-
Zaug AJ, Goodrich KJ, Song JJ, Sullivan AE, Cech TR. Reconstitution of a telomeric replicon organized by CST. Nature. 2022 Jul 13. PMID: 35831508.
-
Kraft K, Yost KE, Murphy SE, Magg A, Long Y, Corces MR, Granja JM, Wittler L, Mundlos S, Cech TR, Boettiger AN, Chang HY. Polycomb-mediated genome architecture enables long-range spreading of H3K27 methylation. Proc Natl Acad Sci U S A. 2022 05 31; 119(22):e2201883119. PMID: 35617427.
-
Cech TR. RNA in biological condensates. RNA. 2022 01; 28(1):1-2. PMID: 34903621.
-
Zaug AJ, Lim CJ, Olson CL, Carilli MT, Goodrich KJ, Wuttke DS, Cech TR. CST does not evict elongating telomerase but prevents initiation by ssDNA binding. Nucleic Acids Res. 2021 11 18; 49(20):11653-11665. PMID: 34718732.
-
Dumbovic G, Braunschweig U, Langner HK, Smallegan M, Biayna J, Hass EP, Jastrzebska K, Blencowe B, Cech TR, Caruthers MH, Rinn JL. Publisher Correction: Nuclear compartmentalization of TERT mRNA and TUG1 lncRNA is driven by intron retention. Nat Commun. 2021 Oct 21; 12(1):6189. PMID: 34675241.
-
Agarwal N, Rinaldetti S, Cheikh BB, Zhou Q, Hass EP, Jones RT, Joshi M, LaBarbera DV, Knott SRV, Cech TR, Theodorescu D. TRIM28 is a transcriptional activator of the mutant TERT promoter in human bladder cancer. Proc Natl Acad Sci U S A. 2021 09 21; 118(38). PMID: 34518220.
-
Dumbovic G, Braunschweig U, Langner HK, Smallegan M, Biayna J, Hass EP, Jastrzebska K, Blencowe B, Cech TR, Caruthers MH, Rinn JL. Nuclear compartmentalization of TERT mRNA and TUG1 lncRNA is driven by intron retention. Nat Commun. 2021 06 03; 12(1):3308. PMID: 34083519.
-
Lim CJ, Cech TR. Publisher Correction: Shaping human telomeres: from shelterin and CST complexes to telomeric chromatin organization. Nat Rev Mol Cell Biol. 2021 Apr; 22(4):299. PMID: 33608692.
-
Lim CJ, Cech TR. Shaping human telomeres: from shelterin and CST complexes to telomeric chromatin organization. Nat Rev Mol Cell Biol. 2021 04; 22(4):283-298. PMID: 33564154.
-
Long Y, Cech TR. Targeted mutagenesis in human iPSCs using CRISPR genome-editing tools. Methods. 2021 07; 191:44-58. PMID: 33444739.
-
Youmans DT, Gooding AR, Dowell RD, Cech TR. Competition between PRC2.1 and 2.2 subcomplexes regulates PRC2 chromatin occupancy in human stem cells. Mol Cell. 2021 02 04; 81(3):488-501.e9. PMID: 33338397.
-
Cornejo C, Hauser A, Beenken L, Cech T, Rigling D. Cryphonectria carpinicola sp. nov. Associated with hornbeam decline in Europe. Fungal Biol. 2021 05; 125(5):347-356. PMID: 33910676.
-
Rowland TJ, Bonham AJ, Cech TR. Allele-specific proximal promoter hypomethylation of the telomerase reverse transcriptase gene (TERT) associates with TERT expression in multiple cancers. Mol Oncol. 2020 10; 14(10):2358-2374. PMID: 33245585.
-
Long Y, Hwang T, Gooding AR, Goodrich KJ, Rinn JL, Cech TR. RNA is essential for PRC2 chromatin occupancy and function in human pluripotent stem cells. Nat Genet. 2020 09; 52(9):931-938. PMID: 32632336.
-
Stern JL, Paucek RD, Huang FW, Ghandi M, Nwumeh R, Costello JC, Cech TR. Allele-Specific DNA Methylation and Its Interplay with Repressive Histone Marks at Promoter-Mutant TERT Genes. Cell Rep. 2020 May 26; 31(8):107718. PMID: 32460014.
-
Stern JL, Hibshman G, Hu K, Ferrara SE, Costello JC, Kim W, Tamayo P, Cech TR, Huang FW. Mesenchymal and MAPK Expression Signatures Associate with Telomerase Promoter Mutations in Multiple Cancers. Mol Cancer Res. 2020 07; 18(7):1050-1062. PMID: 32276990.
-
Heenan PR, Wang X, Gooding AR, Cech TR, Perkins TT. Bending and looping of long DNA by Polycomb repressive complex 2 revealed by AFM imaging in liquid. Nucleic Acids Res. 2020 04 06; 48(6):2969-2981. PMID: 32043141.
-
Wang X, Long Y, Paucek RD, Gooding AR, Lee T, Burdorf RM, Cech TR. Regulation of histone methylation by automethylation of PRC2. Genes Dev. 2019 10 01; 33(19-20):1416-1427. PMID: 31488576.
-
Cech TR. A Lifelong Passion for All Things Ribonucleic. Cell. 2018 09 20; 175(1):14-17. PMID: 30217358.
-
Shoffner GM, Wang R, Podell E, Cech TR, Guo F. In Crystallo Selection to Establish New RNA Crystal Contacts. Structure. 2018 09 04; 26(9):1275-1283.e3. PMID: 29910185.
-
Youmans DT, Schmidt JC, Cech TR. Live-cell imaging reveals the dynamics of PRC2 and recruitment to chromatin by SUZ12-associated subunits. Genes Dev. 2018 06 01; 32(11-12):794-805. PMID: 29891558.
-
Schmidt JC, Zaug AJ, Kufer R, Cech TR. Dynamics of human telomerase recruitment depend on template-telomere base pairing. Mol Biol Cell. 2018 Apr 01; 29(7):869-880. PMID: 29386295.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 29281820.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 29185984.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 29992245.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 31048495.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 31451652.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 27523609.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 24679528.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 24990373.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 24992961.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 25009283.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 25623306.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 26063571.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 26515115.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 26574518.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 1998665.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 2036355.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 8218232.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 2427016.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 1945829.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 7688572.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 2110477.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 8359471.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 12529422.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 2388834.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 9818147.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 6776522.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 18428857.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 12741831.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 32499435.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 19850851.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 3019555.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 12899613.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 3357543.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 12440996.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 9698362.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 8756414.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 15205494.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 9610414.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 3072259.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 9405070.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 8248806.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 2829120.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 16462747.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 19043074.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 7534420.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 2579378.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 2500641.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 1997201.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 8855245.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 10393544.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 2684642.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 277339.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 9548747.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 2590943.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 6562377.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 7489486.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 21177376.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 8378306.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 8846298.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 6323028.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 16043710.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 444530.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 2415924.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 2470150.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 23249733.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 3454258.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 6186917.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 3123321.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 14744437.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 2417724.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 7493313.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 7545072.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 291921.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 11029034.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 18641663.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 3329163.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 2415923.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 11474070.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 17381300.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 12414733.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 7588614.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 6306649.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 8136374.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 2271646.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 15226497.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 7365791.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 2660002.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 9634773.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 12746507.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 5117.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 1959129.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 7926724.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 11015228.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 9524749.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 11080168.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 11772012.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 1157097.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 9409624.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 8374954.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 7524665.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 1066674.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 16894218.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 4208786.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 19443750.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 11232584.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 16174699.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 8619996.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 16357228.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 12781132.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 18768647.
-
Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 22588715.
-
Wang X, Paucek RD, Gooding AR, Brown ZZ, Ge EJ, Muir TW, Cech TR. Molecular analysis of PRC2 recruitment to DNA in chromatin and its inhibition by RNA. Nat Struct Mol Biol. 2017 Dec; 24(12):1028-1038. PMID: 29058709.
