Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Ross McNaul Kedl

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-IMM MICRO GENERAL OPER
Phone303/724-8671

    Collapse Research 
    Collapse research activities and funding
    R21AI171061     (KEDL, ROSS M)Jul 8, 2022 - Jun 30, 2025
    NIH
    mRNA encoding of immune receptor-targeting antibodies for the augmentation of vaccine-elicited cellular immunity.
    Role: Principal Investigator
    U01AI160664     (KEDL, ROSS M)Mar 25, 2021 - Feb 28, 2026
    NIH
    Mechanisms of combined CD40/TLR adjuvant-elicited cellular immunity
    Role: Principal Investigator
    R21AI156456     (KEDL, ROSS M)Jan 28, 2021 - Dec 31, 2023
    NIH
    Exploring the heterogeneity of the vaccine-elicited T cell response by scRNAseq
    Role: Principal Investigator
    R01AI148919     (KEDL, ROSS M)Aug 19, 2020 - Jul 31, 2025
    NIH
    CD8 T cell and B cell collaboration following subunit vaccination
    Role: Principal Investigator
    R01AI126899     (KEDL, ROSS M)Jul 15, 2016 - Jun 30, 2021
    NIH
    Molecular and cellular basis of Combined Adjuvant-Elicited Cellular Immunity
    Role: Principal Investigator
    R01AI117918     (KEDL, ROSS M)Jan 15, 2015 - Dec 31, 2019
    NIH
    Lymphatic endothelial cell capture and maintenance of antigen
    Role: Principal Investigator
    R01AI101205     (KEDL, ROSS M)Mar 11, 2013 - Feb 28, 2019
    NIH
    Virtual Memory T Cell Development and Responses In Vivo
    Role: Principal Investigator
    R21AI099863     (KEDL, ROSS M)Jul 1, 2012 - Jun 30, 2014
    NIH
    Antigen Persistence and Protective Immunity After Protein Vaccination
    Role: Principal Investigator
    R56AI068777     (KEDL, ROSS M)Aug 18, 2011 - Jul 31, 2013
    NIH
    Combined TLR/CD40-Agonist Induced CD8+ T Cell Memory
    Role: Principal Investigator
    R01AI068777     (KEDL, ROSS M)Aug 1, 2006 - Jul 31, 2011
    NIH
    Combined TLR/CD40-agonist induced CD8+ T cell memory
    Role: Principal Investigator
    R21AI070038     (KEDL, ROSS M)Mar 1, 2006 - Feb 28, 2009
    NIH
    Combined TLR/CD40-agonist vaccine
    Role: Principal Investigator
    R01AI066121     (KEDL, ROSS M)Jul 1, 2005 - Mar 31, 2029
    NIH
    Transcriptional and metabolic regulation of vaccine-elicited CD8+ T cell responses
    Role: Principal Investigator
    T32AI007405     (TORRES, RAUL MARTIN)Sep 30, 1991 - Jul 31, 2026
    NIH
    Training Program in Immunology
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Willett BAS, Thompson SB, Chen V, Dareshouri A, Jackson CL, Brunetti T, D'Alessandro A, Klarquist J, Nemkov T, Kedl RM. Mitochondrial protein OPA1 is required for the expansion of effector CD8 T cells. Cell Rep. 2025 May 27; 44(5):115610. PMID: 40261796.
      View in: PubMed
    2. Manes C, Guerrero Moreno M, Cimons J, D'Antonio MA, Brunetti TM, Harbell MG, Selva S, Mizenko C, Borko TL, Lasda EL, Hesselberth JR, Hsieh EW, Verneris MR, Piquet AL, Gapin L, Kedl RM, Klarquist J. B cells shape na?ve CD8 T cell programming. J Clin Invest. 2025 Apr 17. PMID: 40244703.
      View in: PubMed
    3. Sun Z, Torphy RJ, Miller EN, Darehshouri A, Vigil I, Terai T, Eck E, Sun Y, Guo Y, Yee EJ, Hu J, Kedl RM, Lasda EL, Hesselberth JR, MacLean P, Bruce KD, Randolph GJ, Schulick RD, Zhu Y. GPR182 is a lipoprotein receptor for dietary fat absorption. bioRxiv. 2025 Feb 07. PMID: 39975353.
      View in: PubMed
    4. Phan AT, Aunins E, Cruz-Morales E, Dwivedi G, Bunkofske M, Eberhard JN, Aldridge DL, Said H, Banda O, Tam Y, Christian DA, Vonderheide RH, Kedl RM, Weissman D, Alameh MG, Hunter CA. The type I IFN-IL-27 axis promotes mRNA vaccine-induced CD8 + T cell responses. bioRxiv. 2025 Jan 21. PMID: 39896632.
      View in: PubMed
    5. Aldridge DL, Lanzar Z, Phan AT, Christian DA, Pardy R, Min B, Kedl RM, Hunter CA. IL-27 limits HSPC differentiation during infection and protects from stem cell exhaustion. bioRxiv. 2025 Jan 19. PMID: 39868131.
      View in: PubMed
    6. DeGolier KR, Danis E, D'Antonio M, Cimons J, Yarnell M, Kedl RM, Kohler ME, Scott-Browne JP, Fry TJ. Antigen experience history directs distinct functional states of CD8+ CAR T cells during the antileukemia response. Nat Immunol. 2025 Jan; 26(1):68-81. PMID: 39747430.
      View in: PubMed
    7. Darragh LB, Gadwa J, Pham TT, Van Court B, Neupert B, Olimpo NA, Nguyen K, Nguyen D, Knitz MW, Hoen M, Corbo S, Joshi M, Zhuang Y, Amann M, Wang XJ, Dow S, Kedl RM, Samedi V, Boss MK, Karam SD. Author Correction: Elective nodal irradiation mitigates local and systemic immunity generated by combination radiation and immunotherapy in head and neck tumors. Nat Commun. 2024 Oct 10; 15(1):8781. PMID: 39389942.
      View in: PubMed
    8. Baxter RM, Cabrera-Martinez B, Ghosh T, Rester C, Moreno MG, Borko TL, Selva S, Fleischer CL, Haakonsen N, Mayher A, Bowhay E, Evans C, Miller TM, Huey L, McWilliams J, van Bokhoven A, Deane KD, Knight V, Jordan KR, Ghosh D, Klarquist J, Kedl RM, Piquet AL, Hsieh EWY. SARS-CoV-2 Vaccine-Elicited Immunity after B Cell Depletion in Multiple Sclerosis. Immunohorizons. 2024 03 01; 8(3):254-268. PMID: 38483384.
