Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
Keywords
Last Name
Institution
Menu

Contact Us
If you have any questions or feedback please contact us.

Thomas R Cech

TitleDistinguished Professor
InstitutionUniversity of Colorado Boulder
DepartmentBiochemistry
Phone303/492-8606
    Other Positions
    TitleDistinguished Professor
    InstitutionUniversity of Colorado Boulder
    DepartmentBiology-MCD Instruction


    Collapse Research 
    Collapse research activities and funding
    R01GM099705     (CECH, THOMAS ROBERT)May 1, 2012 - Jan 31, 2020
    NIH
    TERT Promoter Mutations and Telomerase Reactivation in Cancer Cells
    Role: Principal Investigator
    C06RR030428     (CECH, THOMAS ROBERT)Mar 18, 2010 - Dec 17, 2012
    NIH
    University of Colorado Systems Biotechnology Building
    Role: Principal Investigator
    R01GM028039     (CECH, THOMAS ROBERT)Aug 1, 1980 - May 31, 2011
    NIH
    Telomerase and Telomeres: Structure, Function and Regulation
    Role: Principal Investigator
    R37GM028039     (CECH, THOMAS R)Aug 1, 1980 - Jul 31, 1998
    NIH
    NUCLEIC ACID STRUCTURE AND REACTIVITY
    Role: Principal Investigator
    R01GM025273     (CECH, THOMAS R)Apr 1, 1978 - Mar 31, 1989
    NIH
    CHROMATIN STRUCTURE OF A TRANSCRIPTION UNIT
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Zaug AJ, Goodrich KJ, Song JJ, Sullivan AE, Cech TR. Reconstitution of a telomeric replicon organized by CST. Nature. 2022 08; 608(7924):819-825. PMID: 35831508.
      View in: PubMed
    2. Kraft K, Yost KE, Murphy SE, Magg A, Long Y, Corces MR, Granja JM, Wittler L, Mundlos S, Cech TR, Boettiger AN, Chang HY. Polycomb-mediated genome architecture enables long-range spreading of H3K27 methylation. Proc Natl Acad Sci U S A. 2022 05 31; 119(22):e2201883119. PMID: 35617427.
      View in: PubMed
    3. Cech TR. RNA in biological condensates. RNA. 2022 01; 28(1):1-2. PMID: 34903621.
      View in: PubMed
    4. Zaug AJ, Lim CJ, Olson CL, Carilli MT, Goodrich KJ, Wuttke DS, Cech TR. CST does not evict elongating telomerase but prevents initiation by ssDNA binding. Nucleic Acids Res. 2021 11 18; 49(20):11653-11665. PMID: 34718732.
      View in: PubMed
    5. Dumbovic G, Braunschweig U, Langner HK, Smallegan M, Biayna J, Hass EP, Jastrzebska K, Blencowe B, Cech TR, Caruthers MH, Rinn JL. Publisher Correction: Nuclear compartmentalization of TERT mRNA and TUG1 lncRNA is driven by intron retention. Nat Commun. 2021 Oct 21; 12(1):6189. PMID: 34675241.
      View in: PubMed
    6. Agarwal N, Rinaldetti S, Cheikh BB, Zhou Q, Hass EP, Jones RT, Joshi M, LaBarbera DV, Knott SRV, Cech TR, Theodorescu D. TRIM28 is a transcriptional activator of the mutant TERT promoter in human bladder cancer. Proc Natl Acad Sci U S A. 2021 09 21; 118(38). PMID: 34518220.
      View in: PubMed
    7. Dumbovic G, Braunschweig U, Langner HK, Smallegan M, Biayna J, Hass EP, Jastrzebska K, Blencowe B, Cech TR, Caruthers MH, Rinn JL. Nuclear compartmentalization of TERT mRNA and TUG1 lncRNA is driven by intron retention. Nat Commun. 2021 06 03; 12(1):3308. PMID: 34083519.
      View in: PubMed
    8. Lim CJ, Cech TR. Publisher Correction: Shaping human telomeres: from shelterin and CST complexes to telomeric chromatin organization. Nat Rev Mol Cell Biol. 2021 Apr; 22(4):299. PMID: 33608692.
      View in: PubMed
    9. Lim CJ, Cech TR. Shaping human telomeres: from shelterin and CST complexes to telomeric chromatin organization. Nat Rev Mol Cell Biol. 2021 04; 22(4):283-298. PMID: 33564154.
      View in: PubMed
    10. Long Y, Cech TR. Targeted mutagenesis in human iPSCs using CRISPR genome-editing tools. Methods. 2021 07; 191:44-58. PMID: 33444739.
      View in: PubMed
    11. Youmans DT, Gooding AR, Dowell RD, Cech TR. Competition between PRC2.1 and 2.2 subcomplexes regulates PRC2 chromatin occupancy in human stem cells. Mol Cell. 2021 02 04; 81(3):488-501.e9. PMID: 33338397.
      View in: PubMed
    12. Cornejo C, Hauser A, Beenken L, Cech T, Rigling D. Cryphonectria carpinicola sp. nov. Associated with hornbeam decline in Europe. Fungal Biol. 2021 05; 125(5):347-356. PMID: 33910676.
      View in: PubMed
    13. Rowland TJ, Bonham AJ, Cech TR. Allele-specific proximal promoter hypomethylation of the telomerase reverse transcriptase gene (TERT) associates with TERT expression in multiple cancers. Mol Oncol. 2020 10; 14(10):2358-2374. PMID: 33245585.
      View in: PubMed
    14. Long Y, Hwang T, Gooding AR, Goodrich KJ, Rinn JL, Cech TR. RNA is essential for PRC2 chromatin occupancy and function in human pluripotent stem cells. Nat Genet. 2020 09; 52(9):931-938. PMID: 32632336.
      View in: PubMed
    15. Lim CJ, Barbour AT, Zaug AJ, Goodrich KJ, McKay AE, Wuttke DS, Cech TR. The structure of human CST reveals a decameric assembly bound to telomeric DNA. Science. 2020 06 05; 368(6495):1081-1085. PMID: 32499435.
      View in: PubMed
    16. Stern JL, Paucek RD, Huang FW, Ghandi M, Nwumeh R, Costello JC, Cech TR. Allele-Specific DNA Methylation and Its Interplay with Repressive Histone Marks at Promoter-Mutant TERT Genes. Cell Rep. 2020 May 26; 31(8):107718. PMID: 32460014.
      View in: PubMed
    17. Stern JL, Hibshman G, Hu K, Ferrara SE, Costello JC, Kim W, Tamayo P, Cech TR, Huang FW. Mesenchymal and MAPK Expression Signatures Associate with Telomerase Promoter Mutations in Multiple Cancers. Mol Cancer Res. 2020 07; 18(7):1050-1062. PMID: 32276990.
      View in: PubMed
    18. Heenan PR, Wang X, Gooding AR, Cech TR, Perkins TT. Bending and looping of long DNA by Polycomb repressive complex 2 revealed by AFM imaging in liquid. Nucleic Acids Res. 2020 04 06; 48(6):2969-2981. PMID: 32043141.
      View in: PubMed
    19. Wang X, Long Y, Paucek RD, Gooding AR, Lee T, Burdorf RM, Cech TR. Regulation of histone methylation by automethylation of PRC2. Genes Dev. 2019 10 01; 33(19-20):1416-1427. PMID: 31488576.
      View in: PubMed
    20. Rowland TJ, Dumbovic G, Hass EP, Rinn JL, Cech TR. Single-cell imaging reveals unexpected heterogeneity of telomerase reverse transcriptase expression across human cancer cell lines. Proc Natl Acad Sci U S A. 2019 09 10; 116(37):18488-18497. PMID: 31451652.
      View in: PubMed
    21. Wang X, Goodrich KJ, Conlon EG, Gao J, Erbse AH, Manley JL, Cech TR. C9orf72 and triplet repeat disorder RNAs: G-quadruplex formation, binding to PRC2 and implications for disease mechanisms. RNA. 2019 08; 25(8):935-947. PMID: 31048495.
      View in: PubMed
    22. Greenwood J, Patel H, Cech TR, Cooper JP. Fission yeast telosomes: non-canonical histone-containing chromatin structures dependent on shelterin and RNA. Nucleic Acids Res. 2018 09 28; 46(17):8865-8875. PMID: 29992245.
      View in: PubMed
    23. Cech TR. A Lifelong Passion for All Things Ribonucleic. Cell. 2018 09 20; 175(1):14-17. PMID: 30217358.
      View in: PubMed
    24. Shoffner GM, Wang R, Podell E, Cech TR, Guo F. In Crystallo Selection to Establish New RNA Crystal Contacts. Structure. 2018 09 04; 26(9):1275-1283.e3. PMID: 29910185.
      View in: PubMed
    25. Youmans DT, Schmidt JC, Cech TR. Live-cell imaging reveals the dynamics of PRC2 and recruitment to chromatin by SUZ12-associated subunits. Genes Dev. 2018 06 01; 32(11-12):794-805. PMID: 29891558.
      View in: PubMed
    26. Schmidt JC, Zaug AJ, Kufer R, Cech TR. Dynamics of human telomerase recruitment depend on template-telomere base pairing. Mol Biol Cell. 2018 Apr 01; 29(7):869-880. PMID: 29386295.
      View in: PubMed
    27. Stern JL, Paucek RD, Huang FW, Ghandi M, Nwumeh R, Costello JC, Cech TR. Allele-Specific DNA Methylation and Its Interplay with Repressive Histone Marks at Promoter-Mutant TERT Genes. Cell Rep. 2017 12 26; 21(13):3700-3707. PMID: 29281820.
      View in: PubMed
    28. Long Y, Bolanos B, Gong L, Liu W, Goodrich KJ, Yang X, Chen S, Gooding AR, Maegley KA, Gajiwala KS, Brooun A, Cech TR, Liu X. Conserved RNA-binding specificity of polycomb repressive complex 2 is achieved by dispersed amino acid patches in EZH2. Elife. 2017 11 29; 6. PMID: 29185984.
      View in: PubMed
    29. Wang X, Paucek RD, Gooding AR, Brown ZZ, Ge EJ, Muir TW, Cech TR. Molecular analysis of PRC2 recruitment to DNA in chromatin and its inhibition by RNA. Nat Struct Mol Biol. 2017 Dec; 24(12):1028-1038. PMID: 29058709.
      View in: PubMed
    30. Lim CJ, Zaug AJ, Kim HJ, Cech TR. Reconstitution of human shelterin complexes reveals unexpected stoichiometry and dual pathways to enhance telomerase processivity. Nat Commun. 2017 10 20; 8(1):1075. PMID: 29057866.
      View in: PubMed
    31. Jung T, Jung MH, Cacciola SO, Cech T, Bakonyi J, Seress D, Mosca S, Schena L, Seddaiu S, Pane A, di San Lio GM, Maia C, Cravador A, Franceschini A, Scanu B. Multiple new cryptic pathogenic Phytophthora species from Fagaceae forests in Austria, Italy and Portugal. IMA Fungus. 2017 Dec; 8(2):219-244. PMID: 29242773.
      View in: PubMed
    32. Long Y, Wang X, Youmans DT, Cech TR. How do lncRNAs regulate transcription? Sci Adv. 2017 09; 3(9):eaao2110. PMID: 28959731.
      View in: PubMed
    33. Wang X, Goodrich KJ, Gooding AR, Naeem H, Archer S, Paucek RD, Youmans DT, Cech TR, Davidovich C. Targeting of Polycomb Repressive Complex 2 to RNA by Short Repeats of Consecutive Guanines. Mol Cell. 2017 Mar 16; 65(6):1056-1067.e5. PMID: 28306504.
      View in: PubMed
    34. Goldfarb KC, Cech TR. Targeted CRISPR disruption reveals a role for RNase MRP RNA in human preribosomal RNA processing. Genes Dev. 2017 01 01; 31(1):59-71. PMID: 28115465.
      View in: PubMed
    35. Dickinson DL, Cazier J, Cech T. A practical validation study of a commercial accelerometer using good and poor sleepers. Health Psychol Open. 2016 Jul; 3(2):2055102916679012. PMID: 28815052.
      View in: PubMed
    36. Schmidt JC, Zaug AJ, Cech TR. Live Cell Imaging Reveals the Dynamics of Telomerase Recruitment to Telomeres. Cell. 2016 Aug 25; 166(5):1188-1197.e9. PMID: 27523609.