-
Lim CJ, Zaug AJ, Kim HJ, Cech TR. Reconstitution of human shelterin complexes reveals unexpected stoichiometry and dual pathways to enhance telomerase processivity. Nat Commun. 2017 10 20; 8(1):1075. PMID: 29057866.
-
Jung T, Jung MH, Cacciola SO, Cech T, Bakonyi J, Seress D, Mosca S, Schena L, Seddaiu S, Pane A, di San Lio GM, Maia C, Cravador A, Franceschini A, Scanu B. Multiple new cryptic pathogenic Phytophthora species from Fagaceae forests in Austria, Italy and Portugal. IMA Fungus. 2017 Dec; 8(2):219-244. PMID: 29242773.
-
Long Y, Wang X, Youmans DT, Cech TR. How do lncRNAs regulate transcription? Sci Adv. 2017 09; 3(9):eaao2110. PMID: 28959731.
-
Wang X, Goodrich KJ, Gooding AR, Naeem H, Archer S, Paucek RD, Youmans DT, Cech TR, Davidovich C. Targeting of Polycomb Repressive Complex 2 to RNA by Short Repeats of Consecutive Guanines. Mol Cell. 2017 Mar 16; 65(6):1056-1067.e5. PMID: 28306504.
-
Goldfarb KC, Cech TR. Targeted CRISPR disruption reveals a role for RNase MRP RNA in human preribosomal RNA processing. Genes Dev. 2017 01 01; 31(1):59-71. PMID: 28115465.
-
Dickinson DL, Cazier J, Cech T. A practical validation study of a commercial accelerometer using good and poor sleepers. Health Psychol Open. 2016 Jul; 3(2):2055102916679012. PMID: 28815052.
-
Lu Z, Zhang QC, Lee B, Flynn RA, Smith MA, Robinson JT, Davidovich C, Gooding AR, Goodrich KJ, Mattick JS, Mesirov JP, Cech TR, Chang HY. RNA Duplex Map in Living Cells Reveals Higher-Order Transcriptome Structure. Cell. 2016 May 19; 165(5):1267-1279. PMID: 27180905.
-
Shukla S, Schmidt JC, Goldfarb KC, Cech TR, Parker R. Inhibition of telomerase RNA decay rescues telomerase deficiency caused by dyskerin or PARN defects. Nat Struct Mol Biol. 2016 Apr; 23(4):286-92. PMID: 26950371.
-
Xi L, Schmidt JC, Zaug AJ, Ascarrunz DR, Cech TR. A novel two-step genome editing strategy with CRISPR-Cas9 provides new insights into telomerase action and TERT gene expression. Genome Biol. 2015 Nov 10; 16:231. PMID: 26553065.
-
Xi L, Cech TR. Protein-RNA interaction restricts telomerase from running through the stop sign. Nat Struct Mol Biol. 2015 Nov; 22(11):835-6. PMID: 26581514.
-
Wang X, Schwartz JC, Cech TR. Nucleic acid-binding specificity of human FUS protein. Nucleic Acids Res. 2015 Sep 03; 43(15):7535-43. PMID: 26150427.
-
Cech TR. RNA World research-still evolving. RNA. 2015 Apr; 21(4):474-5. PMID: 25780099.
-
Borah S, Xi L, Zaug AJ, Powell NM, Dancik GM, Cohen SB, Costello JC, Theodorescu D, Cech TR. Cancer. TERT promoter mutations and telomerase reactivation in urothelial cancer. Science. 2015 Feb 27; 347(6225):1006-10. PMID: 25722414.
-
Davidovich C, Wang X, Cifuentes-Rojas C, Goodrich KJ, Gooding AR, Lee JT, Cech TR. Toward a consensus on the binding specificity and promiscuity of PRC2 for RNA. Mol Cell. 2015 Feb 05; 57(3):552-8. PMID: 25601759.
-
Schwartz JC, Cech TR, Parker RR. Biochemical Properties and Biological Functions of FET Proteins. Annu Rev Biochem. 2015; 84:355-79. PMID: 25494299.
-
Tang M, Li Y, Zhang Y, Chen Y, Huang W, Wang D, Zaug AJ, Liu D, Zhao Y, Cech TR, Ma W, Songyang Z. Disease mutant analysis identifies a new function of DAXX in telomerase regulation and telomere maintenance. J Cell Sci. 2015 Jan 15; 128(2):331-41. PMID: 25416818.
-
Watson-Capps JJ, Cech TR. Academia and industry: Companies on campus. Nature. 2014 Oct 16; 514(7522):297-8. PMID: 25318508.
-
Schmidt JC, Dalby AB, Cech TR. Identification of human TERT elements necessary for telomerase recruitment to telomeres. Elife. 2014 Oct 01; 3. PMID: 25271372.
-
McKay DB, Xi L, Barthel KKB, Cech TR. Structure and function of steroid receptor RNA activator protein, the proposed partner of SRA noncoding RNA. J Mol Biol. 2014 Apr 17; 426(8):1766-1785. PMID: 24486609.
-
Schwartz JC, Wang X, Podell ER, Cech TR. RNA seeds higher-order assembly of FUS protein. Cell Rep. 2013 Nov 27; 5(4):918-25. PMID: 24268778.
-
Theodorescu D, Cech TR. Telomerase in bladder cancer: back to a better future? Eur Urol. 2014 Feb; 65(2):370-1. PMID: 24184027.
-
Nakashima M, Nandakumar J, Sullivan KD, Espinosa JM, Cech TR. Inhibition of telomerase recruitment and cancer cell death. J Biol Chem. 2013 Nov 15; 288(46):33171-80. PMID: 24097987.
-
Davidovich C, Zheng L, Goodrich KJ, Cech TR. Promiscuous RNA binding by Polycomb repressive complex 2. Nat Struct Mol Biol. 2013 Nov; 20(11):1250-7. PMID: 24077223.
-
Goldfarb KC, Cech TR. 3' terminal diversity of MRP RNA and other human noncoding RNAs revealed by deep sequencing. BMC Mol Biol. 2013 Sep 21; 14:23. PMID: 24053768.
-
Zaug AJ, Crary SM, Jesse Fioravanti M, Campbell K, Cech TR. Many disease-associated variants of hTERT retain high telomerase enzymatic activity. Nucleic Acids Res. 2013 Oct; 41(19):8969-78. PMID: 23901009.
-
Dalby AB, Goodrich KJ, Pfingsten JS, Cech TR. RNA recognition by the DNA end-binding Ku heterodimer. RNA. 2013 Jun; 19(6):841-51. PMID: 23610127.
-
Nandakumar J, Cech TR. Finding the end: recruitment of telomerase to telomeres. Nat Rev Mol Cell Biol. 2013 Feb; 14(2):69-82. PMID: 23299958.
-
Cech TR. How a chemist looks at RNA. Angew Chem Int Ed Engl. 2013 Jan 02; 52(1):75-8. PMID: 23203538.
-
Berman AJ, Cech TR. SnapShot: telomeres and telomerase. Cell. 2012 Nov 21; 151(5):1138-1138.e1. PMID: 23178129.
-
Nandakumar J, Bell CF, Weidenfeld I, Zaug AJ, Leinwand LA, Cech TR. The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity. Nature. 2012 Dec 13; 492(7428):285-9. PMID: 23103865.
-
Santini A, Ghelardini L, De Pace C, Desprez-Loustau ML, Capretti P, Chandelier A, Cech T, Chira D, Diamandis S, Gaitniekis T, Hantula J, Holdenrieder O, Jankovsky L, Jung T, Jurc D, Kirisits T, Kunca A, Lygis V, Malecka M, Marcais B, Schmitz S, Schumacher J, Solheim H, Solla A, Szabò I, Tsopelas P, Vannini A, Vettraino AM, Webber J, Woodward S, Stenlid J. Biogeographical patterns and determinants of invasion by forest pathogens in Europe. New Phytol. 2013 Jan; 197(1):238-250. PMID: 23057437.
-
Cech TR. The RNA worlds in context. Cold Spring Harb Perspect Biol. 2012 Jul 01; 4(7):a006742. PMID: 21441585.