      View in: PubMed
    9. Aldridge DL, Moodley D, Park J, Phan AT, Rausch M, White KF, Ren Y, Golin K, Radaelli E, Kedl R, Holland PM, Hill J, Hunter CA. Endogenous IL-27 during toxoplasmosis limits early monocyte responses and their inflammatory activation by pathological T cells. mBio. 2024 Mar 13; 15(3):e0008324. PMID: 38376210.
      View in: PubMed
    10. DeGolier KR, Danis E, D'Antonio M, Cimons J, Yarnell M, Kedl RM, Kohler ME, Scott-Browne JP, Fry TJ. Antigen experience history directs distinct functional states of CD8+ CAR T cells during the anti-leukemia response. Res Sq. 2023 Dec 21. PMID: 38196657.
      View in: PubMed
    11. Weinberg A, Johnson MJ, Garth K, Hsieh EWY, Kedl R, Weiskopf D, Cassaday M, Rester C, Cabrera-Martinez B, Baxter RM, Levin MJ. Innate and Adaptive Cell-Mediated Immune Responses to a COVID-19 mRNA Vaccine in Young Children. Open Forum Infect Dis. 2023 Dec; 10(12):ofad608. PMID: 38107018.
      View in: PubMed
    12. Borko TL, Baxter R, Cabrera-Martinez B, Thiruppathi E, Sabalza M, Venkataraman I, Selva S, Rester C, Sillau S, Pastula DM, Bennett JL, Alvarez E, Gross R, Shah A, Kammeyer R, Corboy JR, Kedl RM, Hsieh EWY, Piquet AL. SARS-CoV-2 mRNA vaccination induces an antigen-specific T cell response correlating with plasma interferon-gamma in B cell depleted patients. J Neuroimmunol. 2023 10 15; 383:578192. PMID: 37666038.
      View in: PubMed
    13. Kedl RM, Jameson SC. Virtual memory is a big hairy deal. Nat Immunol. 2023 Aug; 24(8):1215-1216. PMID: 37429991.
      View in: PubMed
    14. Ivanova DL, Thompson SB, Klarquist J, Harbell MG, Kilgore AM, Lasda EL, Hesselberth JR, Hunter CA, Kedl RM. Vaccine adjuvant-elicited CD8+ T?cell immunity is co-dependent on T-bet and FOXO1. Cell Rep. 2023 08 29; 42(8):112911. PMID: 37516968.
      View in: PubMed
    15. Kedl RM, Hsieh EWY, Morrison TE, Samayoa-Reyes G, Flaherty S, Jackson CL, Rochford R. Evidence for Aerosol Transfer of SARS-CoV-2-Specific Humoral Immunity. Immunohorizons. 2023 05 01; 7(5):307-309. PMID: 37159005.
      View in: PubMed
    16. Piper M, Hoen M, Darragh LB, Knitz MW, Nguyen D, Gadwa J, Durini G, Karakoc I, Grier A, Neupert B, Van Court B, Abdelazeem KNM, Yu J, Olimpo NA, Corbo S, Ross RB, Pham TT, Joshi M, Kedl RM, Saviola AJ, Amann M, Uma?a P, Codarri Deak L, Klein C, D'Alessandro A, Karam SD. Simultaneous targeting of PD-1 and IL-2R?? with radiation therapy inhibits pancreatic cancer growth and metastasis. Cancer Cell. 2023 05 08; 41(5):950-969.e6. PMID: 37116489.
      View in: PubMed
    17. Pritchard GH, Phan AT, Christian DA, Blain TJ, Fang Q, Johnson J, Roy NH, Shallberg L, Kedl RM, Hunter CA. Early T-bet promotes LFA1 upregulation required for CD8+ effector and memory T cell development. J Exp Med. 2023 02 06; 220(2). PMID: 36445307.
      View in: PubMed
    18. Darragh LB, Gadwa J, Pham TT, Van Court B, Neupert B, Olimpo NA, Nguyen K, Nguyen D, Knitz MW, Hoen M, Corbo S, Joshi M, Zhuang Y, Amann M, Wang XJ, Dow S, Kedl RM, Samedi V, Boss MK, Karam SD. Elective nodal irradiation mitigates local and systemic immunity generated by combination radiation and immunotherapy in head and neck tumors. Nat Commun. 2022 11 16; 13(1):7015. PMID: 36385142.
      View in: PubMed
    19. Christian DA, Adams TA, Shallberg LA, Phan AT, Smith TE, Abraha M, Perry J, Ruthel G, Clark JT, Pritchard GH, Aronson LR, Gossa S, McGavern DB, Kedl RM, Hunter CA. cDC1 coordinate innate and adaptive responses in the omentum required for T cell priming and memory. Sci Immunol. 2022 09 30; 7(75):eabq7432. PMID: 36179012.
      View in: PubMed
    20. Camp FA, Brunetti TM, Williams MM, Christenson JL, Sreekanth V, Costello JC, Hay ZLZ, Kedl RM, Richer JK, Slansky JE. Antigens Expressed by Breast Cancer Cells Undergoing EMT Stimulate Cytotoxic CD8+ T Cell Immunity. Cancers (Basel). 2022 Sep 09; 14(18). PMID: 36139558.
      View in: PubMed
    21. Kedl RM. Publisher Correction: An immunological autobiography: my year as a COVID-19 vaccine trial participant. NPJ Vaccines. 2022 Aug 19; 7(1):97. PMID: 35986013.
      View in: PubMed
    22. Kansler ER, Dadi S, Krishna C, Nixon BG, Stamatiades EG, Liu M, Kuo F, Zhang J, Zhang X, Capistrano K, Blum KA, Weiss K, Kedl RM, Cui G, Ikuta K, Chan TA, Leslie CS, Hakimi AA, Li MO. Author Correction: Cytotoxic innate lymphoid cells sense cancer cell-expressed interleukin-15 to suppress human and murine malignancies. Nat Immunol. 2022 Aug; 23(8):1285. PMID: 35705800.
      View in: PubMed
    23. Kedl RM. An immunological autobiography: my year as a COVID-19 vaccine trial participant. NPJ Vaccines. 2022 Jul 18; 7(1):80. PMID: 35851389.
