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Laurel Lawson Lenz Jr.

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-IMM MICRO GENERAL OPER
Phone303/724-8676

    Collapse Research 
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    F32AI010481     (LENZ, LAUREL L)May 1, 2000
    NIH
    PHASE VARIATION IN LISTERIA MONOCYTOGENES
    Role: Principal Investigator

    R01AI055701     (LENZ, LAUREL L)Dec 1, 2004 - Nov 30, 2010
    NIH
    CD8 Mediated Apoptosis During T Cell Development
    Role: Principal Investigator

    R01AI065638     (LENZ, LAUREL L)Apr 1, 2006 - Jul 31, 2011
    NIH
    Active Subversion of Innate Immunity by Bacterial LysM Protein
    Role: Principal Investigator

    R56AI065638     (LENZ, LAUREL L)Aug 1, 2011 - Feb 14, 2012
    NIH
    Active Subversion of Innate Immunity by Bacterial LysM Protein
    Role: Principal Investigator

    R21AI102264     (LENZ, LAUREL L)Jul 1, 2012 - Jun 30, 2014
    NIH
    IFNGR Down Regulation as a Host Target for Therapy of Infectious Diseases
    Role: Principal Investigator

    R21AI103782     (LENZ, LAUREL L)Apr 15, 2013 - Jun 30, 2014
    NIH
    Non-canonical responses to IFNab in the suppression of macrophage immunity
    Role: Principal Investigator

    R33AI102264     (LENZ, LAUREL L)Aug 15, 2014 - Jul 31, 2017
    NIH
    IFNGR Down Regulation as a Host Target for Therapy of Infectious Diseases
    Role: Principal Investigator

    R01AI131662     (LENZ, LAUREL L)May 10, 2017 - Apr 30, 2022
    NIH
    NK cell IL-10 production during bacterial infections
    Role: Principal Investigator

    R21AI140499     (LENZ, LAUREL L)May 10, 2018 - Apr 30, 2020
    NIH
    Myeloid cell IFNGR regulation in persistent viral and secondary bacterial infections
    Role: Principal Investigator

