Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
Keywords
Last Name
Institution

Ding Xue

TitleProfessor
InstitutionUniversity of Colorado Boulder
DepartmentBiology-MCD Instruction
Phone303/492-0271

    Collapse Research 
    Collapse research activities and funding
    R35GM118188     (XUE, DING)Jun 1, 2016 - May 31, 2026
    NIH
    Fundamental mechanisms of paternal mitochondrial eliminationand radiation-induced bystander effects
    Role: Principal Investigator
    R01GM088241     (XUE, DING)Jul 19, 2010 - May 31, 2016
    NIH
    Regulation of Cell Death Activation
    Role: Principal Investigator
    R01GM079097     (XUE, DING)Mar 1, 2007 - May 31, 2016
    NIH
    Chromatin Degradation During Apoptosis
    Role: Principal Investigator
    R01GM066262     (XUE, DING)Sep 1, 2002 - Aug 31, 2007
    NIH
    Regulation of Sexually Dimorphic Apoptosis
    Role: Principal Investigator
    R01GM059083     (XUE, DING)Jul 1, 1999 - Feb 28, 2015
    NIH
    Targets of the Cell Death Proteases
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Zhang H, Zhu Y, Suehiro Y, Mitani S, Xue D. AMPK-FOXO-IP3R signaling pathway mediates neurological and developmental defects caused by mitochondrial DNA mutations. Proc Natl Acad Sci U S A. 2023 09 05; 120(36):e2302490120. PMID: 37639584.
      View in: PubMed
    2. Bhadra J, Sridhar N, Fajrial AK, Hammond N, Xue D, Ding X. Acoustic streaming enabled moderate swimming exercise reduces neurodegeneration in C. elegans. Sci Adv. 2023 02 22; 9(8):eadf5056. PMID: 36812319.
      View in: PubMed
    3. Chen Y, Lu Z, Qi C, Yu C, Li Y, Huan W, Wang R, Luo W, Shen D, Ding L, Ren L, Xie H, Xue D, Wang M, Ni K, Xia L, Qian J, Li G. N6-methyladenosine-modified TRAF1 promotes sunitinib resistance by regulating apoptosis and angiogenesis in a METTL14-dependent manner in renal cell carcinoma. Mol Cancer. 2022 05 10; 21(1):111. PMID: 35538475.
      View in: PubMed
    4. Hu L, Feng M, Wang X, Liu S, Wu J, Yan B, Lu W, Wang F, Hu JS, Xue DJ. Solution-processed Ge(ii)-based chalcogenide thin films with tunable bandgaps for photovoltaics. Chem Sci. 2022 May 25; 13(20):5944-5950. PMID: 35685789.
      View in: PubMed
    5. Li Z, Yan HJ, Liu X, Liu S, Feng M, Wang X, Yan B, Xue DJ. Surface-Defect States in Photovoltaic Absorber GeSe. J Phys Chem Lett. 2021 Oct 28; 12(42):10249-10254. PMID: 34648285.
      View in: PubMed
    6. Wang F, Yang H, Zhang H, Zhou J, Wang J, Hu L, Xue DJ, Xu X. One-Pot Synthesis Enables Magnetic Coupled Cr2Te3/MnTe/Cr2Te3 Integrated Heterojunction Nanorods. Nano Lett. 2021 Sep 22; 21(18):7684-7690. PMID: 34435772.
      View in: PubMed
    7. Xia L, Shen D, Zhang Y, Lu J, Wang M, Wang H, Chen Y, Xue D, Xie D, Li G. Targeting the TR4 nuclear receptor with antagonist bexarotene can suppress the proopiomelanocortin signalling in AtT-20 cells. J Cell Mol Med. 2021 03; 25(5):2404-2417. PMID: 33491272.
      View in: PubMed
    8. Wang H, Wang L, Zheng Q, Lu Z, Chen Y, Shen D, Xue D, Jiang M, Ding L, Zhang J, Wu H, Xia L, Qian J, Li G, Lu J. Oncometabolite L-2-hydroxyglurate directly induces vasculogenic mimicry through PHLDB2 in renal cell carcinoma. Int J Cancer. 2021 04 01; 148(7):1743-1755. PMID: 33320958.