      View in: PubMed
    24. Waldman MM, Rahkola JT, Sigler AL, Chung JW, Willett BAS, Kedl RM, Friedman RS, Jacobelli J. Ena/VASP Protein-Mediated Actin Polymerization Contributes to Na?ve CD8+ T Cell Activation and Expansion by Promoting T Cell-APC Interactions In Vivo. Front Immunol. 2022; 13:856977. PMID: 35757762.
      View in: PubMed
    25. Windsor WJ, Roell Y, Tucker H, Cheng CA, Suliman S, Peek LJ, Pestano GA, Lee WT, Zeichhardt H, Lamb MM, Kammel M, Wang H, Kedl R, Rester C, Morrison TE, Davenport BJ, Carson K, Yates J, Howard K, Kulas K, Walt DR, Dafni A, Taylor D, Chu M. Harmonization of Multiple SARS-CoV-2 Reference Materials Using the WHO IS (NIBSC 20/136): Results and Implications. Front Microbiol. 2022; 13:893801. PMID: 35707164.
      View in: PubMed
    26. Kansler ER, Dadi S, Krishna C, Nixon BG, Stamatiades EG, Liu M, Kuo F, Zhang J, Zhang X, Capistrano K, Blum KA, Weiss K, Kedl RM, Cui G, Ikuta K, Chan TA, Leslie CS, Hakimi AA, Li MO. Cytotoxic innate lymphoid cells sense cancer cell-expressed interleukin-15 to suppress human and murine malignancies. Nat Immunol. 2022 06; 23(6):904-915. PMID: 35618834.
      View in: PubMed
    27. Gaikwad H, Li Y, Wang G, Li R, Dai S, Rester C, Kedl R, Saba L, Banda NK, Scheinman RI, Patrick C, Mallela KMG, Moghimi SM, Simberg D. Antibody-Dependent Complement Responses toward SARS-CoV-2 Receptor-Binding Domain Immobilized on "Pseudovirus-like" Nanoparticles. ACS Nano. 2022 May 04. PMID: 35507641.
      View in: PubMed
    28. Piper M, Van Court B, Mueller A, Watanabe S, Bickett T, Bhatia S, Darragh LB, Mayeda M, Nguyen D, Gadwa J, Knitz M, Corbo S, Morgan R, Lee JJ, Dent A, Goodman K, Messersmith W, Schulick R, Del Chiaro M, Zhu Y, Kedl RM, Lenz L, Karam SD. Targeting Treg-Expressed STAT3 Enhances NK-Mediated Surveillance of Metastasis and Improves Therapeutic Response in Pancreatic Adenocarcinoma. Clin Cancer Res. 2022 Mar 01; 28(5):1013-1026. PMID: 34862244.
      View in: PubMed
    29. Torphy RJ, Sun Y, Lin R, Caffrey-Carr A, Fujiwara Y, Ho F, Miller EN, McCarter MD, Lyons TR, Schulick RD, Kedl RM, Zhu Y. GPR182 limits antitumor immunity via chemokine scavenging in mouse melanoma models. Nat Commun. 2022 01 10; 13(1):97. PMID: 35013216.
      View in: PubMed
    30. Windsor WJ, Knight V, Merkel PA, Lamb MM, Tucker HR, Carson K, Howard KM, Yates JL, Santiago ML, McCarthy MK, Morrison TE, Kedl RM, Frazer-Abel A, Guo K, Andersen G, Huey L, Barrett BS, Col?n-Franco JM, Lee WT, Chu MC. COVID-19 Serology Control Panel Using the Dried-Tube Specimen Method. Am J Trop Med Hyg. 2022 01 07; 106(2):562-565. PMID: 34996045.
      View in: PubMed
    31. Suwanpradid J, Lee MJ, Hoang P, Kwock J, Floyd LP, Smith JS, Yin Z, Atwater AR, Rajagopal S, Kedl RM, Corcoran DL, Zhang JY, MacLeod AS. IL-27 Derived From Macrophages Facilitates IL-15 Production and T Cell Maintenance Following Allergic Hypersensitivity Responses. Front Immunol. 2021; 12:713304. PMID: 34659203.
      View in: PubMed
    32. Klarquist J, Cross EW, Thompson SB, Willett B, Aldridge DL, Caffrey-Carr AK, Xu Z, Hunter CA, Getahun A, Kedl RM. B cells promote CD8 T?cell primary and memory responses to subunit vaccines. Cell Rep. 2021 08 24; 36(8):109591. PMID: 34433030.
      View in: PubMed
    33. Lee W, Kingstad-Bakke B, Kedl RM, Kawaoka Y, Suresh M. CCR2 Regulates Vaccine-Induced Mucosal T-Cell Memory to Influenza A Virus. J Virol. 2021 07 12; 95(15):e0053021. PMID: 33952647.
      View in: PubMed
    34. Schultz JS, McCarthy MK, Rester C, Sabourin KR, Annen K, DomBourian M, Eisenmesser E, Frazer-Abel A, Knight V, Jaenisch T, Morrison TE, Rochford R, Kedl RM. Development and Validation of a Multiplex Microsphere Immunoassay Using Dried Blood Spots for SARS-CoV-2 Seroprevalence: Application in First Responders in Colorado, USA. J Clin Microbiol. 2021 05 19; 59(6). PMID: 33795412.
      View in: PubMed
    35. Davenport BJ, Morrison TE, Kedl RM, Klarquist J. Conserved and Novel Mouse CD8 T Cell Epitopes within SARS-CoV-2 Spike Receptor Binding Domain Protein Identified following Subunit Vaccination. J Immunol. 2021 06 01; 206(11):2503-2507. PMID: 33972373.
      View in: PubMed
    36. Kedl RM. Down but far from out: The durability of SARS-CoV-2 immunity after asymptomatic infection. J Exp Med. 2021 05 03; 218(5). PMID: 33861846.
      View in: PubMed
    37. Lee W, Kingstad-Bakke B, Kedl RM, Kawaoka Y, Suresh M. CCR2 Regulates Vaccine-Induced Mucosal T-Cell Memory to Influenza A Virus. bioRxiv. 2021 Mar 25. PMID: 33791695.