    R21AI161827     (LENZ, LAUREL L)Feb 22, 2021 - Jan 31, 2023
    NIH
    Role of IFNs and IFNGR in susceptibility to bacteria in Down syndrome
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Bortell N, Aguilera ER, Lenz LL. Pulmonary insults exacerbate susceptibility to oral Listeria monocytogenes infection through the production of IL-10 by NK cells. PLoS Pathog. 2021 Apr; 17(4):e1009531. PMID: 33878120.
      View in: PubMed
    2. Larson SR, Bortell N, Illies A, Crisler WJ, Matsuda JL, Lenz LL. Myeloid Cell CK2 Regulates Inflammation and Resistance to Bacterial Infection. Front Immunol. 2020; 11:590266. PMID: 33363536.
      View in: PubMed
    3. Clark SE, Schmidt RL, Aguilera ER, Lenz LL. IL-10-producing NK cells exacerbate sublethal Streptococcus pneumoniae infection in the lung. Transl Res. 2020 12; 226:70-82. PMID: 32634590.
      View in: PubMed
    4. Walker MM, Kim S, Crisler WJ, Nguyen K, Lenz LL, Cambier JC, Getahun A. Selective Loss of Responsiveness to Exogenous but Not Endogenous Cyclic-Dinucleotides in Mice Expressing STING-R231H. Front Immunol. 2020; 11:238. PMID: 32153571.
      View in: PubMed
    5. Aguilera ER, Lenz LL. Inflammation as a Modulator of Host Susceptibility to Pulmonary Influenza, Pneumococcal, and Co-Infections. Front Immunol. 2020; 11:105. PMID: 32117259.
      View in: PubMed
    6. Yang C, McDermot DS, Pasricha S, Brown AS, Bedoui S, Lenz LL, van Driel IR, Hartland EL. IFN? receptor down-regulation facilitates Legionella survival in alveolar macrophages. J Leukoc Biol. 2020 02; 107(2):273-284. PMID: 31793076.
      View in: PubMed
    7. Crisler WJ, Eshleman EM, Lenz LL. Ligand-induced IFNGR1 down-regulation calibrates myeloid cell IFN? responsiveness. Life Sci Alliance. 2019 10; 2(5). PMID: 31585982.
      View in: PubMed
    8. Clark SE, Burrack KS, Jameson SC, Hamilton SE, Lenz LL. NK Cell IL-10 Production Requires IL-15 and IL-10 Driven STAT3 Activation. Front Immunol. 2019; 10:2087. PMID: 31552035.
      View in: PubMed
    9. Soderborg TK, Clark SE, Mulligan CE, Janssen RC, Babcock L, Ir D, Young B, Krebs NF, Lemas DJ, Johnson LK, Weir T, Lenz LL, Frank DN, Hernandez TL, Kuhn KA, D'Alessandro A, Barbour LA, El Kasmi KC, Friedman JE. Author Correction: The gut microbiota in infants of obese mothers increases inflammation and susceptibility to NAFLD. Nat Commun. 2019 Jul 01; 10(1):2965. PMID: 31263097.
      View in: PubMed
    10. Soderborg TK, Clark SE, Mulligan CE, Janssen RC, Babcock L, Ir D, Young B, Krebs N, Lemas DJ, Johnson LK, Weir T, Lenz LL, Frank DN, Hernandez TL, Kuhn KA, D'Alessandro A, Barbour LA, El Kasmi KC, Friedman JE. The gut microbiota in infants of obese mothers increases inflammation and susceptibility to NAFLD. Nat Commun. 2018 10 26; 9(1):4462. PMID: 30367045.
      View in: PubMed
    11. Alper S, Lenz LL. Editorial overview: Tuning the innate immune response to pathogens. Curr Opin Immunol. 2018 10; 54:vi-ix. PMID: 30342707.
      View in: PubMed
    12. Crisler WJ, Lenz LL. Crosstalk between type I and II interferons in regulation of myeloid cell responses during bacterial infection. Curr Opin Immunol. 2018 10; 54:35-41. PMID: 29886270.
      View in: PubMed
    13. Clark SE, Schmidt RL, McDermott DS, Lenz LL. A Batf3/Nlrp3/IL-18 Axis Promotes Natural Killer Cell IL-10 Production during Listeria monocytogenes Infection. Cell Rep. 2018 05 29; 23(9):2582-2594. PMID: 29847790.
      View in: PubMed
    14. Ortiz AL, Lenz LL. A Listeria-derived polypeptide promotes in vivo activation of NK cells for antitumor therapy. Immunohorizons. 2017 Jun 01; 1(4):53-62. PMID: 29658011.
      View in: PubMed
    15. Eshleman EM, Delgado C, Kearney SJ, Friedman RS, Lenz LL. Down regulation of macrophage IFNGR1 exacerbates systemic L. monocytogenes infection. PLoS Pathog. 2017 May; 13(5):e1006388. PMID: 28542482.