-
Pfingsten JS, Goodrich KJ, Taabazuing C, Ouenzar F, Chartrand P, Cech TR. Mutually exclusive binding of telomerase RNA and DNA by Ku alters telomerase recruitment model. Cell. 2012 Mar 02; 148(5):922-32. PMID: 22365814.
-
Berman AJ, Akiyama BM, Stone MD, Cech TR. The RNA accordion model for template positioning by telomerase RNA during telomeric DNA synthesis. Nat Struct Mol Biol. 2011 Nov 20; 18(12):1371-5. PMID: 22101935.
-
Nandakumar J, Cech TR. DNA-induced dimerization of the single-stranded DNA binding telomeric protein Pot1 from Schizosaccharomyces pombe. Nucleic Acids Res. 2012 Jan; 40(1):235-44. PMID: 21911358.
-
Batista LF, Pech MF, Zhong FL, Nguyen HN, Xie KT, Zaug AJ, Crary SM, Choi J, Sebastiano V, Cherry A, Giri N, Wernig M, Alter BP, Cech TR, Savage SA, Reijo Pera RA, Artandi SE. Telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cells. Nature. 2011 May 22; 474(7351):399-402. PMID: 21602826.
-
Taylor DJ, Podell ER, Taatjes DJ, Cech TR. Multiple POT1-TPP1 proteins coat and compact long telomeric single-stranded DNA. J Mol Biol. 2011 Jul 01; 410(1):10-7. PMID: 21596049.
-
Berman AJ, Gooding AR, Cech TR. Tetrahymena telomerase protein p65 induces conformational changes throughout telomerase RNA (TER) and rescues telomerase reverse transcriptase and TER assembly mutants. Mol Cell Biol. 2010 Oct; 30(20):4965-76. PMID: 20713447.
-
Talgø V, Chastagner G, Thomsen IM, Cech T, Riley K, Lange K, Klemsdal SS, Stensvand A. Sydowia polyspora associated with current season needle necrosis (CSNN) on true fir (Abies spp.). Fungal Biol. 2010 Jul; 114(7):545-54. PMID: 20943166.
-
Zaug AJ, Podell ER, Nandakumar J, Cech TR. Functional interaction between telomere protein TPP1 and telomerase. Genes Dev. 2010 Mar 15; 24(6):613-22. PMID: 20231318.
-
Qiao F, Goodrich KJ, Cech TR. Engineering cis-telomerase RNAs that add telomeric repeats to themselves. Proc Natl Acad Sci U S A. 2010 Mar 16; 107(11):4914-8. PMID: 20194781.
-
Latrick CM, Cech TR. POT1-TPP1 enhances telomerase processivity by slowing primer dissociation and aiding translocation. EMBO J. 2010 Mar 03; 29(5):924-33. PMID: 20094033.
-
Nandakumar J, Podell ER, Cech TR. How telomeric protein POT1 avoids RNA to achieve specificity for single-stranded DNA. Proc Natl Acad Sci U S A. 2010 Jan 12; 107(2):651-6. PMID: 20080730.
-
Cech TR. Crawling out of the RNA world. Cell. 2009 Feb 20; 136(4):599-602. PMID: 19239881.
-
Vicens Q, Cech TR. A natural ribozyme with 3',5' RNA ligase activity. Nat Chem Biol. 2009 Feb; 5(2):97-9. PMID: 19125157.
-
Qiao F, Cech TR. Triple-helix structure in telomerase RNA contributes to catalysis. Nat Struct Mol Biol. 2008 Jun; 15(6):634-40. PMID: 18500353.
-
Mozdy AD, Podell ER, Cech TR. Multiple yeast genes, including Paf1 complex genes, affect telomere length via telomerase RNA abundance. Mol Cell Biol. 2008 Jun; 28(12):4152-61. PMID: 18411302.
-
Arai K, Cech T, Chameau JL, Horn P, Mattaj I, Potocnik J, Wiley J. The future of research universities. Is the model of research-intensive universities still valid at the beginning of the twenty-first century? EMBO Rep. 2007 Sep; 8(9):804-10. PMID: 17767189.
-
Cech TR. On the occasion of the 25th anniversary of the discovery of catalytic RNA. Biol Chem. 2007 Jul; 388(7):661-2. PMID: 17570816.
-
Vicens Q, Gooding AR, Laederach A, Cech TR. Local RNA structural changes induced by crystallization are revealed by SHAPE. RNA. 2007 Apr; 13(4):536-48. PMID: 17299128.
-
Wang F, Podell ER, Zaug AJ, Yang Y, Baciu P, Cech TR, Lei M. The POT1-TPP1 telomere complex is a telomerase processivity factor. Nature. 2007 Feb 01; 445(7127):506-10. PMID: 17237768.
-
Guo F, Gooding AR, Cech TR. Comparison of crystal structure interactions and thermodynamics for stabilizing mutations in the Tetrahymena ribozyme. RNA. 2006 Mar; 12(3):387-95. PMID: 16431981.
-
Vicens Q, Cech TR. Atomic level architecture of group I introns revealed. Trends Biochem Sci. 2006 Jan; 31(1):41-51. PMID: 16356725.
-
Zappulla DC, Goodrich K, Cech TR. A miniature yeast telomerase RNA functions in vivo and reconstitutes activity in vitro. Nat Struct Mol Biol. 2005 Dec; 12(12):1072-7. PMID: 16299517.
-
Jacobs SA, Podell ER, Wuttke DS, Cech TR. Soluble domains of telomerase reverse transcriptase identified by high-throughput screening. Protein Sci. 2005 Aug; 14(8):2051-8. PMID: 16046627.
-
Opresko PL, Mason PA, Podell ER, Lei M, Hickson ID, Cech TR, Bohr VA. POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates. J Biol Chem. 2005 Sep 16; 280(37):32069-80. PMID: 16030011.
-
Lei M, Zaug AJ, Podell ER, Cech TR. Switching human telomerase on and off with hPOT1 protein in vitro. J Biol Chem. 2005 May 27; 280(21):20449-56. PMID: 15792951.
-
Mandell JG, Bähler J, Volpe TA, Martienssen RA, Cech TR. Global expression changes resulting from loss of telomeric DNA in fission yeast. Genome Biol. 2005; 6(1):R1. PMID: 15642092.
-
Mandell JG, Goodrich KJ, Bähler J, Cech TR. Expression of a RecQ helicase homolog affects progression through crisis in fission yeast lacking telomerase. J Biol Chem. 2005 Feb 18; 280(7):5249-57. PMID: 15591066.
-
Cech TR, Rubin GM. Nurturing interdisciplinary research. Nat Struct Mol Biol. 2004 Dec; 11(12):1166-9. PMID: 15578058.
-
Lei M, Podell ER, Cech TR. Structure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protection. Nat Struct Mol Biol. 2004 Dec; 11(12):1223-9. PMID: 15558049.
-
Guo F, Gooding AR, Cech TR. Structure of the Tetrahymena ribozyme: base triple sandwich and metal ion at the active site. Mol Cell. 2004 Nov 05; 16(3):351-62. PMID: 15525509.
-
Cech TR. Self-splicing and enzymatic activity of an intervening sequence RNA from Tetrahymena. Biosci Rep. 2004 Aug-Oct; 24(4-5):362-85. PMID: 16134019.
-
Aigner S, Cech TR. The Euplotes telomerase subunit p43 stimulates enzymatic activity and processivity in vitro. RNA. 2004 Jul; 10(7):1108-18. PMID: 15208446.
-
Cech TR. RNA finds a simpler way. Nature. 2004 Mar 18; 428(6980):263-4. PMID: 15029175.
-
Lei M, Podell ER, Baumann P, Cech TR. DNA self-recognition in the structure of Pot1 bound to telomeric single-stranded DNA. Nature. 2003 Nov 13; 426(6963):198-203. PMID: 14614509.
