bernard GR, Thompson BT, Brower R, Truwit J, Steingrub J, Hiten RD, Willson DF, Zimmerman JJ, Nadkarni V, Randolph AG, Curley MAQ, Newth CJL, Lacroix J, Agus MSD, Lee KH, deBoisblanc BP, Moore FA, Evans RS, Sorenson DK, Wong A, Boland MV, Dere WH, Crandall A, Facelli J, Huff SM, Haug PJ, Pielmeier U, Rees SE, Karbing DS, Andreassen S, Fan E, Goldring RM, Berger KI, Oppenheimer BW, Ely EW, Pickering BW, Schoenfeld DA, Tocino I, Gonnering RS, Pronovost PJ, Savitz LA, Dreyfuss D, Slutsky AS, Crapo JD, Pinsky MR, James B, Berwick DM. Computer clinical decision support that automates personalized clinical care: a challenging but needed healthcare delivery strategy. J Am Med Inform Assoc. 2022 12 13; 30(1):178-194. PMID: 36125018.
      View in: PubMed
    20. Bhatt SP, Bodduluri S, Dransfield MT, Reinhardt JM, Crapo JD, Silverman EK, Humphries S, Lynch DA, Strand MJ. Acute Exacerbations Are Associated with Progression of Emphysema. Ann Am Thorac Soc. 2022 12; 19(12):2108-2111. PMID: 35914221.
      View in: PubMed
    21. Boueiz A, Xu Z, Chang Y, Masoomi A, Gregory A, Lutz SM, Qiao D, Crapo JD, Dy JG, Silverman EK, Castaldi PJ. Machine Learning Prediction of Progression in Forced Expiratory Volume in 1 Second in the COPDGene? Study. Chronic Obstr Pulm Dis. 2022 Jul 29; 9(3):349-365. PMID: 35649102.
      View in: PubMed
    22. Strand M, Khatiwada A, Baraghoshi D, Lynch D, Silverman EK, Bhatt SP, Austin E, Regan EA, Boriek AM, Crapo JD. Predicting COPD Progression in Current and Former Smokers Using a Joint Model for Forced Expiratory Volume in 1 Second and Forced Expiratory Volume in 1 Second to Forced Vital Capacity Ratio. Chronic Obstr Pulm Dis. 2022 Jul 29; 9(3):439-453. PMID: 35905755.
      View in: PubMed
    23. Oh AS, Baraghoshi D, Lynch DA, Ash SY, Crapo JD, Humphries SM. Emphysema Progression at CT by Deep Learning Predicts Functional Impairment and Mortality: Results from the COPDGene Study. Radiology. 2022 09; 304(3):672-679. PMID: 35579519.
      View in: PubMed
    24. Ragland MF, Strand M, Baraghoshi D, Young KA, Kinney GL, Austin E, Hokanson JE, Regan E, Crapo J, Silverman EK, Make B. 10-Year Follow-Up of Lung Function, Respiratory Symptoms, and Functional Capacity in the COPDGene Study. Ann Am Thorac Soc. 2022 03; 19(3):381-388. PMID: 34461026.
      View in: PubMed
    25. Koo HK, Hoth KF, Make BJ, Regan EA, Crapo JD, Silverman EK, DeMeo DL. Optimism is associated with respiratory symptoms and functional status in chronic obstructive pulmonary disease. Respir Res. 2022 Jan 29; 23(1):19. PMID: 35093071.
      View in: PubMed
    26. Thomashow BM, Mannino DM, Tal-Singer R, Crapo JD. A rapidly changing understanding of COPD: World COPD Day from the COPD Foundation. Am J Physiol Lung Cell Mol Physiol. 2021 11 01; 321(5):L983-L987. PMID: 34612086.
      View in: PubMed
    27. Wan ES, Hokanson JE, Regan EA, Young KA, Make BJ, DeMeo DL, Mason SE, San Jose Estepar R, Crapo JD, Silverman EK. Significant Spirometric Transitions and Preserved Ratio Impaired Spirometry Among Ever Smokers. Chest. 2022 03; 161(3):651-661. PMID: 34592319.
      View in: PubMed
    28. Wade RC, Simmons JP, Boueiz A, Gregory A, Wan ES, Regan EA, Bhatt SP, Han MK, Bowler RP, Crapo JD, Silverman EK, Washko GR, Dransfield MT, Wells JM. Pulmonary Artery Enlargement Is Associated with Exacerbations and Mortality in Ever-Smokers with Preserved Ratio Impaired Spirometry. Am J Respir Crit Care Med. 2021 08 15; 204(4):481-485. PMID: 34014810.
      View in: PubMed
    29. Lindsay HG, Wamboldt FS, Holm KE, Make BJ, Hokanson J, Crapo JD, Regan EA. Impact of a Medical Diagnosis on Decision to Stop Smoking and Successful Smoking Cessation. Chronic Obstr Pulm Dis. 2021 Jul 28; 8(3):360-370. PMID: 34010545.
      View in: PubMed
    30. Brunette AM, Warner K, Holm KE, Meschede K, Wamboldt FS, Kozora E, Moser DJ, Make BJ, Crapo JD, Moreau KL, Weinberger HD, Bowler R, Hoth KF. Daily Activities: The Impact of COPD and Cognitive Dysfunction. Arch Clin Neuropsychol. 2021 Jul 19; 36(5):acaa090 767 779-767. PMID: 33103191.
      View in: PubMed
    31. Morris AH, Stagg B, Lanspa M, Orme J, Clemmer TP, Weaver LK, Thomas F, Grissom CK, Hirshberg E, East TD, Wallace CJ, Young MP, Sittig DF, Pesenti A, Bombino M, Beck E, Sward KA, Weir C, Phansalkar SS, Bernard GR, Taylor Thompson B, Brower R, Truwit JD, Steingrub J, Duncan Hite R, Willson DF, Zimmerman JJ, Nadkarni VM, Randolph A, Curley MAQ, Newth CJL, Lacroix J, Agus MSD, Lee KH, deBoisblanc BP, Scott Evans R, Sorenson DK, Wong A, Boland MV, Grainger DW, Dere WH, Crandall AS, Facelli JC, Huff SM, Haug PJ, Pielmeier U, Rees SE, Karbing DS, Andreassen S, Fan E, Goldring RM, Berger KI, Oppenheimer BW, Wesley Ely E, Gajic O, Pickering B, Schoenfeld DA, Tocino I, Gonnering RS, Pronovost PJ, Savitz LA, Dreyfuss D, Slutsky AS, Crapo JD, Angus D, Pinsky MR, James B, Berwick D. Enabling a learning healthcare system with automated computer protocols that produce replicable and personalized clinician actions. J Am Med Inform Assoc. 2021 06 12; 28(6):1330-1344. PMID: 33594410.
      View in: PubMed
    32. Luehrs RE, Moreau KL, Pierce GL, Wamboldt F, Aloia M, Weinberger HD, Make B, Bowler R, Crapo JD, Meschede K, Kozora E, Moser DJ, Hoth KF. Cognitive performance is lower among individuals with overlap syndrome than in individuals with COPD or obstructive sleep apnea alone: association with carotid artery stiffness. J Appl Physiol (1985). 2021 07 01; 131(1):131-141. PMID: 33982592.
      View in: PubMed
    33. Pompe E, Moore CM, Mohamed Hoesein FAA, de Jong PA, Charbonnier JP, Han MK, Humphries SM, Hatt CR, Galb?n CJ, Silverman EK, Crapo JD, Washko GR, Regan EA, Make B, Strand M, Lammers JJ, van Rikxoort EM, Lynch DA. Progression of Emphysema and Small Airways Disease in Cigarette Smokers. Chronic Obstr Pulm Dis. 2021 Apr 27; 8(2):198-212. PMID: 33290645.
      View in: PubMed
    34. Crapo J, Gupta A, Lynch DA, Vogel-Claussen J, Watz H, Turner AM, Mroz RM, Janssens W, Ludwig-Sengpiel A, Beck M, Langellier B, Ittrich C, Risse F, Diefenbach C. FOOTPRINTS study protocol: rationale and methodology of a 3-year longitudinal observational study to phenotype patients with COPD. BMJ Open. 2021 03 22; 11(3):e042526. PMID: 33753437.
      View in: PubMed
    35. Lindsay SE, Lindsay HG, Kallet J, Weaver MR, Curran-Everett D, Crapo JD, Regan EA. MnTE-2-PyP disrupts Staphylococcus aureus biofilms in a novel fracture model. J Orthop Res. 2021 11; 39(11):2439-2445. PMID: 33347639.
      View in: PubMed
    36. Fortis S, Wan ES, Kunisaki K, Eyck PT, Ballas ZK, Bowler RP, Crapo JD, Hokanson JE, Wendt C, Silverman EK, Comellas AP. Increased mortality associated with frequent exacerbations in COPD patients with mild-to-moderate lung function impairment, and smokers with normal spirometry. Respir Med X. 2021 Nov; 3. PMID: 35911870.
      View in: PubMed
    37. Strand M, Austin E, Moll M, Pratte KA, Regan EA, Hayden LP, Bhatt SP, Boriek AM, Casaburi R, Silverman EK, Fortis S, Ruczinski I, Koegler H, Rossiter HB, Occhipinti M, Hanania NA, Gebrekristos HT, Lynch DA, Kunisaki KM, Young KA, Sieren JC, Ragland M, Hokanson JE, Lutz SM, Make BJ, Kinney GL, Cho MH, Pistolesi M, DeMeo DL, Sciurba FC, Comellas AP, Diaz AA, Barjaktarevic I, Bowler RP, Kanner RE, Peters SP, Ortega VE, Dransfield MT, Crapo JD. A Risk Prediction Model for Mortality Among Smokers in the COPDGene? Study. Chronic Obstr Pulm Dis. 2020 Oct; 7(4):346-361. PMID: 32877963.
      View in: PubMed
    38. Oh AS, Strand M, Pratte K, Regan EA, Humphries S, Crapo JD, Lynch DA. Visual Emphysema at Chest CT in GOLD Stage 0 Cigarette Smokers Predicts Disease Progression: Results from the COPDGene Study. Radiology. 2020 09; 296(3):641-649. PMID: 32633676.
      View in: PubMed
    39. Moll M, Sakornsakolpat P, Shrine N, Hobbs BD, DeMeo DL, John C, Guyatt AL, McGeachie MJ, Gharib SA, Obeidat M, Lahousse L, Wijnant SRA, Brusselle G, Meyers DA, Bleecker ER, Li X, Tal-Singer R, Manichaikul A, Rich SS, Won S, Kim WJ, Do AR, Washko GR, Barr RG, Psaty BM, Bartz TM, Hansel NN, Barnes K, Hokanson JE, Crapo JD, Lynch D, Bakke P, Gulsvik A, Hall IP, Wain L, Weiss ST, Silverman EK, Dudbridge F, Tobin MD, Cho MH. Chronic obstructive pulmonary disease and related phenotypes: polygenic risk scores in population-based and case-control cohorts. Lancet Respir Med. 2020 07; 8(7):696-708. PMID: 32649918.
      View in: PubMed
    40. Leisman DE, Harhay MO, Lederer DJ, Abramson M, Adjei AA, Bakker J, Ballas ZK, Barreiro E, Bell SC, Bellomo R, Bernstein JA, Branson RD, Brusasco V, Chalmers JD, Chokroverty S, Citerio G, Collop NA, Cooke CR, Crapo JD, Donaldson G, Fitzgerald DA, Grainger E, Hale L, Herth FJ, Kochanek PM, Marks G, Moorman JR, Ost DE, Schatz M, Sheikh A, Smyth AR, Stewart I, Stewart PW, Swenson ER, Szymusiak R, Teboul JL, Vincent JL, Wedzicha JA, Maslove DM. Development and Reporting of Prediction Models: Guidance for Authors From Editors of Respiratory, Sleep, and Critical Care Journals. Crit Care Med. 2020 05; 48(5):623-633. PMID: 32141923.
      View in: PubMed
    41. Occhipinti M, Paoletti M, Crapo JD, Make BJ, Lynch DA, Brusasco V, Lavorini F, Silverman EK, Regan EA, Pistolesi M. Validation of a method to assess emphysema severity by spirometry in the COPDGene study. Respir Res. 2020 May 01; 21(1):103. PMID: 32357885.
      View in: PubMed
    42. Moll M, Qiao D, Regan EA, Hunninghake GM, Make BJ, Tal-Singer R, McGeachie MJ, Castaldi PJ, San Jose Estepar R, Washko GR, Wells JM, LaFon D, Strand M, Bowler RP, Han MK, Vestbo J, Celli B, Calverley P, Crapo J, Silverman EK, Hobbs BD, Cho MH. Machine Learning and Prediction of All-Cause Mortality in COPD. Chest. 2020 09; 158(3):952-964. PMID: 32353417.
      View in: PubMed
    43. Hoth KF, Moreau KL, Weinberger HD, Holm KE, Meschede K, Crapo JD, Make BJ, Moser DJ, Kozora E, Bowler RP, Pierce GL, Ten Eyck P, Wamboldt FS. Carotid Artery Stiffness is Associated With Cognitive Performance in Former Smokers With and Without Chronic Obstructive Pulmonary Disease. J Am Heart Assoc. 2020 05 05; 9(9):e014862. PMID: 32338117.
      View in: PubMed
    44. Lowe KE, Hokanson JE, Make BJ, Pratte KA, Regan EA, Silverman EK, Young KA, Kinney GL, Crapo JD. Letter to the Editor: Response by Authors. Chronic Obstr Pulm Dis. 2020 Apr; 7(2):82-85. PMID: 32324979.
      View in: PubMed
    45. Moll M, Regan EA, Hokanson JE, Lutz SM, Silverman EK, Crapo JD, Make BJ, DeMeo DL. The Association of Multiparity with Lung Function and Chronic Obstructive Pulmonary Disease-Related Phenotypes. Chronic Obstr Pulm Dis. 2020 Apr; 7(2):86-98. PMID: 32324980.
      View in: PubMed
    46. Tal-Singer R, Crapo JD. COPD at the Time of COVID-19: A COPD Foundation Perspective. Chronic Obstr Pulm Dis. 2020 Apr; 7(2):73-75. PMID: 32324976.
      View in: PubMed
    47. Fortis S, Comellas A, Kim V, Casaburi R, Hokanson JE, Crapo JD, Silverman EK, Wan ES. Low FVC/TLC in Preserved Ratio Impaired Spirometry (PRISm) is associated with features of and progression to obstructive lung disease. Sci Rep. 2020 03 20; 10(1):5169. PMID: 32198360.
      View in: PubMed
    48. LaFon DC, Bhatt SP, Labaki WW, Rahaghi FN, Moll M, Bowler RP, Regan EA, Make BJ, Crapo JD, San Jose Estepar R, Diaz AA, Silverman EK, Han MK, Hobbs B, Cho MH, Washko GR, Dransfield MT, Wells JM. Pulmonary artery enlargement and mortality risk in moderate to severe COPD: results from COPDGene. Eur Respir J. 2020 02; 55(2). PMID: 31772001.
      View in: PubMed
    49. Pompe E, Strand M, van Rikxoort EM, Hoffman EA, Barr RG, Charbonnier JP, Humphries S, Han MK, Hokanson JE, Make BJ, Regan EA, Silverman EK, Crapo JD, Lynch DA. Five-year Progression of Emphysema and Air Trapping at CT in Smokers with and Those without Chronic Obstructive Pulmonary Disease: Results from the COPDGene Study. Radiology. 2020 04; 295(1):218-226. PMID: 32013794.
      View in: PubMed
    50. Castaldi PJ, Boueiz A, Yun J, Estepar RSJ, Ross JC, Washko G, Cho MH, Hersh CP, Kinney GL, Young KA, Regan EA, Lynch DA, Criner GJ, Dy JG, Rennard SI, Casaburi R, Make BJ, Crapo J, Silverman EK, Hokanson JE. Machine Learning Characterization of COPD Subtypes: Insights From the COPDGene Study. Chest. 2020 05; 157(5):1147-1157. PMID: 31887283.
      View in: PubMed
    51. Humphries SM, Notary AM, Centeno JP, Strand MJ, Crapo JD, Silverman EK, Lynch DA. Deep Learning Enables Automatic Classification of Emphysema Pattern at CT. Radiology. 2020 02; 294(2):434-444. PMID: 31793851.
