 Bicuculline
"Bicuculline" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An isoquinoline alkaloid obtained from Dicentra cucullaria and other plants. It is a competitive antagonist for GABA-A receptors.
| Descriptor ID |
D001640
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| MeSH Number(s) |
D03.132.098.077 D03.633.100.531.085.077
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| Concept/Terms |
Bicuculline- Bicuculline
- 6-(5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo(4,5-g)isoquinolin-5-yl)furo(3,4-e)1,3-benzodioxol-8(6H)one
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Below are MeSH descriptors whose meaning is more general than "Bicuculline".
Below are MeSH descriptors whose meaning is more specific than "Bicuculline".
This graph shows the total number of publications written about "Bicuculline" by people in this website by year, and whether "Bicuculline" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 | | 2000 | 0 | 1 | 1 | | 2002 | 0 | 3 | 3 | | 2004 | 0 | 1 | 1 | | 2005 | 0 | 1 | 1 | | 2006 | 0 | 2 | 2 | | 2008 | 0 | 2 | 2 | | 2010 | 0 | 3 | 3 | | 2011 | 0 | 2 | 2 | | 2014 | 0 | 1 | 1 | | 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Bicuculline" by people in Profiles.
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Bortz DM, Feistritzer CM, Power CC, Grace AA. Medial septum activation improves strategy switching once strategies are well-learned via bidirectional regulation of dopamine neuron population activity. Neuropsychopharmacology. 2022 11; 47(12):2090-2100.
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Bobeck EN, Chen Q, Morgan MM, Ingram SL. Contribution of adenylyl cyclase modulation of pre- and postsynaptic GABA neurotransmission to morphine antinociception and tolerance. Neuropsychopharmacology. 2014 Aug; 39(9):2142-52.
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Connor SA, Hoeffer CA, Klann E, Nguyen PV. Fragile X mental retardation protein regulates heterosynaptic plasticity in the hippocampus. Learn Mem. 2011; 18(4):207-20.
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Zhao-Shea R, Liu L, Soll LG, Improgo MR, Meyers EE, McIntosh JM, Grady SR, Marks MJ, Gardner PD, Tapper AR. Nicotine-mediated activation of dopaminergic neurons in distinct regions of the ventral tegmental area. Neuropsychopharmacology. 2011 Apr; 36(5):1021-32.
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Wu PH, Coultrap S, Browning MD, Proctor WR. Correlated changes in NMDA receptor phosphorylation, functional activity, and sedation by chronic ethanol consumption. J Neurochem. 2010 Dec; 115(5):1112-22.
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Pandipati S, Gire DH, Schoppa NE. Adrenergic receptor-mediated disinhibition of mitral cells triggers long-term enhancement of synchronized oscillations in the olfactory bulb. J Neurophysiol. 2010 Aug; 104(2):665-74.
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Macey TA, Ingram SL, Bobeck EN, Hegarty DM, Aicher SA, Arttamangkul S, Morgan MM. Opioid receptor internalization contributes to dermorphin-mediated antinociception. Neuroscience. 2010 Jun 30; 168(2):543-50.
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Goebel-Goody SM, Davies KD, Alvestad Linger RM, Freund RK, Browning MD. Phospho-regulation of synaptic and extrasynaptic N-methyl-d-aspartate receptors in adult hippocampal slices. Neuroscience. 2009 Feb 18; 158(4):1446-59.
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Luna VM, Schoppa NE. GABAergic circuits control input-spike coupling in the piriform cortex. J Neurosci. 2008 Aug 27; 28(35):8851-9.
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Baca SM, Marin-Burgin A, Wagenaar DA, Kristan WB. Widespread inhibition proportional to excitation controls the gain of a leech behavioral circuit. Neuron. 2008 Jan 24; 57(2):276-289.
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