      View in: PubMed
    16. Smith C, Jalbert E, de Almeida V, Canniff J, Lenz LL, Mussi-Pinhata MM, Cohen RA, Yu Q, Amaral FR, Pinto J, Alarcon JO, Siberry G, Weinberg A. Altered Natural Killer Cell Function in HIV-Exposed Uninfected Infants. Front Immunol. 2017; 8:470. PMID: 28484464.
      View in: PubMed
    17. Clark SE, Filak HC, Guthrie BS, Schmidt RL, Jamieson A, Merkel P, Knight V, Cole CM, Raulet DH, Lenz LL. Bacterial Manipulation of NK Cell Regulatory Activity Increases Susceptibility to Listeria monocytogenes Infection. PLoS Pathog. 2016 06; 12(6):e1005708. PMID: 27295349.
      View in: PubMed
    18. Mills CD, Lenz LL, Harris RA. A Breakthrough: Macrophage-Directed Cancer Immunotherapy. Cancer Res. 2016 Feb 01; 76(3):513-6. PMID: 26772756.
      View in: PubMed
    19. Mills CD, Lenz LL, Ley K. Macrophages at the fork in the road to health or disease. Front Immunol. 2015; 6:59. PMID: 25762997.
      View in: PubMed
    20. Mills CD, Thomas AC, Lenz LL, Munder M. Macrophage: SHIP of Immunity. Front Immunol. 2014; 5:620. PMID: 25538705.
      View in: PubMed
    21. Kedl RM, Wysocki LJ, Janssen WJ, Born WK, Rosenbaum MD, Granowski J, Kench JA, Fong DL, Switzer LA, Cruse M, Huang H, Jakubzick CV, Kosmider B, Takeda K, Stranova TJ, Klumm RC, Delgado C, Tummala S, De Langhe S, Cambier J, Haskins K, Lenz LL, Curran-Everett D. General parity between trio and pairwise breeding of laboratory mice in static caging. J Immunol. 2014 Nov 15; 193(10):4757-60. PMID: 25381356.
      View in: PubMed
    22. Eshleman EM, Lenz LL. Type I interferons in bacterial infections: taming of myeloid cells and possible implications for autoimmunity. Front Immunol. 2014; 5:431. PMID: 25309533.
      View in: PubMed
    23. Czaja CA, Merkel PA, Chan ED, Lenz LL, Wolf ML, Alam R, Frankel SK, Fischer A, Gogate S, Perez-Velez CM, Knight V. Rituximab as successful adjunct treatment in a patient with disseminated nontuberculous mycobacterial infection due to acquired anti-interferon-? autoantibody. Clin Infect Dis. 2014 Mar; 58(6):e115-8. PMID: 24336756.
      View in: PubMed
    24. Schmidt R, Lenz LL. Biological DNA Sensor: The impact of Nucleic Acids on Diseases and Vaccinology, Ken Ishii and Choon Kit Tang, editors. Adjuvants Targeting the DNA Sensing Pathways – Cyclic-di-GMP and Other Cyclic-di-Nucleotides. 2013; 313-336.
    25. Kearney SJ, Delgado C, Eshleman EM, Hill KK, O'Connor BP, Lenz LL. Type I IFNs downregulate myeloid cell IFN-? receptor by inducing recruitment of an early growth response 3/NGFI-A binding protein 1 complex that silences ifngr1 transcription. J Immunol. 2013 Sep 15; 191(6):3384-92. PMID: 23935197.
      View in: PubMed
    26. Kearney S, Delgado C, Lenz LL. Differential effects of type I and II interferons on myeloid cells and resistance to intracellular bacterial infections. Immunol Res. 2013 Mar; 55(1-3):187-200. PMID: 22983898.
      View in: PubMed
    27. Schmidt RL, Lenz LL. Distinct licensing of IL-18 and IL-1ß secretion in response to NLRP3 inflammasome activation. PLoS One. 2012; 7(9):e45186. PMID: 23028835.
      View in: PubMed
    28. Williams MA, Schmidt RL, Lenz LL. Early events regulating immunity and pathogenesis during Listeria monocytogenes infection. Trends Immunol. 2012 Oct; 33(10):488-95. PMID: 22677184.
      View in: PubMed
    29. Cole C, Thomas S, Filak H, Henson PM, Lenz LL. Nitric oxide increases susceptibility of Toll-like receptor-activated macrophages to spreading Listeria monocytogenes. Immunity. 2012 May 25; 36(5):807-20. PMID: 22542147.
      View in: PubMed
    30. Rayamajhi M, Delgado C, Condon TV, Riches DW, Lenz LL. Lung B cells promote early pathogen dissemination and hasten death from inhalation anthrax. Mucosal Immunol. 2012 Jul; 5(4):444-54. PMID: 22472773.
      View in: PubMed
