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David E. Clouthier

InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSDM-Craniofacial Biology

    Collapse Research 
    Collapse research activities and funding
    R01DE014181     (CLOUTHIER, DAVID E.)Jul 1, 2001 - May 31, 2014
    Role: Principal Investigator

    K02DE014765     (CLOUTHIER, DAVID E.)Aug 1, 2002 - May 31, 2007
    Endothelin A Signaling in Craniofacial Development
    Role: Principal Investigator

    R01DE018899     (CLOUTHIER, DAVID E.)Jul 20, 2009 - Jun 30, 2017
    Hand2 Function and Regulation During Craniofacial Development
    Role: Principal Investigator

    U01DE020076     (CLOUTHIER, DAVID E.)Sep 21, 2009 - Apr 30, 2014
    Idenfication of miRNAs involved midfacial development and clefting
    Role: Principal Investigator

    R01DE023050     (CLOUTHIER, DAVID E.)Jul 1, 2014 - Mar 31, 2019
    Defining an Integrated Signaling Network That Patterns the Craniofacial Skeleton
    Role: Principal Investigator

    R01HD081562     (WILLIAMS, TREVOR J)Sep 20, 2014 - Jun 30, 2019
    Phenotyping Embryonic Lethal Knockout mice with neural crest and neural defects
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Sottnik JL, Mallaredy V, Chauca-Diaz A, Ritterson Lew C, Owens C, Dancik GM, Pagliarani S, Lucchiari S, Moggio M, Ripolone M, Comi GP, Frierson HF, Clouthier D, Theodorescu D. Elucidating the role of Agl in bladder carcinogenesis by generation and characterization of genetically engineered mice. Carcinogenesis. 2019 Mar 12; 40(1):194-201. PMID: 30403777.
      View in: PubMed
    2. Xu J, Liu H, Lan Y, Adam M, Clouthier DE, Potter S, Jiang R. Hedgehog signaling patterns the oral-aboral axis of the mandibular arch. Elife. 2019 Jan 14; 8. PMID: 30638444.
      View in: PubMed
    3. Sharma PP, MacLean AL, Meinecke L, Clouthier DE, Nie Q, Schilling TF. Transcriptomics reveals complex kinetics of dorsal-ventral patterning gene expression in the mandibular arch. Genesis. 2019 01; 57(1):e23275. PMID: 30561090.
      View in: PubMed
    4. Tavares ALP, Cox TC, Maxson RM, Ford HL, Clouthier DE. Negative regulation of endothelin signaling by SIX1 is required for proper maxillary development. Development. 2017 06 01; 144(11):2021-2031. PMID: 28455376.
      View in: PubMed
    5. Iklé JM, Tavares AL, King M, Ding H, Colombo S, Firulli BA, Firulli AB, Targoff KL, Yelon D, Clouthier DE. Nkx2.5 regulates endothelin converting enzyme-1 during pharyngeal arch patterning. Genesis. 2017 03; 55(3). PMID: 28109039.
      View in: PubMed
    6. Ding HL, Hooper JE, Batzel P, Eames BF, Postlethwait JH, Artinger KB, Clouthier DE. MicroRNA Profiling during Craniofacial Development: Potential Roles for Mir23b and Mir133b. Front Physiol. 2016; 7:281. PMID: 27471470; PMCID: PMC4943961.
    7. Vincentz JW, Casasnovas JJ, Barnes RM, Que J, Clouthier DE, Wang J, Firulli AB. Exclusion of Dlx5/6 expression from the distal-most mandibular arches enables BMP-mediated specification of the distal cap. Proc Natl Acad Sci U S A. 2016 07 05; 113(27):7563-8. PMID: 27335460; PMCID: PMC4941460.
    8. Van Otterloo E, Feng W, Jones KL, Hynes NE, Clouthier DE, Niswander L, Williams T. MEMO1 drives cranial endochondral ossification and palatogenesis. Dev Biol. 2016 07 15; 415(2):278-295. PMID: 26746790; PMCID: PMC4914435 [Available on 07/15/17].
    9. Glidewell SC, Miyamoto SD, Grossfeld PD, Clouthier DE, Coldren CD, Stearman RS, Geraci MW. Transcriptional Impact of Rare and Private Copy Number Variants in Hypoplastic Left Heart Syndrome. Clin Transl Sci. 2015 Dec; 8(6):682-9. PMID: 26534787; PMCID: PMC4703543 [Available on 12/01/16].