      View in: PubMed
    38. Sabourin KR, Schultz J, Romero J, Lamb MM, Larremore D, Morrison TE, Frazer-Abel A, Zimmer S, Kedl RM, Jaenisch T, Rochford R. Risk Factors of SARS-CoV-2 Antibodies in Arapahoe County First Responders-The COVID-19 Arapahoe SErosurveillance Study (CASES) Project. J Occup Environ Med. 2021 03 01; 63(3):191-198. PMID: 33298759.
      View in: PubMed
    39. Burrack AL, Rollins MR, Spartz EJ, Mesojednik TD, Schmiechen ZC, Raynor JF, Wang IX, Kedl RM, Stromnes IM. CD40 Agonist Overcomes T Cell Exhaustion Induced by Chronic Myeloid Cell IL-27 Production in a Pancreatic Cancer Preclinical Model. J Immunol. 2021 03 15; 206(6):1372-1384. PMID: 33558374.
      View in: PubMed
    40. Marinaik CB, Kingstad-Bakke B, Lee W, Hatta M, Sonsalla M, Larsen A, Neldner B, Gasper DJ, Kedl RM, Kawaoka Y, Suresh M. Programming Multifaceted Pulmonary T Cell Immunity by Combination Adjuvants. Cell Rep Med. 2020 09 22; 1(6):100095. PMID: 32984856.
      View in: PubMed
    41. Davenport B, Eberlein J, Nguyen TT, Victorino F, van der Heide V, Kuleshov M, Ma'ayan A, Kedl R, Homann D. Chemokine Signatures of Pathogen-Specific T Cells II: Memory T Cells in Acute and Chronic Infection. J Immunol. 2020 10 15; 205(8):2188-2206. PMID: 32948682.
      View in: PubMed
    42. Eberlein J, Davenport B, Nguyen TT, Victorino F, Jhun K, van der Heide V, Kuleshov M, Ma'ayan A, Kedl R, Homann D. Chemokine Signatures of Pathogen-Specific T Cells I: Effector T Cells. J Immunol. 2020 10 15; 205(8):2169-2187. PMID: 32948687.
      View in: PubMed
    43. Davenport BJ, Bullock C, McCarthy MK, Hawman DW, Murphy KM, Kedl RM, Diamond MS, Morrison TE. Chikungunya Virus Evades Antiviral CD8+ T Cell Responses To Establish Persistent Infection in Joint-Associated Tissues. J Virol. 2020 04 16; 94(9). PMID: 32102875.
      View in: PubMed
    44. Kilgore AM, Pennock ND, Kedl RM. cDC1 IL-27p28 Production Predicts Vaccine-Elicited CD8+ T Cell Memory and Protective Immunity. J Immunol. 2020 02 01; 204(3):510-517. PMID: 31871021.
      View in: PubMed
    45. Thompson EA, Darrah PA, Foulds KE, Hoffer E, Caffrey-Carr A, Norenstedt S, Perbeck L, Seder RA, Kedl RM, Lor? K. Monocytes Acquire the Ability to Prime Tissue-Resident T Cells via IL-10-Mediated TGF-? Release. Cell Rep. 2019 07 30; 28(5):1127-1135.e4. PMID: 31365858.
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    46. Pritchard GH, Kedl RM, Hunter CA. The evolving role of T-bet in resistance to infection. Nat Rev Immunol. 2019 06; 19(6):398-410. PMID: 30846856.
      View in: PubMed
    47. Fernandez IZ, Baxter RM, Garcia-Perez JE, Vendrame E, Ranganath T, Kong DS, Lundquist K, Nguyen T, Ogolla S, Black J, Galambos C, Gumbart JC, Dawany N, Kelsen JR, de Zoeten EF, Quinones R, Eissa H, Verneris MR, Sullivan KE, Rochford R, Blish CA, Kedl RM, Dutmer CM, Hsieh EWY. Correction: A novel human IL2RB mutation results in T and NK cell-driven immune dysregulation. J Exp Med. 2019 Jun 03; 216(6):1465. PMID: 31088899.
      View in: PubMed
    48. Fernandez IZ, Baxter RM, Garcia-Perez JE, Vendrame E, Ranganath T, Kong DS, Lundquist K, Nguyen T, Ogolla S, Black J, Galambos C, Gumbart JC, Dawany N, Kelsen JR, de Zoeten EF, Quinones R, Eissa H, Verneris MR, Sullivan KE, Rochford R, Blish CA, Kedl RM, Dutmer CM, Hsieh EWY. A novel human IL2RB mutation results in T and NK cell-driven immune dysregulation. J Exp Med. 2019 06 03; 216(6):1255-1267. PMID: 31040184.
      View in: PubMed
    49. Cross EW, Blain TJ, Mathew D, Kedl RM. Anti-CD8 monoclonal antibody-mediated depletion alters the phenotype and behavior of surviving CD8+ T cells. PLoS One. 2019; 14(2):e0211446. PMID: 30735510.
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    50. DeLong JH, O'Hara Hall A, Rausch M, Moodley D, Perry J, Park J, Phan AT, Beiting DP, Kedl RM, Hill JA, Hunter CA. IL-27 and TCR Stimulation Promote T Cell Expression of Multiple Inhibitory Receptors. Immunohorizons. 2019 01 15; 3(1):13-25. PMID: 31356173.
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    51. Atif SM, Gibbings SL, Redente EF, Camp FA, Torres RM, Kedl RM, Henson PM, Jakubzick CV. Immune Surveillance by Natural IgM Is Required for Early Neoantigen Recognition and Initiation of Adaptive Immunity. Am J Respir Cell Mol Biol. 2018 11; 59(5):580-591. PMID: 29953261.
      View in: PubMed
    52. Klarquist J, Chitrakar A, Pennock ND, Kilgore AM, Blain T, Zheng C, Danhorn T, Walton K, Jiang L, Sun J, Hunter CA, D'Alessandro A, Kedl RM. Clonal expansion of vaccine-elicited T cells is independent of aerobic glycolysis. Sci Immunol. 2018 09 07; 3(27). PMID: 30194241.
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    53. Vartuli RL, Zhou H, Zhang L, Powers RK, Klarquist J, Rudra P, Vincent MY, Ghosh D, Costello JC, Kedl RM, Slansky JE, Zhao R, Ford HL. Eya3 promotes breast tumor-associated immune suppression via threonine phosphatase-mediated PD-L1 upregulation. J Clin Invest. 2018 06 01; 128(6):2535-2550. PMID: 29757193.