      View in: PubMed
    37. Lu Z, Zhang QC, Lee B, Flynn RA, Smith MA, Robinson JT, Davidovich C, Gooding AR, Goodrich KJ, Mattick JS, Mesirov JP, Cech TR, Chang HY. RNA Duplex Map in Living Cells Reveals Higher-Order Transcriptome Structure. Cell. 2016 May 19; 165(5):1267-1279. PMID: 27180905.
      View in: PubMed
    38. Shukla S, Schmidt JC, Goldfarb KC, Cech TR, Parker R. Inhibition of telomerase RNA decay rescues telomerase deficiency caused by dyskerin or PARN defects. Nat Struct Mol Biol. 2016 Apr; 23(4):286-92. PMID: 26950371.
      View in: PubMed
    39. Davidovich C, Cech TR. The recruitment of chromatin modifiers by long noncoding RNAs: lessons from PRC2. RNA. 2015 Dec; 21(12):2007-22. PMID: 26574518.
      View in: PubMed
    40. Xi L, Schmidt JC, Zaug AJ, Ascarrunz DR, Cech TR. A novel two-step genome editing strategy with CRISPR-Cas9 provides new insights into telomerase action and TERT gene expression. Genome Biol. 2015 Nov 10; 16:231. PMID: 26553065.
      View in: PubMed
    41. Xi L, Cech TR. Protein-RNA interaction restricts telomerase from running through the stop sign. Nat Struct Mol Biol. 2015 Nov; 22(11):835-6. PMID: 26581514.
      View in: PubMed
    42. Stern JL, Theodorescu D, Vogelstein B, Papadopoulos N, Cech TR. Mutation of the TERT promoter, switch to active chromatin, and monoallelic TERT expression in multiple cancers. Genes Dev. 2015 Nov 01; 29(21):2219-24. PMID: 26515115.
      View in: PubMed
    43. Wang X, Schwartz JC, Cech TR. Nucleic acid-binding specificity of human FUS protein. Nucleic Acids Res. 2015 Sep 03; 43(15):7535-43. PMID: 26150427.
      View in: PubMed
    44. Schmidt JC, Cech TR. Human telomerase: biogenesis, trafficking, recruitment, and activation. Genes Dev. 2015 Jun 01; 29(11):1095-105. PMID: 26063571.
      View in: PubMed
    45. Cech TR. RNA World research-still evolving. RNA. 2015 Apr; 21(4):474-5. PMID: 25780099.
      View in: PubMed
    46. Borah S, Xi L, Zaug AJ, Powell NM, Dancik GM, Cohen SB, Costello JC, Theodorescu D, Cech TR. Cancer. TERT promoter mutations and telomerase reactivation in urothelial cancer. Science. 2015 Feb 27; 347(6225):1006-10. PMID: 25722414.
      View in: PubMed
    47. Dalby AB, Hofr C, Cech TR. Contributions of the TEL-patch amino acid cluster on TPP1 to telomeric DNA synthesis by human telomerase. J Mol Biol. 2015 Mar 27; 427(6 Pt B):1291-1303. PMID: 25623306.
      View in: PubMed
    48. Davidovich C, Wang X, Cifuentes-Rojas C, Goodrich KJ, Gooding AR, Lee JT, Cech TR. Toward a consensus on the binding specificity and promiscuity of PRC2 for RNA. Mol Cell. 2015 Feb 05; 57(3):552-8. PMID: 25601759.
      View in: PubMed
    49. Schwartz JC, Cech TR, Parker RR. Biochemical Properties and Biological Functions of FET Proteins. Annu Rev Biochem. 2015; 84:355-79. PMID: 25494299.
      View in: PubMed
    50. Tang M, Li Y, Zhang Y, Chen Y, Huang W, Wang D, Zaug AJ, Liu D, Zhao Y, Cech TR, Ma W, Songyang Z. Disease mutant analysis identifies a new function of DAXX in telomerase regulation and telomere maintenance. J Cell Sci. 2015 Jan 15; 128(2):331-41. PMID: 25416818.
      View in: PubMed
    51. Watson-Capps JJ, Cech TR. Academia and industry: Companies on campus. Nature. 2014 Oct 16; 514(7522):297-8. PMID: 25318508.
      View in: PubMed
    52. Schmidt JC, Dalby AB, Cech TR. Identification of human TERT elements necessary for telomerase recruitment to telomeres. Elife. 2014 Oct 01; 3. PMID: 25271372.
      View in: PubMed
    53. Schwartz JC, Podell ER, Han SS, Berry JD, Eggan KC, Cech TR. FUS is sequestered in nuclear aggregates in ALS patient fibroblasts. Mol Biol Cell. 2014 Sep 01; 25(17):2571-8. PMID: 25009283.
      View in: PubMed
    54. Davidovich C, Goodrich KJ, Gooding AR, Cech TR. A dimeric state for PRC2. Nucleic Acids Res. 2014 Aug; 42(14):9236-48. PMID: 24992961.
      View in: PubMed
    55. Xi L, Cech TR. Inventory of telomerase components in human cells reveals multiple subpopulations of hTR and hTERT. Nucleic Acids Res. 2014 Jul; 42(13):8565-77. PMID: 24990373.
      View in: PubMed
    56. Cech TR, Steitz JA. The noncoding RNA revolution-trashing old rules to forge new ones. Cell. 2014 Mar 27; 157(1):77-94. PMID: 24679528.
      View in: PubMed
    57. McKay DB, Xi L, Barthel KKB, Cech TR. Structure and function of steroid receptor RNA activator protein, the proposed partner of SRA noncoding RNA. J Mol Biol. 2014 Apr 17; 426(8):1766-1785. PMID: 24486609.
      View in: PubMed
    58. Schwartz JC, Wang X, Podell ER, Cech TR. RNA seeds higher-order assembly of FUS protein. Cell Rep. 2013 Nov 27; 5(4):918-25. PMID: 24268778.
      View in: PubMed
    59. Theodorescu D, Cech TR. Telomerase in bladder cancer: back to a better future? Eur Urol. 2014 Feb; 65(2):370-1. PMID: 24184027.
      View in: PubMed
    60. Nakashima M, Nandakumar J, Sullivan KD, Espinosa JM, Cech TR. Inhibition of telomerase recruitment and cancer cell death. J Biol Chem. 2013 Nov 15; 288(46):33171-80. PMID: 24097987.
      View in: PubMed
    61. Davidovich C, Zheng L, Goodrich KJ, Cech TR. Promiscuous RNA binding by Polycomb repressive complex 2. Nat Struct Mol Biol. 2013 Nov; 20(11):1250-7. PMID: 24077223.
      View in: PubMed
    62. Goldfarb KC, Cech TR. 3' terminal diversity of MRP RNA and other human noncoding RNAs revealed by deep sequencing. BMC Mol Biol. 2013 Sep 21; 14:23. PMID: 24053768.
      View in: PubMed
    63. Zaug AJ, Crary SM, Jesse Fioravanti M, Campbell K, Cech TR. Many disease-associated variants of hTERT retain high telomerase enzymatic activity. Nucleic Acids Res. 2013 Oct; 41(19):8969-78. PMID: 23901009.
      View in: PubMed
    64. Dalby AB, Goodrich KJ, Pfingsten JS, Cech TR. RNA recognition by the DNA end-binding Ku heterodimer. RNA. 2013 Jun; 19(6):841-51. PMID: 23610127.
      View in: PubMed
    65. Nandakumar J, Cech TR. Finding the end: recruitment of telomerase to telomeres. Nat Rev Mol Cell Biol. 2013 Feb; 14(2):69-82. PMID: 23299958.
      View in: PubMed
    66. Schwartz JC, Ebmeier CC, Podell ER, Heimiller J, Taatjes DJ, Cech TR. FUS binds the CTD of RNA polymerase II and regulates its phosphorylation at Ser2. Genes Dev. 2012 Dec 15; 26(24):2690-5. PMID: 23249733.
      View in: PubMed
    67. Cech TR. How a chemist looks at RNA. Angew Chem Int Ed Engl. 2013 Jan 02; 52(1):75-8. PMID: 23203538.
      View in: PubMed
    68. Berman AJ, Cech TR. SnapShot: telomeres and telomerase. Cell. 2012 Nov 21; 151(5):1138-1138.e1. PMID: 23178129.
      View in: PubMed
    69. Nandakumar J, Bell CF, Weidenfeld I, Zaug AJ, Leinwand LA, Cech TR. The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity. Nature. 2012 Dec 13; 492(7428):285-9. PMID: 23103865.
      View in: PubMed
    70. Santini A, Ghelardini L, De Pace C, Desprez-Loustau ML, Capretti P, Chandelier A, Cech T, Chira D, Diamandis S, Gaitniekis T, Hantula J, Holdenrieder O, Jankovsky L, Jung T, Jurc D, Kirisits T, Kunca A, Lygis V, Malecka M, Marcais B, Schmitz S, Schumacher J, Solheim H, Solla A, Szabò I, Tsopelas P, Vannini A, Vettraino AM, Webber J, Woodward S, Stenlid J. Biogeographical patterns and determinants of invasion by forest pathogens in Europe. New Phytol. 2013 Jan; 197(1):238-250. PMID: 23057437.
      View in: PubMed
    71. Cech TR. The RNA worlds in context. Cold Spring Harb Perspect Biol. 2012 Jul 01; 4(7):a006742. PMID: 21441585.
      View in: PubMed
    72. Goldfarb KC, Borah S, Cech TR. RNase P branches out from RNP to protein: organelle-triggered diversification? Genes Dev. 2012 May 15; 26(10):1005-9. PMID: 22588715.
      View in: PubMed
    73. Pfingsten JS, Goodrich KJ, Taabazuing C, Ouenzar F, Chartrand P, Cech TR. Mutually exclusive binding of telomerase RNA and DNA by Ku alters telomerase recruitment model. Cell. 2012 Mar 02; 148(5):922-32. PMID: 22365814.
      View in: PubMed
    74. Berman AJ, Akiyama BM, Stone MD, Cech TR. The RNA accordion model for template positioning by telomerase RNA during telomeric DNA synthesis. Nat Struct Mol Biol. 2011 Nov 20; 18(12):1371-5. PMID: 22101935.
      View in: PubMed
    75. Nandakumar J, Cech TR. DNA-induced dimerization of the single-stranded DNA binding telomeric protein Pot1 from Schizosaccharomyces pombe. Nucleic Acids Res. 2012 Jan; 40(1):235-44. PMID: 21911358.
      View in: PubMed
    76. Batista LF, Pech MF, Zhong FL, Nguyen HN, Xie KT, Zaug AJ, Crary SM, Choi J, Sebastiano V, Cherry A, Giri N, Wernig M, Alter BP, Cech TR, Savage SA, Reijo Pera RA, Artandi SE. Telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cells. Nature. 2011 May 22; 474(7351):399-402. PMID: 21602826.
      View in: PubMed
    77. Taylor DJ, Podell ER, Taatjes DJ, Cech TR. Multiple POT1-TPP1 proteins coat and compact long telomeric single-stranded DNA. J Mol Biol. 2011 Jul 01; 410(1):10-7. PMID: 21596049.
      View in: PubMed
    78. Zappulla DC, Goodrich KJ, Arthur JR, Gurski LA, Denham EM, Stellwagen AE, Cech TR. Ku can contribute to telomere lengthening in yeast at multiple positions in the telomerase RNP. RNA. 2011 Feb; 17(2):298-311. PMID: 21177376.
      View in: PubMed
    79. Berman AJ, Gooding AR, Cech TR. Tetrahymena telomerase protein p65 induces conformational changes throughout telomerase RNA (TER) and rescues telomerase reverse transcriptase and TER assembly mutants. Mol Cell Biol. 2010 Oct; 30(20):4965-76. PMID: 20713447.
      View in: PubMed
    80. Talgø V, Chastagner G, Thomsen IM, Cech T, Riley K, Lange K, Klemsdal SS, Stensvand A. Sydowia polyspora associated with current season needle necrosis (CSNN) on true fir (Abies spp.). Fungal Biol. 2010 Jul; 114(7):545-54. PMID: 20943166.
      View in: PubMed
    81. Zaug AJ, Podell ER, Nandakumar J, Cech TR. Functional interaction between telomere protein TPP1 and telomerase. Genes Dev. 2010 Mar 15; 24(6):613-22. PMID: 20231318.