      View in: PubMed
    52. Croghan A, Brunette A, Holm KE, Kozora E, Moser DJ, Wamboldt FS, Meschede K, Make BJ, Crapo JD, Weinberger HD, Moreau KL, Bowler RP, Hoth KF. Reduced Attention in Former Smokers with and without COPD. Int J Behav Med. 2019 Dec; 26(6):600-607. PMID: 31732904.
      View in: PubMed
    53. Regan EA, Vaidya A, Margulies PL, Make BJ, Lowe KE, Crapo JD. Primary adrenal insufficiency in the United States: diagnostic error and patient satisfaction with treatment. Diagnosis (Berl). 2019 11 26; 6(4):343-350. PMID: 31256064.
      View in: PubMed
    54. Young KA, Regan EA, Han MK, Lutz SM, Ragland M, Castaldi PJ, Washko GR, Cho MH, Strand M, Curran-Everett D, Beaty TH, Bowler RP, Wan ES, Lynch DA, Make BJ, Silverman EK, Crapo JD, Hokanson JE, Kinney GL. Subtypes of COPD Have Unique Distributions and Differential Risk of Mortality. Chronic Obstr Pulm Dis. 2019 Nov; 6(5):400-413. PMID: 31710795.
      View in: PubMed
    55. Lowe KE, Regan EA, Anzueto A, Austin E, Austin JHM, Beaty TH, Benos PV, Benway CJ, Bhatt SP, Bleecker ER, Bodduluri S, Bon J, Boriek AM, Boueiz AR, Bowler RP, Budoff M, Casaburi R, Castaldi PJ, Charbonnier JP, Cho MH, Comellas A, Conrad D, Costa Davis C, Criner GJ, Curran-Everett D, Curtis JL, DeMeo DL, Diaz AA, Dransfield MT, Dy JG, Fawzy A, Fleming M, Flenaugh EL, Foreman MG, Fortis S, Gebrekristos H, Grant S, Grenier PA, Gu T, Gupta A, Han MK, Hanania NA, Hansel NN, Hayden LP, Hersh CP, Hobbs BD, Hoffman EA, Hogg JC, Hokanson JE, Hoth KF, Hsiao A, Humphries S, Jacobs K, Jacobson FL, Kazerooni EA, Kim V, Kim WJ, Kinney GL, Koegler H, Lutz SM, Lynch DA, MacIntye NR, Make BJ, Marchetti N, Martinez FJ, Maselli DJ, Mathews AM, McCormack MC, McDonald MN, McEvoy CE, Moll M, Molye SS, Murray S, Nath H, Newell JD, Occhipinti M, Paoletti M, Parekh T, Pistolesi M, Pratte KA, Putcha N, Ragland M, Reinhardt JM, Rennard SI, Rosiello RA, Ross JC, Rossiter HB, Ruczinski I, San Jose Estepar R, Sciurba FC, Sieren JC, Singh H, Soler X, Steiner RM, Strand MJ, Stringer WW, Tal-Singer R, Thomashow B, Vegas S?nchez-Ferrero G, Walsh JW, Wan ES, Washko GR, Michael Wells J, Wendt CH, Westney G, Wilson A, Wise RA, Yen A, Young K, Yun J, Silverman EK, Crapo JD. COPDGene? 2019: Redefining the Diagnosis of Chronic Obstructive Pulmonary Disease. Chronic Obstr Pulm Dis. 2019 Nov; 6(5):384-399. PMID: 31710793.
      View in: PubMed
    56. Young KA, Strand M, Ragland MF, Kinney GL, Austin EE, Regan EA, Lowe KE, Make BJ, Silverman EK, Crapo JD, Hokanson JE. Pulmonary Subtypes Exhibit Differential Global Initiative for Chronic Obstructive Lung Disease Spirometry Stage Progression: The COPDGene? Study. Chronic Obstr Pulm Dis. 2019 11; 6(5):414-429. PMID: 31710796.
      View in: PubMed
    57. Crapo JD. Fifty Years of the Division of Lung Diseases and the Evolution of Pulmonary Research and Medicine. Chronic Obstr Pulm Dis. 2019 Oct 23; 6(4). PMID: 31647853.
      View in: PubMed
    58. Ragland MF, Benway CJ, Lutz SM, Bowler RP, Hecker J, Hokanson JE, Crapo JD, Castaldi PJ, DeMeo DL, Hersh CP, Hobbs BD, Lange C, Beaty TH, Cho MH, Silverman EK. Genetic Advances in Chronic Obstructive Pulmonary Disease. Insights from COPDGene. Am J Respir Crit Care Med. 2019 09 15; 200(6):677-690. PMID: 30908940.
      View in: PubMed
    59. Regan EA, Hersh CP, Castaldi PJ, DeMeo DL, Silverman EK, Crapo JD, Bowler RP. Omics and the Search for Blood Biomarkers in Chronic Obstructive Pulmonary Disease. Insights from COPDGene. Am J Respir Cell Mol Biol. 2019 08; 61(2):143-149. PMID: 30874442.
      View in: PubMed
    60. Parker MM, Hao Y, Guo F, Pham B, Chase R, Platig J, Cho MH, Hersh CP, Thannickal VJ, Crapo J, Washko G, Randell SH, Silverman EK, San Jos? Est?par R, Zhou X, Castaldi PJ. Identification of an emphysema-associated genetic variant near TGFB2 with regulatory effects in lung fibroblasts. Elife. 2019 07 25; 8. PMID: 31343404.
      View in: PubMed
    61. Regan EA, Lowe KE, Make BJ, Lynch DA, Kinney GL, Budoff MJ, Mao SS, Dyer D, Curtis JL, Bowler RP, Han MK, Beaty TH, Hokanson JE, Kern E, Humphries S, Curran-Everett D, van Beek EJR, Silverman EK, Crapo JD, Finigan JH. Identifying Smoking-Related Disease on Lung Cancer Screening CT Scans: Increasing the Value. Chronic Obstr Pulm Dis. 2019 Jul 24; 6(3):233-245. PMID: 31342730.
      View in: PubMed
    62. Thomashow B, Crapo JD, Drummond MB, Han MK, Kalhan R, Malanga E, Malanga V, Mannino DM, Rennard S, Sciurba FC, Willard KS, Wise R, Yawn B. Introducing the New COPD Pocket Consultant Guide App: Can A Digital Approach Improve Care? A Statement of the COPD Foundation. Chronic Obstr Pulm Dis. 2019 Jul 24; 6(3):210-220. PMID: 31075813.
      View in: PubMed
    63. Moore C, Blumhagen RZ, Yang IV, Walts A, Powers J, Walker T, Bishop M, Russell P, Vestal B, Cardwell J, Markin CR, Mathai SK, Schwarz MI, Steele MP, Lee J, Brown KK, Loyd JE, Crapo JD, Silverman EK, Cho MH, James JA, Guthridge JM, Cogan JD, Kropski JA, Swigris JJ, Bair C, Kim DS, Ji W, Kim H, Song JW, Maier LA, Pacheco KA, Hirani N, Poon AS, Li F, Jenkins RG, Braybrooke R, Saini G, Maher TM, Molyneaux PL, Saunders P, Zhang Y, Gibson KF, Kass DJ, Rojas M, Sembrat J, Wolters PJ, Collard HR, Sundy JS, O'Riordan T, Strek ME, Noth I, Ma SF, Porteous MK, Kreider ME, Patel NB, Inoue Y, Hirose M, Arai T, Akagawa S, Eickelberg O, Fernandez IE, Behr J, Mogulkoc N, Corte TJ, Glaspole I, Tomassetti S, Ravaglia C, Poletti V, Crestani B, Borie R, Kannengiesser C, Parfrey H, Fiddler C, Rassl D, Molina-Molina M, Machahua C, Worboys AM, Gudmundsson G, Isaksson HJ, Lederer DJ, Podolanczuk AJ, Montesi SB, Bendstrup E, Danchel V, Selman M, Pardo A, Henry MT, Keane MP, Doran P, Va??kov? M, Sterclova M, Ryerson CJ, Wilcox PG, Okamoto T, Furusawa H, Miyazaki Y, Laurent G, Baltic S, Prele C, Moodley Y, Shea BS, Ohta K, Suzukawa M, Narumoto O, Nathan SD, Venuto DC, Woldehanna ML, Kokturk N, de Andrade JA, Luckhardt T, Kulkarni T, Bonella F, Donnelly SC, McElroy A, Armstong ME, Aranda A, Carbone RG, Puppo F, Beckman KB, Nickerson DA, Fingerlin TE, Schwartz DA. Resequencing Study Confirms That Host Defense and Cell Senescence Gene Variants Contribute to the Risk of Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med. 2019 07 15; 200(2):199-208. PMID: 31034279.
      View in: PubMed
    64. Park J, Hobbs BD, Crapo JD, Make BJ, Regan EA, Humphries S, Carey VJ, Lynch DA, Silverman EK. Subtyping COPD by Using Visual and Quantitative CT Imaging Features. Chest. 2020 01; 157(1):47-60. PMID: 31283919.
      View in: PubMed
    65. Gad SC, Sullivan DW, Mujer CV, Spainhour CB, Crapo JD. Nonclinical Safety and Toxicokinetics of MnTE-2-PyP (BMX-010), a Topical Agent in Phase 2 Trials for Psoriasis and Atopic Dermatitis. Int J Toxicol. 2019 Jul/Aug; 38(4):291-302. PMID: 31333066.
      View in: PubMed
    66. Chen J, Cho M, Silverman EK, Hokanson JE, Kinney GL, Crapo JD, Rennard S, Dy J, Castaldi P. Turning subtypes into disease axes to improve prediction of COPD progression. Thorax. 2019 09; 74(9):906-909. PMID: 31189730.
      View in: PubMed
    67. Shrine N, Guyatt AL, Erzurumluoglu AM, Jackson VE, Hobbs BD, Melbourne CA, Batini C, Fawcett KA, Song K, Sakornsakolpat P, Li X, Boxall R, Reeve NF, Obeidat M, Zhao JH, Wielscher M, Weiss S, Kentistou KA, Cook JP, Sun BB, Zhou J, Hui J, Karrasch S, Imboden M, Harris SE, Marten J, Enroth S, Kerr SM, Surakka I, Vitart V, Lehtim?ki T, Allen RJ, Bakke PS, Beaty TH, Bleecker ER, Boss? Y, Brandsma CA, Chen Z, Crapo JD, Danesh J, DeMeo DL, Dudbridge F, Ewert R, Gieger C, Gulsvik A, Hansell AL, Hao K, Hoffman JD, Hokanson JE, Homuth G, Joshi PK, Joubert P, Langenberg C, Li X, Li L, Lin K, Lind L, Locantore N, Luan J, Mahajan A, Maranville JC, Murray A, Nickle DC, Packer R, Parker MM, Paynton ML, Porteous DJ, Prokopenko D, Qiao D, Rawal R, Runz H, Sayers I, Sin DD, Smith BH, Artigas MS, Sparrow D, Tal-Singer R, Timmers PRHJ, Van den Berge M, Whittaker JC, Woodruff PG, Yerges-Armstrong LM, Troyanskaya OG, Raitakari OT, K?h?nen M, Pola?ek O, Gyllensten U, Rudan I, Deary IJ, Probst-Hensch NM, Schulz H, James AL, Wilson JF, Stubbe B, Zeggini E, Jarvelin MR, Wareham N, Silverman EK, Hayward C, Morris AP, Butterworth AS, Scott RA, Walters RG, Meyers DA, Cho MH, Strachan DP, Hall IP, Tobin MD, Wain LV. Author Correction: New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries. Nat Genet. 2019 Jun; 51(6):1067. PMID: 31110354.
      View in: PubMed
    68. Lutz SM, Frederiksen B, Begum F, McDonald MN, Cho MH, Hobbs BD, Parker MM, DeMeo DL, Hersh CP, Ehringer MA, Young K, Jiang L, Foreman MG, Kinney GL, Make BJ, Lomas DA, Bakke P, Gulsvik A, Crapo JD, Silverman EK, Beaty TH, Hokanson JE. Common and Rare Variants Genetic Association Analysis of Cigarettes per Day Among Ever-Smokers in Chronic Obstructive Pulmonary Disease Cases and Controls. Nicotine Tob Res. 2019 05 21; 21(6):714-722. PMID: 29767774.
      View in: PubMed
    69. Kim V, Zhao H, Regan E, Han MK, Make BJ, Crapo JD, Jones PW, Curtis JL, Silverman EK, Criner GJ. The St. George's Respiratory Questionnaire Definition of Chronic Bronchitis May Be a?Better Predictor of COPD Exacerbations Compared With the Classic Definition. Chest. 2019 10; 156(4):685-695. PMID: 31047955.
      View in: PubMed
    70. Oudkerk SF, Mohamed Hoesein FAA, ?ner FC, Verlaan JJ, de Jong PA, Kuperus JS, Cho M, McDonald ML, Lynch DA, Silverman EK, Crapo JD, Make BJ, Lowe KE, Regan EA. Diffuse Idiopathic Skeletal Hyperostosis in Smokers and Restrictive Spirometry Pattern: An Analysis of the COPDGene Cohort. J Rheumatol. 2020 04; 47(4):531-538. PMID: 31043539.
      View in: PubMed
    71. Sakornsakolpat P, McCormack M, Bakke P, Gulsvik A, Make BJ, Crapo JD, Cho MH, Silverman EK. Genome-Wide Association Analysis of Single-Breath DlCO. Am J Respir Cell Mol Biol. 2019 05; 60(5):523-531. PMID: 30694715.
      View in: PubMed
    72. Boueiz A, Pham B, Chase R, Lamb A, Lee S, Naing ZZC, Cho MH, Parker MM, Sakornsakolpat P, Hersh CP, Crapo JD, Stergachis AB, Tal-Singer R, DeMeo DL, Silverman EK, Zhou X, Castaldi PJ. Integrative Genomics Analysis Identifies ACVR1B as a Candidate Causal Gene of Emphysema Distribution. Am J Respir Cell Mol Biol. 2019 04; 60(4):388-398. PMID: 30335480.
      View in: PubMed
    73. Shrine N, Guyatt AL, Erzurumluoglu AM, Jackson VE, Hobbs BD, Melbourne CA, Batini C, Fawcett KA, Song K, Sakornsakolpat P, Li X, Boxall R, Reeve NF, Obeidat M, Zhao JH, Wielscher M, Weiss S, Kentistou KA, Cook JP, Sun BB, Zhou J, Hui J, Karrasch S, Imboden M, Harris SE, Marten J, Enroth S, Kerr SM, Surakka I, Vitart V, Lehtim?ki T, Allen RJ, Bakke PS, Beaty TH, Bleecker ER, Boss? Y, Brandsma CA, Chen Z, Crapo JD, Danesh J, DeMeo DL, Dudbridge F, Ewert R, Gieger C, Gulsvik A, Hansell AL, Hao K, Hoffman JD, Hokanson JE, Homuth G, Joshi PK, Joubert P, Langenberg C, Li X, Li L, Lin K, Lind L, Locantore N, Luan J, Mahajan A, Maranville JC, Murray A, Nickle DC, Packer R, Parker MM, Paynton ML, Porteous DJ, Prokopenko D, Qiao D, Rawal R, Runz H, Sayers I, Sin DD, Smith BH, Soler Artigas M, Sparrow D, Tal-Singer R, Timmers PRHJ, Van den Berge M, Whittaker JC, Woodruff PG, Yerges-Armstrong LM, Troyanskaya OG, Raitakari OT, K?h?nen M, Pola?ek O, Gyllensten U, Rudan I, Deary IJ, Probst-Hensch NM, Schulz H, James AL, Wilson JF, Stubbe B, Zeggini E, Jarvelin MR, Wareham N, Silverman EK, Hayward C, Morris AP, Butterworth AS, Scott RA, Walters RG, Meyers DA, Cho MH, Strachan DP, Hall IP, Tobin MD, Wain LV. New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries. Nat Genet. 2019 03; 51(3):481-493. PMID: 30804560.