      View in: PubMed
    9. Yang H, Wang F, Zhang H, Guo L, Hu L, Wang L, Xue DJ, Xu X. Solution Synthesis of Layered van der Waals (vdW) Ferromagnetic CrGeTe3 Nanosheets from a Non-vdW Cr2Te3Template. J Am Chem Soc. 2020 Mar 04; 142(9):4438-4444. PMID: 31976663.
      View in: PubMed
    10. Li Z, Liu X, Wang X, Yang Y, Liu SC, Shi W, Li Y, Xing X, Xue DJ, Hu JS. Strain-engineering the in-plane electrical anisotropy of GeSe monolayers. Phys Chem Chem Phys. 2020 Jan 02; 22(2):914-918. PMID: 31845940.
      View in: PubMed
    11. Chen Y, Jiang S, Lu Z, Xue D, Xia L, Lu J, Wang H, Xu L, Li L, Li G. Development and verification of a nomogram for prediction of recurrence-free survival in clear cell renal cell carcinoma. J Cell Mol Med. 2020 01; 24(2):1245-1255. PMID: 31782902.
      View in: PubMed
    12. Xue D, Wang H, Chen Y, Shen D, Lu J, Wang M, Zebibula A, Xu L, Wu H, Li G, Xia L. Circ-AKT3 inhibits clear cell renal cell carcinoma metastasis via altering miR-296-3p/E-cadherin signals. Mol Cancer. 2019 11 01; 18(1):151. PMID: 31672157.
      View in: PubMed
    13. Liu SC, Li Z, Yang Y, Wang X, Chen YX, Xue DJ, Hu JS. Investigation of Oxygen Passivation for High-Performance All-Inorganic Perovskite Solar Cells. J Am Chem Soc. 2019 Nov 13; 141(45):18075-18082. PMID: 31638806.
      View in: PubMed
    14. Li Z, Yang Y, Wang X, Shi W, Xue DJ, Hu JS. Three-Dimensional Optical Anisotropy of Low-Symmetry Layered GeS. ACS Appl Mater Interfaces. 2019 Jul 10; 11(27):24247-24253. PMID: 31246410.
      View in: PubMed
    15. Chen YZ, Kl?ditz K, Lee ES, Nguyen DP, Yuan Q, Johnson J, Lee-Yow Y, Hall A, Mitani S, Xia NS, Fadeel B, Xue D. Structure and function analysis of the C. elegans aminophospholipid translocase TAT-1. J Cell Sci. 2019 02 28; 132(5). PMID: 30683797.
      View in: PubMed
    16. Yang Y, Wang X, Liu SC, Li Z, Sun Z, Hu C, Xue DJ, Zhang G, Hu JS. Weak Interlayer Interaction in 2D Anisotropic GeSe2. Adv Sci (Weinh). 2019 Mar 06; 6(5):1801810. PMID: 30886804.
      View in: PubMed
    17. Li Z, Wang X, Shi W, Xing X, Xue DJ, Hu JS. Strain-engineering the electronic properties and anisotropy of GeSe2 monolayers. RSC Adv. 2018 Sep 24; 8(58):33445-33450. PMID: 35548125.
      View in: PubMed
    18. Yang Y, Liu SC, Yang W, Li Z, Wang Y, Wang X, Zhang S, Zhang Y, Long M, Zhang G, Xue DJ, Hu JS, Wan LJ. Air-Stable In-Plane Anisotropic GeSe2 for Highly Polarization-Sensitive Photodetection in Short Wave Region. J Am Chem Soc. 2018 03 21; 140(11):4150-4156. PMID: 29494139.
      View in: PubMed
    19. Chen Y, Lu J, Xia L, Xue D, Yu X, Shen D, Xu L, Li G. Testicular orphan receptor 4 promotes tumor progression and implies poor survival through AKT3 regulation in seminoma. Cancer Sci. 2018 Feb; 109(2):384-394. PMID: 29197138.
      View in: PubMed
    20. Smith CE, Soti S, Jones TA, Nakagawa A, Xue D, Yin H. Non-steroidal Anti-inflammatory Drugs Are Caspase Inhibitors. Cell Chem Biol. 2017 Mar 16; 24(3):281-292. PMID: 28238723.
