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Richard K.P. Benninger

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentCEDC-Bioengineering
Phone303/724-6388
    Other Positions
    TitleDirector-Faculty
    InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
    DepartmentCEDC-Bioengineering


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Briggs JK, Schonblum A, Landsman L, Benninger RKP. Going With the Flow: Pericyte-Regulated Islet Blood Flow Influences Glucose Homeostasis. Diabetes. 2022 Aug 01; 71(8):1611-1613. PMID: 35881835.
      View in: PubMed
    2. Farnsworth NL, Piscopio RA, Schleicher WE, Ramirez DG, Miranda JG, Benninger RKP. Modulation of Gap Junction Coupling Within the Islet of Langerhans During the Development of Type 1 Diabetes. Front Physiol. 2022; 13:913611. PMID: 35837011.
      View in: PubMed
    3. Pham VT, Ciccaglione M, Ramirez DG, Benninger RKP. Ultrasound Imaging of Pancreatic Perfusion Dynamics Predicts Therapeutic Prevention of Diabetes in Preclinical Models of Type 1 Diabetes. Ultrasound Med Biol. 2022 Jul; 48(7):1336-1347. PMID: 35473669.
      View in: PubMed
    4. Cefalu WT, Andersen DK, Arreaza-Rubín G, Pin CL, Sato S, Verchere CB, Woo M, Rosenblum ND, Rosenblum N, Cefalu W, Andersen DK, Arreaza-Rubín G, Dhara C, James SP, Makarchuk MJ, Pin CL, Sato S, Verchere B, Woo M, Powers A, Estall J, Hoesli C, Millman J, Linnemann A, Johnson J, Pin CL, Hawkins M, Woo M, Gloyn A, Cefalu W, Rosenblum N, Huising MO, Benninger RKP, Almaça J, Hull-Meichle RL, MacDonald P, Lynn F, Melero-Martin J, Yoshihara E, Stabler C, Sander M, Evans-Molina C, Engin F, Thompson P, Shalev A, Redondo MJ, Nadeau K, Bellin M, Udler MS, Dennis J, Dash S, Zhou W, Snyder M, Booth G, Butte A, Florez J. Heterogeneity of Diabetes: ß-Cells, Phenotypes, and Precision Medicine: Proceedings of an International Symposium of the Canadian Institutes of Health Research's Institute of Nutrition, Metabolism and Diabetes and the U.S. National Institutes of Health's National Institute of Diabetes and Digestive and Kidney Diseases. Diabetes. 2021 Nov 13. PMID: 34957490.
      View in: PubMed
    5. Benninger RKP, Kravets V. The physiological role of ß-cell heterogeneity in pancreatic islet function. Nat Rev Endocrinol. 2022 01; 18(1):9-22. PMID: 34667280.
      View in: PubMed
    6. Ramirez DG, Ciccaglione M, Upadhyay AK, Pham VT, Borden MA, Benninger RKP. Detecting insulitis in type 1 diabetes with ultrasound phase-change contrast agents. Proc Natl Acad Sci U S A. 2021 10 12; 118(41). PMID: 34607942.
      View in: PubMed
    7. Shi L, Wei M, Miao Y, Qian N, Shi L, Singer RA, Benninger RKP, Min W. Highly-multiplexed volumetric mapping with Raman dye imaging and tissue clearing. Nat Biotechnol. 2022 03; 40(3):364-373. PMID: 34608326.
      View in: PubMed
    8. Docherty FM, Riemondy KA, Castro-Gutierrez R, Dwulet JM, Shilleh AH, Hansen MS, Williams SPM, Armitage LH, Santostefano KE, Wallet MA, Mathews CE, Triolo TM, Benninger RKP, Russ HA. ENTPD3 Marks Mature Stem Cell-Derived ß-Cells Formed by Self-Aggregation In Vitro. Diabetes. 2021 11; 70(11):2554-2567. PMID: 34380694.
      View in: PubMed
    9. Adams MT, Dwulet JM, Briggs JK, Reissaus CA, Jin E, Szulczewski JM, Lyman MR, Sdao SM, Kravets V, Nimkulrat SD, Ponik SM, Merrins MJ, Mirmira RG, Linnemann AK, Benninger RK, Blum B. Reduced synchroneity of intra-islet Ca2+ oscillations in vivo in Robo-deficient ß cells. Elife. 2021 07 07; 10. PMID: 34231467.