      View in: PubMed
    74. Sakornsakolpat P, Prokopenko D, Lamontagne M, Reeve NF, Guyatt AL, Jackson VE, Shrine N, Qiao D, Bartz TM, Kim DK, Lee MK, Latourelle JC, Li X, Morrow JD, Obeidat M, Wyss AB, Bakke P, Barr RG, Beaty TH, Belinsky SA, Brusselle GG, Crapo JD, de Jong K, DeMeo DL, Fingerlin TE, Gharib SA, Gulsvik A, Hall IP, Hokanson JE, Kim WJ, Lomas DA, London SJ, Meyers DA, O'Connor GT, Rennard SI, Schwartz DA, Sliwinski P, Sparrow D, Strachan DP, Tal-Singer R, Tesfaigzi Y, Vestbo J, Vonk JM, Yim JJ, Zhou X, Boss? Y, Manichaikul A, Lahousse L, Silverman EK, Boezen HM, Wain LV, Tobin MD, Hobbs BD, Cho MH. Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations. Nat Genet. 2019 03; 51(3):494-505. PMID: 30804561.
      View in: PubMed
    75. Criner RN, Labaki WW, Regan EA, Bon JM, Soler X, Bhatt SP, Murray S, Hokanson JE, Silverman EK, Crapo JD, Curtis JL, Martinez FJ, Make BJ, Han MK, Martinez CH. Mortality and Exacerbations by Global Initiative for Chronic Obstructive Lung Disease Groups ABCD: 2011 Versus 2017 in the COPDGene? Cohort. Chronic Obstr Pulm Dis. 2019 Jan 10; 6(1):64-73. PMID: 30775425.
      View in: PubMed
    76. Lederer DJ, Bell SC, Branson RD, Chalmers JD, Marshall R, Maslove DM, Ost DE, Punjabi NM, Schatz M, Smyth AR, Stewart PW, Suissa S, Adjei AA, Akdis CA, Azoulay ?, Bakker J, Ballas ZK, Bardin PG, Barreiro E, Bellomo R, Bernstein JA, Brusasco V, Buchman TG, Chokroverty S, Collop NA, Crapo JD, Fitzgerald DA, Hale L, Hart N, Herth FJ, Iwashyna TJ, Jenkins G, Kolb M, Marks GB, Mazzone P, Moorman JR, Murphy TM, Noah TL, Reynolds P, Riemann D, Russell RE, Sheikh A, Sotgiu G, Swenson ER, Szczesniak R, Szymusiak R, Teboul JL, Vincent JL. Control of Confounding and Reporting of Results in Causal Inference Studies. Guidance for Authors from Editors of Respiratory, Sleep, and Critical Care Journals. Ann Am Thorac Soc. 2019 01; 16(1):22-28. PMID: 30230362.
      View in: PubMed
    77. Wan ES, Fortis S, Regan EA, Hokanson J, Han MK, Casaburi R, Make BJ, Crapo JD, DeMeo DL, Silverman EK. Longitudinal Phenotypes and Mortality in Preserved Ratio Impaired Spirometry in the COPDGene Study. Am J Respir Crit Care Med. 2018 12 01; 198(11):1397-1405. PMID: 29874098.
      View in: PubMed
    78. Charbonnier JP, Pompe E, Moore C, Humphries S, van Ginneken B, Make B, Regan E, Crapo JD, van Rikxoort EM, Lynch DA. Airway wall thickening on CT: Relation to smoking status and severity of COPD. Respir Med. 2019 01; 146:36-41. PMID: 30665516.
      View in: PubMed
    79. Wells JM, Parker MM, Oster RA, Bowler RP, Dransfield MT, Bhatt SP, Cho MH, Kim V, Curtis JL, Martinez FJ, Paine R, O'Neal W, Labaki WW, Kaner RJ, Barjaktarevic I, Han MK, Silverman EK, Crapo JD, Barr RG, Woodruff P, Castaldi PJ, Gaggar A. Elevated circulating MMP-9 is linked to increased COPD exacerbation risk in SPIROMICS and COPDGene. JCI Insight. 2018 11 15; 3(22). PMID: 30429371.
      View in: PubMed
    80. Lowe KE, Make BJ, Crapo JD, Kinney GL, Hokanson JE, Kim V, Iyer AS, Bhatt SP, Hoth KF, Holm KE, Wise R, DeMeo D, Foreman MG, Stone TJ, Regan EA. Association of low income with pulmonary disease progression in smokers with and without chronic obstructive pulmonary disease. ERJ Open Res. 2018 Oct; 4(4). PMID: 30443555.
      View in: PubMed
    81. Prokopenko D, Sakornsakolpat P, Fier HL, Qiao D, Parker MM, McDonald MN, Manichaikul A, Rich SS, Barr RG, Williams CJ, Brantly ML, Lange C, Beaty TH, Crapo JD, Silverman EK, Cho MH. Whole-Genome Sequencing in Severe Chronic Obstructive Pulmonary Disease. Am J Respir Cell Mol Biol. 2018 11; 59(5):614-622. PMID: 29949718.
      View in: PubMed
    82. Qiao D, Ameli A, Prokopenko D, Chen H, Kho AT, Parker MM, Morrow J, Hobbs BD, Liu Y, Beaty TH, Crapo JD, Barnes KC, Nickerson DA, Bamshad M, Hersh CP, Lomas DA, Agusti A, Make BJ, Calverley PMA, Donner CF, Wouters EF, Vestbo J, Par? PD, Levy RD, Rennard SI, Tal-Singer R, Spitz MR, Sharma A, Ruczinski I, Lange C, Silverman EK, Cho MH. Whole exome sequencing analysis in severe chronic obstructive pulmonary disease. Hum Mol Genet. 2018 11 01; 27(21):3801-3812. PMID: 30060175.
      View in: PubMed
    83. Seo M, Qiu W, Bailey W, Criner GJ, Dransfield MT, Fuhlbrigge AL, Reilly JJ, Scholand MB, Castaldi P, Chase R, Parker M, Saferali A, Yun JH, Crapo JD, Cho MH, Beaty TH, Silverman EK, Hersh CP. Genomics and response to long-term oxygen therapy in chronic obstructive pulmonary disease. J Mol Med (Berl). 2018 12; 96(12):1375-1385. PMID: 30353303.
      View in: PubMed
    84. Kinney GL, Santorico SA, Young KA, Cho MH, Castaldi PJ, San Jos? Est?par R, Ross JC, Dy JG, Make BJ, Regan EA, Lynch DA, Everett DC, Lutz SM, Silverman EK, Washko GR, Crapo JD, Hokanson JE. Identification of Chronic Obstructive Pulmonary Disease Axes That Predict All-Cause Mortality: The COPDGene Study. Am J Epidemiol. 2018 10 01; 187(10):2109-2116. PMID: 29771274.
      View in: PubMed
    85. Sharma A, Kitsak M, Cho MH, Ameli A, Zhou X, Jiang Z, Crapo JD, Beaty TH, Menche J, Bakke PS, Santolini M, Silverman EK. Integration of Molecular Interactome and Targeted Interaction Analysis to Identify a COPD Disease Network Module. Sci Rep. 2018 09 27; 8(1):14439. PMID: 30262855.
      View in: PubMed
    86. Heinzman JT, Hoth KF, Cho MH, Sakornsakolpat P, Regan EA, Make BJ, Kinney GL, Wamboldt FS, Holm KE, Bormann N, Robles J, Kim V, Iyer AS, Silverman EK, Crapo JD, Han S, Potash JB, Shinozaki G. GWAS and systems biology analysis of depressive symptoms among smokers from the COPDGene cohort. J Affect Disord. 2019 01 15; 243:16-22. PMID: 30219690.
      View in: PubMed
    87. Lynch DA, Moore CM, Wilson C, Nevrekar D, Jennermann T, Humphries SM, Austin JHM, Grenier PA, Kauczor HU, Han MK, Regan EA, Make BJ, Bowler RP, Beaty TH, Curran-Everett D, Hokanson JE, Curtis JL, Silverman EK, Crapo JD. CT-based Visual Classification of Emphysema: Association with Mortality in the COPDGene Study. Radiology. 2018 09; 288(3):859-866. PMID: 29762095.
      View in: PubMed
    88. Diaz AA, Martinez CH, Harmouche R, Young TP, McDonald ML, Ross JC, Han ML, Bowler R, Make B, Regan EA, Silverman EK, Crapo J, Boriek AM, Kinney GL, Hokanson JE, Estepar RSJ, Washko GR. Pectoralis muscle area and mortality in smokers without airflow obstruction. Respir Res. 2018 04 10; 19(1):62. PMID: 29636050.
      View in: PubMed
    89. Suh YJ, McDonald MN, Washko GR, Carolan BJ, Bowler RP, Lynch DA, Kinney GL, Bon JM, Cho MH, Crapo JD, Regan EA. Lung, Fat and Bone: Increased Adiponectin Associates with the Combination of Smoking-Related Lung Disease and Osteoporosis. Chronic Obstr Pulm Dis. 2018 Apr 01; 5(2):134-143. PMID: 30374451.
      View in: PubMed
    90. Bruni A, Pepper AR, Pawlick RL, Gala-Lopez B, Gamble A, Kin T, Malcolm AJ, Jones C, Piganelli JD, Crapo JD, Shapiro AMJ. BMX-001, a novel redox-active metalloporphyrin, improves islet function and engraftment in a murine transplant model. Am J Transplant. 2018 08; 18(8):1879-1889. PMID: 29464912.
      View in: PubMed
    91. Rho JY, Lynch DA, Suh YJ, Nah JW, Zach JA, Schroeder JD, Cox CW, Bowler RP, Fenster BE, Dransfield MT, Wells JM, Hokanson JE, Curran-Everett D, Williams A, Han MK, Crapo JD, Silverman EK. CT measurements of central pulmonary vasculature as predictors of severe exacerbation in COPD. Medicine (Baltimore). 2018 Jan; 97(3):e9542. PMID: 29504975.
      View in: PubMed
    92. Sch?fer M, Barker AJ, Kheyfets V, Stenmark KR, Crapo J, Yeager ME, Truong U, Buckner JK, Fenster BE, Hunter KS. Helicity and Vorticity of Pulmonary Arterial Flow in Patients With Pulmonary Hypertension: Quantitative Analysis of Flow Formations. J Am Heart Assoc. 2017 Dec 20; 6(12). PMID: 29263034.
      View in: PubMed
    93. Hayden LP, Hardin ME, Qiu W, Lynch DA, Strand MJ, van Beek EJ, Crapo JD, Silverman EK, Hersh CP. Asthma Is a Risk Factor for Respiratory Exacerbations Without Increased Rate of Lung Function Decline: Five-Year Follow-up in Adult Smokers From the COPDGene Study. Chest. 2018 02; 153(2):368-377. PMID: 29248621.
      View in: PubMed
    94. Labaki WW, Martinez CH, Martinez FJ, Galb?n CJ, Ross BD, Washko GR, Barr RG, Regan EA, Coxson HO, Hoffman EA, Newell JD, Curran-Everett D, Hogg JC, Crapo JD, Lynch DA, Kazerooni EA, Han MK. The Role of Chest Computed Tomography in the Evaluation and Management of the Patient with Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2017 12 01; 196(11):1372-1379. PMID: 28661698.
      View in: PubMed
    95. Bradford E, Jacobson S, Varasteh J, Comellas AP, Woodruff P, O'Neal W, DeMeo DL, Li X, Kim V, Cho M, Castaldi PJ, Hersh C, Silverman EK, Crapo JD, Kechris K, Bowler RP. The value of blood cytokines and chemokines in assessing COPD. Respir Res. 2017 10 24; 18(1):180. PMID: 29065892.
      View in: PubMed
    96. Diaz AA, Strand M, Coxson HO, Ross JC, San Jose Estepar R, Lynch D, van Rikxoort EM, Rosas IO, Hunninghake GM, Putman RK, Hatabu H, Yen A, Kinney GL, Hokanson JE, Silverman EK, Crapo J, Washko GR. Disease Severity Dependence of the Longitudinal Association Between CT Lung Density and Lung Function in Smokers. Chest. 2018 03; 153(3):638-645. PMID: 29066389.
      View in: PubMed
    97. Boueiz A, Chang Y, Cho MH, Washko GR, San Jos? Est?par R, Bowler RP, Crapo JD, DeMeo DL, Dy JG, Silverman EK, Castaldi PJ. Lobar Emphysema Distribution Is Associated With 5-Year Radiological Disease Progression. Chest. 2018 01; 153(1):65-76. PMID: 28943279.
      View in: PubMed
    98. Radder JE, Gregory AD, Leme AS, Cho MH, Chu Y, Kelly NJ, Bakke P, Gulsvik A, Litonjua AA, Sparrow D, Beaty TH, Crapo JD, Silverman EK, Zhang Y, Berndt A, Shapiro SD. Variable Susceptibility to Cigarette Smoke-Induced Emphysema in 34 Inbred Strains of Mice Implicates Abi3bp in Emphysema Susceptibility. Am J Respir Cell Mol Biol. 2017 09; 57(3):367-375. PMID: 28441029.
      View in: PubMed
    99. Brunette AM, Holm KE, Wamboldt FS, Kozora E, Moser DJ, Make BJ, Crapo JD, Meschede K, Weinberger HD, Moreau KL, Bowler RP, Hoth KF. Subjective cognitive complaints and neuropsychological performance in former smokers with and without chronic obstructive pulmonary disease. J Clin Exp Neuropsychol. 2018 05; 40(4):411-422. PMID: 28766459.
      View in: PubMed
    100. Foreman MG, Wilson C, DeMeo DL, Hersh CP, Beaty TH, Cho MH, Ziniti J, Curran-Everett D, Criner G, Hokanson JE, Brantly M, Rouhani FN, Sandhaus RA, Crapo JD, Silverman EK. Alpha-1 Antitrypsin PiMZ Genotype Is Associated with Chronic Obstructive Pulmonary Disease in Two Racial Groups. Ann Am Thorac Soc. 2017 Aug; 14(8):1280-1287. PMID: 28380308.
      View in: PubMed
    101. Yawn BB, Thomashaw B, Mannino DM, Han MK, Kalhan R, Rennard S, Cerrata S, Crapo JD, Wise R. The 2017 Update to the COPD Foundation COPD Pocket Consultant Guide. Chronic Obstr Pulm Dis. 2017 Jul 15; 4(3):177-185. PMID: 28848929.
      View in: PubMed
    102. Busch R, Hobbs BD, Zhou J, Castaldi PJ, McGeachie MJ, Hardin ME, Hawrylkiewicz I, Sliwinski P, Yim JJ, Kim WJ, Kim DK, Agusti A, Make BJ, Crapo JD, Calverley PM, Donner CF, Lomas DA, Wouters EF, Vestbo J, Tal-Singer R, Bakke P, Gulsvik A, Litonjua AA, Sparrow D, Par? PD, Levy RD, Rennard SI, Beaty TH, Hokanson J, Silverman EK, Cho MH. Genetic Association and Risk Scores in a Chronic Obstructive Pulmonary Disease Meta-analysis of 16,707 Subjects. Am J Respir Cell Mol Biol. 2017 07; 57(1):35-46. PMID: 28170284.
      View in: PubMed
    103. Castaldi PJ, Benet M, Petersen H, Rafaels N, Finigan J, Paoletti M, Marike Boezen H, Vonk JM, Bowler R, Pistolesi M, Puhan MA, Anto J, Wauters E, Lambrechts D, Janssens W, Bigazzi F, Camiciottoli G, Cho MH, Hersh CP, Barnes K, Rennard S, Boorgula MP, Dy J, Hansel NN, Crapo JD, Tesfaigzi Y, Agusti A, Silverman EK, Garcia-Aymerich J. Do COPD subtypes really exist? COPD heterogeneity and clustering in 10 independent cohorts. Thorax. 2017 11; 72(11):998-1006. PMID: 28637835.
      View in: PubMed
    104. Birer SR, Lee CT, Choudhury KR, Young KH, Spasojevic I, Batinic-Haberle I, Crapo JD, Dewhirst MW, Ashcraft KA. Inhibition of the Continuum of Radiation-Induced Normal Tissue Injury by a Redox-Active Mn Porphyrin. Radiat Res. 2017 07; 188(1):94-104. PMID: 28517962.