      View in: PubMed
    21. Chen YX, Ge QQ, Shi Y, Liu J, Xue DJ, Ma JY, Ding J, Yan HJ, Hu JS, Wan LJ. General Space-Confined On-Substrate Fabrication of Thickness-Adjustable Hybrid Perovskite Single-Crystalline Thin Films. J Am Chem Soc. 2016 12 21; 138(50):16196-16199. PMID: 27998083.
      View in: PubMed
    22. Conradt B, Wu YC, Xue D. Programmed Cell Death During Caenorhabditis elegans Development. Genetics. 2016 08; 203(4):1533-62. PMID: 27516615.
      View in: PubMed
    23. Zhou Q, Li H, Li H, Nakagawa A, Lin JL, Lee ES, Harry BL, Skeen-Gaar RR, Suehiro Y, William D, Mitani S, Yuan HS, Kang BH, Xue D. Mitochondrial endonuclease G mediates breakdown of paternal mitochondria upon fertilization. Science. 2016 Jul 22; 353(6297):394-9. PMID: 27338704.
      View in: PubMed
    24. Seervi M, Xue D. Mitochondrial Cell Death Pathways in Caenorhabiditis elegans. Curr Top Dev Biol. 2015; 114:43-65. PMID: 26431563.
      View in: PubMed
    25. Yang H, Chen YZ, Zhang Y, Wang X, Zhao X, Godfroy JI, Liang Q, Zhang M, Zhang T, Yuan Q, Ann Royal M, Driscoll M, Xia NS, Yin H, Xue D. A lysine-rich motif in the phosphatidylserine receptor PSR-1 mediates recognition and removal of apoptotic cells. Nat Commun. 2015 Jan 07; 6:5717. PMID: 25564762.
      View in: PubMed
    26. Sullivan KD, Nakagawa A, Xue D, Espinosa JM. Human ACAP2 is a homolog of C. elegans CNT-1 that promotes apoptosis in cancer cells. Cell Cycle. 2015; 14(12):1771-8. PMID: 25853217.
      View in: PubMed
    27. Weaver BP, Zabinsky R, Weaver YM, Lee ES, Xue D, Han M. CED-3 caspase acts with miRNAs to regulate non-apoptotic gene expression dynamics for robust development in C. elegans. Elife. 2014 Dec 30; 3:e04265. PMID: 25432023.
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    28. Nakagawa A, Sullivan KD, Xue D. Caspase-activated phosphoinositide binding by CNT-1 promotes apoptosis by inhibiting the AKT pathway. Nat Struct Mol Biol. 2014 Dec; 21(12):1082-90. PMID: 25383666.
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    29. Lee ES, Xue D. Caspase protocols in Caenorhabditis elegans. Methods Mol Biol. 2014; 1133:101-8. PMID: 24567097.
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    30. Chen YZ, Mapes J, Lee ES, Skeen-Gaar RR, Xue D. Caspase-mediated activation of Caenorhabditis elegans CED-8 promotes apoptosis and phosphatidylserine externalization. Nat Commun. 2013; 4:2726. PMID: 24225442.
      View in: PubMed
    31. Morton LA, Yang H, Saludes JP, Fiorini Z, Beninson L, Chapman ER, Fleshner M, Xue D, Yin H. MARCKS-ED peptide as a curvature and lipid sensor. ACS Chem Biol. 2013 Jan 18; 8(1):218-25. PMID: 23075500.
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    32. Geng X, Harry BL, Zhou Q, Skeen-Gaar RR, Ge X, Lee ES, Mitani S, Xue D. Hepatitis B virus X protein targets the Bcl-2 protein CED-9 to induce intracellular Ca2+ increase and cell death in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2012 Nov 06; 109(45):18465-70. PMID: 23091037.
      View in: PubMed
    33. Geng X, Huang C, Qin Y, McCombs JE, Yuan Q, Harry BL, Palmer AE, Xia NS, Xue D. Hepatitis B virus X protein targets Bcl-2 proteins to increase intracellular calcium, required for virus replication and cell death induction. Proc Natl Acad Sci U S A. 2012 Nov 06; 109(45):18471-6. PMID: 23091012.