    31. Schmidt RL, Filak HC, Lemon JD, Potter TA, Lenz LL. A LysM and SH3-domain containing region of the Listeria monocytogenes p60 protein stimulates accessory cells to promote activation of host NK cells. PLoS Pathog. 2011 Nov; 7(11):e1002368. PMID: 22072975.
      View in: PubMed
    32. Jin L, Hill KK, Filak H, Mogan J, Knowles H, Zhang B, Perraud AL, Cambier JC, Lenz LL. MPYS is required for IFN response factor 3 activation and type I IFN production in the response of cultured phagocytes to bacterial second messengers cyclic-di-AMP and cyclic-di-GMP. J Immunol. 2011 Sep 01; 187(5):2595-601. PMID: 21813776.
      View in: PubMed
    33. Knowles H, Heizer JW, Li Y, Chapman K, Ogden CA, Andreasen K, Shapland E, Kucera G, Mogan J, Humann J, Lenz LL, Morrison AD, Perraud AL. Transient Receptor Potential Melastatin 2 (TRPM2) ion channel is required for innate immunity against Listeria monocytogenes. Proc Natl Acad Sci U S A. 2011 Jul 12; 108(28):11578-83. PMID: 21709234.
      View in: PubMed
    34. Rayamajhi M, Redente EF, Condon TV, Gonzalez-Juarrero M, Riches DW, Lenz LL. Non-surgical intratracheal instillation of mice with analysis of lungs and lung draining lymph nodes by flow cytometry. J Vis Exp. 2011 May 02; (51). PMID: 21587154.
      View in: PubMed
    35. Boudreau JE, Stephenson KB, Wang F, Ashkar AA, Mossman KL, Lenz LL, Rosenthal KL, Bramson JL, Lichty BD, Wan Y. IL-15 and type I interferon are required for activation of tumoricidal NK cells by virus-infected dendritic cells. Cancer Res. 2011 Apr 01; 71(7):2497-506. PMID: 21307131.
      View in: PubMed
    36. Jin L, Lenz LL, Cambier JC. Cellular reactive oxygen species inhibit MPYS induction of IFNß. PLoS One. 2010 Dec 10; 5(12):e15142. PMID: 21170271.
      View in: PubMed
    37. Rayamajhi M, Humann J, Kearney S, Hill KK, Lenz LL. Antagonistic crosstalk between type I and II interferons and increased host susceptibility to bacterial infections. Virulence. 2010 Sep-Oct; 1(5):418-22. PMID: 21178482.
      View in: PubMed
    38. Humann J, Lenz LL. Activation of naive NK cells in response to Listeria monocytogenes requires IL-18 and contact with infected dendritic cells. J Immunol. 2010 May 01; 184(9):5172-8. PMID: 20351186.
      View in: PubMed
    39. Rayamajhi M, Humann J, Penheiter K, Andreasen K, Lenz LL. Induction of IFN-alphabeta enables Listeria monocytogenes to suppress macrophage activation by IFN-gamma. J Exp Med. 2010 Feb 15; 207(2):327-37. PMID: 20123961.
      View in: PubMed
    40. Lenz LL. CD5 sweetens lymphocyte responses. Proc Natl Acad Sci U S A. 2009 Feb 03; 106(5):1303-4. PMID: 19174525.
      View in: PubMed
    41. Humann J, Lenz LL. Bacterial peptidoglycan degrading enzymes and their impact on host muropeptide detection. J Innate Immun. 2009; 1(2):88-97. PMID: 19319201.
      View in: PubMed
    42. Lenz LL. Encyclopedia of Pestilence, Pandemics, and Plagues, Joseph P. Byrne, editor. Human Immunity and Resistance to Disease. 2008; 282-284.
    43. Lenz LL. Encyclopedia of Pestilence, Pandemics, and Plagues, Joseph P. Byrne, editor. Immunology. 2008; 1:297-299.
    44. Lenz LL, Huang WA, Zhou C, Li Z, Calendar R. Stable integration vector for nutrient broth-based selection of attenuated Listeria monocytogenes strains with recombinant antigen expression. Clin Vaccine Immunol. 2008 Sep; 15(9):1414-9. PMID: 18650400.
      View in: PubMed
    45. Noor S, Goldfine H, Tucker DE, Suram S, Lenz LL, Akira S, Uematsu S, Girotti M, Bonventre JV, Breuel K, Williams DL, Leslie CC. Activation of cytosolic phospholipase A2alpha in resident peritoneal macrophages by Listeria monocytogenes involves listeriolysin O and TLR2. J Biol Chem. 2008 Feb 22; 283(8):4744-55. PMID: 18083708.
      View in: PubMed