-
Seto AG, Umansky K, Tzfati Y, Zaug AJ, Blackburn EH, Cech TR. A template-proximal RNA paired element contributes to Saccharomyces cerevisiae telomerase activity. RNA. 2003 Nov; 9(11):1323-32. PMID: 14561882.
-
Bryan TM, Goodrich KJ, Cech TR. Tetrahymena telomerase is active as a monomer. Mol Biol Cell. 2003 Dec; 14(12):4794-804. PMID: 13679509.
-
Förstemann K, Zaug AJ, Cech TR, Lingner J. Yeast telomerase is specialized for C/A-rich RNA templates. Nucleic Acids Res. 2003 Mar 15; 31(6):1646-55. PMID: 12626706.
-
Cech TR. Rebalancing teaching and research. Science. 2003 Jan 10; 299(5604):165. PMID: 12522218.
-
Lei M, Baumann P, Cech TR. Cooperative binding of single-stranded telomeric DNA by the Pot1 protein of Schizosaccharomyces pombe. Biochemistry. 2002 Dec 10; 41(49):14560-8. PMID: 12463756.
-
Guo F, Cech TR. Evolution of Tetrahymena ribozyme mutants with increased structural stability. Nat Struct Biol. 2002 Nov; 9(11):855-61. PMID: 12368901.
-
Baumann P, Podell E, Cech TR. Human Pot1 (protection of telomeres) protein: cytolocalization, gene structure, and alternative splicing. Mol Cell Biol. 2002 Nov; 22(22):8079-87. PMID: 12391173.
-
Doudna JA, Cech TR. The chemical repertoire of natural ribozymes. Nature. 2002 Jul 11; 418(6894):222-8. PMID: 12110898.
-
Guo F, Cech TR. In vivo selection of better self-splicing introns in Escherichia coli: the role of the P1 extension helix of the Tetrahymena intron. RNA. 2002 May; 8(5):647-58. PMID: 12022231.
-
Livengood AJ, Zaug AJ, Cech TR. Essential regions of Saccharomyces cerevisiae telomerase RNA: separate elements for Est1p and Est2p interaction. Mol Cell Biol. 2002 Apr; 22(7):2366-74. PMID: 11884619.
-
Cech TR. HHMI's attention to Wiley's lab staff. Science. 2002 Jan 04; 295(5552):43. PMID: 11780644.
-
Cech T. Funding above and beyond scientific research. An interview with Thomas R. Cech, President of the Howard Hughes Medical Institute in Chevy Chase, MD. Interviewed by Holger Breithaupt. EMBO Rep. 2001 Sep; 2(9):751-4. PMID: 11559582.
-
Sperger JM, Cech TR. A stem-loop of Tetrahymena telomerase RNA distant from the template potentiates RNA folding and telomerase activity. Biochemistry. 2001 Jun 19; 40(24):7005-16. PMID: 11401544.
-
Baumann P, Cech TR. Pot1, the putative telomere end-binding protein in fission yeast and humans. Science. 2001 May 11; 292(5519):1171-5. PMID: 11349150.
-
Juneau K, Podell E, Harrington DJ, Cech TR. Structural basis of the enhanced stability of a mutant ribozyme domain and a detailed view of RNA--solvent interactions. Structure. 2001 Mar 07; 9(3):221-31. PMID: 11286889.
-
Silverman SK, Cech TR. An early transition state for folding of the P4-P6 RNA domain. RNA. 2001 Feb; 7(2):161-6. PMID: 11233973.
-
Cech TR. Structural biology. The ribosome is a ribozyme. Science. 2000 Aug 11; 289(5481):878-9. PMID: 10960319.
-
Bryan TM, Goodrich KJ, Cech TR. A mutant of Tetrahymena telomerase reverse transcriptase with increased processivity. J Biol Chem. 2000 Aug 04; 275(31):24199-207. PMID: 10807925.
-
Bryan TM, Goodrich KJ, Cech TR. Telomerase RNA bound by protein motifs specific to telomerase reverse transcriptase. Mol Cell. 2000 Aug; 6(2):493-9. PMID: 10983995.
-
Haering CH, Nakamura TM, Baumann P, Cech TR. Analysis of telomerase catalytic subunit mutants in vivo and in vitro in Schizosaccharomycespombe. Proc Natl Acad Sci U S A. 2000 Jun 06; 97(12):6367-72. PMID: 10829083.
-
Silverman SK, Zheng M, Wu M, Tinoco I, Cech TR. Quantifying the energetic interplay of RNA tertiary and secondary structure interactions. RNA. 1999 Dec; 5(12):1665-74. PMID: 10606276.
-
Hagen M, Cech TR. Self-splicing of the Tetrahymena intron from mRNA in mammalian cells. EMBO J. 1999 Nov 15; 18(22):6491-500. PMID: 10562561.
-
Friedman KL, Cech TR. Essential functions of amino-terminal domains in the yeast telomerase catalytic subunit revealed by selection for viable mutants. Genes Dev. 1999 Nov 01; 13(21):2863-74. PMID: 10557213.
-
Silverman SK, Cech TR. RNA tertiary folding monitored by fluorescence of covalently attached pyrene. Biochemistry. 1999 Oct 26; 38(43):14224-37. PMID: 10571996.
-
Seto AG, Zaug AJ, Sobel SG, Wolin SL, Cech TR. Saccharomyces cerevisiae telomerase is an Sm small nuclear ribonucleoprotein particle. Nature. 1999 Sep 09; 401(6749):177-80. PMID: 10490028.
-
Juneau K, Cech TR. In vitro selection of RNAs with increased tertiary structure stability. RNA. 1999 Aug; 5(8):1119-29. PMID: 10445885.
-
Bryan TM, Cech TR. Telomerase and the maintenance of chromosome ends. Curr Opin Cell Biol. 1999 Jun; 11(3):318-24. PMID: 10395557.
-
Jabri E, Cech TR. In vitro selection of the Naegleria GIR1 ribozyme identifies three base changes that dramatically improve activity. RNA. 1998 Dec; 4(12):1481-92. PMID: 9848647.
-
Nakamura TM, Cooper JP, Cech TR. Two modes of survival of fission yeast without telomerase. Science. 1998 Oct 16; 282(5388):493-6. PMID: 9774280.
-
Golden BL, Gooding AR, Podell ER, Cech TR. A preorganized active site in the crystal structure of the Tetrahymena ribozyme. Science. 1998 Oct 09; 282(5387):259-64. PMID: 9841391.
-
Cohen SB, Cech TR. A quantitative study of the flexibility contributed to RNA structures by nicks and single-stranded gaps. RNA. 1998 Oct; 4(10):1179-85. PMID: 9769093.
-
Bryan TM, Sperger JM, Chapman KB, Cech TR. Telomerase reverse transcriptase genes identified in Tetrahymena thermophila and Oxytricha trifallax. Proc Natl Acad Sci U S A. 1998 Jul 21; 95(15):8479-84. PMID: 9671703.
-
Froelich-Ammon SJ, Dickinson BA, Bevilacqua JM, Schultz SC, Cech TR. Modulation of telomerase activity by telomere DNA-binding proteins in Oxytricha. Genes Dev. 1998 May 15; 12(10):1504-14. PMID: 9585510.
-
Bevilacqua PC, George CX, Samuel CE, Cech TR. Binding of the protein kinase PKR to RNAs with secondary structure defects: role of the tandem A-G mismatch and noncontiguous helixes. Biochemistry. 1998 May 05; 37(18):6303-16. PMID: 9572845.
-
Nakamura TM, Cech TR. Reversing time: origin of telomerase. Cell. 1998 Mar 06; 92(5):587-90. PMID: 9506510.
-
Zhang B, Cech TR. Peptide bond formation by in vitro selected ribozymes. Nature. 1997 Nov 06; 390(6655):96-100. PMID: 9363898.
-
Cech TR, Nakamura TM, Lingner J. Telomerase is a true reverse transcriptase. A review. Biochemistry (Mosc). 1997 Nov; 62(11):1202-5. PMID: 9467843.