      View in: PubMed
    105. Crapo JD. Remembering John W. Walsh 1949 - 2017. Chronic Obstr Pulm Dis. 2017 Apr 14; 4(2):81-82. PMID: 28848915.
      View in: PubMed
    106. Boueiz A, Lutz SM, Cho MH, Hersh CP, Bowler RP, Washko GR, Halper-Stromberg E, Bakke P, Gulsvik A, Laird NM, Beaty TH, Coxson HO, Crapo JD, Silverman EK, Castaldi PJ, DeMeo DL. Genome-Wide Association Study of the Genetic Determinants of Emphysema Distribution. Am J Respir Crit Care Med. 2017 03 15; 195(6):757-771. PMID: 27669027.
      View in: PubMed
    107. Hardin M, Cho MH, Sharma S, Glass K, Castaldi PJ, McDonald ML, Aschard H, Senter-Sylvia J, Tantisira K, Weiss ST, Hersh CP, Morrow JD, Lomas D, Agusti A, Bakke P, Gulsvik A, O'Connor GT, Dupuis J, Hokanson J, Crapo JD, Beaty TH, Laird N, Silverman EK, DeMeo DL. Sex-Based Genetic Association Study Identifies CELSR1 as a Possible Chronic Obstructive Pulmonary Disease Risk Locus among Women. Am J Respir Cell Mol Biol. 2017 03; 56(3):332-341. PMID: 27854507.
      View in: PubMed
    108. Wain LV, Shrine N, Artigas MS, Erzurumluoglu AM, Noyvert B, Bossini-Castillo L, Obeidat M, Henry AP, Portelli MA, Hall RJ, Billington CK, Rimington TL, Fenech AG, John C, Blake T, Jackson VE, Allen RJ, Prins BP, Campbell A, Porteous DJ, Jarvelin MR, Wielscher M, James AL, Hui J, Wareham NJ, Zhao JH, Wilson JF, Joshi PK, Stubbe B, Rawal R, Schulz H, Imboden M, Probst-Hensch NM, Karrasch S, Gieger C, Deary IJ, Harris SE, Marten J, Rudan I, Enroth S, Gyllensten U, Kerr SM, Polasek O, K?h?nen M, Surakka I, Vitart V, Hayward C, Lehtim?ki T, Raitakari OT, Evans DM, Henderson AJ, Pennell CE, Wang CA, Sly PD, Wan ES, Busch R, Hobbs BD, Litonjua AA, Sparrow DW, Gulsvik A, Bakke PS, Crapo JD, Beaty TH, Hansel NN, Mathias RA, Ruczinski I, Barnes KC, Boss? Y, Joubert P, van den Berge M, Brandsma CA, Par? PD, Sin DD, Nickle DC, Hao K, Gottesman O, Dewey FE, Bruse SE, Carey DJ, Kirchner HL, Jonsson S, Thorleifsson G, Jonsdottir I, Gislason T, Stefansson K, Schurmann C, Nadkarni G, Bottinger EP, Loos RJ, Walters RG, Chen Z, Millwood IY, Vaucher J, Kurmi OP, Li L, Hansell AL, Brightling C, Zeggini E, Cho MH, Silverman EK, Sayers I, Trynka G, Morris AP, Strachan DP, Hall IP, Tobin MD. Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets. Nat Genet. 2017 Mar; 49(3):416-425. PMID: 28166213.
      View in: PubMed
    109. Hobbs BD, de Jong K, Lamontagne M, Boss? Y, Shrine N, Artigas MS, Wain LV, Hall IP, Jackson VE, Wyss AB, London SJ, North KE, Franceschini N, Strachan DP, Beaty TH, Hokanson JE, Crapo JD, Castaldi PJ, Chase RP, Bartz TM, Heckbert SR, Psaty BM, Gharib SA, Zanen P, Lammers JW, Oudkerk M, Groen HJ, Locantore N, Tal-Singer R, Rennard SI, Vestbo J, Timens W, Par? PD, Latourelle JC, Dupuis J, O'Connor GT, Wilk JB, Kim WJ, Lee MK, Oh YM, Vonk JM, de Koning HJ, Leng S, Belinsky SA, Tesfaigzi Y, Manichaikul A, Wang XQ, Rich SS, Barr RG, Sparrow D, Litonjua AA, Bakke P, Gulsvik A, Lahousse L, Brusselle GG, Stricker BH, Uitterlinden AG, Ampleford EJ, Bleecker ER, Woodruff PG, Meyers DA, Qiao D, Lomas DA, Yim JJ, Kim DK, Hawrylkiewicz I, Sliwinski P, Hardin M, Fingerlin TE, Schwartz DA, Postma DS, MacNee W, Tobin MD, Silverman EK, Boezen HM, Cho MH. Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis. Nat Genet. 2017 Mar; 49(3):426-432. PMID: 28166215.
      View in: PubMed
    110. Hayden LP, Cho MH, McDonald MN, Crapo JD, Beaty TH, Silverman EK, Hersh CP. Susceptibility to Childhood Pneumonia: A Genome-Wide Analysis. Am J Respir Cell Mol Biol. 2017 01; 56(1):20-28. PMID: 27508494.
      View in: PubMed
    111. Halper-Stromberg E, Cho MH, Wilson C, Nevrekar D, Crapo JD, Washko G, Est?par RS, Lynch DA, Silverman EK, Leach S, Castaldi PJ. Visual Assessment of Chest Computed Tomographic Images Is Independently Useful for Genetic Association Analysis in Studies of Chronic Obstructive Pulmonary Disease. Ann Am Thorac Soc. 2017 Jan; 14(1):33-40. PMID: 27739898.
      View in: PubMed
    112. Washko GR, Kinney GL, Ross JC, San Jos? Est?par R, Han MK, Dransfield MT, Kim V, Hatabu H, Come CE, Bowler RP, Silverman EK, Crapo J, Lynch DA, Hokanson J, Diaz AA. Lung Mass in Smokers. Acad Radiol. 2017 04; 24(4):386-392. PMID: 27940230.
      View in: PubMed
    113. Wells JM, Estepar RS, McDonald MN, Bhatt SP, Diaz AA, Bailey WC, Jacobson FL, Dransfield MT, Washko GR, Make BJ, Casaburi R, van Beek EJ, Hoffman EA, Sciurba FC, Crapo JD, Silverman EK, Hersh CP. Clinical, physiologic, and radiographic factors contributing to development of hypoxemia in moderate to severe COPD: a cohort study. BMC Pulm Med. 2016 12 01; 16(1):169. PMID: 27903260.
      View in: PubMed
    114. Begum F, Ruczinski I, Hokanson JE, Lutz SM, Parker MM, Cho MH, Hetmanski JB, Scharpf RB, Crapo JD, Silverman EK, Beaty TH. Hemizygous Deletion on Chromosome 3p26.1 Is Associated with Heavy Smoking among African American Subjects in the COPDGene Study. PLoS One. 2016; 11(10):e0164134. PMID: 27711239.
      View in: PubMed
    115. Stover K, Fukuyama T, Young AT, Daniele MA, Oberley R, Crapo JD, B?umer W. Topically applied manganese-porphyrins BMX-001 and BMX-010 display a significant anti-inflammatory response in a mouse model of allergic dermatitis. Arch Dermatol Res. 2016 Dec; 308(10):711-721. PMID: 27709295.
      View in: PubMed
    116. Cosentino J, Zhao H, Hardin M, Hersh CP, Crapo J, Kim V, Criner GJ. Analysis of Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome Defined on the Basis of Bronchodilator Response and Degree of Emphysema. Ann Am Thorac Soc. 2016 09; 13(9):1483-9. PMID: 27268723.
      View in: PubMed
    117. Sun W, Kechris K, Jacobson S, Drummond MB, Hawkins GA, Yang J, Chen TH, Quibrera PM, Anderson W, Barr RG, Basta PV, Bleecker ER, Beaty T, Casaburi R, Castaldi P, Cho MH, Comellas A, Crapo JD, Criner G, Demeo D, Christenson SA, Couper DJ, Curtis JL, Doerschuk CM, Freeman CM, Gouskova NA, Han MK, Hanania NA, Hansel NN, Hersh CP, Hoffman EA, Kaner RJ, Kanner RE, Kleerup EC, Lutz S, Martinez FJ, Meyers DA, Peters SP, Regan EA, Rennard SI, Scholand MB, Silverman EK, Woodruff PG, O'Neal WK, Bowler RP. Common Genetic Polymorphisms Influence Blood Biomarker Measurements in COPD. PLoS Genet. 2016 Aug; 12(8):e1006011. PMID: 27532455.
      View in: PubMed
    118. Bhatt SP, Soler X, Wang X, Murray S, Anzueto AR, Beaty TH, Boriek AM, Casaburi R, Criner GJ, Diaz AA, Dransfield MT, Curran-Everett D, Galb?n CJ, Hoffman EA, Hogg JC, Kazerooni EA, Kim V, Kinney GL, Lagstein A, Lynch DA, Make BJ, Martinez FJ, Ramsdell JW, Reddy R, Ross BD, Rossiter HB, Steiner RM, Strand MJ, van Beek EJ, Wan ES, Washko GR, Wells JM, Wendt CH, Wise RA, Silverman EK, Crapo JD, Bowler RP, Han MK. Association between Functional Small Airway Disease and FEV1 Decline in Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2016 07 15; 194(2):178-84. PMID: 26808615.
      View in: PubMed
    119. Bruni A, Pepper AR, Gala-Lopez B, Pawlick R, Abualhassan N, Crapo JD, Piganelli JD, Shapiro AM. A novel redox-active metalloporphyrin reduces reactive oxygen species and inflammatory markers but does not improve marginal mass engraftment in a murine donation after circulatory death islet transplantation model. Islets. 2016 07 03; 8(4):e1190058. PMID: 27220256.
      View in: PubMed
    120. Kim V, Zhao H, Boriek AM, Anzueto A, Soler X, Bhatt SP, Rennard SI, Wise R, Comellas A, Ramsdell JW, Kinney GL, Han MK, Martinez CH, Yen A, Black-Shinn J, Porszasz J, Criner GJ, Hanania NA, Sharafkhaneh A, Crapo JD, Make BJ, Silverman EK, Curtis JL. Persistent and Newly Developed Chronic Bronchitis Are Associated with Worse Outcomes in Chronic Obstructive Pulmonary Disease. Ann Am Thorac Soc. 2016 07; 13(7):1016-25. PMID: 27158740.
      View in: PubMed
    121. Hobbs BD, Parker MM, Chen H, Lao T, Hardin M, Qiao D, Hawrylkiewicz I, Sliwinski P, Yim JJ, Kim WJ, Kim DK, Castaldi PJ, Hersh CP, Morrow J, Celli BR, Pinto-Plata VM, Criner GJ, Marchetti N, Bueno R, Agust? A, Make BJ, Crapo JD, Calverley PM, Donner CF, Lomas DA, Wouters EF, Vestbo J, Par? PD, Levy RD, Rennard SI, Zhou X, Laird NM, Lin X, Beaty TH, Silverman EK, Cho MH. Exome Array Analysis Identifies a Common Variant in IL27 Associated with Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2016 07 01; 194(1):48-57. PMID: 26771213.
      View in: PubMed
    122. Qiao D, Lange C, Beaty TH, Crapo JD, Barnes KC, Bamshad M, Hersh CP, Morrow J, Pinto-Plata VM, Marchetti N, Bueno R, Celli BR, Criner GJ, Silverman EK, Cho MH. Exome Sequencing Analysis in Severe, Early-Onset Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2016 06 15; 193(12):1353-63. PMID: 26736064.
      View in: PubMed
    123. Fingerlin TE, Zhang W, Yang IV, Ainsworth HC, Russell PH, Blumhagen RZ, Schwarz MI, Brown KK, Steele MP, Loyd JE, Cosgrove GP, Lynch DA, Groshong S, Collard HR, Wolters PJ, Bradford WZ, Kossen K, Seiwert SD, du Bois RM, Garcia CK, Devine MS, Gudmundsson G, Isaksson HJ, Kaminski N, Zhang Y, Gibson KF, Lancaster LH, Maher TM, Molyneaux PL, Wells AU, Moffatt MF, Selman M, Pardo A, Kim DS, Crapo JD, Make BJ, Regan EA, Walek DS, Daniel JJ, Kamatani Y, Zelenika D, Murphy E, Smith K, McKean D, Pedersen BS, Talbert J, Powers J, Markin CR, Beckman KB, Lathrop M, Freed B, Langefeld CD, Schwartz DA. Genome-wide imputation study identifies novel HLA locus for pulmonary fibrosis and potential role for auto-immunity in fibrotic idiopathic interstitial pneumonia. BMC Genet. 2016 06 07; 17(1):74. PMID: 27266705.
      View in: PubMed
    124. Mathai SK, Pedersen BS, Smith K, Russell P, Schwarz MI, Brown KK, Steele MP, Loyd JE, Crapo JD, Silverman EK, Nickerson D, Fingerlin TE, Yang IV, Schwartz DA. Desmoplakin Variants Are Associated with Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med. 2016 05 15; 193(10):1151-60. PMID: 26669357.
      View in: PubMed
    125. Gad SC, Sullivan DW, Spasojevic I, Mujer CV, Spainhour CB, Crapo JD. Nonclinical Safety and Toxicokinetics of MnTnBuOE-2-PyP5+ (BMX-001). Int J Toxicol. 2016 07; 35(4):438-53. PMID: 27098749.
      View in: PubMed
    126. Ganesh D, Kumarathasan P, Thomson EM, St-Germain C, Blais E, Crapo J, Vincent R. Impact of Superoxide Dismutase Mimetic AEOL 10150 on the Endothelin System of Fischer 344 Rats. PLoS One. 2016; 11(3):e0151810. PMID: 26990293.
      View in: PubMed
    127. Chang Y, Glass K, Liu YY, Silverman EK, Crapo JD, Tal-Singer R, Bowler R, Dy J, Cho M, Castaldi P. COPD subtypes identified by network-based clustering of blood gene expression. Genomics. 2016 Mar; 107(2-3):51-58. PMID: 26773458.
      View in: PubMed
    128. Kinney GL, Baker EH, Klein OL, Black-Shinn JL, Wan ES, Make B, Regan E, Bowler RP, Lutz SM, Young KA, Duca LM, Washko GR, Silverman EK, Crapo JD, Hokanson JE. Pulmonary Predictors of Incident Diabetes in Smokers. Chronic Obstr Pulm Dis. 2016; 3(4):739-747. PMID: 27795984.
      View in: PubMed
    129. Begum F, Ruczinski I, Li S, Silverman EK, Cho MH, Lynch DA, Curran-Everett D, Crapo J, Scharpf RB, Parker MM, Hetmanski JB, Beaty TH. Identifying a Deletion Affecting Total Lung Capacity Among Subjects in the COPDGene Study Cohort. Genet Epidemiol. 2016 Jan; 40(1):81-8. PMID: 26643968.
      View in: PubMed
    130. Lutz SM, Cho MH, Young K, Hersh CP, Castaldi PJ, McDonald ML, Regan E, Mattheisen M, DeMeo DL, Parker M, Foreman M, Make BJ, Jensen RL, Casaburi R, Lomas DA, Bhatt SP, Bakke P, Gulsvik A, Crapo JD, Beaty TH, Laird NM, Lange C, Hokanson JE, Silverman EK. A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry. BMC Genet. 2015 Dec 03; 16:138. PMID: 26634245.
      View in: PubMed
    131. Hayden LP, Hobbs BD, Cohen RT, Wise RA, Checkley W, Crapo JD, Hersh CP. Childhood pneumonia increases risk for chronic obstructive pulmonary disease: the COPDGene study. Respir Res. 2015 Sep 21; 16:115. PMID: 26392057.
      View in: PubMed
    132. Fenster BE, Holm KE, Weinberger HD, Moreau KL, Meschede K, Crapo JD, Make BJ, Bowler R, Wamboldt FS, Hoth KF. Right ventricular diastolic function and exercise capacity in COPD. Respir Med. 2015 Oct; 109(10):1287-92. PMID: 26371994.
