 Transcription Factor TFIIB
"Transcription Factor TFIIB" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An RNA POLYMERASE II specific transcription factor. It plays a role in assembly of the pol II transcriptional preinitiation complex and has been implicated as a target of gene-specific transcriptional activators.
| Descriptor ID |
D035581
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| MeSH Number(s) |
D12.776.260.775.875.562 D12.776.930.930.875.562
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Transcription Factor TFIIB".
Below are MeSH descriptors whose meaning is more specific than "Transcription Factor TFIIB".
This graph shows the total number of publications written about "Transcription Factor TFIIB" by people in this website by year, and whether "Transcription Factor TFIIB" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 1 | 1 | | 2004 | 1 | 0 | 1 | | 2006 | 0 | 1 | 1 | | 2009 | 1 | 1 | 2 | | 2010 | 1 | 0 | 1 | | 2016 | 0 | 1 | 1 | | 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Transcription Factor TFIIB" by people in Profiles.
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Ly E, Powell AE, Goodrich JA, Kugel JF. Release of Human TFIIB from Actively Transcribing Complexes Is Triggered upon Synthesis of 7- and 9-nt RNAs. J Mol Biol. 2020 06 26; 432(14):4049-4060.
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Horn AE, Kugel JF, Goodrich JA. Single molecule microscopy reveals mechanistic insight into RNA polymerase II preinitiation complex assembly and transcriptional activity. Nucleic Acids Res. 2016 09 06; 44(15):7132-43.
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De Carlo S, Lin SC, Taatjes DJ, Hoenger A. Molecular basis of transcription initiation in Archaea. Transcription. 2010 Sep-Oct; 1(2):103-11.
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Yakovchuk P, Goodrich JA, Kugel JF. B2 RNA and Alu RNA repress transcription by disrupting contacts between RNA polymerase II and promoter DNA within assembled complexes. Proc Natl Acad Sci U S A. 2009 Apr 07; 106(14):5569-74.
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Gilman B, Drullinger LF, Kugel JF, Goodrich JA. TATA-binding protein and transcription factor IIB induce transcript slipping during early transcription by RNA polymerase II. J Biol Chem. 2009 Apr 03; 284(14):9093-8.
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Takagi Y, Calero G, Komori H, Brown JA, Ehrensberger AH, Hudmon A, Asturias F, Kornberg RD. Head module control of mediator interactions. Mol Cell. 2006 Aug 04; 23(3):355-64.
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Asturias FJ. Another piece in the transcription initiation puzzle. Nat Struct Mol Biol. 2004 Nov; 11(11):1031-3.
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Ferguson HA, Kugel JF, Goodrich JA. Kinetic and mechanistic analysis of the RNA polymerase II transcrption reaction at the human interleukin-2 promoter. J Mol Biol. 2001 Dec 14; 314(5):993-1006.
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Kosa PF, Ghosh G, DeDecker BS, Sigler PB. The 2.1-A crystal structure of an archaeal preinitiation complex: TATA-box-binding protein/transcription factor (II)B core/TATA-box. Proc Natl Acad Sci U S A. 1997 Jun 10; 94(12):6042-7.
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