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Ding Xue

InstitutionUniversity of Colorado Boulder
DepartmentBiology-MCD Instruction
ORCID ORCID Icon0000-0002-8429-8136 Additional info

    Collapse Research 
    Collapse research activities and funding
    R01GM059083     (XUE, DING)Jul 1, 1999 - Feb 28, 2014
    Targets of the Cell Death Proteases
    Role: Principal Investigator

    R01GM066262     (XUE, DING)Sep 1, 2002 - Aug 31, 2007
    Regulation of Sexually Dimorphic Apoptosis
    Role: Principal Investigator

    R01GM079097     (XUE, DING)Mar 1, 2007 - Feb 29, 2016
    Chromatin Degradation During Apoptosis
    Role: Principal Investigator

    R01GM088241     (XUE, DING)Jul 19, 2010 - May 31, 2014
    Regulation of Cell Death Activation
    Role: Principal Investigator

    R35GM118188     (XUE, DING)Jun 1, 2016 - May 31, 2021
    Fundamental mechanisms of apoptosis and phospholipid asymmetry
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Chen YZ, Klöditz K, Lee ES, Nguyen DP, Yuan Q, Johnson J, Lee-Yow Y, Hall A, Mitani S, Xia NS, Fadeel B, Xue D. Structure and function analysis of the C. elegans aminophospholipid translocase TAT-1. J Cell Sci. 2019 Jan 25. PMID: 30683797.
      View in: PubMed
    2. Smith CE, Soti S, Jones TA, Nakagawa A, Xue D, Yin H. Non-steroidal Anti-inflammatory Drugs Are Caspase Inhibitors. Cell Chem Biol. 2017 Mar 16; 24(3):281-292. PMID: 28238723.
      View in: PubMed
    3. Conradt B, Wu YC, Xue D. Programmed Cell Death During Caenorhabditis elegans Development. Genetics. 2016 08; 203(4):1533-62. PMID: 27516615; PMCID: PMC4981262 [Available on 08/01/17].
    4. Zhou Q, Li H, Li H, Nakagawa A, Lin JL, Lee ES, Harry BL, Skeen-Gaar RR, Suehiro Y, William D, Mitani S, Yuan HS, Kang BH, Xue D. Mitochondrial endonuclease G mediates breakdown of paternal mitochondria upon fertilization. Science. 2016 Jul 22; 353(6297):394-9. PMID: 27338704.
      View in: PubMed
    5. Seervi M, Xue D. Mitochondrial Cell Death Pathways in Caenorhabiditis elegans. Curr Top Dev Biol. 2015; 114:43-65. PMID: 26431563.
      View in: PubMed
    6. Yang H, Chen YZ, Zhang Y, Wang X, Zhao X, Godfroy JI, Liang Q, Zhang M, Zhang T, Yuan Q, Ann Royal M, Driscoll M, Xia NS, Yin H, Xue D. A lysine-rich motif in the phosphatidylserine receptor PSR-1 mediates recognition and removal of apoptotic cells. Nat Commun. 2015 Jan 07; 6:5717. PMID: 25564762; PMCID: PMC4306451.
    7. Sullivan KD, Nakagawa A, Xue D, Espinosa JM. Human ACAP2 is a homolog of C. elegans CNT-1 that promotes apoptosis in cancer cells. Cell Cycle. 2015; 14(12):1771-8. PMID: 25853217; PMCID: PMC4614986.
    8. Weaver BP, Zabinsky R, Weaver YM, Lee ES, Xue D, Han M. CED-3 caspase acts with miRNAs to regulate non-apoptotic gene expression dynamics for robust development in C. elegans. Elife. 2014 Dec 30; 3:e04265. PMID: 25432023; PMCID: PMC4279084.
    9. Nakagawa A, Sullivan KD, Xue D. Caspase-activated phosphoinositide binding by CNT-1 promotes apoptosis by inhibiting the AKT pathway. Nat Struct Mol Biol. 2014 Dec; 21(12):1082-90. PMID: 25383666; PMCID: PMC4256149.
    10. Lee ES, Xue D. Caspase protocols in Caenorhabditis elegans. Methods Mol Biol. 2014; 1133:101-8. PMID: 24567097.
      View in: PubMed
    11. Chen YZ, Mapes J, Lee ES, Skeen-Gaar RR, Xue D. Caspase-mediated activation of Caenorhabditis elegans CED-8 promotes apoptosis and phosphatidylserine externalization. Nat Commun. 2013; 4:2726. PMID: 24225442; PMCID: PMC3939056.
    12. Morton LA, Yang H, Saludes JP, Fiorini Z, Beninson L, Chapman ER, Fleshner M, Xue D, Yin H. MARCKS-ED peptide as a curvature and lipid sensor. ACS Chem Biol. 2013 Jan 18; 8(1):218-25. PMID: 23075500; PMCID: PMC3548944.