      View in: PubMed
    34. Mapes J, Chen YZ, Kim A, Mitani S, Kang BH, Xue D. CED-1, CED-7, and TTR-52 regulate surface phosphatidylserine expression on apoptotic and phagocytic cells. Curr Biol. 2012 Jul 24; 22(14):1267-75. PMID: 22727702.
      View in: PubMed
    35. Zhou Q, Li H, Xue D. Elimination of paternal mitochondria through the lysosomal degradation pathway in C. elegans. Cell Res. 2011 Dec; 21(12):1662-9. PMID: 22105480.
      View in: PubMed
    36. Mapes J, Chen JT, Yu JS, Xue D. Somatic sex determination in Caenorhabditis elegans is modulated by SUP-26 repression of tra-2 translation. Proc Natl Acad Sci U S A. 2010 Oct 19; 107(42):18022-7. PMID: 20921392.
      View in: PubMed
    37. Wang X, Li W, Zhao D, Liu B, Shi Y, Chen B, Yang H, Guo P, Geng X, Shang Z, Peden E, Kage-Nakadai E, Mitani S, Xue D. Caenorhabditis elegans transthyretin-like protein TTR-52 mediates recognition of apoptotic cells by the CED-1 phagocyte receptor. Nat Cell Biol. 2010 Jul; 12(7):655-64. PMID: 20526330.
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    38. Nakagawa A, Shi Y, Kage-Nakadai E, Mitani S, Xue D. Caspase-dependent conversion of Dicer ribonuclease into a death-promoting deoxyribonuclease. Science. 2010 Apr 16; 328(5976):327-34. PMID: 20223951.
      View in: PubMed
    39. Lai HJ, Lo SJ, Kage-Nakadai E, Mitani S, Xue D. The roles and acting mechanism of Caenorhabditis elegans DNase II genes in apoptotic dna degradation and development. PLoS One. 2009 Oct 07; 4(10):e7348. PMID: 19809494.
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    40. Geng X, Zhou QH, Kage-Nakadai E, Shi Y, Yan N, Mitani S, Xue D. Caenorhabditis elegans caspase homolog CSP-2 inhibits CED-3 autoactivation and apoptosis in germ cells. Cell Death Differ. 2009 Oct; 16(10):1385-94. PMID: 19575016.
      View in: PubMed
    41. Breckenridge DG, Kang BH, Xue D. Bcl-2 proteins EGL-1 and CED-9 do not regulate mitochondrial fission or fusion in Caenorhabditis elegans. Curr Biol. 2009 May 12; 19(9):768-73. PMID: 19327994.
      View in: PubMed
    42. Geng X, Shi Y, Nakagawa A, Yoshina S, Mitani S, Shi Y, Xue D. Inhibition of CED-3 zymogen activation and apoptosis in Caenorhabditis elegans by caspase homolog CSP-3. Nat Struct Mol Biol. 2008 Oct; 15(10):1094-101. PMID: 18776901.
      View in: PubMed
    43. Breckenridge DG, Kang BH, Kokel D, Mitani S, Staehelin LA, Xue D. Caenorhabditis elegans drp-1 and fis-2 regulate distinct cell-death execution pathways downstream of ced-3 and independent of ced-9. Mol Cell. 2008 Aug 22; 31(4):586-597. PMID: 18722182.
      View in: PubMed
    44. Peden E, Killian DJ, Xue D. Cell death specification in C. elegans. Cell Cycle. 2008 Aug 15; 7(16):2479-84. PMID: 18719375.
      View in: PubMed
    45. Killian DJ, Harvey E, Johnson P, Otori M, Mitani S, Xue D. SKR-1, a homolog of Skp1 and a member of the SCF(SEL-10) complex, regulates sex-determination and LIN-12/Notch signaling in C. elegans. Dev Biol. 2008 Oct 15; 322(2):322-31. PMID: 18718460.
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    46. Darland-Ransom M, Wang X, Sun CL, Mapes J, Gengyo-Ando K, Mitani S, Xue D. Role of C. elegans TAT-1 protein in maintaining plasma membrane phosphatidylserine asymmetry. Science. 2008 Apr 25; 320(5875):528-31. PMID: 18436785.