    10. Tavares AL, Artinger KB, Clouthier DE. Regulating Craniofacial Development at the 3' End: MicroRNAs and Their Function in Facial Morphogenesis. Curr Top Dev Biol. 2015; 115:335-75. PMID: 26589932.
      View in: PubMed
    11. Van Laarhoven PM, Neitzel LR, Quintana AM, Geiger EA, Zackai EH, Clouthier DE, Artinger KB, Ming JE, Shaikh TH. Kabuki syndrome genes KMT2D and KDM6A: functional analyses demonstrate critical roles in craniofacial, heart and brain development. Hum Mol Genet. 2015 Aug 01; 24(15):4443-53. PMID: 25972376; PMCID: PMC4492403.
    12. Gordon CT, Weaver KN, Zechi-Ceide RM, Madsen EC, Tavares AL, Oufadem M, Kurihara Y, Adameyko I, Picard A, Breton S, Pierrot S, Biosse-Duplan M, Voisin N, Masson C, Bole-Feysot C, Nitschké P, Delrue MA, Lacombe D, Guion-Almeida ML, Moura PP, Garib DG, Munnich A, Ernfors P, Hufnagel RB, Hopkin RJ, Kurihara H, Saal HM, Weaver DD, Katsanis N, Lyonnet S, Golzio C, Clouthier DE, Amiel J. Mutations in the endothelin receptor type A cause mandibulofacial dysostosis with alopecia. Am J Hum Genet. 2015 Apr 02; 96(4):519-31. PMID: 25772936; PMCID: PMC4385188.
    13. Tavares AL, Clouthier DE. Cre recombinase-regulated Endothelin1 transgenic mouse lines: novel tools for analysis of embryonic and adult disorders. Dev Biol. 2015 Apr 15; 400(2):191-201. PMID: 25725491; PMCID: PMC4385399.
    14. Firulli BA, Fuchs RK, Vincentz JW, Clouthier DE, Firulli AB. Hand1 phosphoregulation within the distal arch neural crest is essential for craniofacial morphogenesis. Development. 2014 Aug; 141(15):3050-61. PMID: 25053435; PMCID: PMC4197675.
    15. Clouthier DE, Passos-Bueno MR, Tavares AL, Lyonnet S, Amiel J, Gordon CT. Understanding the basis of auriculocondylar syndrome: Insights from human, mouse and zebrafish genetic studies. Am J Med Genet C Semin Med Genet. 2013 Nov; 163C(4):306-17. PMID: 24123988; PMCID: PMC4038158.
    16. Feng W, Choi I, Clouthier DE, Niswander L, Williams T. The Ptch1(DL) mouse: a new model to study lambdoid craniosynostosis and basal cell nevus syndrome-associated skeletal defects. Genesis. 2013 Oct; 51(10):677-89. PMID: 23897749; PMCID: PMC3918964.
    17. Ding HL, Clouthier DE, Artinger KB. Redundant roles of PRDM family members in zebrafish craniofacial development. Dev Dyn. 2013 Jan; 242(1):67-79. PMID: 23109401.
      View in: PubMed
    18. Tavares AL, Garcia EL, Kuhn K, Woods CM, Williams T, Clouthier DE. Ectodermal-derived Endothelin1 is required for patterning the distal and intermediate domains of the mouse mandibular arch. Dev Biol. 2012 Nov 01; 371(1):47-56. PMID: 22902530; PMCID: PMC3470875.
    19. Iklé JM, Artinger KB, Clouthier DE. Identification and characterization of the zebrafish pharyngeal arch-specific enhancer for the basic helix-loop-helix transcription factor Hand2. Dev Biol. 2012 Aug 01; 368(1):118-26. PMID: 22595513; PMCID: PMC3676283.
    20. Barron F, Woods C, Kuhn K, Bishop J, Howard MJ, Clouthier DE. Downregulation of Dlx5 and Dlx6 expression by Hand2 is essential for initiation of tongue morphogenesis. Development. 2011 Jun; 138(11):2249-59. PMID: 21558373; PMCID: PMC3091495.
    21. Hochheiser H, Aronow BJ, Artinger K, Beaty TH, Brinkley JF, Chai Y, Clouthier D, Cunningham ML, Dixon M, Donahue LR, Fraser SE, Hallgrimsson B, Iwata J, Klein O, Marazita ML, Murray JC, Murray S, de Villena FP, Postlethwait J, Potter S, Shapiro L, Spritz R, Visel A, Weinberg SM, Trainor PA. The FaceBase Consortium: a comprehensive program to facilitate craniofacial research. Dev Biol. 2011 Jul 15; 355(2):175-82. PMID: 21458441; PMCID: PMC3440302.
    22. Clouthier DE, Garcia E, Schilling TF. Regulation of facial morphogenesis by endothelin signaling: insights from mice and fish. Am J Med Genet A. 2010 Dec; 152A(12):2962-73. PMID: 20684004; PMCID: PMC2974943.