    13. Geng X, Harry BL, Zhou Q, Skeen-Gaar RR, Ge X, Lee ES, Mitani S, Xue D. Hepatitis B virus X protein targets the Bcl-2 protein CED-9 to induce intracellular Ca2+ increase and cell death in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2012 Nov 06; 109(45):18465-70. PMID: 23091037; PMCID: PMC3494929.
    14. Geng X, Huang C, Qin Y, McCombs JE, Yuan Q, Harry BL, Palmer AE, Xia NS, Xue D. Hepatitis B virus X protein targets Bcl-2 proteins to increase intracellular calcium, required for virus replication and cell death induction. Proc Natl Acad Sci U S A. 2012 Nov 06; 109(45):18471-6. PMID: 23091012; PMCID: PMC3494919.
    15. Mapes J, Chen YZ, Kim A, Mitani S, Kang BH, Xue D. CED-1, CED-7, and TTR-52 regulate surface phosphatidylserine expression on apoptotic and phagocytic cells. Curr Biol. 2012 Jul 24; 22(14):1267-75. PMID: 22727702; PMCID: PMC3816170.
    16. Zhou Q, Li H, Xue D. Elimination of paternal mitochondria through the lysosomal degradation pathway in C. elegans. Cell Res. 2011 Dec; 21(12):1662-9. PMID: 22105480; PMCID: PMC3234996.
    17. Mapes J, Chen JT, Yu JS, Xue D. Somatic sex determination in Caenorhabditis elegans is modulated by SUP-26 repression of tra-2 translation. Proc Natl Acad Sci U S A. 2010 Oct 19; 107(42):18022-7. PMID: 20921392; PMCID: PMC2964189.
    18. Wang X, Li W, Zhao D, Liu B, Shi Y, Chen B, Yang H, Guo P, Geng X, Shang Z, Peden E, Kage-Nakadai E, Mitani S, Xue D. Caenorhabditis elegans transthyretin-like protein TTR-52 mediates recognition of apoptotic cells by the CED-1 phagocyte receptor. Nat Cell Biol. 2010 Jul; 12(7):655-64. PMID: 20526330; PMCID: PMC2896453.
    19. Nakagawa A, Shi Y, Kage-Nakadai E, Mitani S, Xue D. Caspase-dependent conversion of Dicer ribonuclease into a death-promoting deoxyribonuclease. Science. 2010 Apr 16; 328(5976):327-34. PMID: 20223951; PMCID: PMC4313557.
    20. Lai HJ, Lo SJ, Kage-Nakadai E, Mitani S, Xue D. The roles and acting mechanism of Caenorhabditis elegans DNase II genes in apoptotic dna degradation and development. PLoS One. 2009 Oct 07; 4(10):e7348. PMID: 19809494.
      View in: PubMed
    21. Geng X, Zhou QH, Kage-Nakadai E, Shi Y, Yan N, Mitani S, Xue D. Caenorhabditis elegans caspase homolog CSP-2 inhibits CED-3 autoactivation and apoptosis in germ cells. Cell Death Differ. 2009 Oct; 16(10):1385-94. PMID: 19575016; PMCID: PMC2743765.
    22. Breckenridge DG, Kang BH, Xue D. Bcl-2 proteins EGL-1 and CED-9 do not regulate mitochondrial fission or fusion in Caenorhabditis elegans. Curr Biol. 2009 May 12; 19(9):768-73. PMID: 19327994; PMCID: PMC2739285.
    23. Geng X, Shi Y, Nakagawa A, Yoshina S, Mitani S, Shi Y, Xue D. Inhibition of CED-3 zymogen activation and apoptosis in Caenorhabditis elegans by caspase homolog CSP-3. Nat Struct Mol Biol. 2008 Oct; 15(10):1094-101. PMID: 18776901; PMCID: PMC2574878.
    24. Breckenridge DG, Kang BH, Kokel D, Mitani S, Staehelin LA, Xue D. Caenorhabditis elegans drp-1 and fis-2 regulate distinct cell-death execution pathways downstream of ced-3 and independent of ced-9. Mol Cell. 2008 Aug 22; 31(4):586-97. PMID: 18722182; PMCID: PMC2548325.
    25. Peden E, Killian DJ, Xue D. Cell death specification in C. elegans. Cell Cycle. 2008 Aug 15; 7(16):2479-84. PMID: 18719375; PMCID: PMC2651394.
    26. Killian DJ, Harvey E, Johnson P, Otori M, Mitani S, Xue D. SKR-1, a homolog of Skp1 and a member of the SCF(SEL-10) complex, regulates sex-determination and LIN-12/Notch signaling in C. elegans. Dev Biol. 2008 Oct 15; 322(2):322-31. PMID: 18718460; PMCID: PMC2626169.
    27. Darland-Ransom M, Wang X, Sun CL, Mapes J, Gengyo-Ando K, Mitani S, Xue D. Role of C. elegans TAT-1 protein in maintaining plasma membrane phosphatidylserine asymmetry. Science. 2008 Apr 25; 320(5875):528-31. PMID: 18436785.