-
Lingner J, Cech TR, Hughes TR, Lundblad V. Three Ever Shorter Telomere (EST) genes are dispensable for in vitro yeast telomerase activity. Proc Natl Acad Sci U S A. 1997 Oct 14; 94(21):11190-5. PMID: 9326584.
-
Hammond PW, Cech TR. dGTP-dependent processivity and possible template switching of euplotes telomerase. Nucleic Acids Res. 1997 Sep 15; 25(18):3698-704. PMID: 9278493.
-
Tanner MA, Anderson EM, Gutell RR, Cech TR. Mutagenesis and comparative sequence analysis of a base triple joining the two domains of group I ribozymes. RNA. 1997 Sep; 3(9):1037-51. PMID: 9292502.
-
Weinstein LB, Jones BC, Cosstick R, Cech TR. A second catalytic metal ion in group I ribozyme. Nature. 1997 Aug 21; 388(6644):805-8. PMID: 9285596.
-
Nakamura TM, Morin GB, Chapman KB, Weinrich SL, Andrews WH, Lingner J, Harley CB, Cech TR. Telomerase catalytic subunit homologs from fission yeast and human. Science. 1997 Aug 15; 277(5328):955-9. PMID: 9252327.
-
Golden BL, Podell ER, Gooding AR, Cech TR. Crystals by design: a strategy for crystallization of a ribozyme derived from the Tetrahymena group I intron. J Mol Biol. 1997 Aug 01; 270(5):711-23. PMID: 9245599.
-
Szewczak AA, Cech TR. An RNA internal loop acts as a hinge to facilitate ribozyme folding and catalysis. RNA. 1997 Aug; 3(8):838-49. PMID: 9257643.
-
McConnell TS, Herschlag D, Cech TR. Effects of divalent metal ions on individual steps of the Tetrahymena ribozyme reaction. Biochemistry. 1997 Jul 08; 36(27):8293-303. PMID: 9204875.
-
Lingner J, Hughes TR, Shevchenko A, Mann M, Lundblad V, Cech TR. Reverse transcriptase motifs in the catalytic subunit of telomerase. Science. 1997 Apr 25; 276(5312):561-7. PMID: 9110970.
-
Cooper JP, Nimmo ER, Allshire RC, Cech TR. Regulation of telomere length and function by a Myb-domain protein in fission yeast. Nature. 1997 Feb 20; 385(6618):744-7. PMID: 9034194.
-
Tanner MA, Cech TR. Joining the two domains of a group I ribozyme to form the catalytic core. Science. 1997 Feb 07; 275(5301):847-9. PMID: 9012355.
-
Hammond PW, Lively TN, Cech TR. The anchor site of telomerase from Euplotes aediculatus revealed by photo-cross-linking to single- and double-stranded DNA primers. Mol Cell Biol. 1997 Jan; 17(1):296-308. PMID: 8972210.
-
Golden BL, Gooding AR, Podell ER, Cech TR. X-ray crystallography of large RNAs: heavy-atom derivatives by RNA engineering. RNA. 1996 Dec; 2(12):1295-305. PMID: 8972777.
-
Rusconi CP, Cech TR. The anticodon is the signal sequence for mitochondrial import of glutamine tRNA in Tetrahymena. Genes Dev. 1996 Nov 15; 10(22):2870-80. PMID: 8918888.
-
Kuo LY, Cech TR. Conserved thermochemistry of guanosine nucleophile binding for structurally distinct group I ribozymes. Nucleic Acids Res. 1996 Oct 01; 24(19):3722-7. PMID: 8871550.
-
Cate JH, Gooding AR, Podell E, Zhou K, Golden BL, Kundrot CE, Cech TR, Doudna JA. Crystal structure of a group I ribozyme domain: principles of RNA packing. Science. 1996 Sep 20; 273(5282):1678-85. PMID: 8781224.
-
Cate JH, Gooding AR, Podell E, Zhou K, Golden BL, Szewczak AA, Kundrot CE, Cech TR, Doudna JA. RNA tertiary structure mediation by adenosine platforms. Science. 1996 Sep 20; 273(5282):1696-9. PMID: 8781229.
-
Campbell TB, Cech TR. Mutations in the Tetrahymena ribozyme internal guide sequence: effects on docking of the P1 helix into the catalytic core and correlation with catalytic activity. Biochemistry. 1996 Sep 03; 35(35):11493-502. PMID: 8784205.
-
Bevilacqua PC, Cech TR. Minor-groove recognition of double-stranded RNA by the double-stranded RNA-binding domain from the RNA-activated protein kinase PKR. Biochemistry. 1996 Aug 06; 35(31):9983-94. PMID: 8756460.
-
Cech TR, Szewczak AA. Selecting apt RNAs for NMR. RNA. 1996 Jul; 2(7):625-7. PMID: 8756405.
-
Rusconi CP, Cech TR. Mitochondrial import of only one of three nuclear-encoded glutamine tRNAs in Tetrahymena thermophila. EMBO J. 1996 Jul 01; 15(13):3286-95. PMID: 8670829.
-
Zaug AJ, Linger J, Cech TR. Method for determining RNA 3' ends and application to human telomerase RNA. Nucleic Acids Res. 1996 Feb 01; 24(3):532-3. PMID: 8602368.
-
Strobel SA, Cech TR. Exocyclic amine of the conserved G.U pair at the cleavage site of the Tetrahymena ribozyme contributes to 5'-splice site selection and transition state stabilization. Biochemistry. 1996 Jan 30; 35(4):1201-11. PMID: 8573575.
-
Weeks KM, Cech TR. Assembly of a ribonucleoprotein catalyst by tertiary structure capture. Science. 1996 Jan 19; 271(5247):345-8. PMID: 8553068.
-
Lingner J, Cooper JP, Cech TR. Telomerase and DNA end replication: no longer a lagging strand problem? Science. 1995 Sep 15; 269(5230):1533-4. PMID: 7545310.
-
Campbell TB, Cech TR. Identification of ribozymes within a ribozyme library that efficiently cleave a long substrate RNA. RNA. 1995 Aug; 1(6):598-609. PMID: 7489519.
-
Weeks KM, Cech TR. Protein facilitation of group I intron splicing by assembly of the catalytic core and the 5' splice site domain. Cell. 1995 Jul 28; 82(2):221-30. PMID: 7628013.
-
Fang G, Cech TR. Telomerase RNA localized in the replication band and spherical subnuclear organelles in hypotrichous ciliates. J Cell Biol. 1995 Jul; 130(2):243-53. PMID: 7615628.
-
Weeks KM, Cech TR. Efficient protein-facilitated splicing of the yeast mitochondrial bI5 intron. Biochemistry. 1995 Jun 13; 34(23):7728-38. PMID: 7540041.
-
Hicke B, Rempel R, Maller J, Swank RA, Hamaguchi JR, Bradbury EM, Prescott DM, Cech TR. Phosphorylation of the Oxytricha telomere protein: possible cell cycle regulation. Nucleic Acids Res. 1995 Jun 11; 23(11):1887-93. PMID: 7596814.
-
Zaug AJ, Cech TR. Analysis of the structure of Tetrahymena nuclear RNAs in vivo: telomerase RNA, the self-splicing rRNA intron, and U2 snRNA. RNA. 1995 Jun; 1(4):363-74. PMID: 7493315.
-
McConnell TS, Cech TR. A positive entropy change for guanosine binding and for the chemical step in the Tetrahymena ribozyme reaction. Biochemistry. 1995 Mar 28; 34(12):4056-67. PMID: 7696271.
-
Strobel SA, Cech TR. Minor groove recognition of the conserved G.U pair at the Tetrahymena ribozyme reaction site. Science. 1995 Feb 03; 267(5198):675-9. PMID: 7839142.
-
Zaug AJ, Dávila-Aponte JA, Cech TR. Catalysis of RNA cleavage by a ribozyme derived from the group I intron of Anabaena pre-tRNA(Leu). Biochemistry. 1994 Dec 13; 33(49):14935-47. PMID: 7527660.