    23. Ruest LB, Clouthier DE. Elucidating timing and function of endothelin-A receptor signaling during craniofacial development using neural crest cell-specific gene deletion and receptor antagonism. Dev Biol. 2009 Apr 01; 328(1):94-108. PMID: 19185569; PMCID: PMC2821796.
    24. Clouthier DE, Gray J, Artinger KB. Micromanaging Palate Development. Perspect Speech Sci Orofac Disord. 2008 Oct 01; 18(2):62-72. PMID: 20016765.
      View in: PubMed
    25. Hendershot TJ, Liu H, Clouthier DE, Shepherd IT, Coppola E, Studer M, Firulli AB, Pittman DL, Howard MJ. Conditional deletion of Hand2 reveals critical functions in neurogenesis and cell type-specific gene expression for development of neural crest-derived noradrenergic sympathetic ganglion neurons. Dev Biol. 2008 Jul 15; 319(2):179-91. PMID: 18501887; PMCID: PMC2517160.
    26. Clouthier DE. MicroRNAs in facial development. Nat Genet. 2008 Mar; 40(3):268-9. PMID: 18305475.
      View in: PubMed
    27. Hendershot TJ, Liu H, Sarkar AA, Giovannucci DR, Clouthier DE, Abe M, Howard MJ. Expression of Hand2 is sufficient for neurogenesis and cell type-specific gene expression in the enteric nervous system. Dev Dyn. 2007 Jan; 236(1):93-105. PMID: 17075884.
      View in: PubMed
    28. Abe M, Ruest LB, Clouthier DE. Fate of cranial neural crest cells during craniofacial development in endothelin-A receptor-deficient mice. Int J Dev Biol. 2007; 51(2):97-105. PMID: 17294360; PMCID: PMC2810159.
    29. Kanzaki-Kato N, Tamakoshi T, Fu Y, Chandra A, Itakura T, Uezato T, Tanaka T, Clouthier DE, Sugiyama T, Yanagisawa M, Miura N. Roles of forkhead transcription factor Foxc2 (MFH-1) and endothelin receptor A in cardiovascular morphogenesis. Cardiovasc Res. 2005 Feb 15; 65(3):711-8. PMID: 15664398.
      View in: PubMed
    30. Ruest LB, Kedzierski R, Yanagisawa M, Clouthier DE. Deletion of the endothelin-A receptor gene within the developing mandible. Cell Tissue Res. 2005 Mar; 319(3):447-53. PMID: 15647918; PMCID: PMC2806232.
    31. Maurer M, Wedemeyer J, Metz M, Piliponsky AM, Weller K, Chatterjea D, Clouthier DE, Yanagisawa MM, Tsai M, Galli SJ. Mast cells promote homeostasis by limiting endothelin-1-induced toxicity. Nature. 2004 Nov 25; 432(7016):512-6. PMID: 15543132.
      View in: PubMed
    32. Ruest LB, Xiang X, Lim KC, Levi G, Clouthier DE. Endothelin-A receptor-dependent and -independent signaling pathways in establishing mandibular identity. Development. 2004 Sep; 131(18):4413-23. PMID: 15306564; PMCID: PMC2818681.
    33. Clouthier DE, Schilling TF. Understanding endothelin-1 function during craniofacial development in the mouse and zebrafish. Birth Defects Res C Embryo Today. 2004 Jun; 72(2):190-9. PMID: 15269892.
      View in: PubMed
    34. Ruest LB, Hammer RE, Yanagisawa M, Clouthier DE. Dlx5/6-enhancer directed expression of Cre recombinase in the pharyngeal arches and brain. Genesis. 2003 Dec; 37(4):188-94. PMID: 14666512; PMCID: PMC2830754.
    35. Clouthier DE, Williams SC, Hammer RE, Richardson JA, Yanagisawa M. Cell-autonomous and nonautonomous actions of endothelin-A receptor signaling in craniofacial and cardiovascular development. Dev Biol. 2003 Sep 15; 261(2):506-19. PMID: 14499656.
      View in: PubMed
    36. Ruest LB, Dager M, Yanagisawa H, Charité J, Hammer RE, Olson EN, Yanagisawa M, Clouthier DE. dHAND-Cre transgenic mice reveal specific potential functions of dHAND during craniofacial development. Dev Biol. 2003 May 15; 257(2):263-77. PMID: 12729557; PMCID: PMC2830752.
    37. Comerford SA, Clouthier DE, Hinnant EA, Hammer RE. Induction of hepatocyte proliferation and death by modulation of T-Antigen expression. Oncogene. 2003 Apr 24; 22(16):2515-30. PMID: 12717428.