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    47. Peden E, Kimberly E, Gengyo-Ando K, Mitani S, Xue D. Control of sex-specific apoptosis in C. elegans by the BarH homeodomain protein CEH-30 and the transcriptional repressor UNC-37/Groucho. Genes Dev. 2007 Dec 01; 21(23):3195-207. PMID: 18056429.
      View in: PubMed
    48. Wang X, Wang J, Gengyo-Ando K, Gu L, Sun CL, Yang C, Shi Y, Kobayashi T, Shi Y, Mitani S, Xie XS, Xue D. C. elegans mitochondrial factor WAH-1 promotes phosphatidylserine externalization in apoptotic cells through phospholipid scramblase SCRM-1. Nat Cell Biol. 2007 May; 9(5):541-9. PMID: 17401362.
      View in: PubMed
    49. Xue D, Elliott CM, Gong P, Grainger DW, Bignozzi CA, Caramori S. Indirect electrochemical sensing of DNA hybridization based on the catalytic oxidation of cobalt (II). J Am Chem Soc. 2007 Feb 21; 129(7):1854-5. PMID: 17260990.
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    50. Kokel D, Xue D. A class of benzenoid chemicals suppresses apoptosis in C. elegans. Chembiochem. 2006 Dec; 7(12):2010-5. PMID: 17051661.
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    51. Kokel D, Li Y, Qin J, Xue D. The nongenotoxic carcinogens naphthalene and para-dichlorobenzene suppress apoptosis in Caenorhabditis elegans. Nat Chem Biol. 2006 Jun; 2(6):338-45. PMID: 16699520.
      View in: PubMed
    52. Yang C, Yan N, Parish J, Wang X, Shi Y, Xue D. RNA aptamers targeting the cell death inhibitor CED-9 induce cell killing in Caenorhabditis elegans. J Biol Chem. 2006 Apr 07; 281(14):9137-44. PMID: 16467303.
      View in: PubMed
    53. Parrish JZ, Xue D. Cuts can kill: the roles of apoptotic nucleases in cell death and animal development. Chromosoma. 2006 Apr; 115(2):89-97. PMID: 16418867.
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    54. Breckenridge DG, Xue D. Regulation of mitochondrial membrane permeabilization by BCL-2 family proteins and caspases. Curr Opin Cell Biol. 2004 Dec; 16(6):647-52. PMID: 15530776.
      View in: PubMed
    55. Friedman J, Xue D. To live or die by the sword: the regulation of apoptosis by the proteasome. Dev Cell. 2004 Apr; 6(4):460-1. PMID: 15068786.
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    56. Wang X, Wu YC, Fadok VA, Lee MC, Gengyo-Ando K, Cheng LC, Ledwich D, Hsu PK, Chen JY, Chou BK, Henson P, Mitani S, Xue D. Cell corpse engulfment mediated by C. elegans phosphatidylserine receptor through CED-5 and CED-12. Science. 2003 Nov 28; 302(5650):1563-6. PMID: 14645848.
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    57. Parrish JZ, Yang C, Shen B, Xue D. CRN-1, a Caenorhabditis elegans FEN-1 homologue, cooperates with CPS-6/EndoG to promote apoptotic DNA degradation. EMBO J. 2003 Jul 01; 22(13):3451-60. PMID: 12840007.
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    58. Parrish JZ, Xue D. Functional genomic analysis of apoptotic DNA degradation in C. elegans. Mol Cell. 2003 Apr; 11(4):987-96. PMID: 12718884.
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    59. Parrish J, Li L, Klotz K, Ledwich D, Wang X, Xue D. Mitochondrial endonuclease G is important for apoptosis in C. elegans. Nature. 2001 Jul 05; 412(6842):90-4. PMID: 11452313.
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    60. Parrish J, Metters H, Chen L, Xue D. Demonstration of the in vivo interaction of key cell death regulators by structure-based design of second-site suppressors. Proc Natl Acad Sci U S A. 2000 Oct 24; 97(22):11916-21. PMID: 11027303.
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    61. Ledwich D, Wu YC, Driscoll M, Xue D. Analysis of programmed cell death in the nematode Caenorhabditis elegans. Methods Enzymol. 2000; 322:76-88. PMID: 10914006.
      View in: PubMed
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