      View in: PubMed
    10. Thomas AN, Song KH, Upadhyay A, Papadopoulou V, Ramirez D, Benninger RKP, Lowerison M, Song P, Murray TW, Borden MA. Contrast-Enhanced Sonography with Biomimetic Lung Surfactant Nanodrops. Langmuir. 2021 02 23; 37(7):2386-2396. PMID: 33566623.
      View in: PubMed
    11. Corezola do Amaral ME, Kravets V, Dwulet JM, Farnsworth NL, Piscopio R, Schleicher WE, Miranda JG, Benninger RKP. Caloric restriction recovers impaired ß-cell-ß-cell gap junction coupling, calcium oscillation coordination, and insulin secretion in prediabetic mice. Am J Physiol Endocrinol Metab. 2020 10 01; 319(4):E709-E720. PMID: 32830549.
      View in: PubMed
    12. Ramirez DG, Abenojar E, Hernandez C, Lorberbaum DS, Papazian LA, Passman S, Pham V, Exner AA, Benninger RKP. Contrast-enhanced ultrasound with sub-micron sized contrast agents detects insulitis in mouse models of type1 diabetes. Nat Commun. 2020 05 07; 11(1):2238. PMID: 32382089.
      View in: PubMed
    13. Reusser TD, Song KH, Ramirez D, Benninger RK, Papadopoulou V, Borden MA. Phospholipid Oxygen Microbubbles for Image-Guided Therapy. Nanotheranostics. 2020; 4(2):83-90. PMID: 32190535.
      View in: PubMed
    14. Dwulet JM, Ludin NWF, Piscopio RA, Schleicher WE, Moua O, Westacott MJ, Benninger RKP. How Heterogeneity in Glucokinase and Gap-Junction Coupling Determines the Islet [Ca2+] Response. Biophys J. 2019 12 03; 117(11):2188-2203. PMID: 31753287.
      View in: PubMed
    15. St Clair JR, Ramirez D, Passman S, Benninger RKP. Contrast-enhanced ultrasound measurement of pancreatic blood flow dynamics predicts type 1 diabetes progression in preclinical models. Nat Commun. 2018 05 01; 9(1):1742. PMID: 29717116.
      View in: PubMed
    16. Benninger RKP, Hodson DJ. New Understanding of ß-Cell Heterogeneity and In Situ Islet Function. Diabetes. 2018 04; 67(4):537-547. PMID: 29559510.
      View in: PubMed
    17. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 30251179.
      View in: PubMed
    18. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 30412665.
      View in: PubMed
    19. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 31273433.
      View in: PubMed
    20. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 33939712.
      View in: PubMed
    21. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 32375060.
      View in: PubMed
    22. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 33574598.
      View in: PubMed
    23. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 34979329.
      View in: PubMed
    24. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 19350094.
      View in: PubMed
    25. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 19167281.
      View in: PubMed
    26. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 19498640.
      View in: PubMed
    27. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 18281383.
      View in: PubMed
    28. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 23728746.
      View in: PubMed
    29. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 15520272.
      View in: PubMed
    30. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 20622165.
      View in: PubMed
    31. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 20885774.
      View in: PubMed
    32. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 25172942.
      View in: PubMed
    33. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 25188228.
      View in: PubMed
    34. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 26668311.
      View in: PubMed
    35. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 27681078.
      View in: PubMed
    36. Westacott MJ, Ludin NWF, Benninger RKP. Spatially Organized ß-Cell Subpopulations Control Electrical Dynamics across Islets of Langerhans. Biophys J. 2017 Sep 05; 113(5):1093-1108. PMID: 28877492.
      View in: PubMed
    37. Westacott MJ, Farnsworth NL, St Clair JR, Poffenberger G, Heintz A, Ludin NW, Hart NJ, Powers AC, Benninger RKP. Age-Dependent Decline in the Coordinated [Ca2+] and Insulin Secretory Dynamics in Human Pancreatic Islets. Diabetes. 2017 09; 66(9):2436-2445. PMID: 28588099.