      View in: PubMed
    82. Qiao F, Goodrich KJ, Cech TR. Engineering cis-telomerase RNAs that add telomeric repeats to themselves. Proc Natl Acad Sci U S A. 2010 Mar 16; 107(11):4914-8. PMID: 20194781.
      View in: PubMed
    83. Latrick CM, Cech TR. POT1-TPP1 enhances telomerase processivity by slowing primer dissociation and aiding translocation. EMBO J. 2010 Mar 03; 29(5):924-33. PMID: 20094033.
      View in: PubMed
    84. Nandakumar J, Podell ER, Cech TR. How telomeric protein POT1 avoids RNA to achieve specificity for single-stranded DNA. Proc Natl Acad Sci U S A. 2010 Jan 12; 107(2):651-6. PMID: 20080730.
      View in: PubMed
    85. Cech TR. Evolution of biological catalysis: ribozyme to RNP enzyme. Cold Spring Harb Symp Quant Biol. 2009; 74:11-6. PMID: 19850851.
      View in: PubMed
    86. Andrews N, Burris JE, Cech TR, Coller BS, Crowley WF, Gallin EK, Kelner KL, Kirch DG, Leshner AI, Morris CD, Nguyen FT, Oates J, Sung NS. Translational careers. Science. 2009 May 15; 324(5929):855. PMID: 19443750.
      View in: PubMed
    87. Cech TR. Crawling out of the RNA world. Cell. 2009 Feb 20; 136(4):599-602. PMID: 19239881.
      View in: PubMed
    88. Vicens Q, Cech TR. A natural ribozyme with 3',5' RNA ligase activity. Nat Chem Biol. 2009 Feb; 5(2):97-9. PMID: 19125157.
      View in: PubMed
    89. Zappulla DC, Roberts JN, Goodrich KJ, Cech TR, Wuttke DS. Inhibition of yeast telomerase action by the telomeric ssDNA-binding protein, Cdc13p. Nucleic Acids Res. 2009 Feb; 37(2):354-67. PMID: 19043074.
      View in: PubMed
    90. Vicens Q, Paukstelis PJ, Westhof E, Lambowitz AM, Cech TR. Toward predicting self-splicing and protein-facilitated splicing of group I introns. RNA. 2008 Oct; 14(10):2013-29. PMID: 18768647.
      View in: PubMed
    91. Zaug AJ, Podell ER, Cech TR. Mutation in TERT separates processivity from anchor-site function. Nat Struct Mol Biol. 2008 Aug; 15(8):870-2. PMID: 18641663.
      View in: PubMed
    92. Qiao F, Cech TR. Triple-helix structure in telomerase RNA contributes to catalysis. Nat Struct Mol Biol. 2008 Jun; 15(6):634-40. PMID: 18500353.
      View in: PubMed
    93. Mozdy AD, Podell ER, Cech TR. Multiple yeast genes, including Paf1 complex genes, affect telomere length via telomerase RNA abundance. Mol Cell Biol. 2008 Jun; 28(12):4152-61. PMID: 18411302.
      View in: PubMed
    94. Arai K, Cech T, Chameau JL, Horn P, Mattaj I, Potocnik J, Wiley J. The future of research universities. Is the model of research-intensive universities still valid at the beginning of the twenty-first century? EMBO Rep. 2007 Sep; 8(9):804-10. PMID: 17767189.
      View in: PubMed
    95. Cech TR. On the occasion of the 25th anniversary of the discovery of catalytic RNA. Biol Chem. 2007 Jul; 388(7):661-2. PMID: 17570816.
      View in: PubMed
    96. Vicens Q, Gooding AR, Laederach A, Cech TR. Local RNA structural changes induced by crystallization are revealed by SHAPE. RNA. 2007 Apr; 13(4):536-48. PMID: 17299128.
      View in: PubMed
    97. Wang F, Podell ER, Zaug AJ, Yang Y, Baciu P, Cech TR, Lei M. The POT1-TPP1 telomere complex is a telomerase processivity factor. Nature. 2007 Feb 01; 445(7127):506-10. PMID: 17237768.
      View in: PubMed
    98. Mozdy AD, Cech TR. Low abundance of telomerase in yeast: implications for telomerase haploinsufficiency. RNA. 2006 Sep; 12(9):1721-37. PMID: 16894218.
      View in: PubMed
    99. Jacobs SA, Podell ER, Cech TR. Crystal structure of the essential N-terminal domain of telomerase reverse transcriptase. Nat Struct Mol Biol. 2006 Mar; 13(3):218-25. PMID: 16462747.
      View in: PubMed
    100. Guo F, Gooding AR, Cech TR. Comparison of crystal structure interactions and thermodynamics for stabilizing mutations in the Tetrahymena ribozyme. RNA. 2006 Mar; 12(3):387-95. PMID: 16431981.
      View in: PubMed
    101. Zappulla DC, Cech TR. RNA as a flexible scaffold for proteins: yeast telomerase and beyond. Cold Spring Harb Symp Quant Biol. 2006; 71:217-24. PMID: 17381300.
      View in: PubMed
    102. Cech T, Kennedy D. Doing more for Kate. Science. 2005 Dec 16; 310(5755):1741. PMID: 16357228.
      View in: PubMed
    103. Vicens Q, Cech TR. Atomic level architecture of group I introns revealed. Trends Biochem Sci. 2006 Jan; 31(1):41-51. PMID: 16356725.
      View in: PubMed
    104. Zappulla DC, Goodrich K, Cech TR. A miniature yeast telomerase RNA functions in vivo and reconstitutes activity in vitro. Nat Struct Mol Biol. 2005 Dec; 12(12):1072-7. PMID: 16299517.
      View in: PubMed
    105. Cech TR. Fostering innovation and discovery in biomedical research. JAMA. 2005 Sep 21; 294(11):1390-3. PMID: 16174699.
      View in: PubMed
    106. Jacobs SA, Podell ER, Wuttke DS, Cech TR. Soluble domains of telomerase reverse transcriptase identified by high-throughput screening. Protein Sci. 2005 Aug; 14(8):2051-8. PMID: 16046627.
      View in: PubMed
    107. Zaug AJ, Podell ER, Cech TR. Human POT1 disrupts telomeric G-quadruplexes allowing telomerase extension in vitro. Proc Natl Acad Sci U S A. 2005 Aug 02; 102(31):10864-9. PMID: 16043710.
      View in: PubMed
    108. Opresko PL, Mason PA, Podell ER, Lei M, Hickson ID, Cech TR, Bohr VA. POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates. J Biol Chem. 2005 Sep 16; 280(37):32069-80. PMID: 16030011.
      View in: PubMed
    109. Lei M, Zaug AJ, Podell ER, Cech TR. Switching human telomerase on and off with hPOT1 protein in vitro. J Biol Chem. 2005 May 27; 280(21):20449-56. PMID: 15792951.
      View in: PubMed
    110. Mandell JG, Bähler J, Volpe TA, Martienssen RA, Cech TR. Global expression changes resulting from loss of telomeric DNA in fission yeast. Genome Biol. 2005; 6(1):R1. PMID: 15642092.
      View in: PubMed
    111. Mandell JG, Goodrich KJ, Bähler J, Cech TR. Expression of a RecQ helicase homolog affects progression through crisis in fission yeast lacking telomerase. J Biol Chem. 2005 Feb 18; 280(7):5249-57. PMID: 15591066.
      View in: PubMed
    112. Cech TR, Rubin GM. Nurturing interdisciplinary research. Nat Struct Mol Biol. 2004 Dec; 11(12):1166-9. PMID: 15578058.
      View in: PubMed
    113. Lei M, Podell ER, Cech TR. Structure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protection. Nat Struct Mol Biol. 2004 Dec; 11(12):1223-9. PMID: 15558049.
      View in: PubMed
    114. Guo F, Gooding AR, Cech TR. Structure of the Tetrahymena ribozyme: base triple sandwich and metal ion at the active site. Mol Cell. 2004 Nov 05; 16(3):351-62. PMID: 15525509.
      View in: PubMed
    115. Cech TR. Self-splicing and enzymatic activity of an intervening sequence RNA from Tetrahymena. Biosci Rep. 2004 Aug-Oct; 24(4-5):362-85. PMID: 16134019.
      View in: PubMed
    116. Aigner S, Cech TR. The Euplotes telomerase subunit p43 stimulates enzymatic activity and processivity in vitro. RNA. 2004 Jul; 10(7):1108-18. PMID: 15208446.
      View in: PubMed
    117. Zappulla DC, Cech TR. Yeast telomerase RNA: a flexible scaffold for protein subunits. Proc Natl Acad Sci U S A. 2004 Jul 06; 101(27):10024-9. PMID: 15226497.
      View in: PubMed
    118. Cech TR, Bond E. Managing your own lab. Science. 2004 Jun 18; 304(5678):1717. PMID: 15205494.
      View in: PubMed
    119. Cech TR. RNA finds a simpler way. Nature. 2004 Mar 18; 428(6980):263-4. PMID: 15029175.
      View in: PubMed
    120. Cech TR. Beginning to understand the end of the chromosome. Cell. 2004 Jan 23; 116(2):273-9. PMID: 14744437.
      View in: PubMed
    121. Lei M, Podell ER, Baumann P, Cech TR. DNA self-recognition in the structure of Pot1 bound to telomeric single-stranded DNA. Nature. 2003 Nov 13; 426(6963):198-203. PMID: 14614509.
      View in: PubMed
    122. Seto AG, Umansky K, Tzfati Y, Zaug AJ, Blackburn EH, Cech TR. A template-proximal RNA paired element contributes to Saccharomyces cerevisiae telomerase activity. RNA. 2003 Nov; 9(11):1323-32. PMID: 14561882.
      View in: PubMed
    123. Bryan TM, Goodrich KJ, Cech TR. Tetrahymena telomerase is active as a monomer. Mol Biol Cell. 2003 Dec; 14(12):4794-804. PMID: 13679509.
      View in: PubMed
    124. Classen S, Lyons D, Cech TR, Schultz SC. Sequence-specific and 3'-end selective single-strand DNA binding by the Oxytricha nova telomere end binding protein alpha subunit. Biochemistry. 2003 Aug 12; 42(31):9269-77. PMID: 12899613.
      View in: PubMed
    125. Colgin LM, Baran K, Baumann P, Cech TR, Reddel RR. Human POT1 facilitates telomere elongation by telomerase. Curr Biol. 2003 May 27; 13(11):942-6. PMID: 12781132.
      View in: PubMed
    126. Aigner S, Postberg J, Lipps HJ, Cech TR. The Euplotes La motif protein p43 has properties of a telomerase-specific subunit. Biochemistry. 2003 May 20; 42(19):5736-47. PMID: 12741831.
      View in: PubMed
    127. Cech TR, Eddy SR, Eisenberg D, Hersey K, Holtzman SH, Poste GH, Raikhel NV, Scheller RH, Singer DB, Waltham MC. Sharing publication-related data and materials: responsibilities of authorship in the life sciences. Plant Physiol. 2003 May; 132(1):19-24. PMID: 12746507.
      View in: PubMed
    128. Förstemann K, Zaug AJ, Cech TR, Lingner J. Yeast telomerase is specialized for C/A-rich RNA templates. Nucleic Acids Res. 2003 Mar 15; 31(6):1646-55. PMID: 12626706.
      View in: PubMed
    129. Cech TR. Rebalancing teaching and research. Science. 2003 Jan 10; 299(5604):165. PMID: 12522218.
      View in: PubMed
    130. Friedman KL, Heit JJ, Long DM, Cech TR. N-terminal domain of yeast telomerase reverse transcriptase: recruitment of Est3p to the telomerase complex. Mol Biol Cell. 2003 Jan; 14(1):1-13. PMID: 12529422.
      View in: PubMed
    131. Lei M, Baumann P, Cech TR. Cooperative binding of single-stranded telomeric DNA by the Pot1 protein of Schizosaccharomyces pombe. Biochemistry. 2002 Dec 10; 41(49):14560-8. PMID: 12463756.
      View in: PubMed
    132. Guo F, Cech TR. Evolution of Tetrahymena ribozyme mutants with increased structural stability. Nat Struct Biol. 2002 Nov; 9(11):855-61. PMID: 12368901.
