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Richard K.P. Benninger

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Farnsworth NL, Walter R, Piscopio R, Schleicher WE, Benninger RKP. Exendin-4 Overcomes Cytokine-Induced Decreases in Gap Junction Coupling via PKA and Epac2 in Mouse and Human Islets. J Physiol. 2018 Nov 09. PMID: 30412665.
      View in: PubMed
    2. Benninger RKP, Dorrell C, Hodson DJ, Rutter GA. The Impact of Pancreatic Beta Cell Heterogeneity on Type 1 Diabetes Pathogenesis. Curr Diab Rep. 2018 Sep 24; 18(11):112. PMID: 30251179.
      View in: PubMed
    3. St Clair JR, Ramirez D, Passman S, Benninger RKP. Contrast-enhanced ultrasound measurement of pancreatic blood flow dynamics predicts type 1 diabetes progression in preclinical models. Nat Commun. 2018 05 01; 9(1):1742. PMID: 29717116.
      View in: PubMed
    4. Benninger RKP, Hodson DJ. New Understanding of ß-Cell Heterogeneity and In Situ Islet Function. Diabetes. 2018 04; 67(4):537-547. PMID: 29559510.
      View in: PubMed
    5. Westacott MJ, Ludin NWF, Benninger RKP. Spatially Organized ß-Cell Subpopulations Control Electrical Dynamics across Islets of Langerhans. Biophys J. 2017 Sep 05; 113(5):1093-1108. PMID: 28877492.
      View in: PubMed
    6. Westacott MJ, Farnsworth NL, St Clair JR, Poffenberger G, Heintz A, Ludin NW, Hart NJ, Powers AC, Benninger RKP. Age-Dependent Decline in the Coordinated [Ca2+] and Insulin Secretory Dynamics in Human Pancreatic Islets. Diabetes. 2017 09; 66(9):2436-2445. PMID: 28588099.
      View in: PubMed
    7. Nunemaker CS, Benninger RK. Zinc Transport Gets Its Zing Back: Double-Knockout of ZnT7 and ZnT8 Reveals the Importance of Zinc Transporters to Insulin Secretion. Endocrinology. 2016 12; 157(12):4542-4544. PMID: 27911147.
      View in: PubMed
    8. Notary AM, Westacott MJ, Hraha TH, Pozzoli M, Benninger RK. Decreases in Gap Junction Coupling Recovers Ca2+ and Insulin Secretion in Neonatal Diabetes Mellitus, Dependent on Beta Cell Heterogeneity and Noise. PLoS Comput Biol. 2016 Sep; 12(9):e1005116. PMID: 27681078.
      View in: PubMed
    9. Farnsworth NL, Walter RL, Hemmati A, Westacott MJ, Benninger RK. Low Level Pro-inflammatory Cytokines Decrease Connexin36 Gap Junction Coupling in Mouse and Human Islets through Nitric Oxide-mediated Protein Kinase Cd. J Biol Chem. 2016 Feb 12; 291(7):3184-96. PMID: 26668311; PMCID: PMC4751367 [Available on 02/12/17].
    10. Benninger RK. Fluorescence linear dichroism imaging for quantifying membrane order. Methods Mol Biol. 2015; 1232:161-79. PMID: 25331136; PMCID: PMC4560120.
    11. Benninger RK, Hutchens T, Head WS, McCaughey MJ, Zhang M, Le Marchand SJ, Satin LS, Piston DW. Intrinsic islet heterogeneity and gap junction coupling determine spatiotemporal Ca²? wave dynamics. Biophys J. 2014 Dec 02; 107(11):2723-33. PMID: 25468351; PMCID: PMC4255172.
    12. Nozik-Grayck E, Woods C, Taylor JM, Benninger RK, Johnson RD, Villegas LR, Stenmark KR, Harrison DG, Majka SM, Irwin D, Farrow KN. Selective depletion of vascular EC-SOD augments chronic hypoxic pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2014 Dec 01; 307(11):L868-76. PMID: 25326578; PMCID: PMC4254965.
    13. Hraha TH, Westacott MJ, Pozzoli M, Notary AM, McClatchey PM, Benninger RK. Phase transitions in the multi-cellular regulatory behavior of pancreatic islet excitability. PLoS Comput Biol. 2014 Sep; 10(9):e1003819. PMID: 25188228; PMCID: PMC4154652.
    14. Farnsworth NL, Hemmati A, Pozzoli M, Benninger RK. Fluorescence recovery after photobleaching reveals regulation and distribution of connexin36 gap junction coupling within mouse islets of Langerhans. J Physiol. 2014 Oct 15; 592(20):4431-46. PMID: 25172942; PMCID: PMC4287745.