-
Pyle AM, Moran S, Strobel SA, Chapman T, Turner DH, Cech TR. Replacement of the conserved G.U with a G-C pair at the cleavage site of the Tetrahymena ribozyme decreases binding, reactivity, and fidelity. Biochemistry. 1994 Nov 22; 33(46):13856-63. PMID: 7947794.
-
Cech TR, Uhlenbeck OC. Ribozymes. Hammerhead nailed down. Nature. 1994 Nov 03; 372(6501):39-40. PMID: 7969416.
-
Cech TR. Chromosome end games. Science. 1994 Oct 21; 266(5184):387-8. PMID: 7939679.
-
Sullenger BA, Cech TR. Ribozyme-mediated repair of defective mRNA by targeted, trans-splicing. Nature. 1994 Oct 13; 371(6498):619-22. PMID: 7935797.
-
Murphy FL, Wang YH, Griffith JD, Cech TR. Coaxially stacked RNA helices in the catalytic center of the Tetrahymena ribozyme. Science. 1994 Sep 16; 265(5179):1709-12. PMID: 8085157.
-
Lingner J, Hendrick LL, Cech TR. Telomerase RNAs of different ciliates have a common secondary structure and a permuted template. Genes Dev. 1994 Aug 15; 8(16):1984-98. PMID: 7958872.
-
Laggerbauer B, Murphy FL, Cech TR. Two major tertiary folding transitions of the Tetrahymena catalytic RNA. EMBO J. 1994 Jun 01; 13(11):2669-76. PMID: 8013466.
-
Wang YH, Murphy FL, Cech TR, Griffith JD. Visualization of a tertiary structural domain of the Tetrahymena group I intron by electron microscopy. J Mol Biol. 1994 Feb 11; 236(1):64-71. PMID: 7508985.
-
Murphy FL, Cech TR. GAAA tetraloop and conserved bulge stabilize tertiary structure of a group I intron domain. J Mol Biol. 1994 Feb 11; 236(1):49-63. PMID: 8107125.
-
Strobel SA, Cech TR. Translocation of an RNA duplex on a ribozyme. Nat Struct Biol. 1994 Jan; 1(1):13-7. PMID: 7544680.
-
Cech TR. The efficiency and versatility of catalytic RNA: implications for an RNA world. Gene. 1993 Dec 15; 135(1-2):33-6. PMID: 8276275.
-
Strobel SA, Cech TR. Tertiary interactions with the internal guide sequence mediate docking of the P1 helix into the catalytic core of the Tetrahymena ribozyme. Biochemistry. 1993 Dec 14; 32(49):13593-604. PMID: 7504953.
-
Willis MC, Hicke BJ, Uhlenbeck OC, Cech TR, Koch TH. Photocrosslinking of 5-iodouracil-substituted RNA and DNA to proteins. Science. 1993 Nov 19; 262(5137):1255-7. PMID: 7694369.
-
Cech TR. RNA. Fishing for fresh catalysts. Nature. 1993 Sep 16; 365(6443):204-5. PMID: 7690464.
-
Herschlag D, Eckstein F, Cech TR. The importance of being ribose at the cleavage site in the Tetrahymena ribozyme reaction. Biochemistry. 1993 Aug 17; 32(32):8312-21. PMID: 7688573.
-
Zaug AJ, McEvoy MM, Cech TR. Self-splicing of the group I intron from Anabaena pre-tRNA: requirement for base-pairing of the exons in the anticodon stem. Biochemistry. 1993 Aug 10; 32(31):7946-53. PMID: 8347600.
-
Ishikawa F, Matunis MJ, Dreyfuss G, Cech TR. Nuclear proteins that bind the pre-mRNA 3' splice site sequence r(UUAG/G) and the human telomeric DNA sequence d(TTAGGG)n. Mol Cell Biol. 1993 Jul; 13(7):4301-10. PMID: 8321232.
-
Fang G, Cech TR. Oxytricha telomere-binding protein: DNA-dependent dimerization of the alpha and beta subunits. Proc Natl Acad Sci U S A. 1993 Jul 01; 90(13):6056-60. PMID: 8327484.
-
Murphy FL, Cech TR. An independently folding domain of RNA tertiary structure within the Tetrahymena ribozyme. Biochemistry. 1993 May 25; 32(20):5291-300. PMID: 7684607.
-
Fang G, Gray JT, Cech TR. Oxytricha telomere-binding protein: separable DNA-binding and dimerization domains of the alpha-subunit. Genes Dev. 1993 May; 7(5):870-82. PMID: 8491383.
-
Wang JF, Downs WD, Cech TR. Movement of the guide sequence during RNA catalysis by a group I ribozyme. Science. 1993 Apr 23; 260(5107):504-8. PMID: 7682726.
-
Piccirilli JA, Vyle JS, Caruthers MH, Cech TR. Metal ion catalysis in the Tetrahymena ribozyme reaction. Nature. 1993 Jan 07; 361(6407):85-8. PMID: 8421499.
-
Legault P, Herschlag D, Celander DW, Cech TR. Mutations at the guanosine-binding site of the Tetrahymena ribozyme also affect site-specific hydrolysis. Nucleic Acids Res. 1992 Dec 25; 20(24):6613-9. PMID: 1480482.
-
Cech TR, Herschlag D, Piccirilli JA, Pyle AM. RNA catalysis by a group I ribozyme. Developing a model for transition state stabilization. J Biol Chem. 1992 Sep 05; 267(25):17479-82. PMID: 1381347.
-
Pyle AM, Murphy FL, Cech TR. RNA substrate binding site in the catalytic core of the Tetrahymena ribozyme. Nature. 1992 Jul 09; 358(6382):123-8. PMID: 1377367.
-
Piccirilli JA, McConnell TS, Zaug AJ, Noller HF, Cech TR. Aminoacyl esterase activity of the Tetrahymena ribozyme. Science. 1992 Jun 05; 256(5062):1420-4. PMID: 1604316.
-
Wang JF, Cech TR. Tertiary structure around the guanosine-binding site of the Tetrahymena ribozyme. Science. 1992 Apr 24; 256(5056):526-9. PMID: 1315076.
-
Zaug AJ, Cech TR. The intervening sequence RNA of Tetrahymena is an enzyme. 1986. Biotechnology. 1992; 24:57-62. PMID: 1422070.
-
Heuer TS, Chandry PS, Belfort M, Celander DW, Cech TR. Folding of group I introns from bacteriophage T4 involves internalization of the catalytic core. Proc Natl Acad Sci U S A. 1991 Dec 15; 88(24):11105-9. PMID: 1763026.
-
Gray JT, Celander DW, Price CM, Cech TR. Cloning and expression of genes for the Oxytricha telomere-binding protein: specific subunit interactions in the telomeric complex. Cell. 1991 Nov 15; 67(4):807-14. PMID: 1840510.
-
Gampel A, Cech TR. Binding of the CBP2 protein to a yeast mitochondrial group I intron requires the catalytic core of the RNA. Genes Dev. 1991 Oct; 5(10):1870-80. PMID: 1916266.
-
Dávila-Aponte JA, Huss VA, Sogin ML, Cech TR. A self-splicing group I intron in the nuclear pre-rRNA of the green alga, Ankistrodesmus stipitatus. Nucleic Acids Res. 1991 Aug 25; 19(16):4429-36. PMID: 1886767.
-
Grosshans CA, Cech TR. A hammerhead ribozyme allows synthesis of a new form of the Tetrahymena ribozyme homogeneous in length with a 3' end blocked for transesterification. Nucleic Acids Res. 1991 Jul 25; 19(14):3875-80. PMID: 1650453.
-
Zahler AM, Williamson JR, Cech TR, Prescott DM. Inhibition of telomerase by G-quartet DNA structures. Nature. 1991 Apr 25; 350(6320):718-20. PMID: 2023635.
-
Pyle AM, Cech TR. Ribozyme recognition of RNA by tertiary interactions with specific ribose 2'-OH groups. Nature. 1991 Apr 18; 350(6319):628-31. PMID: 1708111.