      View in: PubMed
    133. Cho MH, Castaldi PJ, Hersh CP, Hobbs BD, Barr RG, Tal-Singer R, Bakke P, Gulsvik A, San Jos? Est?par R, Van Beek EJ, Coxson HO, Lynch DA, Washko GR, Laird NM, Crapo JD, Beaty TH, Silverman EK. A Genome-Wide Association Study of Emphysema and Airway Quantitative Imaging Phenotypes. Am J Respir Crit Care Med. 2015 Sep 01; 192(5):559-69. PMID: 26030696.
      View in: PubMed
    134. Regan EA, Lynch DA, Curran-Everett D, Curtis JL, Austin JH, Grenier PA, Kauczor HU, Bailey WC, DeMeo DL, Casaburi RH, Friedman P, Van Beek EJ, Hokanson JE, Bowler RP, Beaty TH, Washko GR, Han MK, Kim V, Kim SS, Yagihashi K, Washington L, McEvoy CE, Tanner C, Mannino DM, Make BJ, Silverman EK, Crapo JD. Clinical and Radiologic Disease in Smokers With Normal Spirometry. JAMA Intern Med. 2015 Sep; 175(9):1539-49. PMID: 26098755.
      View in: PubMed
    135. Bhatt SP, Wells JM, Kinney GL, Washko GR, Budoff M, Kim YI, Bailey WC, Nath H, Hokanson JE, Silverman EK, Crapo J, Dransfield MT. ?-Blockers are associated with a reduction in COPD exacerbations. Thorax. 2016 Jan; 71(1):8-14. PMID: 26283710.
      View in: PubMed
    136. Wan ES, Qiu W, Carey VJ, Morrow J, Bacherman H, Foreman MG, Hokanson JE, Bowler RP, Crapo JD, DeMeo DL. Smoking-Associated Site-Specific Differential Methylation in Buccal Mucosa in the COPDGene Study. Am J Respir Cell Mol Biol. 2015 Aug; 53(2):246-54. PMID: 25517428.
      View in: PubMed
    137. Dijkstra AE, Smolonska J, van den Berge M, Wijmenga C, Zanen P, Luinge MA, Platteel M, Lammers JW, Dahlback M, Tosh K, Hiemstra PS, Sterk PJ, Spira A, Vestbo J, Nordestgaard BG, Benn M, Nielsen SF, Dahl M, Verschuren WM, Picavet HS, Smit HA, Owsijewitsch M, Kauczor HU, de Koning HJ, Nizankowska-Mogilnicka E, Mejza F, Nastalek P, van Diemen CC, Cho MH, Silverman EK, Crapo JD, Beaty TH, Lomas DA, Bakke P, Gulsvik A, Boss? Y, Obeidat M, Loth DW, Lahousse L, Rivadeneira F, Uitterlinden AG, Hofman A, Stricker BH, Brusselle GG, van Duijn CM, Brouwer U, Koppelman GH, Vonk JM, Nawijn MC, Groen HJ, Timens W, Boezen HM, Postma DS. Correction: Susceptibility to chronic mucus hypersecretion, a genome wide association study. PLoS One. 2015; 10(5):e0129524. PMID: 26024482.
      View in: PubMed
    138. Lynch DA, Austin JH, Hogg JC, Grenier PA, Kauczor HU, Bankier AA, Barr RG, Colby TV, Galvin JR, Gevenois PA, Coxson HO, Hoffman EA, Newell JD, Pistolesi M, Silverman EK, Crapo JD. CT-Definable Subtypes of Chronic Obstructive Pulmonary Disease: A Statement of the Fleischner Society. Radiology. 2015 Oct; 277(1):192-205. PMID: 25961632.
      View in: PubMed
    139. Jaramillo JD, Wilson C, Stinson DS, Stinson DJ, Lynch DA, Bowler RP, Lutz S, Bon JM, Arnold B, McDonald ML, Washko GR, Wan ES, DeMeo DL, Foreman MG, Soler X, Lindsay SE, Lane NE, Genant HK, Silverman EK, Hokanson JE, Make BJ, Crapo JD, Regan EA. Reduced Bone Density and Vertebral Fractures in Smokers. Men and COPD Patients at Increased Risk. Ann Am Thorac Soc. 2015 May; 12(5):648-56. PMID: 25719895.
      View in: PubMed
    140. Roger VL, Boerwinkle E, Crapo JD, Douglas PS, Epstein JA, Granger CB, Greenland P, Kohane I, Psaty BM. Roger et al. respond to "future of population studies". Am J Epidemiol. 2015 Mar 15; 181(6):372-3. PMID: 25743323.
      View in: PubMed
    141. Roger VL, Boerwinkle E, Crapo JD, Douglas PS, Epstein JA, Granger CB, Greenland P, Kohane I, Psaty BM. Strategic transformation of population studies: recommendations of the working group on epidemiology and population sciences from the National Heart, Lung, and Blood Advisory Council and Board of External Experts. Am J Epidemiol. 2015 Mar 15; 181(6):363-8. PMID: 25743324.
      View in: PubMed
    142. Kim V, Crapo J, Zhao H, Jones PW, Silverman EK, Comellas A, Make BJ, Criner GJ. Comparison between an alternative and the classic definition of chronic bronchitis in COPDGene. Ann Am Thorac Soc. 2015 Mar; 12(3):332-9. PMID: 25575351.
      View in: PubMed
    143. Lee JH, Cho MH, Hersh CP, McDonald ML, Wells JM, Dransfield MT, Bowler RP, Lynch DA, Lomas DA, Crapo JD, Silverman EK. IREB2 and GALC are associated with pulmonary artery enlargement in chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol. 2015 Mar; 52(3):365-76. PMID: 25101718.
      View in: PubMed
    144. Pate KM, Sherk VD, Carpenter RD, Weaver M, Crapo S, Gally F, Chatham LS, Goldstrohm DA, Crapo JD, Kohrt WM, Bowler RP, Oberley-Deegan RE, Regan EA. The beneficial effects of exercise on cartilage are lost in mice with reduced levels of ECSOD in tissues. J Appl Physiol (1985). 2015 Mar 15; 118(6):760-7. PMID: 25593283.
      View in: PubMed
    145. Qiu W, Wan E, Morrow J, Cho MH, Crapo JD, Silverman EK, DeMeo DL. The impact of genetic variation and cigarette smoke on DNA methylation in current and former smokers from the COPDGene study. Epigenetics. 2015; 10(11):1064-73. PMID: 26646902.
      View in: PubMed
    146. Putcha N, Puhan MA, Drummond MB, Han MK, Regan EA, Hanania NA, Martinez CH, Foreman M, Bhatt SP, Make B, Ramsdell J, DeMeo DL, Barr RG, Rennard SI, Martinez F, Silverman EK, Crapo J, Wise RA, Hansel NN. A simplified score to quantify comorbidity in COPD. PLoS One. 2014; 9(12):e114438. PMID: 25514500.
      View in: PubMed
    147. Diaz AA, Hardin ME, Come CE, San Jos? Est?par R, Ross JC, Kurugol S, Okajima Y, Han MK, Kim V, Ramsdell J, Silverman EK, Crapo JD, Lynch DA, Make B, Barr RG, Hersh CP, Washko GR. Childhood-onset asthma in smokers. association between CT measures of airway size, lung function, and chronic airflow obstruction. Ann Am Thorac Soc. 2014 Nov; 11(9):1371-8. PMID: 25296268.
      View in: PubMed
    148. McDonald ML, Cho MH, S?rheim IC, Lutz SM, Castaldi PJ, Lomas DA, Coxson HO, Edwards LD, MacNee W, Vestbo J, Yates JC, Agusti A, Calverley PM, Celli B, Crim C, Rennard SI, Wouters EF, Bakke P, Tal-Singer R, Miller BE, Gulsvik A, Casaburi R, Wells JM, Regan EA, Make BJ, Hokanson JE, Lange C, Crapo JD, Beaty TH, Silverman EK, Hersh CP. Common genetic variants associated with resting oxygenation in chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol. 2014 Nov; 51(5):678-87. PMID: 24825563.
      View in: PubMed
    149. Hersh CP, Make BJ, Lynch DA, Barr RG, Bowler RP, Calverley PM, Castaldi PJ, Cho MH, Coxson HO, DeMeo DL, Foreman MG, Han MK, Harshfield BJ, Hokanson JE, Lutz S, Ramsdell JW, Regan EA, Rennard SI, Schroeder JD, Sciurba FC, Steiner RM, Tal-Singer R, van Beek E, Silverman EK, Crapo JD. Non-emphysematous chronic obstructive pulmonary disease is associated with diabetes mellitus. BMC Pulm Med. 2014 Oct 24; 14:164. PMID: 25341556.
      View in: PubMed
    150. Castaldi PJ, Cho MH, Zhou X, Qiu W, Mcgeachie M, Celli B, Bakke P, Gulsvik A, Lomas DA, Crapo JD, Beaty TH, Rennard S, Harshfield B, Lange C, Singh D, Tal-Singer R, Riley JH, Quackenbush J, Raby BA, Carey VJ, Silverman EK, Hersh CP. Genetic control of gene expression at novel and established chronic obstructive pulmonary disease loci. Hum Mol Genet. 2015 Feb 15; 24(4):1200-10. PMID: 25315895.
      View in: PubMed
    151. Bowler RP, Kim V, Regan E, Williams AAA, Santorico SA, Make BJ, Lynch DA, Hokanson JE, Washko GR, Bercz P, Soler X, Marchetti N, Criner GJ, Ramsdell J, Han MK, Demeo D, Anzueto A, Comellas A, Crapo JD, Dransfield M, Wells JM, Hersh CP, MacIntyre N, Martinez F, Nath HP, Niewoehner D, Sciurba F, Sharafkhaneh A, Silverman EK, van Beek EJR, Wilson C, Wendt C, Wise RA. Prediction of acute respiratory disease in current and former smokers with and without COPD. Chest. 2014 Oct; 146(4):941-950. PMID: 24945159.
      View in: PubMed
    152. Marchetti N, Garshick E, Kinney GL, McKenzie A, Stinson D, Lutz SM, Lynch DA, Criner GJ, Silverman EK, Crapo JD. Association between occupational exposure and lung function, respiratory symptoms, and high-resolution computed tomography imaging in COPDGene. Am J Respir Crit Care Med. 2014 Oct 01; 190(7):756-62. PMID: 25133327.
      View in: PubMed
    153. Lee JH, Cho MH, Hersh CP, McDonald ML, Crapo JD, Bakke PS, Gulsvik A, Comellas AP, Wendt CH, Lomas DA, Kim V, Silverman EK. Genetic susceptibility for chronic bronchitis in chronic obstructive pulmonary disease. Respir Res. 2014 Sep 21; 15:113. PMID: 25241909.
      View in: PubMed
    154. Dijkstra AE, Boezen HM, van den Berge M, Vonk JM, Hiemstra PS, Barr RG, Burkart KM, Manichaikul A, Pottinger TD, Silverman EK, Cho MH, Crapo JD, Beaty TH, Bakke P, Gulsvik A, Lomas DA, Boss? Y, Nickle DC, Par? PD, de Koning HJ, Lammers JW, Zanen P, Smolonska J, Wijmenga C, Brandsma CA, Groen HJ, Postma DS. Dissecting the genetics of chronic mucus hypersecretion in smokers with and without COPD. Eur Respir J. 2015 Jan; 45(1):60-75. PMID: 25234806.
      View in: PubMed
    155. Lee JH, McDonald ML, Cho MH, Wan ES, Castaldi PJ, Hunninghake GM, Marchetti N, Lynch DA, Crapo JD, Lomas DA, Coxson HO, Bakke PS, Silverman EK, Hersh CP. DNAH5 is associated with total lung capacity in chronic obstructive pulmonary disease. Respir Res. 2014 Aug 20; 15:97. PMID: 25134640.
      View in: PubMed
    156. Castaldi PJ, Cho MH, San Jos? Est?par R, McDonald ML, Laird N, Beaty TH, Washko G, Crapo JD, Silverman EK. Genome-wide association identifies regulatory Loci associated with distinct local histogram emphysema patterns. Am J Respir Crit Care Med. 2014 Aug 15; 190(4):399-409. PMID: 25006744.
      View in: PubMed
    157. Lee JH, Cho MH, McDonald ML, Hersh CP, Castaldi PJ, Crapo JD, Wan ES, Dy JG, Chang Y, Regan EA, Hardin M, DeMeo DL, Silverman EK. Phenotypic and genetic heterogeneity among subjects with mild airflow obstruction in COPDGene. Respir Med. 2014 Oct; 108(10):1469-80. PMID: 25154699.
      View in: PubMed
    158. Parker MM, Foreman MG, Abel HJ, Mathias RA, Hetmanski JB, Crapo JD, Silverman EK, Beaty TH. Admixture mapping identifies a quantitative trait locus associated with FEV1/FVC in the COPDGene Study. Genet Epidemiol. 2014 Nov; 38(7):652-9. PMID: 25112515.
      View in: PubMed
    159. Kim V, Desai P, Newell JD, Make BJ, Washko GR, Silverman EK, Crapo JD, Bhatt SP, Criner GJ. Airway wall thickness is increased in COPD patients with bronchodilator responsiveness. Respir Res. 2014 Aug 08; 15:84. PMID: 25248436.
      View in: PubMed
    160. Wan ES, Castaldi PJ, Cho MH, Hokanson JE, Regan EA, Make BJ, Beaty TH, Han MK, Curtis JL, Curran-Everett D, Lynch DA, DeMeo DL, Crapo JD, Silverman EK. Epidemiology, genetics, and subtyping of preserved ratio impaired spirometry (PRISm) in COPDGene. Respir Res. 2014 Aug 06; 15:89. PMID: 25096860.
      View in: PubMed
    161. Martinez CH, Okajima Y, Murray S, Washko GR, Martinez FJ, Silverman EK, Lee JH, Regan EA, Crapo JD, Curtis JL, Hatabu H, Han MK. Impact of self-reported gastroesophageal reflux disease in subjects from COPDGene cohort. Respir Res. 2014 Jun 03; 15:62. PMID: 24894541.
      View in: PubMed
    162. Hardin M, Cho M, McDonald ML, Beaty T, Ramsdell J, Bhatt S, van Beek EJ, Make BJ, Crapo JD, Silverman EK, Hersh CP. The clinical and genetic features of COPD-asthma overlap syndrome. Eur Respir J. 2014 Aug; 44(2):341-50. PMID: 24876173.
      View in: PubMed
    163. Black-Shinn JL, Kinney GL, Wise AL, Regan EA, Make B, Krantz MJ, Barr RG, Murphy JR, Lynch D, Silverman EK, Crapo JD, Hokanson JE. Cardiovascular disease is associated with COPD severity and reduced functional status and quality of life. COPD. 2014 Sep; 11(5):546-51. PMID: 24831864.
      View in: PubMed
    164. Thomashow B, Crapo J, Yawn B, McIvor A, Cerreta S, Walsh J, Mannino D, Rennard S. The COPD Foundation Pocket Consultant Guide. Chronic Obstr Pulm Dis. 2014 May 06; 1(1):83-87. PMID: 28848814.
      View in: PubMed
    165. Crapo JD, Barnes PJ, Jones PW, Make BJ, Mannino DM. The Launch of a New COPD Journal. Chronic Obstr Pulm Dis. 2014 May 06; 1(1):1-3. PMID: 28848805.
      View in: PubMed
    166. Kim V, Davey A, Comellas AP, Han MK, Washko G, Martinez CH, Lynch D, Lee JH, Silverman EK, Crapo JD, Make BJ, Criner GJ. Clinical and computed tomographic predictors of chronic bronchitis in COPD: a cross sectional analysis of the COPDGene study. Respir Res. 2014 Apr 27; 15:52. PMID: 24766722.