      View in: PubMed
    133. Seto AG, Livengood AJ, Tzfati Y, Blackburn EH, Cech TR. A bulged stem tethers Est1p to telomerase RNA in budding yeast. Genes Dev. 2002 Nov 01; 16(21):2800-12. PMID: 12414733.
      View in: PubMed
    134. Baumann P, Podell E, Cech TR. Human Pot1 (protection of telomeres) protein: cytolocalization, gene structure, and alternative splicing. Mol Cell Biol. 2002 Nov; 22(22):8079-87. PMID: 12391173.
      View in: PubMed
    135. Cech TR. Ribozymes, the first 20 years. Biochem Soc Trans. 2002 Nov; 30(Pt 6):1162-6. PMID: 12440996.
      View in: PubMed
    136. Doudna JA, Cech TR. The chemical repertoire of natural ribozymes. Nature. 2002 Jul 11; 418(6894):222-8. PMID: 12110898.
      View in: PubMed
    137. Guo F, Cech TR. In vivo selection of better self-splicing introns in Escherichia coli: the role of the P1 extension helix of the Tetrahymena intron. RNA. 2002 May; 8(5):647-58. PMID: 12022231.
      View in: PubMed
    138. Livengood AJ, Zaug AJ, Cech TR. Essential regions of Saccharomyces cerevisiae telomerase RNA: separate elements for Est1p and Est2p interaction. Mol Cell Biol. 2002 Apr; 22(7):2366-74. PMID: 11884619.
      View in: PubMed
    139. Jarstfer MB, Cech TR. Effects of nucleotide analogues on Euplotes aediculatus telomerase processivity: evidence for product-assisted translocation. Biochemistry. 2002 Jan 08; 41(1):151-61. PMID: 11772012.
      View in: PubMed
    140. Cech TR. HHMI's attention to Wiley's lab staff. Science. 2002 Jan 04; 295(5552):43. PMID: 11780644.
      View in: PubMed
    141. Cech T. Funding above and beyond scientific research. An interview with Thomas R. Cech, President of the Howard Hughes Medical Institute in Chevy Chase, MD. Interviewed by Holger Breithaupt. EMBO Rep. 2001 Sep; 2(9):751-4. PMID: 11559582.
      View in: PubMed
    142. Cech TR, Egan LW, Doyle C, Gallin E, Lichtman MA, Queenan CJ, Sung N. The biomedical research bottleneck. Science. 2001 Jul 27; 293(5530):573. PMID: 11474070.
      View in: PubMed
    143. Sperger JM, Cech TR. A stem-loop of Tetrahymena telomerase RNA distant from the template potentiates RNA folding and telomerase activity. Biochemistry. 2001 Jun 19; 40(24):7005-16. PMID: 11401544.
      View in: PubMed
    144. Baumann P, Cech TR. Pot1, the putative telomere end-binding protein in fission yeast and humans. Science. 2001 May 11; 292(5519):1171-5. PMID: 11349150.
      View in: PubMed
    145. Cohen SB, Cech TR. Engineering disulfide cross-links in RNA using thiol-disulfide interchange chemistry. Curr Protoc Nucleic Acid Chem. 2001 May; Chapter 5:Unit 5.1. PMID: 18428857.
      View in: PubMed
    146. Juneau K, Podell E, Harrington DJ, Cech TR. Structural basis of the enhanced stability of a mutant ribozyme domain and a detailed view of RNA--solvent interactions. Structure. 2001 Mar 07; 9(3):221-31. PMID: 11286889.
      View in: PubMed
    147. Cech TR, Leonard JS. Science and business. Conflicts of interest--moving beyond disclosure. Science. 2001 Feb 09; 291(5506):989. PMID: 11232584.
      View in: PubMed
    148. Silverman SK, Cech TR. An early transition state for folding of the P4-P6 RNA domain. RNA. 2001 Feb; 7(2):161-6. PMID: 11233973.
      View in: PubMed
    149. Aigner S, Lingner J, Goodrich KJ, Grosshans CA, Shevchenko A, Mann M, Cech TR. Euplotes telomerase contains an La motif protein produced by apparent translational frameshifting. EMBO J. 2000 Nov 15; 19(22):6230-9. PMID: 11080168.
      View in: PubMed
    150. Silverman SK, Deras ML, Woodson SA, Scaringe SA, Cech TR. Multiple folding pathways for the P4-P6 RNA domain. Biochemistry. 2000 Oct 10; 39(40):12465-75. PMID: 11015228.
      View in: PubMed
    151. Baumann P, Cech TR. Protection of telomeres by the Ku protein in fission yeast. Mol Biol Cell. 2000 Oct; 11(10):3265-75. PMID: 11029034.
      View in: PubMed
    152. Cech TR. Structural biology. The ribosome is a ribozyme. Science. 2000 Aug 11; 289(5481):878-9. PMID: 10960319.
      View in: PubMed
    153. Bryan TM, Goodrich KJ, Cech TR. A mutant of Tetrahymena telomerase reverse transcriptase with increased processivity. J Biol Chem. 2000 Aug 04; 275(31):24199-207. PMID: 10807925.
      View in: PubMed
    154. Bryan TM, Goodrich KJ, Cech TR. Telomerase RNA bound by protein motifs specific to telomerase reverse transcriptase. Mol Cell. 2000 Aug; 6(2):493-9. PMID: 10983995.
      View in: PubMed
    155. Haering CH, Nakamura TM, Baumann P, Cech TR. Analysis of telomerase catalytic subunit mutants in vivo and in vitro in Schizosaccharomycespombe. Proc Natl Acad Sci U S A. 2000 Jun 06; 97(12):6367-72. PMID: 10829083.
      View in: PubMed
    156. Silverman SK, Zheng M, Wu M, Tinoco I, Cech TR. Quantifying the energetic interplay of RNA tertiary and secondary structure interactions. RNA. 1999 Dec; 5(12):1665-74. PMID: 10606276.
      View in: PubMed
    157. Hagen M, Cech TR. Self-splicing of the Tetrahymena intron from mRNA in mammalian cells. EMBO J. 1999 Nov 15; 18(22):6491-500. PMID: 10562561.
      View in: PubMed
    158. Friedman KL, Cech TR. Essential functions of amino-terminal domains in the yeast telomerase catalytic subunit revealed by selection for viable mutants. Genes Dev. 1999 Nov 01; 13(21):2863-74. PMID: 10557213.
      View in: PubMed
    159. Silverman SK, Cech TR. RNA tertiary folding monitored by fluorescence of covalently attached pyrene. Biochemistry. 1999 Oct 26; 38(43):14224-37. PMID: 10571996.
      View in: PubMed
    160. Seto AG, Zaug AJ, Sobel SG, Wolin SL, Cech TR. Saccharomyces cerevisiae telomerase is an Sm small nuclear ribonucleoprotein particle. Nature. 1999 Sep 09; 401(6749):177-80. PMID: 10490028.
      View in: PubMed
    161. Juneau K, Cech TR. In vitro selection of RNAs with increased tertiary structure stability. RNA. 1999 Aug; 5(8):1119-29. PMID: 10445885.
      View in: PubMed
    162. Silverman SK, Cech TR. Energetics and cooperativity of tertiary hydrogen bonds in RNA structure. Biochemistry. 1999 Jul 06; 38(27):8691-702. PMID: 10393544.
      View in: PubMed
    163. Bryan TM, Cech TR. Telomerase and the maintenance of chromosome ends. Curr Opin Cell Biol. 1999 Jun; 11(3):318-24. PMID: 10395557.
      View in: PubMed
    164. Jabri E, Cech TR. In vitro selection of the Naegleria GIR1 ribozyme identifies three base changes that dramatically improve activity. RNA. 1998 Dec; 4(12):1481-92. PMID: 9848647.
      View in: PubMed
    165. Nakamura TM, Cooper JP, Cech TR. Two modes of survival of fission yeast without telomerase. Science. 1998 Oct 16; 282(5388):493-6. PMID: 9774280.
      View in: PubMed
    166. Golden BL, Gooding AR, Podell ER, Cech TR. A preorganized active site in the crystal structure of the Tetrahymena ribozyme. Science. 1998 Oct 09; 282(5387):259-64. PMID: 9841391.
      View in: PubMed
    167. Cohen SB, Cech TR. A quantitative study of the flexibility contributed to RNA structures by nicks and single-stranded gaps. RNA. 1998 Oct; 4(10):1179-85. PMID: 9769093.
      View in: PubMed
    168. Zhang B, Cech TR. Peptidyl-transferase ribozymes: trans reactions, structural characterization and ribosomal RNA-like features. Chem Biol. 1998 Oct; 5(10):539-53. PMID: 9818147.
      View in: PubMed
    169. Szewczak AA, Podell ER, Bevilacqua PC, Cech TR. Thermodynamic stability of the P4-P6 domain RNA tertiary structure measured by temperature gradient gel electrophoresis. Biochemistry. 1998 Aug 11; 37(32):11162-70. PMID: 9698362.
      View in: PubMed
    170. Bryan TM, Sperger JM, Chapman KB, Cech TR. Telomerase reverse transcriptase genes identified in Tetrahymena thermophila and Oxytricha trifallax. Proc Natl Acad Sci U S A. 1998 Jul 21; 95(15):8479-84. PMID: 9671703.
      View in: PubMed
    171. Froelich-Ammon SJ, Dickinson BA, Bevilacqua JM, Schultz SC, Cech TR. Modulation of telomerase activity by telomere DNA-binding proteins in Oxytricha. Genes Dev. 1998 May 15; 12(10):1504-14. PMID: 9585510.
      View in: PubMed
    172. Bevilacqua PC, George CX, Samuel CE, Cech TR. Binding of the protein kinase PKR to RNAs with secondary structure defects: role of the tandem A-G mismatch and noncontiguous helixes. Biochemistry. 1998 May 05; 37(18):6303-16. PMID: 9572845.
      View in: PubMed
    173. Hammond PW, Cech TR. Euplotes telomerase: evidence for limited base-pairing during primer elongation and dGTP as an effector of translocation. Biochemistry. 1998 Apr 14; 37(15):5162-72. PMID: 9548747.
      View in: PubMed
    174. Lingner J, Cech TR. Telomerase and chromosome end maintenance. Curr Opin Genet Dev. 1998 Apr; 8(2):226-32. PMID: 9610414.
      View in: PubMed
    175. Nakamura TM, Cech TR. Reversing time: origin of telomerase. Cell. 1998 Mar 06; 92(5):587-90. PMID: 9506510.
      View in: PubMed
    176. Jabri E, Aigner S, Cech TR. Kinetic and secondary structure analysis of Naegleria andersoni GIR1, a group I ribozyme whose putative biological function is site-specific hydrolysis. Biochemistry. 1997 Dec 23; 36(51):16345-54. PMID: 9405070.
      View in: PubMed
    177. Zhang B, Cech TR. Peptide bond formation by in vitro selected ribozymes. Nature. 1997 Nov 06; 390(6655):96-100. PMID: 9363898.
      View in: PubMed
    178. Cech TR, Nakamura TM, Lingner J. Telomerase is a true reverse transcriptase. A review. Biochemistry (Mosc). 1997 Nov; 62(11):1202-5. PMID: 9467843.
      View in: PubMed
    179. Chapon C, Cech TR, Zaug AJ. Polyadenylation of telomerase RNA in budding yeast. RNA. 1997 Nov; 3(11):1337-51. PMID: 9409624.
      View in: PubMed
    180. Lingner J, Cech TR, Hughes TR, Lundblad V. Three Ever Shorter Telomere (EST) genes are dispensable for in vitro yeast telomerase activity. Proc Natl Acad Sci U S A. 1997 Oct 14; 94(21):11190-5. PMID: 9326584.
      View in: PubMed
    181. Hammond PW, Cech TR. dGTP-dependent processivity and possible template switching of euplotes telomerase. Nucleic Acids Res. 1997 Sep 15; 25(18):3698-704. PMID: 9278493.
      View in: PubMed
    182. Tanner MA, Anderson EM, Gutell RR, Cech TR. Mutagenesis and comparative sequence analysis of a base triple joining the two domains of group I ribozymes. RNA. 1997 Sep; 3(9):1037-51. PMID: 9292502.
      View in: PubMed
    183. Weinstein LB, Jones BC, Cosstick R, Cech TR. A second catalytic metal ion in group I ribozyme. Nature. 1997 Aug 21; 388(6644):805-8. PMID: 9285596.