      View in: PubMed
    38. Nunemaker CS, Benninger RK. Zinc Transport Gets Its Zing Back: Double-Knockout of ZnT7 and ZnT8 Reveals the Importance of Zinc Transporters to Insulin Secretion. Endocrinology. 2016 12; 157(12):4542-4544. PMID: 27911147.
      View in: PubMed
    39. Benninger RK. Fluorescence linear dichroism imaging for quantifying membrane order. Methods Mol Biol. 2015; 1232:161-79. PMID: 25331136.
      View in: PubMed
    40. Benninger RK, Hutchens T, Head WS, McCaughey MJ, Zhang M, Le Marchand SJ, Satin LS, Piston DW. Intrinsic islet heterogeneity and gap junction coupling determine spatiotemporal Ca²? wave dynamics. Biophys J. 2014 Dec 02; 107(11):2723-33. PMID: 25468351.
      View in: PubMed
    41. Nozik-Grayck E, Woods C, Taylor JM, Benninger RK, Johnson RD, Villegas LR, Stenmark KR, Harrison DG, Majka SM, Irwin D, Farrow KN. Selective depletion of vascular EC-SOD augments chronic hypoxic pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2014 Dec 01; 307(11):L868-76. PMID: 25326578.
      View in: PubMed
    42. Hartney JM, Stidham T, Goldstrohm DA, Oberley-Deegan RE, Weaver MR, Valnickova-Hansen Z, Scavenius C, Benninger RK, Leahy KF, Johnson R, Gally F, Kosmider B, Zimmermann AK, Enghild JJ, Nozik-Grayck E, Bowler RP. A common polymorphism in extracellular superoxide dismutase affects cardiopulmonary disease risk by altering protein distribution. Circ Cardiovasc Genet. 2014 Oct; 7(5):659-66. PMID: 25085920.
      View in: PubMed
    43. Benninger RK, Piston DW. Cellular communication and heterogeneity in pancreatic islet insulin secretion dynamics. Trends Endocrinol Metab. 2014 Aug; 25(8):399-406. PMID: 24679927.
      View in: PubMed
    44. Farnsworth NL, Benninger RK. New insights into the role of connexins in pancreatic islet function and diabetes. FEBS Lett. 2014 Apr 17; 588(8):1278-87. PMID: 24583073.
      View in: PubMed
    45. Hang Y, Yamamoto T, Benninger RK, Brissova M, Guo M, Bush W, Piston DW, Powers AC, Magnuson M, Thurmond DC, Stein R. The MafA transcription factor becomes essential to islet ß-cells soon after birth. Diabetes. 2014 Jun; 63(6):1994-2005. PMID: 24520122.
      View in: PubMed
    46. Nguyen LM, Pozzoli M, Hraha TH, Benninger RK. Decreasing cx36 gap junction coupling compensates for overactive KATP channels to restore insulin secretion and prevent hyperglycemia in a mouse model of neonatal diabetes. Diabetes. 2014 May; 63(5):1685-97. PMID: 24458355.
      View in: PubMed
    47. Hraha TH, Bernard AB, Nguyen LM, Anseth KS, Benninger RK. Dimensionality and size scaling of coordinated Ca(2+) dynamics in MIN6 ß-cell clusters. Biophys J. 2014 Jan 07; 106(1):299-309. PMID: 24411262.
      View in: PubMed
    48. Head WS, Orseth ML, Nunemaker CS, Satin LS, Piston DW, Benninger RK. Connexin-36 gap junctions regulate in vivo first- and second-phase insulin secretion dynamics and glucose tolerance in the conscious mouse. Diabetes. 2012 Jul; 61(7):1700-7. PMID: 22511206.
      View in: PubMed
    49. Benninger RK, Head WS, Zhang M, Satin LS, Piston DW. Gap junctions and other mechanisms of cell-cell communication regulate basal insulin secretion in the pancreatic islet. J Physiol. 2011 Nov 15; 589(Pt 22):5453-66. PMID: 21930600.