    46. Lenz LL, Andrews-Polymenis HL. Silencing the alarm: insights into the interaction between host and pathogen. Conference on Microbial Pathogenesis: Mechanisms of Infectious Disease. . 2008 Jan; 9(1):27-32. PMID: 18084188.
      View in: PubMed
    47. Humann J, Bjordahl R, Andreasen K, Lenz LL. Expression of the p60 autolysin enhances NK cell activation and is required for listeria monocytogenes expansion in IFN-gamma-responsive mice. J Immunol. 2007 Feb 15; 178(4):2407-14. PMID: 17277147.
      View in: PubMed
    48. Lenz LL. Everything you always wanted to know about NK cells but were afraid to ask, Laurent Brossay, Ed. NK cells and the innate response to intracellular bacterial infections. 2007; 147-166.
    49. Muraille E, Narni-Mancinelli E, Gounon P, Bassand D, Glaichenhaus N, Lenz LL, Lauvau G. Cytosolic expression of SecA2 is a prerequisite for long-term protective immunity. Cell Microbiol. 2007 Jun; 9(6):1445-54. PMID: 17244189.
      View in: PubMed
    50. Arrunategui-Correa V, Lenz L, Kim HS. CD1d-independent regulation of NKT cell migration and cytokine production upon Listeria monocytogenes infection. Cell Immunol. 2004 Nov-Dec; 232(1-2):38-48. PMID: 15922714.
      View in: PubMed
    51. Diehl GE, Yue HH, Hsieh K, Kuang AA, Ho M, Morici LA, Lenz LL, Cado D, Riley LW, Winoto A. TRAIL-R as a negative regulator of innate immune cell responses. Immunity. 2004 Dec; 21(6):877-89. PMID: 15589175.
      View in: PubMed
    52. Ploss A, Lauvau G, Contos B, Kerksiek KM, Guirnalda PD, Leiner I, Lenz LL, Bevan MJ, Pamer EG. Promiscuity of MHC class Ib-restricted T cell responses. J Immunol. 2003 Dec 01; 171(11):5948-55. PMID: 14634106.
      View in: PubMed
    53. Lenz LL, Mohammadi S, Geissler A, Portnoy DA. SecA2-dependent secretion of autolytic enzymes promotes Listeria monocytogenes pathogenesis. Proc Natl Acad Sci U S A. 2003 Oct 14; 100(21):12432-7. PMID: 14527997.
      View in: PubMed
    54. Lenz LL, Portnoy DA. Identification of a second Listeria secA gene associated with protein secretion and the rough phenotype. Mol Microbiol. 2002 Aug; 45(4):1043-56. PMID: 12180923.
      View in: PubMed
    55. Auerbuch V, Lenz LL, Portnoy DA. Development of a competitive index assay to evaluate the virulence of Listeria monocytogenes actA mutants during primary and secondary infection of mice. Infect Immun. 2001 Sep; 69(9):5953-7. PMID: 11500481.
      View in: PubMed
    56. Lenz LL, Butz EA, Bevan MJ. Requirements for bone marrow-derived antigen-presenting cells in priming cytotoxic T cell responses to intracellular pathogens. J Exp Med. 2000 Oct 16; 192(8):1135-42. PMID: 11034603.
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    57. Princiotta MF, Lenz LL, Bevan MJ, Staerz UD. H2-M3 restricted presentation of a Listeria-derived leader peptide. J Exp Med. 1998 May 18; 187(10):1711-9. PMID: 9584149.
      View in: PubMed
    58. Lenz LL, Bevan MJ. CTL responses to H2-M3-restricted Listeria epitopes. Immunol Rev. 1997 Aug; 158:115-21. PMID: 9314079.
      View in: PubMed
    59. Harty JT, Lenz LL, Bevan MJ. Primary and secondary immune responses to Listeria monocytogenes. Curr Opin Immunol. 1996 Aug; 8(4):526-30. PMID: 8794012.
      View in: PubMed
    60. Lenz LL, Dere B, Bevan MJ. Identification of an H2-M3-restricted Listeria epitope: implications for antigen presentation by M3. Immunity. 1996 Jul; 5(1):63-72. PMID: 8758895.
      View in: PubMed
    61. Lenz LL, Bevan MJ. H2-M3 restricted presentation of Listeria monocytogenes antigens. Immunol Rev. 1996 Jun; 151:107-21. PMID: 8872487.
      View in: PubMed
    62. Fattaey A, Lenz L, Consigli RA. Production and characterization of monoclonal antibodies to budgerigar fledgling disease virus major capsid protein VP. Avian Dis. 1992 Jul-Sep; 36(3):543-53. PMID: 1417586.
      View in: PubMed
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