    15. Hartney JM, Stidham T, Goldstrohm DA, Oberley-Deegan RE, Weaver MR, Valnickova-Hansen Z, Scavenius C, Benninger RK, Leahy KF, Johnson R, Gally F, Kosmider B, Zimmermann AK, Enghild JJ, Nozik-Grayck E, Bowler RP. A common polymorphism in extracellular superoxide dismutase affects cardiopulmonary disease risk by altering protein distribution. Circ Cardiovasc Genet. 2014 Oct; 7(5):659-66. PMID: 25085920; PMCID: PMC4270938.
    16. Benninger RK, Piston DW. Cellular communication and heterogeneity in pancreatic islet insulin secretion dynamics. Trends Endocrinol Metab. 2014 Aug; 25(8):399-406. PMID: 24679927; PMCID: PMC4112137.
    17. Farnsworth NL, Benninger RK. New insights into the role of connexins in pancreatic islet function and diabetes. FEBS Lett. 2014 Apr 17; 588(8):1278-87. PMID: 24583073; PMCID: PMC4004767.
    18. Hang Y, Yamamoto T, Benninger RK, Brissova M, Guo M, Bush W, Piston DW, Powers AC, Magnuson M, Thurmond DC, Stein R. The MafA transcription factor becomes essential to islet ß-cells soon after birth. Diabetes. 2014 Jun; 63(6):1994-2005. PMID: 24520122; PMCID: PMC4030115.
    19. Nguyen LM, Pozzoli M, Hraha TH, Benninger RK. Decreasing cx36 gap junction coupling compensates for overactive KATP channels to restore insulin secretion and prevent hyperglycemia in a mouse model of neonatal diabetes. Diabetes. 2014 May; 63(5):1685-97. PMID: 24458355; PMCID: PMC3994954.
    20. Hraha TH, Bernard AB, Nguyen LM, Anseth KS, Benninger RK. Dimensionality and size scaling of coordinated Ca(2+) dynamics in MIN6 ß-cell clusters. Biophys J. 2014 Jan 07; 106(1):299-309. PMID: 24411262; PMCID: PMC3907241.
    21. Benninger RK, Piston DW. Two-photon excitation microscopy for the study of living cells and tissues. Curr Protoc Cell Biol. 2013 Jun; Chapter 4:Unit 4.11.1-24. PMID: 23728746; PMCID: PMC4004770.
    22. Head WS, Orseth ML, Nunemaker CS, Satin LS, Piston DW, Benninger RK. Connexin-36 gap junctions regulate in vivo first- and second-phase insulin secretion dynamics and glucose tolerance in the conscious mouse. Diabetes. 2012 Jul; 61(7):1700-7. PMID: 22511206; PMCID: PMC3379660.
    23. Benninger RK, Head WS, Zhang M, Satin LS, Piston DW. Gap junctions and other mechanisms of cell-cell communication regulate basal insulin secretion in the pancreatic islet. J Physiol. 2011 Nov 15; 589(Pt 22):5453-66. PMID: 21930600; PMCID: PMC3240884.
    24. Benninger RK, Remedi MS, Head WS, Ustione A, Piston DW, Nichols CG. Defects in beta cell Ca²+ signalling, glucose metabolism and insulin secretion in a murine model of K(ATP) channel-induced neonatal diabetes mellitus. Diabetologia. 2011 May; 54(5):1087-97. PMID: 21271337; PMCID: PMC3245714.
    25. Zhao A, Ohara-Imaizumi M, Brissova M, Benninger RK, Xu Y, Hao Y, Abramowitz J, Boulay G, Powers AC, Piston D, Jiang M, Nagamatsu S, Birnbaumer L, Gu G. Gao represses insulin secretion by reducing vesicular docking in pancreatic beta-cells. Diabetes. 2010 Oct; 59(10):2522-9. PMID: 20622165; PMCID: PMC3279551.
    26. Meyer-Hermann M, Benninger RK. A mathematical model of ß-cells in an islet of Langerhans sensing a glucose gradient. HFSP J. 2010 Apr; 4(2):61-71. PMID: 20885774; PMCID: PMC2931298.
    27. Pound LD, Sarkar SA, Benninger RK, Wang Y, Suwanichkul A, Shadoan MK, Printz RL, Oeser JK, Lee CE, Piston DW, McGuinness OP, Hutton JC, Powell DR, O'Brien RM. Deletion of the mouse Slc30a8 gene encoding zinc transporter-8 results in impaired insulin secretion. Biochem J. 2009 Jul 15; 421(3):371-6. PMID: 19450229; PMCID: PMC2929527.
    28. Easley CJ, Benninger RK, Shaver JH, Steven Head W, Piston DW. Rapid and inexpensive fabrication of polymeric microfluidic devices via toner transfer masking. Lab Chip. 2009 Apr 21; 9(8):1119-27. PMID: 19350094; PMCID: PMC2752280.