      View in: PubMed
    184. Nakamura TM, Morin GB, Chapman KB, Weinrich SL, Andrews WH, Lingner J, Harley CB, Cech TR. Telomerase catalytic subunit homologs from fission yeast and human. Science. 1997 Aug 15; 277(5328):955-9. PMID: 9252327.
      View in: PubMed
    185. Golden BL, Podell ER, Gooding AR, Cech TR. Crystals by design: a strategy for crystallization of a ribozyme derived from the Tetrahymena group I intron. J Mol Biol. 1997 Aug 01; 270(5):711-23. PMID: 9245599.
      View in: PubMed
    186. Szewczak AA, Cech TR. An RNA internal loop acts as a hinge to facilitate ribozyme folding and catalysis. RNA. 1997 Aug; 3(8):838-49. PMID: 9257643.
      View in: PubMed
    187. McConnell TS, Herschlag D, Cech TR. Effects of divalent metal ions on individual steps of the Tetrahymena ribozyme reaction. Biochemistry. 1997 Jul 08; 36(27):8293-303. PMID: 9204875.
      View in: PubMed
    188. Lingner J, Hughes TR, Shevchenko A, Mann M, Lundblad V, Cech TR. Reverse transcriptase motifs in the catalytic subunit of telomerase. Science. 1997 Apr 25; 276(5312):561-7. PMID: 9110970.
      View in: PubMed
    189. Cooper JP, Nimmo ER, Allshire RC, Cech TR. Regulation of telomere length and function by a Myb-domain protein in fission yeast. Nature. 1997 Feb 20; 385(6618):744-7. PMID: 9034194.
      View in: PubMed
    190. Tanner MA, Cech TR. Joining the two domains of a group I ribozyme to form the catalytic core. Science. 1997 Feb 07; 275(5301):847-9. PMID: 9012355.
      View in: PubMed
    191. Hammond PW, Lively TN, Cech TR. The anchor site of telomerase from Euplotes aediculatus revealed by photo-cross-linking to single- and double-stranded DNA primers. Mol Cell Biol. 1997 Jan; 17(1):296-308. PMID: 8972210.
      View in: PubMed
    192. Cech TR, Lingner J. Telomerase and the chromosome end replication problem. Ciba Found Symp. 1997; 211:20-8; discussion 28-34. PMID: 9524749.
      View in: PubMed
    193. Golden BL, Gooding AR, Podell ER, Cech TR. X-ray crystallography of large RNAs: heavy-atom derivatives by RNA engineering. RNA. 1996 Dec; 2(12):1295-305. PMID: 8972777.
      View in: PubMed
    194. Rusconi CP, Cech TR. The anticodon is the signal sequence for mitochondrial import of glutamine tRNA in Tetrahymena. Genes Dev. 1996 Nov 15; 10(22):2870-80. PMID: 8918888.
      View in: PubMed
    195. Lingner J, Cech TR. Purification of telomerase from Euplotes aediculatus: requirement of a primer 3' overhang. Proc Natl Acad Sci U S A. 1996 Oct 01; 93(20):10712-7. PMID: 8855245.
      View in: PubMed
    196. Kuo LY, Cech TR. Conserved thermochemistry of guanosine nucleophile binding for structurally distinct group I ribozymes. Nucleic Acids Res. 1996 Oct 01; 24(19):3722-7. PMID: 8871550.
      View in: PubMed
    197. Cate JH, Gooding AR, Podell E, Zhou K, Golden BL, Kundrot CE, Cech TR, Doudna JA. Crystal structure of a group I ribozyme domain: principles of RNA packing. Science. 1996 Sep 20; 273(5282):1678-85. PMID: 8781224.
      View in: PubMed
    198. Cate JH, Gooding AR, Podell E, Zhou K, Golden BL, Szewczak AA, Kundrot CE, Cech TR, Doudna JA. RNA tertiary structure mediation by adenosine platforms. Science. 1996 Sep 20; 273(5282):1696-9. PMID: 8781229.
      View in: PubMed
    199. Campbell TB, Cech TR. Mutations in the Tetrahymena ribozyme internal guide sequence: effects on docking of the P1 helix into the catalytic core and correlation with catalytic activity. Biochemistry. 1996 Sep 03; 35(35):11493-502. PMID: 8784205.
      View in: PubMed
    200. Bevilacqua PC, Cech TR. Minor-groove recognition of double-stranded RNA by the double-stranded RNA-binding domain from the RNA-activated protein kinase PKR. Biochemistry. 1996 Aug 06; 35(31):9983-94. PMID: 8756460.
      View in: PubMed
    201. Rusconi CP, Cech TR. Mitochondrial import of only one of three nuclear-encoded glutamine tRNAs in Tetrahymena thermophila. EMBO J. 1996 Jul 01; 15(13):3286-95. PMID: 8670829.
      View in: PubMed
    202. Downs WD, Cech TR. Kinetic pathway for folding of the Tetrahymena ribozyme revealed by three UV-inducible crosslinks. RNA. 1996 Jul; 2(7):718-32. PMID: 8756414.
      View in: PubMed
    203. Cech TR, Szewczak AA. Selecting apt RNAs for NMR. RNA. 1996 Jul; 2(7):625-7. PMID: 8756405.
      View in: PubMed
    204. Golden BL, Cech TR. Conformational switches involved in orchestrating the successive steps of group I RNA splicing. Biochemistry. 1996 Mar 26; 35(12):3754-63. PMID: 8619996.
      View in: PubMed
    205. Zaug AJ, Linger J, Cech TR. Method for determining RNA 3' ends and application to human telomerase RNA. Nucleic Acids Res. 1996 Feb 01; 24(3):532-3. PMID: 8602368.
      View in: PubMed
    206. Strobel SA, Cech TR. Exocyclic amine of the conserved G.U pair at the cleavage site of the Tetrahymena ribozyme contributes to 5'-splice site selection and transition state stabilization. Biochemistry. 1996 Jan 30; 35(4):1201-11. PMID: 8573575.
      View in: PubMed
    207. Weeks KM, Cech TR. Assembly of a ribonucleoprotein catalyst by tertiary structure capture. Science. 1996 Jan 19; 271(5247):345-8. PMID: 8553068.
      View in: PubMed
    208. Tanner M, Cech T. Activity and thermostability of the small self-splicing group I intron in the pre-tRNA(lle) of the purple bacterium Azoarcus. RNA. 1996 Jan; 2(1):74-83. PMID: 8846298.
      View in: PubMed
    209. Nakamura TM, Wang YH, Zaug AJ, Griffith JD, Cech TR. Relative orientation of RNA helices in a group 1 ribozyme determined by helix extension electron microscopy. EMBO J. 1995 Oct 02; 14(19):4849-59. PMID: 7588614.
      View in: PubMed
    210. Lingner J, Cooper JP, Cech TR. Telomerase and DNA end replication: no longer a lagging strand problem? Science. 1995 Sep 15; 269(5230):1533-4. PMID: 7545310.
      View in: PubMed
    211. Campbell TB, Cech TR. Identification of ribozymes within a ribozyme library that efficiently cleave a long substrate RNA. RNA. 1995 Aug; 1(6):598-609. PMID: 7489519.
      View in: PubMed
    212. Weeks KM, Cech TR. Protein facilitation of group I intron splicing by assembly of the catalytic core and the 5' splice site domain. Cell. 1995 Jul 28; 82(2):221-30. PMID: 7628013.
      View in: PubMed
    213. Fang G, Cech TR. Telomerase RNA localized in the replication band and spherical subnuclear organelles in hypotrichous ciliates. J Cell Biol. 1995 Jul; 130(2):243-53. PMID: 7615628.
      View in: PubMed
    214. Weeks KM, Cech TR. Efficient protein-facilitated splicing of the yeast mitochondrial bI5 intron. Biochemistry. 1995 Jun 13; 34(23):7728-38. PMID: 7540041.
      View in: PubMed
    215. Hicke B, Rempel R, Maller J, Swank RA, Hamaguchi JR, Bradbury EM, Prescott DM, Cech TR. Phosphorylation of the Oxytricha telomere protein: possible cell cycle regulation. Nucleic Acids Res. 1995 Jun 11; 23(11):1887-93. PMID: 7596814.
      View in: PubMed
    216. Zaug AJ, Cech TR. Analysis of the structure of Tetrahymena nuclear RNAs in vivo: telomerase RNA, the self-splicing rRNA intron, and U2 snRNA. RNA. 1995 Jun; 1(4):363-74. PMID: 7493315.
      View in: PubMed
    217. Tanner MA, Cech TR. An important RNA tertiary interaction of group I and group II introns is implicated in gram-positive RNase P RNAs. RNA. 1995 Jun; 1(4):349-50. PMID: 7493313.
      View in: PubMed
    218. Cech T. Group I introns: new molecular mechanisms for mRNA repair. Biotechnology (N Y). 1995 Apr; 13(4):323-6. PMID: 9634773.
      View in: PubMed
    219. McConnell TS, Cech TR. A positive entropy change for guanosine binding and for the chemical step in the Tetrahymena ribozyme reaction. Biochemistry. 1995 Mar 28; 34(12):4056-67. PMID: 7696271.
      View in: PubMed
    220. Doudna JA, Cech TR, Sullenger BA. Selection of an RNA molecule that mimics a major autoantigenic epitope of human insulin receptor. Proc Natl Acad Sci U S A. 1995 Mar 14; 92(6):2355-9. PMID: 7534420.
      View in: PubMed
    221. Doudna JA, Cech TR. Self-assembly of a group I intron active site from its component tertiary structural domains. RNA. 1995 Mar; 1(1):36-45. PMID: 7489486.
      View in: PubMed
    222. Strobel SA, Cech TR. Minor groove recognition of the conserved G.U pair at the Tetrahymena ribozyme reaction site. Science. 1995 Feb 03; 267(5198):675-9. PMID: 7839142.
      View in: PubMed
    223. Zaug AJ, Dávila-Aponte JA, Cech TR. Catalysis of RNA cleavage by a ribozyme derived from the group I intron of Anabaena pre-tRNA(Leu). Biochemistry. 1994 Dec 13; 33(49):14935-47. PMID: 7527660.
      View in: PubMed
    224. Strobel SA, Cech TR, Usman N, Beigelman L. The 2,6-diaminopurine riboside.5-methylisocytidine wobble base pair: an isoenergetic substitution for the study of G.U pairs in RNA. Biochemistry. 1994 Nov 22; 33(46):13824-35. PMID: 7524665.
      View in: PubMed
    225. Pyle AM, Moran S, Strobel SA, Chapman T, Turner DH, Cech TR. Replacement of the conserved G.U with a G-C pair at the cleavage site of the Tetrahymena ribozyme decreases binding, reactivity, and fidelity. Biochemistry. 1994 Nov 22; 33(46):13856-63. PMID: 7947794.
      View in: PubMed
    226. Cech TR, Uhlenbeck OC. Ribozymes. Hammerhead nailed down. Nature. 1994 Nov 03; 372(6501):39-40. PMID: 7969416.
      View in: PubMed
    227. Cech TR. Chromosome end games. Science. 1994 Oct 21; 266(5184):387-8. PMID: 7939679.
      View in: PubMed
    228. Sullenger BA, Cech TR. Ribozyme-mediated repair of defective mRNA by targeted, trans-splicing. Nature. 1994 Oct 13; 371(6498):619-22. PMID: 7935797.
      View in: PubMed
    229. Murphy FL, Wang YH, Griffith JD, Cech TR. Coaxially stacked RNA helices in the catalytic center of the Tetrahymena ribozyme. Science. 1994 Sep 16; 265(5179):1709-12. PMID: 8085157.
      View in: PubMed
    230. Lingner J, Hendrick LL, Cech TR. Telomerase RNAs of different ciliates have a common secondary structure and a permuted template. Genes Dev. 1994 Aug 15; 8(16):1984-98. PMID: 7958872.
      View in: PubMed
    231. Laggerbauer B, Murphy FL, Cech TR. Two major tertiary folding transitions of the Tetrahymena catalytic RNA. EMBO J. 1994 Jun 01; 13(11):2669-76. PMID: 8013466.
      View in: PubMed
    232. Downs WD, Cech TR. A tertiary interaction in the Tetrahymena intron contributes to selection of the 5' splice site. Genes Dev. 1994 May 15; 8(10):1198-211. PMID: 7926724.