      View in: PubMed
    38. Yanagisawa H, Clouthier DE, Richardson JA, Charité J, Olson EN. Targeted deletion of a branchial arch-specific enhancer reveals a role of dHAND in craniofacial development. Development. 2003 Mar; 130(6):1069-78. PMID: 12571099.
      View in: PubMed
    39. Charité J, McFadden DG, Merlo G, Levi G, Clouthier DE, Yanagisawa M, Richardson JA, Olson EN. Role of Dlx6 in regulation of an endothelin-1-dependent, dHAND branchial arch enhancer. Genes Dev. 2001 Nov 15; 15(22):3039-49. PMID: 11711438; PMCID: PMC312822.
    40. Yanagisawa H, Hammer RE, Richardson JA, Emoto N, Williams SC, Takeda Si, Clouthier DE, Yanagisawa M. Disruption of ECE-1 and ECE-2 reveals a role for endothelin-converting enzyme-2 in murine cardiac development. J Clin Invest. 2000 May; 105(10):1373-82. PMID: 10811845; PMCID: PMC315458.
    41. Clouthier DE, Williams SC, Yanagisawa H, Wieduwilt M, Richardson JA, Yanagisawa M. Signaling pathways crucial for craniofacial development revealed by endothelin-A receptor-deficient mice. Dev Biol. 2000 Jan 01; 217(1):10-24. PMID: 10625532.
      View in: PubMed
    42. Devine JH, Eubank DW, Clouthier DE, Tontonoz P, Spiegelman BM, Hammer RE, Beale EG. Adipose expression of the phosphoenolpyruvate carboxykinase promoter requires peroxisome proliferator-activated receptor gamma and 9-cis-retinoic acid receptor binding to an adipocyte-specific enhancer in vivo. J Biol Chem. 1999 May 07; 274(19):13604-12. PMID: 10224131.
      View in: PubMed
    43. Yanagisawa H, Hammer RE, Richardson JA, Williams SC, Clouthier DE, Yanagisawa M. Role of Endothelin-1/Endothelin-A receptor-mediated signaling pathway in the aortic arch patterning in mice. J Clin Invest. 1998 Jul 01; 102(1):22-33. PMID: 9649553; PMCID: PMC509061.
    44. Clouthier DE, Hosoda K, Richardson JA, Williams SC, Yanagisawa H, Kuwaki T, Kumada M, Hammer RE, Yanagisawa M. Cranial and cardiac neural crest defects in endothelin-A receptor-deficient mice. Development. 1998 Mar; 125(5):813-24. PMID: 9449664.
      View in: PubMed
    45. Yanagisawa H, Yanagisawa M, Kapur RP, Richardson JA, Williams SC, Clouthier DE, de Wit D, Emoto N, Hammer RE. Dual genetic pathways of endothelin-mediated intercellular signaling revealed by targeted disruption of endothelin converting enzyme-1 gene. Development. 1998 Mar; 125(5):825-36. PMID: 9449665.
      View in: PubMed
    46. Clouthier DE, Comerford SA, Hammer RE. Hepatic fibrosis, glomerulosclerosis, and a lipodystrophy-like syndrome in PEPCK-TGF-beta1 transgenic mice. J Clin Invest. 1997 Dec 01; 100(11):2697-713. PMID: 9389733; PMCID: PMC508473.
    47. Clouthier DE, Avarbock MR, Maika SD, Hammer RE, Brinster RL. Rat spermatogenesis in mouse testis. Nature. 1996 May 30; 381(6581):418-21. PMID: 8632797; PMCID: PMC4889340.
    48. Beale EG, Clouthier DE, Hammer RE. Cell-specific expression of cytosolic phosphoenolpyruvate carboxykinase in transgenic mice. FASEB J. 1992 Dec; 6(15):3330-7. PMID: 1281456.
      View in: PubMed
    49. Herz J, Clouthier DE, Hammer RE. LDL receptor-related protein internalizes and degrades uPA-PAI-1 complexes and is essential for embryo implantation. Cell. 1992 Oct 30; 71(3):411-21. PMID: 1423604.
      View in: PubMed
    50. Short MK, Clouthier DE, Schaefer IM, Hammer RE, Magnuson MA, Beale EG. Tissue-specific, developmental, hormonal, and dietary regulation of rat phosphoenolpyruvate carboxykinase-human growth hormone fusion genes in transgenic mice. Mol Cell Biol. 1992 Mar; 12(3):1007-20. PMID: 1545785; PMCID: PMC369533.
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