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    54. Homann D, Kedl RM. Dimensions of immunologic memory. Immunol Rev. 2018 05; 283(1):5-6. PMID: 29664575.
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    55. Kedl RM, White JT. Foreign antigen-independent memory-phenotype CD4+ T cells: a new player in innate immunity? Nat Rev Immunol. 2018 02 26; 18(3):1. PMID: 29480288.
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    56. Kilgore AM, Welsh S, Cheney EE, Chitrakar A, Blain TJ, Kedl BJ, Hunter CA, Pennock ND, Kedl RM. IL-27p28 Production by XCR1+ Dendritic Cells and Monocytes Effectively Predicts Adjuvant-Elicited CD8+ T Cell Responses. Immunohorizons. 2018 Jan 01; 2(1):1-11. PMID: 29354801.
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    57. Kedl RM, Lindsay RS, Finlon JM, Lucas ED, Friedman RS, Tamburini BAJ. Migratory dendritic cells acquire and present lymphatic endothelial cell-archived antigens during lymph node contraction. Nat Commun. 2017 12 11; 8(1):2034. PMID: 29229919.
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    58. Kedl RM, Seder R. Editorial overview: Vaccines. Curr Opin Immunol. 2017 08; 47:A1-A2. PMID: 28969845.
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    59. Pritchard GH, Cross EW, Strobel M, Jameson SC, Kedl RM, Hogquist KA, Hunter CA. Corrigendum: Spontaneous partial loss of the OT-I transgene. Nat Immunol. 2017 07 19; 18(8):951. PMID: 28722721.
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    60. White JT, Cross EW, Kedl RM. Antigen-inexperienced memory CD8+ T cells: where they come from and why we need them. Nat Rev Immunol. 2017 Jun; 17(6):391-400. PMID: 28480897.
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    61. Barrett BS, Harper MS, Jones ST, Guo K, Heilman KJ, Kedl RM, Hasenkrug KJ, Santiago ML. Type I interferon signaling is required for the APOBEC3/Rfv3-dependent neutralizing antibody response but not innate retrovirus restriction. Retrovirology. 2017 04 17; 14(1):25. PMID: 28415995.
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    62. Nelsen MK, Beard KS, Plenter RJ, Kedl RM, Clambey ET, Gill RG. Disruption of Transplant Tolerance by an "Incognito" Form of CD8 T Cell-Dependent Memory. Am J Transplant. 2017 Jul; 17(7):1742-1753. PMID: 28066981.
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    63. Eberlein J, Davenport B, Nguyen T, Victorino F, Haist K, Jhun K, Karimpour-Fard A, Hunter L, Kedl R, Clambey ET, Homann D. Aging promotes acquisition of naive-like CD8+ memory T cell traits and enhanced functionalities. J Clin Invest. 2016 10 03; 126(10):3942-3960. PMID: 27617858.
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    64. Pritchard GH, Cross EW, Strobel M, Jameson SC, Kedl RM, Hogquist KA, Hunter CA. Spontaneous partial loss of the OT-I transgene. Nat Immunol. 2016 May; 17(5):471. PMID: 27092794.
      View in: PubMed
    65. White JT, Cross EW, Burchill MA, Danhorn T, McCarter MD, Rosen HR, O'Connor B, Kedl RM. Virtual memory T cells develop and mediate bystander protective immunity in an IL-15-dependent manner. Nat Commun. 2016 Apr 21; 7:11291. PMID: 27097762.
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    66. Pennock ND, Kedl JD, Kedl RM. T Cell Vaccinology: Beyond the Reflection of Infectious Responses. Trends Immunol. 2016 Mar; 37(3):170-180. PMID: 26830540.
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    67. Thompson EA, Liang F, Lindgren G, Sandgren KJ, Quinn KM, Darrah PA, Koup RA, Seder RA, Kedl RM, Lor? K. Correction: Human Anti-CD40 Antibody and Poly IC:LC Adjuvant Combination Induces Potent T Cell Responses in the Lung of Nonhuman Primates. J Immunol. 2015 Oct 01; 195(7):3497-8. PMID: 26386039.
      View in: PubMed
    68. Kedl RM, Tamburini BA. Antigen archiving by lymph node stroma: A novel function for the lymphatic endothelium. Eur J Immunol. 2015 Oct; 45(10):2721-9. PMID: 26278423.
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    69. Burchill MA, Tamburini BA, Kedl RM. T cells compete by cleaving cell surface CD27 and blocking access to CD70-bearing APCs. Eur J Immunol. 2015 Nov; 45(11):3140-9. PMID: 26179759.
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    70. Thompson EA, Liang F, Lindgren G, Sandgren KJ, Quinn KM, Darrah PA, Koup RA, Seder RA, Kedl RM, Lor? K. Human Anti-CD40 Antibody and Poly IC:LC Adjuvant Combination Induces Potent T Cell Responses in the Lung of Nonhuman Primates. J Immunol. 2015 Aug 01; 195(3):1015-24. PMID: 26123354.
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    71. Atif SM, Nelsen MK, Gibbings SL, Desch AN, Kedl RM, Gill RG, Marrack P, Murphy KM, Grazia TJ, Henson PM, Jakubzick CV. Cutting Edge: Roles for Batf3-Dependent APCs in the Rejection of Minor Histocompatibility Antigen-Mismatched Grafts. J Immunol. 2015 Jul 01; 195(1):46-50. PMID: 26034174.
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    72. Kedl JD, Kedl RM. How squalene GLAdly helps generate antigen-specific T cells via antigen-carrying neutrophils and IL-18. Eur J Immunol. 2015 Feb; 45(2):376-9. PMID: 25641415.
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    73. Zhang Y, Tian S, Liu Z, Zhang J, Zhang M, Bosenberg MW, Kedl RM, Waldmann TA, Storkus WJ, Falo LD, You Z. Dendritic cell-derived interleukin-15 is crucial for therapeutic cancer vaccine potency. Oncoimmunology. 2014 Nov; 3(10):e959321. PMID: 25941586.