      View in: PubMed
    233. Cech TR, Damberger SH, Gutell RR. Representation of the secondary and tertiary structure of group I introns. Nat Struct Biol. 1994 May; 1(5):273-80. PMID: 7545072.
      View in: PubMed
    234. Hicke BJ, Willis MC, Koch TH, Cech TR. Telomeric protein-DNA point contacts identified by photo-cross-linking using 5-bromodeoxyuridine. Biochemistry. 1994 Mar 22; 33(11):3364-73. PMID: 8136374.
      View in: PubMed
    235. Murphy FL, Cech TR. GAAA tetraloop and conserved bulge stabilize tertiary structure of a group I intron domain. J Mol Biol. 1994 Feb 11; 236(1):49-63. PMID: 8107125.
      View in: PubMed
    236. Wang YH, Murphy FL, Cech TR, Griffith JD. Visualization of a tertiary structural domain of the Tetrahymena group I intron by electron microscopy. J Mol Biol. 1994 Feb 11; 236(1):64-71. PMID: 7508985.
      View in: PubMed
    237. Strobel SA, Cech TR. Translocation of an RNA duplex on a ribozyme. Nat Struct Biol. 1994 Jan; 1(1):13-7. PMID: 7544680.
      View in: PubMed
    238. Cech TR. The efficiency and versatility of catalytic RNA: implications for an RNA world. Gene. 1993 Dec 15; 135(1-2):33-6. PMID: 8276275.
      View in: PubMed
    239. Strobel SA, Cech TR. Tertiary interactions with the internal guide sequence mediate docking of the P1 helix into the catalytic core of the Tetrahymena ribozyme. Biochemistry. 1993 Dec 14; 32(49):13593-604. PMID: 7504953.
      View in: PubMed
    240. Sullenger BA, Cech TR. Tethering ribozymes to a retroviral packaging signal for destruction of viral RNA. Science. 1993 Dec 03; 262(5139):1566-9. PMID: 8248806.
      View in: PubMed
    241. Willis MC, Hicke BJ, Uhlenbeck OC, Cech TR, Koch TH. Photocrosslinking of 5-iodouracil-substituted RNA and DNA to proteins. Science. 1993 Nov 19; 262(5137):1255-7. PMID: 7694369.
      View in: PubMed
    242. Fang G, Cech TR. Characterization of a G-quartet formation reaction promoted by the beta-subunit of the Oxytricha telomere-binding protein. Biochemistry. 1993 Nov 02; 32(43):11646-57. PMID: 8218232.
      View in: PubMed
    243. Cech TR. RNA. Fishing for fresh catalysts. Nature. 1993 Sep 16; 365(6443):204-5. PMID: 7690464.
      View in: PubMed
    244. McConnell TS, Cech TR, Herschlag D. Guanosine binding to the Tetrahymena ribozyme: thermodynamic coupling with oligonucleotide binding. Proc Natl Acad Sci U S A. 1993 Sep 15; 90(18):8362-6. PMID: 8378306.
      View in: PubMed
    245. Fang G, Cech TR. The beta subunit of Oxytricha telomere-binding protein promotes G-quartet formation by telomeric DNA. Cell. 1993 Sep 10; 74(5):875-85. PMID: 8374954.
      View in: PubMed
    246. Herschlag D, Eckstein F, Cech TR. The importance of being ribose at the cleavage site in the Tetrahymena ribozyme reaction. Biochemistry. 1993 Aug 17; 32(32):8312-21. PMID: 7688573.
      View in: PubMed
    247. Herschlag D, Eckstein F, Cech TR. Contributions of 2'-hydroxyl groups of the RNA substrate to binding and catalysis by the Tetrahymena ribozyme. An energetic picture of an active site composed of RNA. Biochemistry. 1993 Aug 17; 32(32):8299-311. PMID: 7688572.
      View in: PubMed
    248. Zaug AJ, McEvoy MM, Cech TR. Self-splicing of the group I intron from Anabaena pre-tRNA: requirement for base-pairing of the exons in the anticodon stem. Biochemistry. 1993 Aug 10; 32(31):7946-53. PMID: 8347600.
      View in: PubMed
    249. Ishikawa F, Matunis MJ, Dreyfuss G, Cech TR. Nuclear proteins that bind the pre-mRNA 3' splice site sequence r(UUAG/G) and the human telomeric DNA sequence d(TTAGGG)n. Mol Cell Biol. 1993 Jul; 13(7):4301-10. PMID: 8321232.
      View in: PubMed
    250. Fang G, Cech TR. Oxytricha telomere-binding protein: DNA-dependent dimerization of the alpha and beta subunits. Proc Natl Acad Sci U S A. 1993 Jul 01; 90(13):6056-60. PMID: 8327484.
      View in: PubMed
    251. Murphy FL, Cech TR. An independently folding domain of RNA tertiary structure within the Tetrahymena ribozyme. Biochemistry. 1993 May 25; 32(20):5291-300. PMID: 7684607.
      View in: PubMed
    252. Fang G, Gray JT, Cech TR. Oxytricha telomere-binding protein: separable DNA-binding and dimerization domains of the alpha-subunit. Genes Dev. 1993 May; 7(5):870-82. PMID: 8491383.
      View in: PubMed
    253. Cech TR. Catalytic RNA: structure and mechanism. Biochem Soc Trans. 1993 May; 21(2):229-34. PMID: 8359471.
      View in: PubMed
    254. Wang JF, Downs WD, Cech TR. Movement of the guide sequence during RNA catalysis by a group I ribozyme. Science. 1993 Apr 23; 260(5107):504-8. PMID: 7682726.
      View in: PubMed
    255. Piccirilli JA, Vyle JS, Caruthers MH, Cech TR. Metal ion catalysis in the Tetrahymena ribozyme reaction. Nature. 1993 Jan 07; 361(6407):85-8. PMID: 8421499.
      View in: PubMed
    256. Legault P, Herschlag D, Celander DW, Cech TR. Mutations at the guanosine-binding site of the Tetrahymena ribozyme also affect site-specific hydrolysis. Nucleic Acids Res. 1992 Dec 25; 20(24):6613-9. PMID: 1480482.
      View in: PubMed
    257. Cech TR, Herschlag D, Piccirilli JA, Pyle AM. RNA catalysis by a group I ribozyme. Developing a model for transition state stabilization. J Biol Chem. 1992 Sep 05; 267(25):17479-82. PMID: 1381347.
      View in: PubMed
    258. Pyle AM, Murphy FL, Cech TR. RNA substrate binding site in the catalytic core of the Tetrahymena ribozyme. Nature. 1992 Jul 09; 358(6382):123-8. PMID: 1377367.
      View in: PubMed
    259. Piccirilli JA, McConnell TS, Zaug AJ, Noller HF, Cech TR. Aminoacyl esterase activity of the Tetrahymena ribozyme. Science. 1992 Jun 05; 256(5062):1420-4. PMID: 1604316.
      View in: PubMed
    260. Wang JF, Cech TR. Tertiary structure around the guanosine-binding site of the Tetrahymena ribozyme. Science. 1992 Apr 24; 256(5056):526-9. PMID: 1315076.
      View in: PubMed
    261. Zaug AJ, Cech TR. The intervening sequence RNA of Tetrahymena is an enzyme. 1986. Biotechnology. 1992; 24:57-62. PMID: 1422070.
      View in: PubMed
    262. Heuer TS, Chandry PS, Belfort M, Celander DW, Cech TR. Folding of group I introns from bacteriophage T4 involves internalization of the catalytic core. Proc Natl Acad Sci U S A. 1991 Dec 15; 88(24):11105-9. PMID: 1763026.
      View in: PubMed
    263. Young B, Herschlag D, Cech TR. Mutations in a nonconserved sequence of the Tetrahymena ribozyme increase activity and specificity. Cell. 1991 Nov 29; 67(5):1007-19. PMID: 1959129.
      View in: PubMed
    264. Gray JT, Celander DW, Price CM, Cech TR. Cloning and expression of genes for the Oxytricha telomere-binding protein: specific subunit interactions in the telomeric complex. Cell. 1991 Nov 15; 67(4):807-14. PMID: 1840510.
      View in: PubMed
    265. Fang GW, Cech TR. Molecular cloning of telomere-binding protein genes from Stylonychia mytilis. Nucleic Acids Res. 1991 Oct 25; 19(20):5515-8. PMID: 1945829.
      View in: PubMed
    266. Gampel A, Cech TR. Binding of the CBP2 protein to a yeast mitochondrial group I intron requires the catalytic core of the RNA. Genes Dev. 1991 Oct; 5(10):1870-80. PMID: 1916266.
      View in: PubMed
    267. Dávila-Aponte JA, Huss VA, Sogin ML, Cech TR. A self-splicing group I intron in the nuclear pre-rRNA of the green alga, Ankistrodesmus stipitatus. Nucleic Acids Res. 1991 Aug 25; 19(16):4429-36. PMID: 1886767.
      View in: PubMed
    268. Grosshans CA, Cech TR. A hammerhead ribozyme allows synthesis of a new form of the Tetrahymena ribozyme homogeneous in length with a 3' end blocked for transesterification. Nucleic Acids Res. 1991 Jul 25; 19(14):3875-80. PMID: 1650453.
      View in: PubMed
    269. Herschlag D, Piccirilli JA, Cech TR. Ribozyme-catalyzed and nonenzymatic reactions of phosphate diesters: rate effects upon substitution of sulfur for a nonbridging phosphoryl oxygen atom. Biochemistry. 1991 May 21; 30(20):4844-54. PMID: 2036355.
      View in: PubMed
    270. Zahler AM, Williamson JR, Cech TR, Prescott DM. Inhibition of telomerase by G-quartet DNA structures. Nature. 1991 Apr 25; 350(6320):718-20. PMID: 2023635.
      View in: PubMed
    271. Pyle AM, Cech TR. Ribozyme recognition of RNA by tertiary interactions with specific ribose 2'-OH groups. Nature. 1991 Apr 18; 350(6319):628-31. PMID: 1708111.
      View in: PubMed
    272. Woodson SA, Cech TR. Alternative secondary structures in the 5' exon affect both forward and reverse self-splicing of the Tetrahymena intervening sequence RNA. Biochemistry. 1991 Feb 26; 30(8):2042-50. PMID: 1998665.
      View in: PubMed
    273. Cech TR. RNA editing: world's smallest introns? Cell. 1991 Feb 22; 64(4):667-9. PMID: 1997201.
      View in: PubMed
    274. Celander DW, Cech TR. Visualizing the higher order folding of a catalytic RNA molecule. Science. 1991 Jan 25; 251(4992):401-7. PMID: 1989074.
      View in: PubMed
    275. Herschlag D, Cech TR. Catalysis of RNA cleavage by the Tetrahymena thermophila ribozyme. 1. Kinetic description of the reaction of an RNA substrate complementary to the active site. Biochemistry. 1990 Nov 06; 29(44):10159-71. PMID: 2271645.
      View in: PubMed
    276. Herschlag D, Cech TR. Catalysis of RNA cleavage by the Tetrahymena thermophila ribozyme. 2. Kinetic description of the reaction of an RNA substrate that forms a mismatch at the active site. Biochemistry. 1990 Nov 06; 29(44):10172-80. PMID: 2271646.
      View in: PubMed
    277. Pyle AM, McSwiggen JA, Cech TR. Direct measurement of oligonucleotide substrate binding to wild-type and mutant ribozymes from Tetrahymena. Proc Natl Acad Sci U S A. 1990 Nov; 87(21):8187-91. PMID: 2236030.
      View in: PubMed
    278. Raghuraman MK, Cech TR. Effect of monovalent cation-induced telomeric DNA structure on the binding of Oxytricha telomeric protein. Nucleic Acids Res. 1990 Aug 11; 18(15):4543-52. PMID: 2388834.
      View in: PubMed
    279. Downs WD, Cech TR. An ultraviolet-inducible adenosine-adenosine cross-link reflects the catalytic structure of the Tetrahymena ribozyme. Biochemistry. 1990 Jun 12; 29(23):5605-13. PMID: 2201409.
      View in: PubMed
    280. Cech TR. Nobel lecture. Self-splicing and enzymatic activity of an intervening sequence RNA from Tetrahymena. Biosci Rep. 1990 Jun; 10(3):239-61. PMID: 1699616.