-
Celander DW, Cech TR. Visualizing the higher order folding of a catalytic RNA molecule. Science. 1991 Jan 25; 251(4992):401-7. PMID: 1989074.
-
Herschlag D, Cech TR. Catalysis of RNA cleavage by the Tetrahymena thermophila ribozyme. 1. Kinetic description of the reaction of an RNA substrate complementary to the active site. Biochemistry. 1990 Nov 06; 29(44):10159-71. PMID: 2271645.
-
Pyle AM, McSwiggen JA, Cech TR. Direct measurement of oligonucleotide substrate binding to wild-type and mutant ribozymes from Tetrahymena. Proc Natl Acad Sci U S A. 1990 Nov; 87(21):8187-91. PMID: 2236030.
-
Downs WD, Cech TR. An ultraviolet-inducible adenosine-adenosine cross-link reflects the catalytic structure of the Tetrahymena ribozyme. Biochemistry. 1990 Jun 12; 29(23):5605-13. PMID: 2201409.
-
Cech TR. Nobel lecture. Self-splicing and enzymatic activity of an intervening sequence RNA from Tetrahymena. Biosci Rep. 1990 Jun; 10(3):239-61. PMID: 1699616.
-
Herschlag D, Cech TR. DNA cleavage catalysed by the ribozyme from Tetrahymena. Nature. 1990 Mar 29; 344(6265):405-9. PMID: 1690858.
-
Hicke BJ, Celander DW, MacDonald GH, Price CM, Cech TR. Two versions of the gene encoding the 41-kilodalton subunit of the telomere binding protein of Oxytricha nova. Proc Natl Acad Sci U S A. 1990 Feb; 87(4):1481-5. PMID: 1689486.
-
Cech TR. Self-splicing of group I introns. Annu Rev Biochem. 1990; 59:543-68. PMID: 2197983.
-
Latham JA, Zaug AJ, Cech TR. Self-splicing and enzymatic cleavage of RNA by a group I intervening sequence. Methods Enzymol. 1990; 181:558-69. PMID: 2199766.
-
Woodson SA, Cech TR, Young M, Perriman R, Kelly L, Graf L, Llewellyn D, Gerlach W, Plückthun A, Collins J. Symposium 3: Non-enzymatic biocatalysts in nature and biotechnology. Fresenius J Anal Chem. 1990; 337(1):12-14. PMID: 32226232.
-
Young B, Cech TR. Specificity for 3',5'-linked substrates in RNA-catalyzed RNA polymerization. J Mol Evol. 1989 Dec; 29(6):480-5. PMID: 2482370.
-
Murphy FL, Cech TR. Alteration of substrate specificity for the endoribonucleolytic cleavage of RNA by the Tetrahymena ribozyme. Proc Natl Acad Sci U S A. 1989 Dec; 86(23):9218-22. PMID: 2480597.
-
Raghuraman MK, Cech TR. Assembly and self-association of oxytricha telomeric nucleoprotein complexes. Cell. 1989 Nov 17; 59(4):719-28. PMID: 2582492.
-
Yarus M, Levine J, Morin GB, Cech TR. A Tetrahymena intron nucleotide connected to the GTP/arginine site. Nucleic Acids Res. 1989 Sep 12; 17(17):6969-81. PMID: 2674904.
-
Barfod ET, Cech TR. The conserved U.G pair in the 5' splice site duplex of a group I intron is required in the first but not the second step of self-splicing. Mol Cell Biol. 1989 Sep; 9(9):3657-66. PMID: 2779562.
-
Grosshans CA, Cech TR. Metal ion requirements for sequence-specific endoribonuclease activity of the Tetrahymena ribozyme. Biochemistry. 1989 Aug 22; 28(17):6888-94. PMID: 2684268.
-
Latham JA, Cech TR. Defining the inside and outside of a catalytic RNA molecule. Science. 1989 Jul 21; 245(4915):276-82. PMID: 2501870.
-
Woodson SA, Cech TR. Reverse self-splicing of the tetrahymena group I intron: implication for the directionality of splicing and for intron transposition. Cell. 1989 Apr 21; 57(2):335-45. PMID: 2702692.
-
Price CM, Cech TR. Properties of the telomeric DNA-binding protein from Oxytricha nova. Biochemistry. 1989 Jan 24; 28(2):769-74. PMID: 2713343.
-
Cech TR. RNA as an enzyme. Biochem Int. 1989 Jan; 18(1):7-14. PMID: 2470377.
-
Zaug AJ, Grosshans CA, Cech TR. Sequence-specific endoribonuclease activity of the Tetrahymena ribozyme: enhanced cleavage of certain oligonucleotide substrates that form mismatched ribozyme-substrate complexes. Biochemistry. 1988 Dec 13; 27(25):8924-31. PMID: 3069131.
-
Cech TR. Ribozymes and their medical implications. JAMA. 1988 Nov 25; 260(20):3030-4. PMID: 2460649.
-
Price JV, Cech TR. Determinants of the 3' splice site for self-splicing of the Tetrahymena pre-rRNA. Genes Dev. 1988 Nov; 2(11):1439-47. PMID: 3209068.
-
Morin GB, Cech TR. Telomeric repeats of Tetrahymena malaccensis mitochondrial DNA: a multimodal distribution that fluctuates erratically during growth. Mol Cell Biol. 1988 Oct; 8(10):4450-8. PMID: 3185556.
-
Barfod ET, Cech TR. Deletion of nonconserved helices near the 3' end of the rRNA intron of Tetrahymena thermophila alters self-splicing but not core catalytic activity. Genes Dev. 1988 Jun; 2(6):652-63. PMID: 3417146.
-
Been MD, Cech TR. RNA as an RNA polymerase: net elongation of an RNA primer catalyzed by the Tetrahymena ribozyme. Science. 1988 Mar 18; 239(4846):1412-6. PMID: 2450400.
-
Morin GB, Cech TR. Mitochondrial telomeres: surprising diversity of repeated telomeric DNA sequences among six species of Tetrahymena. Cell. 1988 Feb 12; 52(3):367-74. PMID: 3125982.
-
Kim SH, Cech TR. Three-dimensional model of the active site of the self-splicing rRNA precursor of Tetrahymena. Proc Natl Acad Sci U S A. 1987 Dec; 84(24):8788-92. PMID: 3480510.
-
Zaug AJ, Cech TR. Self-splicing RNA and an RNA enzyme in Tetrahymena. J Protozool. 1987 Nov; 34(4):416-7. PMID: 3323479.
-
Burke JM, Belfort M, Cech TR, Davies RW, Schweyen RJ, Shub DA, Szostak JW, Tabak HF. Structural conventions for group I introns. Nucleic Acids Res. 1987 Sep 25; 15(18):7217-21. PMID: 3658691.
-
Been MD, Cech TR. Selection of circularization sites in a group I IVS RNA requires multiple alignments of an internal template-like sequence. Cell. 1987 Sep 11; 50(6):951-61. PMID: 2441876.
-
Price JV, Engberg J, Cech TR. 5' exon requirement for self-splicing of the Tetrahymena thermophila pre-ribosomal RNA and identification of a cryptic 5' splice site in the 3' exon. J Mol Biol. 1987 Jul 05; 196(1):49-60. PMID: 2443717.
-
Cech TR. The chemistry of self-splicing RNA and RNA enzymes. Science. 1987 Jun 19; 236(4808):1532-9. PMID: 2438771.
-
Tanner NK, Cech TR. Guanosine binding required for cyclization of the self-splicing intervening sequence ribonucleic acid from Tetrahymena thermophila. Biochemistry. 1987 Jun 16; 26(12):3330-40. PMID: 2443161.
-
Zaug AJ, Been MD, Cech TR. The Tetrahymena ribozyme acts like an RNA restriction endonuclease. Nature. 1986 Dec 4-10; 324(6096):429-33. PMID: 3537808.
-
Cech TR. RNA as an enzyme. Sci Am. 1986 Nov; 255(5):64-75. PMID: 2430331.