      View in: PubMed
    167. Dijkstra AE, Smolonska J, van den Berge M, Wijmenga C, Zanen P, Luinge MA, Platteel M, Lammers JW, Dahlback M, Tosh K, Hiemstra PS, Sterk PJ, Spira A, Vestbo J, Nordestgaard BG, Benn M, Nielsen SF, Dahl M, Verschuren WM, Picavet HS, Smit HA, Owsijewitsch M, Kauczor HU, de Koning HJ, Nizankowska-Mogilnicka E, Mejza F, Nastalek P, van Diemen CC, Cho MH, Silverman EK, Crapo JD, Beaty TH, Lomas DA, Bakke P, Gulsvik A, Boss? Y, Obeidat M, Obeidat MA, Loth DW, Lahousse L, Rivadeneira F, Uitterlinden AG, Hofman A, Stricker BH, Brusselle GG, van Duijn CM, Brouwer U, Koppelman GH, Vonk JM, Nawijn MC, Groen HJ, Timens W, Boezen HM, Postma DS. Susceptibility to chronic mucus hypersecretion, a genome wide association study. PLoS One. 2014; 9(4):e91621. PMID: 24714607.
      View in: PubMed
    168. Drummond MB, Buist AS, Crapo JD, Wise RA, Rennard SI. Chronic obstructive pulmonary disease: NHLBI Workshop on the Primary Prevention of Chronic Lung Diseases. Ann Am Thorac Soc. 2014 Apr; 11 Suppl 3:S154-60. PMID: 24754824.
      View in: PubMed
    169. Castaldi PJ, Dy J, Ross J, Chang Y, Washko GR, Curran-Everett D, Williams A, Lynch DA, Make BJ, Crapo JD, Bowler RP, Regan EA, Hokanson JE, Kinney GL, Han MK, Soler X, Ramsdell JW, Barr RG, Foreman M, van Beek E, Casaburi R, Criner GJ, Lutz SM, Rennard SI, Santorico S, Sciurba FC, DeMeo DL, Hersh CP, Silverman EK, Cho MH. Cluster analysis in the COPDGene study identifies subtypes of smokers with distinct patterns of airway disease and emphysema. Thorax. 2014 May; 69(5):415-22. PMID: 24563194.
      View in: PubMed
    170. Manichaikul A, Hoffman EA, Smolonska J, Gao W, Cho MH, Baumhauer H, Budoff M, Austin JH, Washko GR, Carr JJ, Kaufman JD, Pottinger T, Powell CA, Wijmenga C, Zanen P, Groen HJ, Postma DS, Wanner A, Rouhani FN, Brantly ML, Powell R, Smith BM, Rabinowitz D, Raffel LJ, Hinckley Stukovsky KD, Crapo JD, Beaty TH, Hokanson JE, Silverman EK, Dupuis J, O'Connor GT, Boezen HM, Rich SS, Barr RG. Genome-wide study of percent emphysema on computed tomography in the general population. The Multi-Ethnic Study of Atherosclerosis Lung/SNP Health Association Resource Study. Am J Respir Crit Care Med. 2014 Feb 15; 189(4):408-18. PMID: 24383474.
      View in: PubMed
    171. Cho MH, McDonald ML, Zhou X, Mattheisen M, Castaldi PJ, Hersh CP, Demeo DL, Sylvia JS, Ziniti J, Laird NM, Lange C, Litonjua AA, Sparrow D, Casaburi R, Barr RG, Regan EA, Make BJ, Hokanson JE, Lutz S, Dudenkov TM, Farzadegan H, Hetmanski JB, Tal-Singer R, Lomas DA, Bakke P, Gulsvik A, Crapo JD, Silverman EK, Beaty TH. Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis. Lancet Respir Med. 2014 Mar; 2(3):214-25. PMID: 24621683.
      View in: PubMed
    172. Putcha N, Han MK, Martinez CH, Foreman MG, Anzueto AR, Casaburi R, Cho MH, Hanania NA, Hersh CP, Kinney GL, Make BJ, Steiner RM, Lutz SM, Thomashow BM, Williams AA, Bhatt SP, Beaty TH, Bowler RP, Ramsdell JW, Curtis JL, Everett D, Hokanson JE, Lynch DA, Sutherland ER, Silverman EK, Crapo JD, Wise RA, Regan EA, Hansel NN. Comorbidities of COPD have a major impact on clinical outcomes, particularly in African Americans. Chronic Obstr Pulm Dis. 2014; 1(1):105-114. PMID: 25695106.
      View in: PubMed
    173. Kim SS, Yagihashi K, Stinson DS, Zach JA, McKenzie AS, Curran-Everett D, Wan ES, Silverman EK, Crapo JD, Lynch DA. Visual Assessment of CT Findings in Smokers With Nonobstructed Spirometric Abnormalities in The COPDGene? Study. Chronic Obstr Pulm Dis. 2014; 1(1):88-96. PMID: 25197723.
      View in: PubMed
    174. Kim V, Goel N, Gangar J, Zhao H, Ciccolella DE, Silverman EK, Crapo JD, Criner GJ. Risk Factors for Venous Thromboembolism in Chronic Obstructive Pulmonary Disease. Chronic Obstr Pulm Dis. 2014; 1(2):239-249. PMID: 25844397.
      View in: PubMed
    175. Martinez CH, Kim V, Chen Y, Kazerooni EA, Murray S, Criner GJ, Curtis JL, Regan EA, Wan E, Hersh CP, Silverman EK, Crapo JD, Martinez FJ, Han MK. The clinical impact of non-obstructive chronic bronchitis in current and former smokers. Respir Med. 2014 Mar; 108(3):491-9. PMID: 24280543.
      View in: PubMed
    176. Castaldi PJ, San Jos? Est?par R, Mendoza CS, Hersh CP, Laird N, Crapo JD, Lynch DA, Silverman EK, Washko GR. Distinct quantitative computed tomography emphysema patterns are associated with physiology and function in smokers. Am J Respir Crit Care Med. 2013 Nov 01; 188(9):1083-90. PMID: 23980521.
      View in: PubMed
    177. Archambeau JO, Tovmasyan A, Pearlstein RD, Crapo JD, Batinic-Haberle I. Superoxide dismutase mimic, MnTE-2-PyP(5+) ameliorates acute and chronic proctitis following focal proton irradiation of the rat rectum. Redox Biol. 2013; 1:599-607. PMID: 24363995.
      View in: PubMed
    178. Kinney GL, Black-Shinn JL, Wan ES, Make B, Regan E, Lutz S, Soler X, Silverman EK, Crapo J, Hokanson JE. Pulmonary function reduction in diabetes with and without chronic obstructive pulmonary disease. Diabetes Care. 2014 Feb; 37(2):389-95. PMID: 24026562.
      View in: PubMed
    179. Boiselle PM, Crapo JD, Han MK, Lynch DA, Tashkin DP. Expert opinion: how can quantitative CT benefit patients with COPD and idiopathic interstitial pneumonias? J Thorac Imaging. 2013 Sep; 28(5):263. PMID: 23934143.
      View in: PubMed
    180. Est?par RS, Kinney GL, Black-Shinn JL, Bowler RP, Kindlmann GL, Ross JC, Kikinis R, Han MK, Come CE, Diaz AA, Cho MH, Hersh CP, Schroeder JD, Reilly JJ, Lynch DA, Crapo JD, Wells JM, Dransfield MT, Hokanson JE, Washko GR. Computed tomographic measures of pulmonary vascular morphology in smokers and their clinical implications. Am J Respir Crit Care Med. 2013 Jul 15; 188(2):231-9. PMID: 23656466.
      View in: PubMed
    181. Casaburi R, Celli B, Crapo J, Criner G, Croxton T, Gaw A, Jones P, Kline-Leidy N, Lomas DA, Merrill D, Polkey M, Rennard S, Sciurba F, Tal-Singer R, Stockley R, Turino G, Vestbo J, Walsh J. The COPD Biomarker Qualification Consortium (CBQC). COPD. 2013 Jun; 10(3):367-77. PMID: 23713597.
      View in: PubMed
    182. Rennard S, Thomashow B, Crapo J, Yawn B, McIvor A, Cerreta S, Walsh J, Mannino D. Introducing the COPD Foundation Guide for Diagnosis and Management of COPD, recommendations of the COPD Foundation. COPD. 2013 Jun; 10(3):378-89. PMID: 23713598.
      View in: PubMed
    183. Gad SC, Sullivan DW, Crapo JD, Spainhour CB. A nonclinical safety assessment of MnTE-2-PyP, a manganese porphyrin. Int J Toxicol. 2013 Jul; 32(4):274-87. PMID: 23704100.
      View in: PubMed
    184. Fingerlin TE, Murphy E, Zhang W, Peljto AL, Brown KK, Steele MP, Loyd JE, Cosgrove GP, Lynch D, Groshong S, Collard HR, Wolters PJ, Bradford WZ, Kossen K, Seiwert SD, du Bois RM, Garcia CK, Devine MS, Gudmundsson G, Isaksson HJ, Kaminski N, Zhang Y, Gibson KF, Lancaster LH, Cogan JD, Mason WR, Maher TM, Molyneaux PL, Wells AU, Moffatt MF, Selman M, Pardo A, Kim DS, Crapo JD, Make BJ, Regan EA, Walek DS, Daniel JJ, Kamatani Y, Zelenika D, Smith K, McKean D, Pedersen BS, Talbert J, Kidd RN, Markin CR, Beckman KB, Lathrop M, Schwarz MI, Schwartz DA. Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis. Nat Genet. 2013 Jun; 45(6):613-20. PMID: 23583980.
      View in: PubMed
    185. Hersh CP, Washko GR, Est?par RS, Lutz S, Friedman PJ, Han MK, Hokanson JE, Judy PF, Lynch DA, Make BJ, Marchetti N, Newell JD, Sciurba FC, Crapo JD, Silverman EK. Paired inspiratory-expiratory chest CT scans to assess for small airways disease in COPD. Respir Res. 2013 Apr 08; 14:42. PMID: 23566024.
      View in: PubMed
    186. Hansel NN, Washko GR, Foreman MG, Han MK, Hoffman EA, DeMeo DL, Barr RG, Van Beek EJ, Kazerooni EA, Wise RA, Brown RH, Black-Shinn J, Hokanson JE, Hanania NA, Make B, Silverman EK, Crapo JD, Dransfield MT. Racial differences in CT phenotypes in COPD. COPD. 2013 Feb; 10(1):20-7. PMID: 23413893.
      View in: PubMed
    187. Siedlinski M, Tingley D, Lipman PJ, Cho MH, Litonjua AA, Sparrow D, Bakke P, Gulsvik A, Lomas DA, Anderson W, Kong X, Rennard SI, Beaty TH, Hokanson JE, Crapo JD, Lange C, Silverman EK. Dissecting direct and indirect genetic effects on chronic obstructive pulmonary disease (COPD) susceptibility. Hum Genet. 2013 Apr; 132(4):431-41. PMID: 23299987.
      View in: PubMed
    188. Kim SS, Seo JB, Lee HY, Nevrekar DV, Forssen AV, Crapo JD, Schroeder JD, Lynch DA. Chronic obstructive pulmonary disease: lobe-based visual assessment of volumetric CT by Using standard images--comparison with quantitative CT and pulmonary function test in the COPDGene study. Radiology. 2013 Feb; 266(2):626-35. PMID: 23220894.
      View in: PubMed
    189. Kim DK, Cho MH, Hersh CP, Lomas DA, Miller BE, Kong X, Bakke P, Gulsvik A, Agust? A, Wouters E, Celli B, Coxson H, Vestbo J, MacNee W, Yates JC, Rennard S, Litonjua A, Qiu W, Beaty TH, Crapo JD, Riley JH, Tal-Singer R, Silverman EK. Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2012 Dec 15; 186(12):1238-47. PMID: 23144326.
      View in: PubMed
    190. Naidich DP, Bankier AA, MacMahon H, Schaefer-Prokop CM, Pistolesi M, Goo JM, Macchiarini P, Crapo JD, Herold CJ, Austin JH, Travis WD. Recommendations for the management of subsolid pulmonary nodules detected at CT: a statement from the Fleischner Society. Radiology. 2013 Jan; 266(1):304-17. PMID: 23070270.
      View in: PubMed
    191. Zach JA, Newell JD, Schroeder J, Murphy JR, Curran-Everett D, Hoffman EA, Westgate PM, Han MK, Silverman EK, Crapo JD, Lynch DA. Quantitative computed tomography of the lungs and airways in healthy nonsmoking adults. Invest Radiol. 2012 Oct; 47(10):596-602. PMID: 22836310.
      View in: PubMed
    192. Oberley-Deegan RE, Steffan JJ, Rove KO, Pate KM, Weaver MW, Spasojevic I, Frederick B, Raben D, Meacham RB, Crapo JD, Koul HK. The antioxidant, MnTE-2-PyP, prevents side-effects incurred by prostate cancer irradiation. PLoS One. 2012; 7(9):e44178. PMID: 22984473.
      View in: PubMed
    193. Wells JM, Washko GR, Han MK, Abbas N, Nath H, Mamary AJ, Regan E, Bailey WC, Martinez FJ, Westfall E, Beaty TH, Curran-Everett D, Curtis JL, Hokanson JE, Lynch DA, Make BJ, Crapo JD, Silverman EK, Bowler RP, Dransfield MT. Pulmonary arterial enlargement and acute exacerbations of COPD. N Engl J Med. 2012 Sep 06; 367(10):913-21. PMID: 22938715.
      View in: PubMed
    194. Han MK, Muellerova H, Curran-Everett D, Dransfield MT, Washko GR, Regan EA, Bowler RP, Beaty TH, Hokanson JE, Lynch DA, Jones PW, Anzueto A, Martinez FJ, Crapo JD, Silverman EK, Make BJ. GOLD 2011 disease severity classification in COPDGene: a prospective cohort study. Lancet Respir Med. 2013 Mar; 1(1):43-50. PMID: 24321803.
      View in: PubMed
    195. Wilk JB, Shrine NR, Loehr LR, Zhao JH, Manichaikul A, Lopez LM, Smith AV, Heckbert SR, Smolonska J, Tang W, Loth DW, Curjuric I, Hui J, Cho MH, Latourelle JC, Henry AP, Aldrich M, Bakke P, Beaty TH, Bentley AR, Borecki IB, Brusselle GG, Burkart KM, Chen TH, Couper D, Crapo JD, Davies G, Dupuis J, Franceschini N, Gulsvik A, Hancock DB, Harris TB, Hofman A, Imboden M, James AL, Khaw KT, Lahousse L, Launer LJ, Litonjua A, Liu Y, Lohman KK, Lomas DA, Lumley T, Marciante KD, McArdle WL, Meibohm B, Morrison AC, Musk AW, Myers RH, North KE, Postma DS, Psaty BM, Rich SS, Rivadeneira F, Rochat T, Rotter JI, Soler Artigas M, Starr JM, Uitterlinden AG, Wareham NJ, Wijmenga C, Zanen P, Province MA, Silverman EK, Deary IJ, Palmer LJ, Cassano PA, Gudnason V, Barr RG, Loos RJ, Strachan DP, London SJ, Boezen HM, Probst-Hensch N, Gharib SA, Hall IP, O'Connor GT, Tobin MD, Stricker BH. Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction. Am J Respir Crit Care Med. 2012 Oct 01; 186(7):622-32. PMID: 22837378.
      View in: PubMed
    196. Mao XW, Crapo JD, Gridley DS. Mitochondrial oxidative stress-induced apoptosis and radioprotection in proton-irradiated rat retina. Radiat Res. 2012 Sep; 178(3):118-25. PMID: 22780102.
      View in: PubMed
    197. Stewart JI, Moyle S, Criner GJ, Wilson C, Tanner R, Bowler RP, Crapo JD, Zeldin RK, Make BJ, Regan EA. Automated telecommunication to obtain longitudinal follow-up in a multicenter cross-sectional COPD study. COPD. 2012 Aug; 9(5):466-72. PMID: 22676387.
      View in: PubMed
    198. Barr RG, Berkowitz EA, Bigazzi F, Bode F, Bon J, Bowler RP, Chiles C, Crapo JD, Criner GJ, Curtis JL, Dass C, Dirksen A, Dransfield MT, Edula G, Erikkson L, Friedlander A, Galperin-Aizenberg M, Gefter WB, Gierada DS, Grenier PA, Goldin J, Han MK, Hanania NA, Hansel NN, Jacobson FL, Kauczor HU, Kinnula VL, Lipson DA, Lynch DA, MacNee W, Make BJ, Mamary AJ, Mann H, Marchetti N, Mascalchi M, McLennan G, Murphy JR, Naidich D, Nath H, Newell JD, Pistolesi M, Regan EA, Reilly JJ, Sandhaus R, Schroeder JD, Sciurba F, Shaker S, Sharafkhaneh A, Silverman EK, Steiner RM, Strange C, Sverzellati N, Tashjian JH, van Beek EJ, Washington L, Washko GR, Westney G, Wood SA, Woodruff PG. A combined pulmonary-radiology workshop for visual evaluation of COPD: study design, chest CT findings and concordance with quantitative evaluation. COPD. 2012 Apr; 9(2):151-9. PMID: 22429093.