      View in: PubMed
    281. Herschlag D, Cech TR. DNA cleavage catalysed by the ribozyme from Tetrahymena. Nature. 1990 Mar 29; 344(6265):405-9. PMID: 1690858.
      View in: PubMed
    282. Celander DW, Cech TR. Iron(II)-ethylenediaminetetraacetic acid catalyzed cleavage of RNA and DNA oligonucleotides: similar reactivity toward single- and double-stranded forms. Biochemistry. 1990 Feb 13; 29(6):1355-61. PMID: 2110477.
      View in: PubMed
    283. Hicke BJ, Celander DW, MacDonald GH, Price CM, Cech TR. Two versions of the gene encoding the 41-kilodalton subunit of the telomere binding protein of Oxytricha nova. Proc Natl Acad Sci U S A. 1990 Feb; 87(4):1481-5. PMID: 1689486.
      View in: PubMed
    284. Cech TR. Self-splicing of group I introns. Annu Rev Biochem. 1990; 59:543-68. PMID: 2197983.
      View in: PubMed
    285. Latham JA, Zaug AJ, Cech TR. Self-splicing and enzymatic cleavage of RNA by a group I intervening sequence. Methods Enzymol. 1990; 181:558-69. PMID: 2199766.
      View in: PubMed
    286. Woodson SA, Cech TR, Young M, Perriman R, Kelly L, Graf L, Llewellyn D, Gerlach W, Plückthun A, Collins J. Symposium 3: Non-enzymatic biocatalysts in nature and biotechnology. Fresenius J Anal Chem. 1990; 337(1):12-14. PMID: 32226232.
      View in: PubMed
    287. Young B, Cech TR. Specificity for 3',5'-linked substrates in RNA-catalyzed RNA polymerization. J Mol Evol. 1989 Dec; 29(6):480-5. PMID: 2482370.
      View in: PubMed
    288. Murphy FL, Cech TR. Alteration of substrate specificity for the endoribonucleolytic cleavage of RNA by the Tetrahymena ribozyme. Proc Natl Acad Sci U S A. 1989 Dec; 86(23):9218-22. PMID: 2480597.
      View in: PubMed
    289. Williamson JR, Raghuraman MK, Cech TR. Monovalent cation-induced structure of telomeric DNA: the G-quartet model. Cell. 1989 Dec 01; 59(5):871-80. PMID: 2590943.
      View in: PubMed
    290. Raghuraman MK, Cech TR. Assembly and self-association of oxytricha telomeric nucleoprotein complexes. Cell. 1989 Nov 17; 59(4):719-28. PMID: 2582492.
      View in: PubMed
    291. Flor PJ, Flanegan JB, Cech TR. A conserved base pair within helix P4 of the Tetrahymena ribozyme helps to form the tertiary structure required for self-splicing. EMBO J. 1989 Nov; 8(11):3391-9. PMID: 2684642.
      View in: PubMed
    292. Yarus M, Levine J, Morin GB, Cech TR. A Tetrahymena intron nucleotide connected to the GTP/arginine site. Nucleic Acids Res. 1989 Sep 12; 17(17):6969-81. PMID: 2674904.
      View in: PubMed
    293. Barfod ET, Cech TR. The conserved U.G pair in the 5' splice site duplex of a group I intron is required in the first but not the second step of self-splicing. Mol Cell Biol. 1989 Sep; 9(9):3657-66. PMID: 2779562.
      View in: PubMed
    294. Grosshans CA, Cech TR. Metal ion requirements for sequence-specific endoribonuclease activity of the Tetrahymena ribozyme. Biochemistry. 1989 Aug 22; 28(17):6888-94. PMID: 2684268.
      View in: PubMed
    295. Latham JA, Cech TR. Defining the inside and outside of a catalytic RNA molecule. Science. 1989 Jul 21; 245(4915):276-82. PMID: 2501870.
      View in: PubMed
    296. Cech TR. RNA chemistry. Ribozyme self-replication? Nature. 1989 Jun 15; 339(6225):507-8. PMID: 2660002.
      View in: PubMed
    297. Raghuraman MK, Dunn CJ, Hicke BJ, Cech TR. Oxytricha telomeric nucleoprotein complexes reconstituted with synthetic DNA. Nucleic Acids Res. 1989 Jun 12; 17(11):4235-53. PMID: 2500641.
      View in: PubMed
    298. McSwiggen JA, Cech TR. Stereochemistry of RNA cleavage by the Tetrahymena ribozyme and evidence that the chemical step is not rate-limiting. Science. 1989 May 12; 244(4905):679-83. PMID: 2470150.
      View in: PubMed
    299. Woodson SA, Cech TR. Reverse self-splicing of the tetrahymena group I intron: implication for the directionality of splicing and for intron transposition. Cell. 1989 Apr 21; 57(2):335-45. PMID: 2702692.
      View in: PubMed
    300. Price CM, Cech TR. Properties of the telomeric DNA-binding protein from Oxytricha nova. Biochemistry. 1989 Jan 24; 28(2):769-74. PMID: 2713343.
      View in: PubMed
    301. Cech TR. RNA as an enzyme. Biochem Int. 1989 Jan; 18(1):7-14. PMID: 2470377.
      View in: PubMed
    302. Cech TR. Conserved sequences and structures of group I introns: building an active site for RNA catalysis--a review. Gene. 1988 Dec 20; 73(2):259-71. PMID: 3072259.
      View in: PubMed
    303. Zaug AJ, Grosshans CA, Cech TR. Sequence-specific endoribonuclease activity of the Tetrahymena ribozyme: enhanced cleavage of certain oligonucleotide substrates that form mismatched ribozyme-substrate complexes. Biochemistry. 1988 Dec 13; 27(25):8924-31. PMID: 3069131.
      View in: PubMed
    304. Cech TR. Ribozymes and their medical implications. JAMA. 1988 Nov 25; 260(20):3030-4. PMID: 2460649.
      View in: PubMed
    305. Price JV, Cech TR. Determinants of the 3' splice site for self-splicing of the Tetrahymena pre-rRNA. Genes Dev. 1988 Nov; 2(11):1439-47. PMID: 3209068.
      View in: PubMed
    306. Morin GB, Cech TR. Telomeric repeats of Tetrahymena malaccensis mitochondrial DNA: a multimodal distribution that fluctuates erratically during growth. Mol Cell Biol. 1988 Oct; 8(10):4450-8. PMID: 3185556.
      View in: PubMed
    307. Barfod ET, Cech TR. Deletion of nonconserved helices near the 3' end of the rRNA intron of Tetrahymena thermophila alters self-splicing but not core catalytic activity. Genes Dev. 1988 Jun; 2(6):652-63. PMID: 3417146.
      View in: PubMed
    308. Cech TR. G-strings at chromosome ends. Nature. 1988 Apr 28; 332(6167):777-8. PMID: 3357543.
      View in: PubMed
    309. Been MD, Cech TR. RNA as an RNA polymerase: net elongation of an RNA primer catalyzed by the Tetrahymena ribozyme. Science. 1988 Mar 18; 239(4846):1412-6. PMID: 2450400.
      View in: PubMed
    310. Morin GB, Cech TR. Mitochondrial telomeres: surprising diversity of repeated telomeric DNA sequences among six species of Tetrahymena. Cell. 1988 Feb 12; 52(3):367-74. PMID: 3125982.
      View in: PubMed
    311. Morin GB, Cech TR. Phylogenetic relationships and altered genome structures among Tetrahymena mitochondrial DNAs. Nucleic Acids Res. 1988 Jan 11; 16(1):327-46. PMID: 2829120.
      View in: PubMed
    312. Kim SH, Cech TR. Three-dimensional model of the active site of the self-splicing rRNA precursor of Tetrahymena. Proc Natl Acad Sci U S A. 1987 Dec; 84(24):8788-92. PMID: 3480510.
      View in: PubMed
    313. Zaug AJ, Cech TR. Self-splicing RNA and an RNA enzyme in Tetrahymena. J Protozool. 1987 Nov; 34(4):416-7. PMID: 3323479.
      View in: PubMed
    314. Price CM, Cech TR. Telomeric DNA-protein interactions of Oxytricha macronuclear DNA. Genes Dev. 1987 Oct; 1(8):783-93. PMID: 3123321.
      View in: PubMed
    315. Burke JM, Belfort M, Cech TR, Davies RW, Schweyen RJ, Shub DA, Szostak JW, Tabak HF. Structural conventions for group I introns. Nucleic Acids Res. 1987 Sep 25; 15(18):7217-21. PMID: 3658691.
      View in: PubMed
    316. Been MD, Cech TR. Selection of circularization sites in a group I IVS RNA requires multiple alignments of an internal template-like sequence. Cell. 1987 Sep 11; 50(6):951-61. PMID: 2441876.
      View in: PubMed
    317. Price JV, Engberg J, Cech TR. 5' exon requirement for self-splicing of the Tetrahymena thermophila pre-ribosomal RNA and identification of a cryptic 5' splice site in the 3' exon. J Mol Biol. 1987 Jul 05; 196(1):49-60. PMID: 2443717.
      View in: PubMed
    318. Cech TR. The chemistry of self-splicing RNA and RNA enzymes. Science. 1987 Jun 19; 236(4808):1532-9. PMID: 2438771.
      View in: PubMed
    319. Tanner NK, Cech TR. Guanosine binding required for cyclization of the self-splicing intervening sequence ribonucleic acid from Tetrahymena thermophila. Biochemistry. 1987 Jun 16; 26(12):3330-40. PMID: 2443161.
      View in: PubMed
    320. Been MD, Barfod ET, Burke JM, Price JV, Tanner NK, Zaug AJ, Cech TR. Structures involved in Tetrahymena rRNA self-splicing and RNA enzyme activity. Cold Spring Harb Symp Quant Biol. 1987; 52:147-57. PMID: 3454258.
      View in: PubMed
    321. Zaug AJ, Been MD, Cech TR. The Tetrahymena ribozyme acts like an RNA restriction endonuclease. Nature. 1986 Dec 4-10; 324(6096):429-33. PMID: 3537808.
      View in: PubMed
    322. Cech TR. RNA as an enzyme. Sci Am. 1986 Nov; 255(5):64-75. PMID: 2430331.
      View in: PubMed
    323. Been MD, Cech TR. One binding site determines sequence specificity of Tetrahymena pre-rRNA self-splicing, trans-splicing, and RNA enzyme activity. Cell. 1986 Oct 24; 47(2):207-16. PMID: 3021333.
      View in: PubMed
    324. Morin GB, Cech TR. The telomeres of the linear mitochondrial DNA of Tetrahymena thermophila consist of 53 bp tandem repeats. Cell. 1986 Sep 12; 46(6):873-83. PMID: 3019555.
      View in: PubMed
    325. Zaug AJ, Cech TR. The Tetrahymena intervening sequence ribonucleic acid enzyme is a phosphotransferase and an acid phosphatase. Biochemistry. 1986 Aug 12; 25(16):4478-82. PMID: 2429688.
      View in: PubMed
    326. Bass BL, Cech TR. Ribozyme inhibitors: deoxyguanosine and dideoxyguanosine are competitive inhibitors of self-splicing of the Tetrahymena ribosomal ribonucleic acid precursor. Biochemistry. 1986 Aug 12; 25(16):4473-7. PMID: 3639741.
      View in: PubMed
    327. Garriga G, Lambowitz AM, Inoue T, Cech TR. Mechanism of recognition of the 5' splice site in self-splicing group I introns. Nature. 1986 Jul 3-9; 322(6074):86-9. PMID: 3636598.
      View in: PubMed
    328. Cech TR. A model for the RNA-catalyzed replication of RNA. Proc Natl Acad Sci U S A. 1986 Jun; 83(12):4360-3. PMID: 2424025.
      View in: PubMed
    329. Inoue T, Sullivan FX, Cech TR. New reactions of the ribosomal RNA precursor of Tetrahymena and the mechanism of self-splicing. J Mol Biol. 1986 May 05; 189(1):143-65. PMID: 2431151.
      View in: PubMed
    330. Burke JM, Irvine KD, Kaneko KJ, Kerker BJ, Oettgen AB, Tierney WM, Williamson CL, Zaug AJ, Cech TR. Role of conserved sequence elements 9L and 2 in self-splicing of the Tetrahymena ribosomal RNA precursor. Cell. 1986 Apr 25; 45(2):167-76. PMID: 2421916.