      View in: PubMed
    28. Peden E, Kimberly E, Gengyo-Ando K, Mitani S, Xue D. Control of sex-specific apoptosis in C. elegans by the BarH homeodomain protein CEH-30 and the transcriptional repressor UNC-37/Groucho. Genes Dev. 2007 Dec 01; 21(23):3195-207. PMID: 18056429; PMCID: PMC2081983.
    29. Wang X, Wang J, Gengyo-Ando K, Gu L, Sun CL, Yang C, Shi Y, Kobayashi T, Shi Y, Mitani S, Xie XS, Xue D. C. elegans mitochondrial factor WAH-1 promotes phosphatidylserine externalization in apoptotic cells through phospholipid scramblase SCRM-1. Nat Cell Biol. 2007 May; 9(5):541-9. PMID: 17401362.
      View in: PubMed
    30. Xue D, Elliott CM, Gong P, Grainger DW, Bignozzi CA, Caramori S. Indirect electrochemical sensing of DNA hybridization based on the catalytic oxidation of cobalt (II). J Am Chem Soc. 2007 Feb 21; 129(7):1854-5. PMID: 17260990; PMCID: PMC2546519.
    31. Kokel D, Xue D. A class of benzenoid chemicals suppresses apoptosis in C. elegans. Chembiochem. 2006 Dec; 7(12):2010-5. PMID: 17051661.
      View in: PubMed
    32. Kokel D, Li Y, Qin J, Xue D. The nongenotoxic carcinogens naphthalene and para-dichlorobenzene suppress apoptosis in Caenorhabditis elegans. Nat Chem Biol. 2006 Jun; 2(6):338-45. PMID: 16699520.
      View in: PubMed
    33. Yang C, Yan N, Parish J, Wang X, Shi Y, Xue D. RNA aptamers targeting the cell death inhibitor CED-9 induce cell killing in Caenorhabditis elegans. J Biol Chem. 2006 Apr 07; 281(14):9137-44. PMID: 16467303.
      View in: PubMed
    34. Parrish JZ, Xue D. Cuts can kill: the roles of apoptotic nucleases in cell death and animal development. Chromosoma. 2006 Apr; 115(2):89-97. PMID: 16418867.
      View in: PubMed
    35. Breckenridge DG, Xue D. Regulation of mitochondrial membrane permeabilization by BCL-2 family proteins and caspases. Curr Opin Cell Biol. 2004 Dec; 16(6):647-52. PMID: 15530776.
      View in: PubMed
    36. Friedman J, Xue D. To live or die by the sword: the regulation of apoptosis by the proteasome. Dev Cell. 2004 Apr; 6(4):460-1. PMID: 15068786.
      View in: PubMed
    37. Wang X, Wu YC, Fadok VA, Lee MC, Gengyo-Ando K, Cheng LC, Ledwich D, Hsu PK, Chen JY, Chou BK, Henson P, Mitani S, Xue D. Cell corpse engulfment mediated by C. elegans phosphatidylserine receptor through CED-5 and CED-12. Science. 2003 Nov 28; 302(5650):1563-6. PMID: 14645848.
      View in: PubMed
    38. Parrish JZ, Yang C, Shen B, Xue D. CRN-1, a Caenorhabditis elegans FEN-1 homologue, cooperates with CPS-6/EndoG to promote apoptotic DNA degradation. EMBO J. 2003 Jul 01; 22(13):3451-60. PMID: 12840007; PMCID: PMC165645.
    39. Parrish JZ, Xue D. Functional genomic analysis of apoptotic DNA degradation in C. elegans. Mol Cell. 2003 Apr; 11(4):987-96. PMID: 12718884.
      View in: PubMed
    40. Wang X, Yang C, Chai J, Shi Y, Xue D. Mechanisms of AIF-mediated apoptotic DNA degradation in Caenorhabditis elegans. Science. 2002 Nov 22; 298(5598):1587-92. PMID: 12446902.
      View in: PubMed
    41. Parrish J, Li L, Klotz K, Ledwich D, Wang X, Xue D. Mitochondrial endonuclease G is important for apoptosis in C. elegans. Nature. 2001 Jul 05; 412(6842):90-4. PMID: 11452313.
      View in: PubMed
    42. Parrish J, Metters H, Chen L, Xue D. Demonstration of the in vivo interaction of key cell death regulators by structure-based design of second-site suppressors. Proc Natl Acad Sci U S A. 2000 Oct 24; 97(22):11916-21. PMID: 11027303; PMCID: PMC17269.
    43. Ledwich D, Wu YC, Driscoll M, Xue D. Analysis of programmed cell death in the nematode Caenorhabditis elegans. Methods Enzymol. 2000; 322:76-88. PMID: 10914006.
      View in: PubMed
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