    29. Benninger RK, Vanherberghen B, Young S, Taner SB, Culley FJ, Schnyder T, Neil MA, Wüstner D, French PM, Davis DM, Onfelt B. Live cell linear dichroism imaging reveals extensive membrane ruffling within the docking structure of natural killer cell immune synapses. Biophys J. 2009 Jan; 96(2):L13-5. PMID: 19167281; PMCID: PMC2716478.
    30. Benninger RK, Ashby WJ, Ring EA, Piston DW. Single-photon-counting detector for increased sensitivity in two-photon laser scanning microscopy. Opt Lett. 2008 Dec 15; 33(24):2895-7. PMID: 19079484; PMCID: PMC2749309.
    31. Gunawardana SC, Benninger RK, Piston DW. Subcutaneous transplantation of embryonic pancreas for correction of type 1 diabetes. Am J Physiol Endocrinol Metab. 2009 Feb; 296(2):E323-32. PMID: 19066321; PMCID: PMC2645017.
    32. Benninger RK, Zhang M, Head WS, Satin LS, Piston DW. Gap junction coupling and calcium waves in the pancreatic islet. Biophys J. 2008 Dec; 95(11):5048-61. PMID: 18805925; PMCID: PMC2586567.
    33. Mao S, Benninger RK, Yan Y, Petchprayoon C, Jackson D, Easley CJ, Piston DW, Marriott G. Optical lock-in detection of FRET using synthetic and genetically encoded optical switches. Biophys J. 2008 Jun; 94(11):4515-24. PMID: 18281383; PMCID: PMC2480664.
    34. Benninger RK, Hao M, Piston DW. Multi-photon excitation imaging of dynamic processes in living cells and tissues. Rev Physiol Biochem Pharmacol. 2008; 160:71-92. PMID: 18418560.
      View in: PubMed
    35. Kumar S, Dunsby C, De Beule PA, Owen DM, Anand U, Lanigan PM, Benninger RK, Davis DM, Neil MA, Anand P, Benham C, Naylor A, French PM. Multifocal multiphoton excitation and time correlated single photon counting detection for 3-D fluorescence lifetime imaging. Opt Express. 2007 Oct 01; 15(20):12548-61. PMID: 19550524.
      View in: PubMed
    36. De Beule P, Owen DM, Manning HB, Talbot CB, Requejo-Isidro J, Dunsby C, McGinty J, Benninger RK, Elson DS, Munro I, John Lever M, Anand P, Neil MA, French PM. Rapid hyperspectral fluorescence lifetime imaging. Microsc Res Tech. 2007 May; 70(5):481-4. PMID: 17366615.
      View in: PubMed
    37. Benninger RK, Hofmann O, Onfelt B, Munro I, Dunsby C, Davis DM, Neil MA, French PM, de Mello AJ. Fluorescence-lifetime imaging of DNA-dye interactions within continuous-flow microfluidic systems. Angew Chem Int Ed Engl. 2007; 46(13):2228-31. PMID: 17436333.
      View in: PubMed
    38. Onfelt B, Nedvetzki S, Benninger RK, Purbhoo MA, Sowinski S, Hume AN, Seabra MC, Neil MA, French PM, Davis DM. Structurally distinct membrane nanotubes between human macrophages support long-distance vesicular traffic or surfing of bacteria. J Immunol. 2006 Dec 15; 177(12):8476-83. PMID: 17142745.
      View in: PubMed
    39. Benninger RK, Koç Y, Hofmann O, Requejo-Isidro J, Neil MA, French PM, DeMello AJ. Quantitative 3D mapping of fluidic temperatures within microchannel networks using fluorescence lifetime imaging. Anal Chem. 2006 Apr 01; 78(7):2272-8. PMID: 16579608.
      View in: PubMed
    40. Benninger R, Hofmann O, McGinty J, Requejo-Isidro J, Munro I, Neil M, Demello A, French P. Time-resolved fluorescence imaging of solvent interactions in microfluidic devices. Opt Express. 2005 Aug 08; 13(16):6275-85. PMID: 19498640.
      View in: PubMed
    41. Benninger RK, Onfelt B, Neil MA, Davis DM, French PM. Fluorescence imaging of two-photon linear dichroism: cholesterol depletion disrupts molecular orientation in cell membranes. Biophys J. 2005 Jan; 88(1):609-22. PMID: 15520272; PMCID: PMC1305038.
    42. Elson D, Requejo-Isidro J, Munro I, Reavell F, Siegel J, Suhling K, Tadrous P, Benninger R, Lanigan P, McGinty J, Talbot C, Treanor B, Webb S, Sandison A, Wallace A, Davis D, Lever J, Neil M, Phillips D, Stamp G, French P. Time-domain fluorescence lifetime imaging applied to biological tissue. Photochem Photobiol Sci. 2004 Aug; 3(8):795-801. PMID: 15295637.
      View in: PubMed
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