      View in: PubMed
    331. Cech TR. The generality of self-splicing RNA: relationship to nuclear mRNA splicing. Cell. 1986 Jan 31; 44(2):207-10. PMID: 2417724.
      View in: PubMed
    332. Zaug AJ, Cech TR. The intervening sequence RNA of Tetrahymena is an enzyme. Science. 1986 Jan 31; 231(4737):470-5. PMID: 3941911.
      View in: PubMed
    333. Cech TR. Biologic catalysis by RNA. Harvey Lect. 1986-1987; 82:123-44. PMID: 3329163.
      View in: PubMed
    334. Cech TR, Bass BL. Biological catalysis by RNA. Annu Rev Biochem. 1986; 55:599-629. PMID: 2427016.
      View in: PubMed
    335. Been MD, Cech TR. Sites of circularization of the Tetrahymena rRNA IVS are determined by sequence and influenced by position and secondary structure. Nucleic Acids Res. 1985 Dec 09; 13(23):8389-408. PMID: 4080546.
      View in: PubMed
    336. Inoue T, Sullivan FX, Cech TR. Intermolecular exon ligation of the rRNA precursor of Tetrahymena: oligonucleotides can function as 5' exons. Cell. 1985 Dec; 43(2 Pt 1):431-7. PMID: 3865712.
      View in: PubMed
    337. Tanner NK, Cech TR. Self-catalyzed cyclization of the intervening sequence RNA of Tetrahymena: inhibition by methidiumpropyl.EDTA and localization of the major dye binding sites. Nucleic Acids Res. 1985 Nov 11; 13(21):7759-79. PMID: 2415924.
      View in: PubMed
    338. Tanner NK, Cech TR. Self-catalyzed cyclization of the intervening sequence RNA of Tetrahymena: inhibition by intercalating dyes. Nucleic Acids Res. 1985 Nov 11; 13(21):7741-58. PMID: 2415923.
      View in: PubMed
    339. Zaug AJ, Kent JR, Cech TR. Reactions of the intervening sequence of the Tetrahymena ribosomal ribonucleic acid precursor: pH dependence of cyclization and site-specific hydrolysis. Biochemistry. 1985 Oct 22; 24(22):6211-8. PMID: 4084515.
      View in: PubMed
    340. Zaug AJ, Cech TR. Oligomerization of intervening sequence RNA molecules in the absence of proteins. Science. 1985 Sep 13; 229(4718):1060-4. PMID: 2412290.
      View in: PubMed
    341. Sullivan FX, Cech TR. Reversibility of cyclization of the Tetrahymena rRNA intervening sequence: implication for the mechanism of splice site choice. Cell. 1985 Sep; 42(2):639-48. PMID: 3849344.
      View in: PubMed
    342. Price JV, Cech TR. Coupling of Tetrahymena ribosomal RNA splicing to beta-galactosidase expression in Escherichia coli. Science. 1985 May 10; 228(4700):719-22. PMID: 2986286.
      View in: PubMed
    343. Price JV, Kieft GL, Kent JR, Sievers EL, Cech TR. Sequence requirements for self-splicing of the Tetrahymena thermophila pre-ribosomal RNA. Nucleic Acids Res. 1985 Mar 25; 13(6):1871-89. PMID: 4000946.
      View in: PubMed
    344. Inoue T, Cech TR. Secondary structure of the circular form of the Tetrahymena rRNA intervening sequence: a technique for RNA structure analysis using chemical probes and reverse transcriptase. Proc Natl Acad Sci U S A. 1985 Feb; 82(3):648-52. PMID: 2579378.
      View in: PubMed
    345. Cech TR. Self-splicing RNA: implications for evolution. Int Rev Cytol. 1985; 93:3-22. PMID: 3891660.
      View in: PubMed
    346. Gottschling DE, Cech TR. Chromatin structure of the molecular ends of Oxytricha macronuclear DNA: phased nucleosomes and a telomeric complex. Cell. 1984 Sep; 38(2):501-10. PMID: 6432344.
      View in: PubMed
    347. Zaug AJ, Kent JR, Cech TR. A labile phosphodiester bond at the ligation junction in a circular intervening sequence RNA. Science. 1984 May 11; 224(4649):574-8. PMID: 6200938.
      View in: PubMed
    348. Palen TE, Cech TR. Chromatin structure at the replication origins and transcription-initiation regions of the ribosomal RNA genes of Tetrahymena. Cell. 1984 Apr; 36(4):933-42. PMID: 6323028.
      View in: PubMed
    349. Bass BL, Cech TR. Specific interaction between the self-splicing RNA of Tetrahymena and its guanosine substrate: implications for biological catalysis by RNA. Nature. 1984 Apr 26-May 2; 308(5962):820-6. PMID: 6562377.
      View in: PubMed
    350. Pardue ML, Fostel JM, Cech TR. DNA-protein interactions in the Drosophila virilis mitochondrial chromosome. Nucleic Acids Res. 1984 Feb 24; 12(4):1991-9. PMID: 6322130.
      View in: PubMed
    351. Cech TR. RNA splicing: three themes with variations. Cell. 1983 Oct; 34(3):713-6. PMID: 6354470.
      View in: PubMed
    352. Cech TR, Tanner NK, Tinoco I, Weir BR, Zuker M, Perlman PS. Secondary structure of the Tetrahymena ribosomal RNA intervening sequence: structural homology with fungal mitochondrial intervening sequences. Proc Natl Acad Sci U S A. 1983 Jul; 80(13):3903-7. PMID: 6306649.
      View in: PubMed
    353. Brehm SL, Cech TR. Fate of an intervening sequence ribonucleic acid: excision and cyclization of the Tetrahymena ribosomal ribonucleic acid intervening sequence in vivo. Biochemistry. 1983 May 10; 22(10):2390-7. PMID: 6860634.
      View in: PubMed
    354. Gottschling DE, Palen TE, Cech TR. Different nucleosome spacing in transcribed and non-transcribed regions of the ribosomal RNA gene in Tetrahymena thermophila. Nucleic Acids Res. 1983 Apr 11; 11(7):2093-109. PMID: 6835846.
      View in: PubMed
    355. Palen TE, Cech TR. Transcribed and non-transcribed regions of Tetrahymena ribosomal gene chromatin have different accessibilities to micrococcal nuclease. Nucleic Acids Res. 1983 Apr 11; 11(7):2077-91. PMID: 6300792.
      View in: PubMed
    356. Zaug AJ, Grabowski PJ, Cech TR. Autocatalytic cyclization of an excised intervening sequence RNA is a cleavage-ligation reaction. Nature. 1983 Feb 17-23; 301(5901):578-83. PMID: 6186917.
      View in: PubMed
    357. Kruger K, Grabowski PJ, Zaug AJ, Sands J, Gottschling DE, Cech TR. Self-splicing RNA: autoexcision and autocyclization of the ribosomal RNA intervening sequence of Tetrahymena. Cell. 1982 Nov; 31(1):147-57. PMID: 6297745.
      View in: PubMed
    358. Zaug AJ, Cech TR. The intervening sequence excised from the ribosomal RNA precursor of Tetrahymena contains a 5-terminal guanosine residue not encoded by the DNA. Nucleic Acids Res. 1982 May 11; 10(9):2823-38. PMID: 7099968.
      View in: PubMed
    359. Cech TR, Zaug AJ, Grabowski PJ. In vitro splicing of the ribosomal RNA precursor of Tetrahymena: involvement of a guanosine nucleotide in the excision of the intervening sequence. Cell. 1981 Dec; 27(3 Pt 2):487-96. PMID: 6101203.
      View in: PubMed
    360. Cech TR, Brehm SL. Replication of the extrachromosomal ribosomal RNA genes of Tetrahymena thermophilia. Nucleic Acids Res. 1981 Jul 24; 9(14):3531-43. PMID: 7279667.
      View in: PubMed
    361. Cech TR. Alkaline gel electrophoresis of deoxyribonucleic acid photoreacted with trimethylpsoralen: rapid and sensitive detection of interstrand cross-links. Biochemistry. 1981 Mar 17; 20(6):1431-7. PMID: 6261794.
      View in: PubMed
    362. Grabowski PJ, Zaug AJ, Cech TR. The intervening sequence of the ribosomal RNA precursor is converted to a circular RNA in isolated nuclei of Tetrahymena. Cell. 1981 Feb; 23(2):467-76. PMID: 6162571.
      View in: PubMed
    363. Potter DA, Fostel JM, Berninger M, Pardue ML, Cech TR. DNA-protein interactions in the Drosophila melanogaster mitochondrial genome as deduced from trimethylpsoralen crosslinking patterns. Proc Natl Acad Sci U S A. 1980 Jul; 77(7):4118-22. PMID: 6776522.
      View in: PubMed
    364. Cech TR, Karrer KM. Chromatin structure of the ribosomal RNA genes of Tetrahymena thermophila as analyzed by trimethylpsoralen crosslinking in vivo. J Mol Biol. 1980 Feb 05; 136(4):395-416. PMID: 7365791.
      View in: PubMed
    365. Zaug AJ, Cech TR. In vitro splicing of the ribosomal RNA precursor in nuclei of Tetrahymena. Cell. 1980 Feb; 19(2):331-8. PMID: 7357611.
      View in: PubMed
    366. Cech TR, Rio DC. Localization of transcribed regions on extrachromosomal ribosomal RNA genes of Tetrahymena thermophila by R-loop mapping. Proc Natl Acad Sci U S A. 1979 Oct; 76(10):5051-5. PMID: 291921.
      View in: PubMed
    367. Cech T, Pathak MA, Biswas RK. An electron microscopic study of the photochemical cross-linking of DNA in guinea pig epidermis by psoralen derivatives. Biochim Biophys Acta. 1979 Apr 26; 562(2):342-60. PMID: 444530.
      View in: PubMed
    368. Cech TR, Potter D, Pardue ML. Chromatin structure in living cells. Cold Spring Harb Symp Quant Biol. 1978; 42 Pt 1:191-8. PMID: 277339.
      View in: PubMed
    369. Cech T, Potter D, Pardue ML. Electron microscopy of DNA cross-linked with trimethylpsoralen: a probe for chromatin structure. Biochemistry. 1977 Nov 29; 16(24):5313-21. PMID: 921934.
      View in: PubMed
    370. Cech T, Pardue ML. Cross-linking of DNA with trimethylpsoralen is a probe for chromatin structure. Cell. 1977 Jul; 11(3):631-40. PMID: 560256.
      View in: PubMed
    371. Cech TR, Pardue ML. Electron microscopy of DNA crosslinked with trimethylpsoralen: test of the secondary structure of eukaryotic inverted repeat sequences. Proc Natl Acad Sci U S A. 1976 Aug; 73(8):2644-8. PMID: 1066674.
      View in: PubMed
    372. Cech TR, Reisler F, Hearst JE. Partial denaturation of mouse DNA in preparative CsCl density gradients at alkaline pH. Biochemistry. 1976 May 04; 15(9):1865-73. PMID: 5117.
      View in: PubMed
    373. Cech TR, Hearst JE. Organization of highly repeated sequences in mouse main-band DNA. J Mol Biol. 1976 Jan 25; 100(3):227-56. PMID: 768484.
      View in: PubMed
    374. Cech TR, Hearst JE. An electron microscopic study of mouse foldback DNA. Cell. 1975 Aug; 5(4):429-46. PMID: 1157097.
      View in: PubMed
    375. Hearst JE, Cech TR, Marx KA, Rosenfeld A, Allen JR. Characterization of the rapidly renaturing sequences in the main CsCl density bands of Drosophila, mouse, and human DNA. Cold Spring Harb Symp Quant Biol. 1974; 38:329-39. PMID: 4208786.
      View in: PubMed
    376. Cech TR, Rosenfeld A, Hearst JE. Characterization of the most rapidly renaturing sequences in mouse main-band DNA. J Mol Biol. 1973 Dec 15; 81(3):299-325. PMID: 4767458.
      View in: PubMed
    Cech's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    See all (710) concept(s)
    _
    Co-Authors Expand Description
    See all (18) people
    _
    Similar People Expand Description
    See all (60) people
    _
    Same Department Expand Description
    Search Department

    Copyright © 2022 The Regents of the University of Colorado, a body corporate. All rights reserved. (Harvard PROFILES RNS software version: 2.11.1)