-
Been MD, Cech TR. One binding site determines sequence specificity of Tetrahymena pre-rRNA self-splicing, trans-splicing, and RNA enzyme activity. Cell. 1986 Oct 24; 47(2):207-16. PMID: 3021333.
-
Zaug AJ, Cech TR. The Tetrahymena intervening sequence ribonucleic acid enzyme is a phosphotransferase and an acid phosphatase. Biochemistry. 1986 Aug 12; 25(16):4478-82. PMID: 2429688.
-
Bass BL, Cech TR. Ribozyme inhibitors: deoxyguanosine and dideoxyguanosine are competitive inhibitors of self-splicing of the Tetrahymena ribosomal ribonucleic acid precursor. Biochemistry. 1986 Aug 12; 25(16):4473-7. PMID: 3639741.
-
Garriga G, Lambowitz AM, Inoue T, Cech TR. Mechanism of recognition of the 5' splice site in self-splicing group I introns. Nature. 1986 Jul 3-9; 322(6074):86-9. PMID: 3636598.
-
Cech TR. A model for the RNA-catalyzed replication of RNA. Proc Natl Acad Sci U S A. 1986 Jun; 83(12):4360-3. PMID: 2424025.
-
Inoue T, Sullivan FX, Cech TR. New reactions of the ribosomal RNA precursor of Tetrahymena and the mechanism of self-splicing. J Mol Biol. 1986 May 05; 189(1):143-65. PMID: 2431151.
-
Burke JM, Irvine KD, Kaneko KJ, Kerker BJ, Oettgen AB, Tierney WM, Williamson CL, Zaug AJ, Cech TR. Role of conserved sequence elements 9L and 2 in self-splicing of the Tetrahymena ribosomal RNA precursor. Cell. 1986 Apr 25; 45(2):167-76. PMID: 2421916.
-
Zaug AJ, Cech TR. The intervening sequence RNA of Tetrahymena is an enzyme. Science. 1986 Jan 31; 231(4737):470-5. PMID: 3941911.
-
Been MD, Cech TR. Sites of circularization of the Tetrahymena rRNA IVS are determined by sequence and influenced by position and secondary structure. Nucleic Acids Res. 1985 Dec 09; 13(23):8389-408. PMID: 4080546.
-
Inoue T, Sullivan FX, Cech TR. Intermolecular exon ligation of the rRNA precursor of Tetrahymena: oligonucleotides can function as 5' exons. Cell. 1985 Dec; 43(2 Pt 1):431-7. PMID: 3865712.
-
Zaug AJ, Kent JR, Cech TR. Reactions of the intervening sequence of the Tetrahymena ribosomal ribonucleic acid precursor: pH dependence of cyclization and site-specific hydrolysis. Biochemistry. 1985 Oct 22; 24(22):6211-8. PMID: 4084515.
-
Zaug AJ, Cech TR. Oligomerization of intervening sequence RNA molecules in the absence of proteins. Science. 1985 Sep 13; 229(4718):1060-4. PMID: 2412290.
-
Sullivan FX, Cech TR. Reversibility of cyclization of the Tetrahymena rRNA intervening sequence: implication for the mechanism of splice site choice. Cell. 1985 Sep; 42(2):639-48. PMID: 3849344.
-
Price JV, Cech TR. Coupling of Tetrahymena ribosomal RNA splicing to beta-galactosidase expression in Escherichia coli. Science. 1985 May 10; 228(4700):719-22. PMID: 2986286.
-
Price JV, Kieft GL, Kent JR, Sievers EL, Cech TR. Sequence requirements for self-splicing of the Tetrahymena thermophila pre-ribosomal RNA. Nucleic Acids Res. 1985 Mar 25; 13(6):1871-89. PMID: 4000946.
-
Cech TR. Self-splicing RNA: implications for evolution. Int Rev Cytol. 1985; 93:3-22. PMID: 3891660.
-
Gottschling DE, Cech TR. Chromatin structure of the molecular ends of Oxytricha macronuclear DNA: phased nucleosomes and a telomeric complex. Cell. 1984 Sep; 38(2):501-10. PMID: 6432344.
-
Zaug AJ, Kent JR, Cech TR. A labile phosphodiester bond at the ligation junction in a circular intervening sequence RNA. Science. 1984 May 11; 224(4649):574-8. PMID: 6200938.
-
Pardue ML, Fostel JM, Cech TR. DNA-protein interactions in the Drosophila virilis mitochondrial chromosome. Nucleic Acids Res. 1984 Feb 24; 12(4):1991-9. PMID: 6322130.
-
Cech TR. RNA splicing: three themes with variations. Cell. 1983 Oct; 34(3):713-6. PMID: 6354470.
-
Brehm SL, Cech TR. Fate of an intervening sequence ribonucleic acid: excision and cyclization of the Tetrahymena ribosomal ribonucleic acid intervening sequence in vivo. Biochemistry. 1983 May 10; 22(10):2390-7. PMID: 6860634.
-
Palen TE, Cech TR. Transcribed and non-transcribed regions of Tetrahymena ribosomal gene chromatin have different accessibilities to micrococcal nuclease. Nucleic Acids Res. 1983 Apr 11; 11(7):2077-91. PMID: 6300792.
-
Gottschling DE, Palen TE, Cech TR. Different nucleosome spacing in transcribed and non-transcribed regions of the ribosomal RNA gene in Tetrahymena thermophila. Nucleic Acids Res. 1983 Apr 11; 11(7):2093-109. PMID: 6835846.
-
Kruger K, Grabowski PJ, Zaug AJ, Sands J, Gottschling DE, Cech TR. Self-splicing RNA: autoexcision and autocyclization of the ribosomal RNA intervening sequence of Tetrahymena. Cell. 1982 Nov; 31(1):147-57. PMID: 6297745.
-
Zaug AJ, Cech TR. The intervening sequence excised from the ribosomal RNA precursor of Tetrahymena contains a 5-terminal guanosine residue not encoded by the DNA. Nucleic Acids Res. 1982 May 11; 10(9):2823-38. PMID: 7099968.
-
Cech TR, Zaug AJ, Grabowski PJ. In vitro splicing of the ribosomal RNA precursor of Tetrahymena: involvement of a guanosine nucleotide in the excision of the intervening sequence. Cell. 1981 Dec; 27(3 Pt 2):487-96. PMID: 6101203.
-
Cech TR, Brehm SL. Replication of the extrachromosomal ribosomal RNA genes of Tetrahymena thermophilia. Nucleic Acids Res. 1981 Jul 24; 9(14):3531-43. PMID: 7279667.
-
Cech TR. Alkaline gel electrophoresis of deoxyribonucleic acid photoreacted with trimethylpsoralen: rapid and sensitive detection of interstrand cross-links. Biochemistry. 1981 Mar 17; 20(6):1431-7. PMID: 6261794.
-
Grabowski PJ, Zaug AJ, Cech TR. The intervening sequence of the ribosomal RNA precursor is converted to a circular RNA in isolated nuclei of Tetrahymena. Cell. 1981 Feb; 23(2):467-76. PMID: 6162571.
-
Zaug AJ, Cech TR. In vitro splicing of the ribosomal RNA precursor in nuclei of Tetrahymena. Cell. 1980 Feb; 19(2):331-8. PMID: 7357611.
-
Cech T, Potter D, Pardue ML. Electron microscopy of DNA cross-linked with trimethylpsoralen: a probe for chromatin structure. Biochemistry. 1977 Nov 29; 16(24):5313-21. PMID: 921934.
-
Cech T, Pardue ML. Cross-linking of DNA with trimethylpsoralen is a probe for chromatin structure. Cell. 1977 Jul; 11(3):631-40. PMID: 560256.
-
Cech TR, Hearst JE. Organization of highly repeated sequences in mouse main-band DNA. J Mol Biol. 1976 Jan 25; 100(3):227-56. PMID: 768484.
-
Cech TR, Rosenfeld A, Hearst JE. Characterization of the most rapidly renaturing sequences in mouse main-band DNA. J Mol Biol. 1973 Dec 15; 81(3):299-325. PMID: 4767458.