      View in: PubMed
    199. Jaramillo MC, Briehl MM, Crapo JD, Batinic-Haberle I, Tome ME. Manganese porphyrin, MnTE-2-PyP5+, Acts as a pro-oxidant to potentiate glucocorticoid-induced apoptosis in lymphoma cells. Free Radic Biol Med. 2012 Apr 15; 52(8):1272-84. PMID: 22330065.
      View in: PubMed
    200. Xu JF, Washko GR, Nakahira K, Hatabu H, Patel AS, Fernandez IE, Nishino M, Okajima Y, Yamashiro T, Ross JC, Est?par RS, Diaz AA, Li HP, Qu JM, Himes BE, Come CE, D'Aco K, Martinez FJ, Han MK, Lynch DA, Crapo JD, Morse D, Ryter SW, Silverman EK, Rosas IO, Choi AM, Hunninghake GM. Statins and pulmonary fibrosis: the potential role of NLRP3 inflammasome activation. Am J Respir Crit Care Med. 2012 Mar 01; 185(5):547-56. PMID: 22246178.
      View in: PubMed
    201. Cho MH, Castaldi PJ, Wan ES, Siedlinski M, Hersh CP, Demeo DL, Himes BE, Sylvia JS, Klanderman BJ, Ziniti JP, Lange C, Litonjua AA, Sparrow D, Regan EA, Make BJ, Hokanson JE, Murray T, Hetmanski JB, Pillai SG, Kong X, Anderson WH, Tal-Singer R, Lomas DA, Coxson HO, Edwards LD, MacNee W, Vestbo J, Yates JC, Agusti A, Calverley PM, Celli B, Crim C, Rennard S, Wouters E, Bakke P, Gulsvik A, Crapo JD, Beaty TH, Silverman EK. A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13. Hum Mol Genet. 2012 Feb 15; 21(4):947-57. PMID: 22080838.
      View in: PubMed
    202. Bai X, Ovrutsky AR, Kartalija M, Chmura K, Kamali A, Honda JR, Oberley-Deegan RE, Dinarello CA, Crapo JD, Chang LY, Chan ED. IL-32 expression in the airway epithelial cells of patients with Mycobacterium avium complex lung disease. Int Immunol. 2011 Nov; 23(11):679-91. PMID: 22033195.
      View in: PubMed
    203. Karaaslan C, Hirakawa H, Yasumatsu R, Chang LY, Pierce RA, Crapo JD, Cataltepe S. Elastase inhibitory activity of airway a1-antitrypsin is protected by treatment with a catalytic antioxidant in a baboon model of severe bronchopulmonary dysplasia. Pediatr Res. 2011 Oct; 70(4):363-7. PMID: 21705962.
      View in: PubMed
    204. Rambod M, Porszasz J, Make BJ, Crapo JD, Casaburi R. Six-minute walk distance predictors, including CT scan measures, in the COPDGene cohort. Chest. 2012 Apr; 141(4):867-875. PMID: 21960696.
      View in: PubMed
    205. Hardin M, Silverman EK, Barr RG, Hansel NN, Schroeder JD, Make BJ, Crapo JD, Hersh CP. The clinical features of the overlap between COPD and asthma. Respir Res. 2011 Sep 27; 12:127. PMID: 21951550.
      View in: PubMed
    206. Qiu W, Cho MH, Riley JH, Anderson WH, Singh D, Bakke P, Gulsvik A, Litonjua AA, Lomas DA, Crapo JD, Beaty TH, Celli BR, Rennard S, Tal-Singer R, Fox SM, Silverman EK, Hersh CP. Genetics of sputum gene expression in chronic obstructive pulmonary disease. PLoS One. 2011; 6(9):e24395. PMID: 21949713.
      View in: PubMed
    207. Foreman MG, Zhang L, Murphy J, Hansel NN, Make B, Hokanson JE, Washko G, Regan EA, Crapo JD, Silverman EK, DeMeo DL. Early-onset chronic obstructive pulmonary disease is associated with female sex, maternal factors, and African American race in the COPDGene Study. Am J Respir Crit Care Med. 2011 Aug 15; 184(4):414-20. PMID: 21562134.
      View in: PubMed
    208. Han MK, Kazerooni EA, Lynch DA, Liu LX, Murray S, Curtis JL, Criner GJ, Kim V, Bowler RP, Hanania NA, Anzueto AR, Make BJ, Hokanson JE, Crapo JD, Silverman EK, Martinez FJ, Washko GR. Chronic obstructive pulmonary disease exacerbations in the COPDGene study: associated radiologic phenotypes. Radiology. 2011 Oct; 261(1):274-82. PMID: 21788524.
      View in: PubMed
    209. Young RP, Hopkins RJ, Gamble GD, Etzel C, El-Zein R, Crapo JD. Genetic evidence linking lung cancer and COPD: a new perspective. Appl Clin Genet. 2011; 4:99-111. PMID: 23776371.
      View in: PubMed
    210. Siedlinski M, Cho MH, Bakke P, Gulsvik A, Lomas DA, Anderson W, Kong X, Rennard SI, Beaty TH, Hokanson JE, Crapo JD, Silverman EK. Genome-wide association study of smoking behaviours in patients with COPD. Thorax. 2011 Oct; 66(10):894-902. PMID: 21685187.
      View in: PubMed
    211. Castaldi PJ, Cho MH, Litonjua AA, Bakke P, Gulsvik A, Lomas DA, Anderson W, Beaty TH, Hokanson JE, Crapo JD, Laird N, Silverman EK. The association of genome-wide significant spirometric loci with chronic obstructive pulmonary disease susceptibility. Am J Respir Cell Mol Biol. 2011 Dec; 45(6):1147-53. PMID: 21659657.
      View in: PubMed
    212. Manni ML, Tomai LP, Norris CA, Thomas LM, Kelley EE, Salter RD, Crapo JD, Chang LY, Watkins SC, Piganelli JD, Oury TD. Extracellular superoxide dismutase in macrophages augments bacterial killing by promoting phagocytosis. Am J Pathol. 2011 Jun; 178(6):2752-9. PMID: 21641397.
      View in: PubMed
    213. Regan EA, Mazur W, Meoni E, Toljamo T, Millar J, Vuopala K, Bowler RP, Rahman I, Nicks ME, Crapo JD, Kinnula VL. Smoking and COPD increase sputum levels of extracellular superoxide dismutase. Free Radic Biol Med. 2011 Aug 01; 51(3):726-32. PMID: 21621610.
      View in: PubMed
    214. Wan ES, Hokanson JE, Murphy JR, Regan EA, Make BJ, Lynch DA, Crapo JD, Silverman EK. Clinical and radiographic predictors of GOLD-unclassified smokers in the COPDGene study. Am J Respir Crit Care Med. 2011 Jul 01; 184(1):57-63. PMID: 21493737.
      View in: PubMed
    215. Silverman EK, Vestbo J, Agusti A, Anderson W, Bakke PS, Barnes KC, Barr RG, Bleecker ER, Boezen HM, Burkart KM, Celli BR, Cho MH, Cookson WO, Croxton T, Daley D, DeMeo DL, Gan W, Garcia-Aymerich J, Hall IP, Hansel NN, Hersh CP, Kalsheker N, Kiley JP, Kim WJ, Lambrechts D, Lee SD, Litonjua AA, Lomas DA, London SJ, Nishimura M, N?rdestgaard BG, O'Donnell CJ, Postma DS, Puhan MA, Tesfaigzi Y, Tobin MD, Vogelmeier C, Wilk JB, Wouters E, Young RP, Ziegler-Heitbrock L, MacNee W, Crapo JD. Opportunities and challenges in the genetics of COPD 2010: an International COPD Genetics Conference report. COPD. 2011 Apr; 8(2):121-35. PMID: 21495840.
      View in: PubMed
    216. Kim DK, Jacobson FL, Washko GR, Casaburi R, Make BJ, Crapo JD, Silverman EK, Hersh CP. Clinical and radiographic correlates of hypoxemia and oxygen therapy in the COPDGene study. Respir Med. 2011 Aug; 105(8):1211-21. PMID: 21396809.
      View in: PubMed
    217. Hersh CP, Hokanson JE, Lynch DA, Washko GR, Make BJ, Crapo JD, Silverman EK. Family history is a risk factor for COPD. Chest. 2011 Aug; 140(2):343-350. PMID: 21310839.
      View in: PubMed
    218. Kim DK, Hersh CP, Washko GR, Hokanson JE, Lynch DA, Newell JD, Murphy JR, Crapo JD, Silverman EK. Epidemiology, radiology, and genetics of nicotine dependence in COPD. Respir Res. 2011 Jan 13; 12:9. PMID: 21232152.
      View in: PubMed
    219. Wan ES, Cho MH, Boutaoui N, Klanderman BJ, Sylvia JS, Ziniti JP, Won S, Lange C, Pillai SG, Anderson WH, Kong X, Lomas DA, Bakke PS, Gulsvik A, Regan EA, Murphy JR, Make BJ, Crapo JD, Wouters EF, Celli BR, Silverman EK, DeMeo DL. Genome-wide association analysis of body mass in chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol. 2011 Aug; 45(2):304-10. PMID: 21037115.
      View in: PubMed
    220. Oberley-Deegan RE, Rebits BW, Weaver MR, Tollefson AK, Bai X, McGibney M, Ovrutsky AR, Chan ED, Crapo JD. An oxidative environment promotes growth of Mycobacterium abscessus. Free Radic Biol Med. 2010 Dec 01; 49(11):1666-73. PMID: 20807564.
      View in: PubMed
    221. Yao H, Arunachalam G, Hwang JW, Chung S, Sundar IK, Kinnula VL, Crapo JD, Rahman I. Extracellular superoxide dismutase protects against pulmonary emphysema by attenuating oxidative fragmentation of ECM. Proc Natl Acad Sci U S A. 2010 Aug 31; 107(35):15571-6. PMID: 20713693.
      View in: PubMed
    222. Petersen SV, Th?gersen IB, Valnickova Z, Nielsen MS, Petersen JS, Poulsen ET, Jacobsen C, Oury TD, Moestrup SK, Crapo JD, Nielsen NC, Kristensen T, Enghild JJ. The concentration of extracellular superoxide dismutase in plasma is maintained by LRP-mediated endocytosis. Free Radic Biol Med. 2010 Sep 01; 49(5):894-9. PMID: 20600835.
      View in: PubMed
    223. Crapo JD. Preclinical vascular disease identifies smokers at risk for COPD. Proc Natl Acad Sci U S A. 2010 May 11; 107(19):8503-4. PMID: 20442330.
      View in: PubMed
    224. Sklavos MM, Bertera S, Tse HM, Bottino R, He J, Beilke JN, Coulombe MG, Gill RG, Crapo JD, Trucco M, Piganelli JD. Redox modulation protects islets from transplant-related injury. Diabetes. 2010 Jul; 59(7):1731-8. PMID: 20413509.
      View in: PubMed
    225. Makinde AY, Rizvi A, Crapo JD, Pearlstein RD, Slater JM, Gridley DS. A metalloporphyrin antioxidant alters cytokine responses after irradiation in a prostate tumor model. Radiat Res. 2010 Apr; 173(4):441-52. PMID: 20334516.
      View in: PubMed
    226. Cho MH, Boutaoui N, Klanderman BJ, Sylvia JS, Ziniti JP, Hersh CP, DeMeo DL, Hunninghake GM, Litonjua AA, Sparrow D, Lange C, Won S, Murphy JR, Beaty TH, Regan EA, Make BJ, Hokanson JE, Crapo JD, Kong X, Anderson WH, Tal-Singer R, Lomas DA, Bakke P, Gulsvik A, Pillai SG, Silverman EK. Variants in FAM13A are associated with chronic obstructive pulmonary disease. Nat Genet. 2010 Mar; 42(3):200-2. PMID: 20173748.
      View in: PubMed
    227. Regan EA, Hokanson JE, Murphy JR, Make B, Lynch DA, Beaty TH, Curran-Everett D, Silverman EK, Crapo JD. Genetic epidemiology of COPD (COPDGene) study design. COPD. 2010 Feb; 7(1):32-43. PMID: 20214461.
      View in: PubMed
    228. Pearlstein RD, Higuchi Y, Moldovan M, Johnson K, Fukuda S, Gridley DS, Crapo JD, Warner DS, Slater JM. Metalloporphyrin antioxidants ameliorate normal tissue radiation damage in rat brain. Int J Radiat Biol. 2010 Feb; 86(2):145-63. PMID: 20148700.
      View in: PubMed
    229. Kinnula VL, Crapo JD. Smoking and COPD-mechanisms and prevention. COPD. 2009 Aug; 6(4):231-3. PMID: 19811380.
      View in: PubMed
    230. Oberley-Deegan RE, Regan EA, Kinnula VL, Crapo JD. Extracellular superoxide dismutase and risk of COPD. COPD. 2009 Aug; 6(4):307-12. PMID: 19811392.
      View in: PubMed
    231. Sheng H, Yang W, Fukuda S, Tse HM, Paschen W, Johnson K, Batinic-Haberle I, Crapo JD, Pearlstein RD, Piganelli J, Warner DS. Long-term neuroprotection from a potent redox-modulating metalloporphyrin in the rat. Free Radic Biol Med. 2009 Oct 01; 47(7):917-23. PMID: 19631268.
      View in: PubMed
    232. Jaramillo MC, Frye JB, Crapo JD, Briehl MM, Tome ME. Increased manganese superoxide dismutase expression or treatment with manganese porphyrin potentiates dexamethasone-induced apoptosis in lymphoma cells. Cancer Res. 2009 Jul 01; 69(13):5450-7. PMID: 19549914.
      View in: PubMed
    233. McCurnin DC, Pierce RA, Willis BC, Chang LY, Yoder BA, Yuhanna IS, Ballard PL, Clyman RI, Waleh N, Maniscalco W, Crapo JD, Grubb PH, Shaul PW. Postnatal estradiol up-regulates lung nitric oxide synthases and improves lung function in bronchopulmonary dysplasia. Am J Respir Crit Care Med. 2009 Mar 15; 179(6):492-500. PMID: 19151197.
      View in: PubMed
    234. Makinde AY, Luo-Owen X, Rizvi A, Crapo JD, Pearlstein RD, Slater JM, Gridley DS. Effect of a metalloporphyrin antioxidant (MnTE-2-PyP) on the response of a mouse prostate cancer model to radiation. Anticancer Res. 2009 Jan; 29(1):107-18. PMID: 19331139.
      View in: PubMed
    235. Oberley-Deegan RE, Lee YM, Morey GE, Cook DM, Chan ED, Crapo JD. The antioxidant mimetic, MnTE-2-PyP, reduces intracellular growth of Mycobacterium abscessus. Am J Respir Cell Mol Biol. 2009 Aug; 41(2):170-8. PMID: 19097985.
      View in: PubMed
    236. Arcaroli JJ, Hokanson JE, Abraham E, Geraci M, Murphy JR, Bowler RP, Dinarello CA, Silveira L, Sankoff J, Heyland D, Wischmeyer P, Crapo JD. Extracellular superoxide dismutase haplotypes are associated with acute lung injury and mortality. Am J Respir Crit Care Med. 2009 Jan 15; 179(2):105-12. PMID: 18948423.
      View in: PubMed
    237. Dahl M, Bowler RP, Juul K, Crapo JD, Levy S, Nordestgaard BG. Superoxide dismutase 3 polymorphism associated with reduced lung function in two large populations. Am J Respir Crit Care Med. 2008 Nov 01; 178(9):906-12. PMID: 18703790.