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    74. Kedl RM, Wysocki LJ, Janssen WJ, Born WK, Rosenbaum MD, Granowski J, Kench JA, Fong DL, Switzer LA, Cruse M, Huang H, Jakubzick CV, Kosmider B, Takeda K, Stranova TJ, Klumm RC, Delgado C, Tummala S, De Langhe S, Cambier J, Haskins K, Lenz LL, Curran-Everett D. General parity between trio and pairwise breeding of laboratory mice in static caging. J Immunol. 2014 Nov 15; 193(10):4757-60. PMID: 25381356.
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    75. Pennock ND, Gapin L, Kedl RM. IL-27 is required for shaping the magnitude, affinity distribution, and memory of T cells responding to subunit immunization. Proc Natl Acad Sci U S A. 2014 Nov 18; 111(46):16472-7. PMID: 25267651.
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    76. Desch AN, Gibbings SL, Clambey ET, Janssen WJ, Slansky JE, Kedl RM, Henson PM, Jakubzick C. Dendritic cell subsets require cis-activation for cytotoxic CD8 T-cell induction. Nat Commun. 2014 Aug 19; 5:4674. PMID: 25135627.
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    77. Tamburini BA, Burchill MA, Kedl RM. Antigen capture and archiving by lymphatic endothelial cells following vaccination or viral infection. Nat Commun. 2014 Jun 06; 5:3989. PMID: 24905362.
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    78. Pennock ND, White JT, Cross EW, Cheney EE, Tamburini BA, Kedl RM. T cell responses: naive to memory and everything in between. Adv Physiol Educ. 2013 Dec; 37(4):273-83. PMID: 24292902.
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    79. Christie M, Torres RM, Kedl RM, Randolph TW, Carpenter JF. Recombinant murine growth hormone particles are more immunogenic with intravenous than subcutaneous administration. J Pharm Sci. 2014 Jan; 103(1):128-39. PMID: 25133276.
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    80. Bahr TM, Hughes GJ, Armstrong M, Reisdorph R, Coldren CD, Edwards MG, Schnell C, Kedl R, LaFlamme DJ, Reisdorph N, Kechris KJ, Bowler RP. Peripheral blood mononuclear cell gene expression in chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol. 2013 Aug; 49(2):316-23. PMID: 23590301.
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    81. Edwards LE, Haluszczak C, Kedl RM. Phenotype and function of protective, CD4-independent CD8 T cell memory. Immunol Res. 2013 Mar; 55(1-3):135-45. PMID: 22948808.
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    82. Friend SF, Peterson LK, Kedl RM, Dragone LL. SLAP deficiency increases TCR avidity leading to altered repertoire and negative selection of cognate antigen-specific CD8+ T cells. Immunol Res. 2013 Mar; 55(1-3):116-24. PMID: 22956467.
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    83. Sosinowski T, White JT, Cross EW, Haluszczak C, Marrack P, Gapin L, Kedl RM. CD8a+ dendritic cell trans presentation of IL-15 to naive CD8+ T cells produces antigen-inexperienced T cells in the periphery with memory phenotype and function. J Immunol. 2013 Mar 01; 190(5):1936-47. PMID: 23355737.
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    84. Lang J, Kelly M, Freed BM, McCarter MD, Kedl RM, Torres RM, Pelanda R. Studies of lymphocyte reconstitution in a humanized mouse model reveal a requirement of T cells for human B cell maturation. J Immunol. 2013 Mar 01; 190(5):2090-101. PMID: 23335750.
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    85. Huang Y, Aydintug MK, Loomis J, Macleod MK, McKee AS, Kirchenbaum G, Jakubzick CV, Kedl RM, Sun D, Jacobelli J, O'Brien RL, Born WK. Antigen-specific regulation of IgE antibodies by non-antigen-specific ?d T cells. J Immunol. 2013 Feb 01; 190(3):913-21. PMID: 23275606.
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    86. Burchill MA, Tamburini BA, Pennock ND, White JT, Kurche JS, Kedl RM. T cell vaccinology: exploring the known unknowns. Vaccine. 2013 Jan 02; 31(2):297-305. PMID: 23137843.
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    87. Nakagawa P, Liu Y, Liao TD, Chen X, Gonz?lez GE, Bobbitt KR, Smolarek D, Peterson EL, Kedl R, Yang XP, Rhaleb NE, Carretero OA. Treatment with N-acetyl-seryl-aspartyl-lysyl-proline prevents experimental autoimmune myocarditis in rats. Am J Physiol Heart Circ Physiol. 2012 Nov 01; 303(9):H1114-27. PMID: 22923621.
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    88. Lu L, Faubel S, He Z, Andres Hernando A, Jani A, Kedl R, Edelstein CL. Depletion of macrophages and dendritic cells in ischemic acute kidney injury. Am J Nephrol. 2012; 35(2):181-90. PMID: 22286667.
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    89. Tamburini BA, Kedl RM, Bellgrau D. IL-6-inducing whole yeast-based immunotherapy directly controls IL-12-dependent CD8 T-cell responses. J Immunother. 2012 Jan; 35(1):14-22. PMID: 22130158.
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    90. Sanchez PJ, Kedl RM. An alternative signal 3: CD8? T cell memory independent of IL-12 and type I IFN is dependent on CD27/OX40 signaling. Vaccine. 2012 Feb 01; 30(6):1154-61. PMID: 22178730.
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    91. Kurche JS, Haluszczak C, McWilliams JA, Sanchez PJ, Kedl RM. Type I IFN-dependent T cell activation is mediated by IFN-dependent dendritic cell OX40 ligand expression and is independent of T cell IFNR expression. J Immunol. 2012 Jan 15; 188(2):585-93. PMID: 22156349.
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    92. Kemmler CB, Clambey ET, Kedl RM, Slansky JE. Elevated tumor-associated antigen expression suppresses variant peptide vaccine responses. J Immunol. 2011 Nov 01; 187(9):4431-9. PMID: 21940675.
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    93. Desch AN, Randolph GJ, Murphy K, Gautier EL, Kedl RM, Lahoud MH, Caminschi I, Shortman K, Henson PM, Jakubzick CV. CD103+ pulmonary dendritic cells preferentially acquire and present apoptotic cell-associated antigen. J Exp Med. 2011 Aug 29; 208(9):1789-97. PMID: 21859845.
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    94. Oh JZ, Kurche JS, Burchill MA, Kedl RM. TLR7 enables cross-presentation by multiple dendritic cell subsets through a type I IFN-dependent pathway. Blood. 2011 Sep 15; 118(11):3028-38. PMID: 21813451.