      View in: PubMed
    50. Benninger RK, Remedi MS, Head WS, Ustione A, Piston DW, Nichols CG. Defects in beta cell Ca²+ signalling, glucose metabolism and insulin secretion in a murine model of K(ATP) channel-induced neonatal diabetes mellitus. Diabetologia. 2011 May; 54(5):1087-97. PMID: 21271337.
      View in: PubMed
    51. Pound LD, Sarkar SA, Benninger RK, Wang Y, Suwanichkul A, Shadoan MK, Printz RL, Oeser JK, Lee CE, Piston DW, McGuinness OP, Hutton JC, Powell DR, O'Brien RM. Deletion of the mouse Slc30a8 gene encoding zinc transporter-8 results in impaired insulin secretion. Biochem J. 2009 Jul 15; 421(3):371-6. PMID: 19450229.
      View in: PubMed
    52. Benninger RK, Ashby WJ, Ring EA, Piston DW. Single-photon-counting detector for increased sensitivity in two-photon laser scanning microscopy. Opt Lett. 2008 Dec 15; 33(24):2895-7. PMID: 19079484.
      View in: PubMed
    53. Gunawardana SC, Benninger RK, Piston DW. Subcutaneous transplantation of embryonic pancreas for correction of type 1 diabetes. Am J Physiol Endocrinol Metab. 2009 Feb; 296(2):E323-32. PMID: 19066321.
      View in: PubMed
    54. Benninger RK, Zhang M, Head WS, Satin LS, Piston DW. Gap junction coupling and calcium waves in the pancreatic islet. Biophys J. 2008 Dec; 95(11):5048-61. PMID: 18805925.
      View in: PubMed
    55. Benninger RK, Hao M, Piston DW. Multi-photon excitation imaging of dynamic processes in living cells and tissues. Rev Physiol Biochem Pharmacol. 2008; 160:71-92. PMID: 18418560.
      View in: PubMed
    56. Kumar S, Dunsby C, De Beule PA, Owen DM, Anand U, Lanigan PM, Benninger RK, Davis DM, Neil MA, Anand P, Benham C, Naylor A, French PM. Multifocal multiphoton excitation and time correlated single photon counting detection for 3-D fluorescence lifetime imaging. Opt Express. 2007 Oct 01; 15(20):12548-61. PMID: 19550524.
      View in: PubMed
    57. De Beule P, Owen DM, Manning HB, Talbot CB, Requejo-Isidro J, Dunsby C, McGinty J, Benninger RK, Elson DS, Munro I, John Lever M, Anand P, Neil MA, French PM. Rapid hyperspectral fluorescence lifetime imaging. Microsc Res Tech. 2007 May; 70(5):481-4. PMID: 17366615.
      View in: PubMed
    58. Benninger RK, Hofmann O, Onfelt B, Munro I, Dunsby C, Davis DM, Neil MA, French PM, de Mello AJ. Fluorescence-lifetime imaging of DNA-dye interactions within continuous-flow microfluidic systems. Angew Chem Int Ed Engl. 2007; 46(13):2228-31. PMID: 17436333.
      View in: PubMed
    59. Onfelt B, Nedvetzki S, Benninger RK, Purbhoo MA, Sowinski S, Hume AN, Seabra MC, Neil MA, French PM, Davis DM. Structurally distinct membrane nanotubes between human macrophages support long-distance vesicular traffic or surfing of bacteria. J Immunol. 2006 Dec 15; 177(12):8476-83. PMID: 17142745.
      View in: PubMed
    60. Benninger RK, Koç Y, Hofmann O, Requejo-Isidro J, Neil MA, French PM, DeMello AJ. Quantitative 3D mapping of fluidic temperatures within microchannel networks using fluorescence lifetime imaging. Anal Chem. 2006 Apr 01; 78(7):2272-8. PMID: 16579608.
      View in: PubMed
    61. Elson D, Requejo-Isidro J, Munro I, Reavell F, Siegel J, Suhling K, Tadrous P, Benninger R, Lanigan P, McGinty J, Talbot C, Treanor B, Webb S, Sandison A, Wallace A, Davis D, Lever J, Neil M, Phillips D, Stamp G, French P. Time-domain fluorescence lifetime imaging applied to biological tissue. Photochem Photobiol Sci. 2004 Aug; 3(8):795-801. PMID: 15295637.
      View in: PubMed
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