      View in: PubMed
    238. Ueda J, Starr ME, Takahashi H, Du J, Chang LY, Crapo JD, Evers BM, Saito H. Decreased pulmonary extracellular superoxide dismutase during systemic inflammation. Free Radic Biol Med. 2008 Sep 15; 45(6):897-904. PMID: 18640266.
      View in: PubMed
    239. Petersen SV, Kristensen T, Petersen JS, Ramsgaard L, Oury TD, Crapo JD, Nielsen NC, Enghild JJ. The folding of human active and inactive extracellular superoxide dismutases is an intracellular event. J Biol Chem. 2008 May 30; 283(22):15031-6. PMID: 18385137.
      View in: PubMed
    240. Petersen SV, Valnickova Z, Oury TD, Crapo JD, Chr Nielsen N, Enghild JJ. The subunit composition of human extracellular superoxide dismutase (EC-SOD) regulates enzymatic activity. BMC Biochem. 2007 Oct 15; 8:19. PMID: 17937792.
      View in: PubMed
    241. Gridley DS, Makinde AY, Luo X, Rizvi A, Crapo JD, Dewhirst MW, Moeller BJ, Pearlstein RD, Slater JM. Radiation and a metalloporphyrin radioprotectant in a mouse prostate tumor model. Anticancer Res. 2007 Sep-Oct; 27(5A):3101-9. PMID: 17970050.
      View in: PubMed
    242. Subramaniam M, Bausch C, Twomey A, Andreeva S, Yoder BA, Chang L, Crapo JD, Pierce RA, Cuttitta F, Sunday ME. Bombesin-like peptides modulate alveolarization and angiogenesis in bronchopulmonary dysplasia. Am J Respir Crit Care Med. 2007 Nov 01; 176(9):902-12. PMID: 17585105.
      View in: PubMed
    243. Sutherland ER, Crapo JD, Bowler RP. N-acetylcysteine and exacerbations of chronic obstructive pulmonary disease. COPD. 2006 Dec; 3(4):195-202. PMID: 17361500.
      View in: PubMed
    244. Crapo JD. The burden of tobacco on life and health and the voice of the Journal of COPD. COPD. 2006 Aug; 3(3):121-2. PMID: 17240612.
      View in: PubMed
    245. Asikainen TM, Chang LY, Coalson JJ, Schneider BK, Waleh NS, Ikegami M, Shannon JM, Winter VT, Grubb P, Clyman RI, Yoder BA, Crapo JD, White CW. Improved lung growth and function through hypoxia-inducible factor in primate chronic lung disease of prematurity. FASEB J. 2006 Aug; 20(10):1698-700. PMID: 16807366.
      View in: PubMed
    246. Sharma S, Dewald O, Adrogue J, Salazar RL, Razeghi P, Crapo JD, Bowler RP, Entman ML, Taegtmeyer H. Induction of antioxidant gene expression in a mouse model of ischemic cardiomyopathy is dependent on reactive oxygen species. Free Radic Biol Med. 2006 Jun 15; 40(12):2223-31. PMID: 16785036.
      View in: PubMed
    247. Leinenweber SB, Sheng H, Lynch JR, Wang H, Batinic-Haberle I, Laskowitz DT, Crapo JD, Pearlstein RD, Warner DS. Effects of a manganese (III) porphyrin catalytic antioxidant in a mouse closed head injury model. Eur J Pharmacol. 2006 Feb 15; 531(1-3):126-32. PMID: 16455070.
      View in: PubMed
    248. Due AV, Petersen SV, Valnickova Z, ?stergaard L, Oury TD, Crapo JD, Enghild JJ. Extracellular superoxide dismutase exists as an octamer. FEBS Lett. 2006 Feb 20; 580(5):1485-9. PMID: 16469315.
      View in: PubMed
    249. Heijnen HF, van Donselaar E, Slot JW, Fries DM, Blachard-Fillion B, Hodara R, Lightfoot R, Polydoro M, Spielberg D, Thomson L, Regan EA, Crapo J, Ischiropoulos H. Subcellular localization of tyrosine-nitrated proteins is dictated by reactive oxygen species generating enzymes and by proximity to nitric oxide synthase. Free Radic Biol Med. 2006 Jun 01; 40(11):1903-13. PMID: 16716892.
      View in: PubMed
    250. Regan E, Flannelly J, Bowler R, Tran K, Nicks M, Carbone BD, Glueck D, Heijnen H, Mason R, Crapo J. Extracellular superoxide dismutase and oxidant damage in osteoarthritis. Arthritis Rheum. 2005 Nov; 52(11):3479-91. PMID: 16255039.
      View in: PubMed
    251. Dewald O, Sharma S, Adrogue J, Salazar R, Duerr GD, Crapo JD, Entman ML, Taegtmeyer H. Downregulation of peroxisome proliferator-activated receptor-alpha gene expression in a mouse model of ischemic cardiomyopathy is dependent on reactive oxygen species and prevents lipotoxicity. Circulation. 2005 Jul 19; 112(3):407-15. PMID: 16009788.
      View in: PubMed
    252. Levin ED, Christopher NC, Crapo JD. Memory decline of aging reduced by extracellular superoxide dismutase overexpression. Behav Genet. 2005 Jul; 35(4):447-53. PMID: 15971025.
      View in: PubMed
    253. Reid L, Meyrick B, Antony VB, Chang LY, Crapo JD, Reynolds HY. The mysterious pulmonary brush cell: a cell in search of a function. Am J Respir Crit Care Med. 2005 Jul 01; 172(1):136-9. PMID: 15817800.
      View in: PubMed
    254. Petersen SV, Olsen DA, Kenney JM, Oury TD, Valnickova Z, Th?gersen IB, Crapo JD, Enghild JJ. The high concentration of Arg213-->Gly extracellular superoxide dismutase (EC-SOD) in plasma is caused by a reduction of both heparin and collagen affinities. Biochem J. 2005 Jan 15; 385(Pt 2):427-32. PMID: 15362977.
      View in: PubMed
    255. Patel M, Li QY, Chang LY, Crapo J, Liang LP. Activation of NADPH oxidase and extracellular superoxide production in seizure-induced hippocampal damage. J Neurochem. 2005 Jan; 92(1):123-31. PMID: 15606902.
      View in: PubMed
    256. McCurnin DC, Pierce RA, Chang LY, Gibson LL, Osborne-Lawrence S, Yoder BA, Kerecman JD, Albertine KH, Winter VT, Coalson JJ, Crapo JD, Grubb PH, Shaul PW. Inhaled NO improves early pulmonary function and modifies lung growth and elastin deposition in a baboon model of neonatal chronic lung disease. Am J Physiol Lung Cell Mol Physiol. 2005 Mar; 288(3):L450-9. PMID: 15591412.
      View in: PubMed
    257. Bowler RP, Ellison MC, Duda B, Tran K, Nicks M, Cool C, Greene K, Crapo JD. Lung inflation with direct injection of agarose: a technique for simultaneous molecular and morphometric measurements. Exp Lung Res. 2004 Dec; 30(8):673-86. PMID: 15700546.
      View in: PubMed
    258. Petersen SV, Due AV, Valnickova Z, Oury TD, Crapo JD, Enghild JJ. The structure of rabbit extracellular superoxide dismutase differs from the human protein. Biochemistry. 2004 Nov 09; 43(44):14275-81. PMID: 15518578.
      View in: PubMed
    259. Heijnen HF, Waaijenborg S, Crapo JD, Bowler RP, Akkerman JW, Slot JW. Colocalization of eNOS and the catalytic subunit of PKA in endothelial cell junctions: a clue for regulated NO production. J Histochem Cytochem. 2004 Oct; 52(10):1277-85. PMID: 15385574.
      View in: PubMed
    260. Crapo JD, Barnes PJ, Fabbri L, Hurd S, Make BJ, Balkissoon RC. Editorial: the Journal of COPD--new directions in disease understanding and management. COPD. 2004 Apr; 1(1):1-3. PMID: 16997733.
      View in: PubMed
    261. Olsen DA, Petersen SV, Oury TD, Valnickova Z, Th?gersen IB, Kristensen T, Bowler RP, Crapo JD, Enghild JJ. The intracellular proteolytic processing of extracellular superoxide dismutase (EC-SOD) is a two-step event. J Biol Chem. 2004 May 21; 279(21):22152-7. PMID: 15044467.
      View in: PubMed
    262. Kinnula VL, Crapo JD. Superoxide dismutases in malignant cells and human tumors. Free Radic Biol Med. 2004 Mar 15; 36(6):718-44. PMID: 14990352.
      View in: PubMed
    263. Petersen SV, Oury TD, Ostergaard L, Valnickova Z, Wegrzyn J, Th?gersen IB, Jacobsen C, Bowler RP, Fattman CL, Crapo JD, Enghild JJ. Extracellular superoxide dismutase (EC-SOD) binds to type i collagen and protects against oxidative fragmentation. J Biol Chem. 2004 Apr 02; 279(14):13705-10. PMID: 14736885.
      View in: PubMed
    264. Bowler RP, Barnes PJ, Crapo JD. The role of oxidative stress in chronic obstructive pulmonary disease. COPD. 2004; 1(2):255-77. PMID: 17136992.
      View in: PubMed
    265. Petersen SV, Oury TD, Valnickova Z, Th?gersen IB, H?jrup P, Crapo JD, Enghild JJ. The dual nature of human extracellular superoxide dismutase: one sequence and two structures. Proc Natl Acad Sci U S A. 2003 Nov 25; 100(24):13875-80. PMID: 14615576.
      View in: PubMed
    266. Crapo JD. Redox active agents in inflammatory lung injury. Am J Respir Crit Care Med. 2003 Nov 01; 168(9):1027-8. PMID: 14581288.
      View in: PubMed
    267. Crapo JD, Broaddus VC, Brody AR, Malindzak G, Samet J, Wright JR. Workshop on lung disease and the environment: where do we go from here? Am J Respir Crit Care Med. 2003 Jul 15; 168(2):250-4. PMID: 12851246.
      View in: PubMed
    268. Trova MP, Gauuan PJ, Pechulis AD, Bubb SM, Bocckino SB, Crapo JD, Day BJ. Superoxide dismutase mimetics. Part 2: synthesis and structure-activity relationship of glyoxylate- and glyoxamide-derived metalloporphyrins. Bioorg Med Chem. 2003 Jul 03; 11(13):2695-707. PMID: 12788343.
      View in: PubMed
    269. Kinnula VL, Crapo JD. Superoxide dismutases in the lung and human lung diseases. Am J Respir Crit Care Med. 2003 Jun 15; 167(12):1600-19. PMID: 12796054.
      View in: PubMed
    270. Lubbers NL, Polakowski JS, Crapo JD, Wegner CD, Cox BF. Preischemic and postischemic administration of AEOL10113 reduces infarct size in a rat model of myocardial ischemia and reperfusion. J Cardiovasc Pharmacol. 2003 May; 41(5):714-9. PMID: 12717101.
      View in: PubMed
    271. Croxton TL, Weinmann GG, Senior RM, Wise RA, Crapo JD, Buist AS. Clinical research in chronic obstructive pulmonary disease: needs and opportunities. Am J Respir Crit Care Med. 2003 Apr 15; 167(8):1142-9. PMID: 12684252.
      View in: PubMed
    272. Wang W, Jittikanont S, Falk SA, Li P, Feng L, Gengaro PE, Poole BD, Bowler RP, Day BJ, Crapo JD, Schrier RW. Interaction among nitric oxide, reactive oxygen species, and antioxidants during endotoxemia-related acute renal failure. Am J Physiol Renal Physiol. 2003 Mar; 284(3):F532-7. PMID: 12556364.
      View in: PubMed
    273. Chang LY, Crapo JD. Inhibition of airway inflammation and hyperreactivity by a catalytic antioxidant. Chest. 2003 Mar; 123(3 Suppl):446S. PMID: 12629031.
      View in: PubMed
    274. Dewald O, Frangogiannis NG, Zoerlein M, Duerr GD, Klemm C, Knuefermann P, Taffet G, Michael LH, Crapo JD, Welz A, Entman ML. Development of murine ischemic cardiomyopathy is associated with a transient inflammatory reaction and depends on reactive oxygen species. Proc Natl Acad Sci U S A. 2003 Mar 04; 100(5):2700-5. PMID: 12586861.
      View in: PubMed
    275. Bowler RP, Arcaroli J, Abraham E, Patel M, Chang LY, Crapo JD. Evidence for extracellular superoxide dismutase as a mediator of hemorrhage-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2003 Apr; 284(4):L680-7. PMID: 12618426.
      View in: PubMed
    276. Chang LY, Subramaniam M, Yoder BA, Day BJ, Ellison MC, Sunday ME, Crapo JD. A catalytic antioxidant attenuates alveolar structural remodeling in bronchopulmonary dysplasia. Am J Respir Crit Care Med. 2003 Jan 01; 167(1):57-64. PMID: 12502477.
      View in: PubMed
    277. Bowler RP, Crapo JD. Oxidative stress in airways: is there a role for extracellular superoxide dismutase? Am J Respir Crit Care Med. 2002 Dec 15; 166(12 Pt 2):S38-43. PMID: 12471087.
      View in: PubMed
    278. Ross AD, Sheng H, Warner DS, Piantadosi CA, Batinic-Haberle I, Day BJ, Crapo JD. Hemodynamic effects of metalloporphyrin catalytic antioxidants: structure-activity relationships and species specificity. Free Radic Biol Med. 2002 Dec 15; 33(12):1657-69. PMID: 12488134.
      View in: PubMed
    279. Smith KR, Uyeminami DL, Kodavanti UP, Crapo JD, Chang LY, Pinkerton KE. Inhibition of tobacco smoke-induced lung inflammation by a catalytic antioxidant. Free Radic Biol Med. 2002 Oct 15; 33(8):1106-14. PMID: 12374622.
      View in: PubMed
    280. Gauuan PJ, Trova MP, Gregor-Boros L, Bocckino SB, Crapo JD, Day BJ. Superoxide dismutase mimetics: synthesis and structure-activity relationship study of MnTBAP analogues. Bioorg Med Chem. 2002 Sep; 10(9):3013-21. PMID: 12110324.
      View in: PubMed
    281. Bowler RP, Crapo JD. Oxidative stress in allergic respiratory diseases. J Allergy Clin Immunol. 2002 Sep; 110(3):349-56. PMID: 12209079.
      View in: PubMed
    282. Chang LY, Crapo JD. Inhibition of airway inflammation and hyperreactivity by an antioxidant mimetic. Free Radic Biol Med. 2002 Aug 01; 33(3):379-86. PMID: 12126760.
      View in: PubMed
    283. Bowler RP, Nicks M, Warnick K, Crapo JD. Role of extracellular superoxide dismutase in bleomycin-induced pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2002 Apr; 282(4):L719-26. PMID: 11880297.
      View in: PubMed
    284. Levin ED, Christopher NC, Lateef S, Elamir BM, Patel M, Liang LP, Crapo JD. Extracellular superoxide dismutase overexpression protects against aging-induced cognitive impairment in mice. Behav Genet. 2002 Mar; 32(2):119-25. PMID: 12036109.
      View in: PubMed
    285. Bowler RP, Nicks M, Olsen DA, Th?gersen IB, Valnickova Z, H?jrup P, Franzusoff A, Enghild JJ, Crapo JD. Furin proteolytically processes the heparin-binding region of extracellular superoxide dismutase. J Biol Chem. 2002 May 10; 277(19):16505-11. PMID: 11861638.
      View in: PubMed
    286. Piganelli JD, Flores SC, Cruz C, Koepp J, Batinic-Haberle I, Crapo J, Day B, Kachadourian R, Young R, Bradley B, Haskins K. A metalloporphyrin-based superoxide dismutase mimic inhibits adoptive transfer of autoimmune diabetes by a diabetogenic T-cell clone. Diabetes. 2002 Feb; 51(2):347-55. PMID: 11812741.
      View in: PubMed
    Crapo's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    See all (829) concept(s)
    _
    Co-Authors Expand Description
    See all (50) people
    _
    Similar People Expand Description
    See all (60) people
    _
    Same Department Expand Description
    Search Department

    Copyright © 2024 The Regents of the University of Colorado, a body corporate. All rights reserved. (Harvard PROFILES RNS software version: 2.11.1)