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    95. Henderson A, Propst K, Kedl R, Dow S. Mucosal immunization with liposome-nucleic acid adjuvants generates effective humoral and cellular immunity. Vaccine. 2011 Jul 18; 29(32):5304-12. PMID: 21600950.
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    96. Oh JZ, Kedl RM. The capacity to induce cross-presentation dictates the success of a TLR7 agonist-conjugate vaccine for eliciting cellular immunity. J Immunol. 2010 Oct 15; 185(8):4602-8. PMID: 20844205.
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    97. Kurche JS, Burchill MA, Sanchez PJ, Haluszczak C, Kedl RM. Comparison of OX40 ligand and CD70 in the promotion of CD4+ T cell responses. J Immunol. 2010 Aug 15; 185(4):2106-15. PMID: 20639485.
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    98. McWilliams JA, Sanchez PJ, Haluszczak C, Gapin L, Kedl RM. Multiple innate signaling pathways cooperate with CD40 to induce potent, CD70-dependent cellular immunity. Vaccine. 2010 Feb 10; 28(6):1468-76. PMID: 19995538.
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    99. Cubillos-Ruiz JR, Engle X, Scarlett UK, Martinez D, Barber A, Elgueta R, Wang L, Nesbeth Y, Durant Y, Gewirtz AT, Sentman CL, Kedl R, Conejo-Garcia JR. Polyethylenimine-based siRNA nanocomplexes reprogram tumor-associated dendritic cells via TLR5 to elicit therapeutic antitumor immunity. J Clin Invest. 2009 Aug; 119(8):2231-44. PMID: 19620771.
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    100. Takeda K, Dow SW, Miyahara N, Kodama T, Koya T, Taube C, Joetham A, Park JW, Dakhama A, Kedl RM, Gelfand EW. Vaccine-induced CD8+ T cell-dependent suppression of airway hyperresponsiveness and inflammation. J Immunol. 2009 Jul 01; 183(1):181-90. PMID: 19542429.
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    101. Kedl RM. Revolving doors: from academia to industry and back again. Nat Immunol. 2009 Mar; 10(3):227-9. PMID: 19221549.
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    102. Haluszczak C, Akue AD, Hamilton SE, Johnson LD, Pujanauski L, Teodorovic L, Jameson SC, Kedl RM. The antigen-specific CD8+ T cell repertoire in unimmunized mice includes memory phenotype cells bearing markers of homeostatic expansion. J Exp Med. 2009 02 16; 206(2):435-48. PMID: 19188498.
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    103. Zhang X, Kedl RM, Xiang J. CD40 ligation converts TGF-beta-secreting tolerogenic CD4-8- dendritic cells into IL-12-secreting immunogenic ones. Biochem Biophys Res Commun. 2009 Feb 20; 379(4):954-8. PMID: 19135981.
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    104. You Q, Cheng L, Kedl RM, Ju C. Mechanism of T cell tolerance induction by murine hepatic Kupffer cells. Hepatology. 2008 Sep; 48(3):978-90. PMID: 18712788.
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    105. Ahonen CL, Wasiuk A, Fuse S, Turk MJ, Ernstoff MS, Suriawinata AA, Gorham JD, Kedl RM, Usherwood EJ, Noelle RJ. Enhanced efficacy and reduced toxicity of multifactorial adjuvants compared with unitary adjuvants as cancer vaccines. Blood. 2008 Mar 15; 111(6):3116-25. PMID: 18202224.
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    106. Jordan KR, McMahan RH, Oh JZ, Pipeling MR, Pardoll DM, Kedl RM, Kappler JW, Slansky JE. Baculovirus-infected insect cells expressing peptide-MHC complexes elicit protective antitumor immunity. J Immunol. 2008 Jan 01; 180(1):188-97. PMID: 18097019.
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    107. Moon JJ, Chu HH, Pepper M, McSorley SJ, Jameson SC, Kedl RM, Jenkins MK. Naive CD4(+) T cell frequency varies for different epitopes and predicts repertoire diversity and response magnitude. Immunity. 2007 Aug; 27(2):203-13. PMID: 17707129.
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    108. Sanchez PJ, McWilliams JA, Haluszczak C, Yagita H, Kedl RM. Combined TLR/CD40 stimulation mediates potent cellular immunity by regulating dendritic cell expression of CD70 in vivo. J Immunol. 2007 Feb 01; 178(3):1564-72. PMID: 17237405.
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    109. U'Ren L, Kedl R, Dow S. Vaccination with liposome--DNA complexes elicits enhanced antitumor immunity. Cancer Gene Ther. 2006 Nov; 13(11):1033-44. PMID: 16841080.
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    110. McWilliams JA, McGurran SM, Dow SW, Slansky JE, Kedl RM. A modified tyrosinase-related protein 2 epitope generates high-affinity tumor-specific T cells but does not mediate therapeutic efficacy in an intradermal tumor model. J Immunol. 2006 Jul 01; 177(1):155-61. PMID: 16785510.
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    111. Zaks K, Jordan M, Guth A, Sellins K, Kedl R, Izzo A, Bosio C, Dow S. Efficient immunization and cross-priming by vaccine adjuvants containing TLR3 or TLR9 agonists complexed to cationic liposomes. J Immunol. 2006 Jun 15; 176(12):7335-45. PMID: 16751377.
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    112. Wille-Reece U, Flynn BJ, Lor? K, Koup RA, Miles AP, Saul A, Kedl RM, Mattapallil JJ, Weiss WR, Roederer M, Seder RA. Toll-like receptor agonists influence the magnitude and quality of memory T cell responses after prime-boost immunization in nonhuman primates. J Exp Med. 2006 May 15; 203(5):1249-58. PMID: 16636134.
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    113. Wille-Reece U, Flynn BJ, Lor? K, Koup RA, Kedl RM, Mattapallil JJ, Weiss WR, Roederer M, Seder RA. HIV Gag protein conjugated to a Toll-like receptor 7/8 agonist improves the magnitude and quality of Th1 and CD8+ T cell responses in nonhuman primates. Proc Natl Acad Sci U S A. 2005 Oct 18; 102(42):15190-4. PMID: 16219698.
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    114. Wille-Reece U, Wu CY, Flynn BJ, Kedl RM, Seder RA. Immunization with HIV-1 Gag protein conjugated to a TLR7/8 agonist results in the generation of HIV-1 Gag-specific Th1 and CD8+ T cell responses. J Immunol. 2005 Jun 15; 174(12):7676-83. PMID: 15944268.
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    115. Gorden KB, Gorski KS, Gibson SJ, Kedl RM, Kieper WC, Qiu X, Tomai MA, Alkan SS, Vasilakos JP. Synthetic TLR agonists reveal functional differences between human TLR7 and TLR8. J Immunol. 2005 Feb 01; 174(3):1259-68. PMID: 15661881.
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    116. Ahonen CL, Doxsee CL, McGurran SM, Riter TR, Wade WF, Barth RJ, Vasilakos JP, Noelle RJ, Kedl RM. Combined TLR and CD40 triggering induces potent CD8+ T cell expansion with variable dependence on type I IFN. J Exp Med. 2004 Mar 15; 199(6):775-84. PMID: 15007094.
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    117. Doxsee CL, Riter TR, Reiter MJ, Gibson SJ, Vasilakos JP, Kedl RM. The immune response modifier and Toll-like receptor 7 agonist S-27609 selectively induces IL-12 and TNF-alpha production in CD11c+CD11b+CD8- dendritic cells. J Immunol. 2003 Aug 01; 171(3):1156-63. PMID: 12874201.
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    118. Kedl RM, Kappler JW, Marrack P. Epitope dominance, competition and T cell affinity maturation. Curr Opin Immunol. 2003 Feb; 15(1):120-7. PMID: 12495743.
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    119. Mitchell TC, Teague TK, Hildeman DA, Bender J, Rees WA, Kedl RM, Swanson B, Kappler JW, Marrack P. Stronger correlation of bcl-3 than bcl-2, bcl-xL, costimulation, or antioxidants with adjuvant-induced T cell survival. Ann N Y Acad Sci. 2002 Dec; 975:114-31. PMID: 12538159.
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    120. Gibson SJ, Lindh JM, Riter TR, Gleason RM, Rogers LM, Fuller AE, Oesterich JL, Gorden KB, Qiu X, McKane SW, Noelle RJ, Miller RL, Kedl RM, Fitzgerald-Bocarsly P, Tomai MA, Vasilakos JP. Plasmacytoid dendritic cells produce cytokines and mature in response to the TLR7 agonists, imiquimod and resiquimod. Cell Immunol. 2002 Jul-Aug; 218(1-2):74-86. PMID: 12470615.
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    121. Schaefer BC, Schaefer ML, Kappler JW, Marrack P, Kedl RM. Observation of antigen-dependent CD8+ T-cell/ dendritic cell interactions in vivo. Cell Immunol. 2001 Dec 15; 214(2):110-22. PMID: 12088410.
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    122. Kedl RM, Schaefer BC, Kappler JW, Marrack P. T cells down-modulate peptide-MHC complexes on APCs in vivo. Nat Immunol. 2002 Jan; 3(1):27-32. PMID: 11731800.
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    123. Kedl RM, Jordan M, Potter T, Kappler J, Marrack P, Dow S. CD40 stimulation accelerates deletion of tumor-specific CD8(+) T cells in the absence of tumor-antigen vaccination. Proc Natl Acad Sci U S A. 2001 Sep 11; 98(19):10811-6. PMID: 11526222.
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    124. Mitchell TC, Hildeman D, Kedl RM, Teague TK, Schaefer BC, White J, Zhu Y, Kappler J, Marrack P. Immunological adjuvants promote activated T cell survival via induction of Bcl-3. Nat Immunol. 2001 May; 2(5):397-402. PMID: 11323692.
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    125. Kedl RM, Rees WA, Hildeman DA, Schaefer B, Mitchell T, Kappler J, Marrack P. T cells compete for access to antigen-bearing antigen-presenting cells. J Exp Med. 2000 Oct 16; 192(8):1105-13. PMID: 11034600.
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    126. Marrack P, Mitchell T, Hildeman D, Kedl R, Teague TK, Bender J, Rees W, Schaefer BC, Kappler J. Genomic-scale analysis of gene expression in resting and activated T cells. Curr Opin Immunol. 2000 Apr; 12(2):206-9. PMID: 10712937.
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    127. Teague TK, Hildeman D, Kedl RM, Mitchell T, Rees W, Schaefer BC, Bender J, Kappler J, Marrack P. Activation changes the spectrum but not the diversity of genes expressed by T cells. Proc Natl Acad Sci U S A. 1999 Oct 26; 96(22):12691-6. PMID: 10535984.
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    128. Rees W, Bender J, Teague TK, Kedl RM, Crawford F, Marrack P, Kappler J. An inverse relationship between T cell receptor affinity and antigen dose during CD4(+) T cell responses in vivo and in vitro. Proc Natl Acad Sci U S A. 1999 Aug 17; 96(17):9781-6. PMID: 10449771.
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    129. Deeths MJ, Kedl RM, Mescher MF. CD8+ T cells become nonresponsive (anergic) following activation in the presence of costimulation. J Immunol. 1999 Jul 01; 163(1):102-10. PMID: 10384105.
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    130. Curtsinger JM, Schmidt CS, Mondino A, Lins DC, Kedl RM, Jenkins MK, Mescher MF. Inflammatory cytokines provide a third signal for activation of naive CD4+ and CD8+ T cells. J Immunol. 1999 Mar 15; 162(6):3256-62. PMID: 10092777.
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    131. Marrack P, Mitchell T, Bender J, Hildeman D, Kedl R, Teague K, Kappler J. T-cell survival. Immunol Rev. 1998 Oct; 165:279-85. PMID: 9850867.
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    132. Kedl RM, Mescher MF. Qualitative differences between naive and memory T cells make a major contribution to the more rapid and efficient memory CD8+ T cell response. J Immunol. 1998 Jul 15; 161(2):674-83. PMID: 9670942.
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    133. Kedl RM, Mescher MF. Migration and activation of antigen-specific CD8+ T cells upon in vivo stimulation with allogeneic tumor. J Immunol. 1997 Jul 15; 159(2):650-63. PMID: 9218580.
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    134. Kedl R, Schmechel S, Schiff L. Comparative sequence analysis of the reovirus S4 genes from 13 serotype 1 and serotype 3 field isolates. J Virol. 1995 Jan; 69(1):552-9. PMID: 7527088.
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