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Ross McNaul Kedl

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-Immunology Microbiology
Phone303/724-8671

    Collapse Research 
    Collapse research activities and funding
    R01AI066121     (KEDL, ROSS M)Jul 1, 2005 - Dec 31, 2022
    NIH/NIAID
    Transcriptional regulation of vaccine-elicited and infection-elicited CD8+ T cell responses
    Role: Principal Investigator
    R21AI070038     (KEDL, ROSS M)Mar 1, 2006 - Feb 28, 2009
    NIH/NIAID
    Combined TLR/CD40-agonist vaccine
    Role: Principal Investigator
    R01AI068777     (KEDL, ROSS M)Aug 1, 2006 - Jul 31, 2011
    NIH/NIAID
    Combined TLR/CD40-agonist induced CD8+ T cell memory
    Role: Principal Investigator
    R56AI068777     (KEDL, ROSS M)Aug 18, 2011 - Jul 31, 2013
    NIH/NIAID
    Combined TLR/CD40-Agonist Induced CD8+ T Cell Memory
    Role: Principal Investigator
    R21AI099863     (KEDL, ROSS M)Jul 1, 2012 - Jun 30, 2014
    NIH/NIAID
    Antigen Persistence and Protective Immunity After Protein Vaccination
    Role: Principal Investigator
    R01AI101205     (KEDL, ROSS M)Mar 11, 2013 - Feb 28, 2018
    NIH/NIAID
    Virtual Memory T Cell Development and Responses In Vivo
    Role: Principal Investigator
    R01AI117918     (KEDL, ROSS M)Jan 15, 2015 - Dec 31, 2019
    NIH/NIAID
    Lymphatic endothelial cell capture and maintenance of antigen
    Role: Principal Investigator
    R01AI126899     (KEDL, ROSS M)Jul 15, 2016 - Jun 30, 2021
    NIH/NIAID
    Molecular and cellular basis of Combined Adjuvant-Elicited Cellular Immunity
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Pritchard GH, Kedl RM, Hunter CA. The evolving role of T-bet in resistance to infection. Nat Rev Immunol. 2019 Mar 07. PMID: 30846856.
      View in: PubMed
    2. Cross EW, Blain TJ, Mathew D, Kedl RM. Anti-CD8 monoclonal antibody-mediated depletion alters the phenotype and behavior of surviving CD8+ T cells. PLoS One. 2019; 14(2):e0211446. PMID: 30735510.
      View in: PubMed
    3. Atif SM, Gibbings SL, Redente EF, Camp FA, Torres RM, Kedl RM, Henson PM, Jakubzick CV. Immune Surveillance by Natural IgM Is Required for Early Neoantigen Recognition and Initiation of Adaptive Immunity. Am J Respir Cell Mol Biol. 2018 Nov; 59(5):580-591. PMID: 29953261.
      View in: PubMed
    4. Klarquist J, Chitrakar A, Pennock ND, Kilgore AM, Blain T, Zheng C, Danhorn T, Walton K, Jiang L, Sun J, Hunter CA, D'Alessandro A, Kedl RM. Clonal expansion of vaccine-elicited T cells is independent of aerobic glycolysis. Sci Immunol. 2018 Sep 07; 3(27). PMID: 30194241.
      View in: PubMed
    5. Vartuli RL, Zhou H, Zhang L, Powers RK, Klarquist J, Rudra P, Vincent MY, Ghosh D, Costello JC, Kedl RM, Slansky JE, Zhao R, Ford HL. Eya3 promotes breast tumor-associated immune suppression via threonine phosphatase-mediated PD-L1 upregulation. J Clin Invest. 2018 Jun 01; 128(6):2535-2550. PMID: 29757193.
      View in: PubMed
    6. Homann D, Kedl RM. Dimensions of immunologic memory. Immunol Rev. 2018 05; 283(1):5-6. PMID: 29664575.
      View in: PubMed
    7. Kedl RM, White JT. Foreign antigen-independent memory-phenotype CD4+ T cells: a new player in innate immunity? Nat Rev Immunol. 2018 Feb 26; 18(3):1. PMID: 29480288.
      View in: PubMed
    8. Kilgore AM, Welsh S, Cheney EE, Chitrakar A, Blain TJ, Kedl BJ, Hunter CA, Pennock ND, Kedl RM. IL-27p28 Production by XCR1+ Dendritic Cells and Monocytes Effectively Predicts Adjuvant-Elicited CD8+ T Cell Responses. Immunohorizons. 2018 Jan 01; 2(1):1-11. PMID: 29354801.
      View in: PubMed
    9. Kedl RM, Lindsay RS, Finlon JM, Lucas ED, Friedman RS, Tamburini BAJ. Migratory dendritic cells acquire and present lymphatic endothelial cell-archived antigens during lymph node contraction. Nat Commun. 2017 12 11; 8(1):2034. PMID: 29229919.
      View in: PubMed
    10. Kedl RM, Seder R. Editorial overview: Vaccines. Curr Opin Immunol. 2017 08; 47:A1-A2. PMID: 28969845.
      View in: PubMed
    11. Pritchard GH, Cross EW, Strobel M, Jameson SC, Kedl RM, Hogquist KA, Hunter CA. Corrigendum: Spontaneous partial loss of the OT-I transgene. Nat Immunol. 2017 07 19; 18(8):951. PMID: 28722721.
      View in: PubMed
    12. White JT, Cross EW, Kedl RM. Antigen-inexperienced memory CD8+ T cells: where they come from and why we need them. Nat Rev Immunol. 2017 Jun; 17(6):391-400. PMID: 28480897.
      View in: PubMed
    13. Barrett BS, Harper MS, Jones ST, Guo K, Heilman KJ, Kedl RM, Hasenkrug KJ, Santiago ML. Type I interferon signaling is required for the APOBEC3/Rfv3-dependent neutralizing antibody response but not innate retrovirus restriction. Retrovirology. 2017 04 17; 14(1):25. PMID: 28415995.
      View in: PubMed
    14. Nelsen MK, Beard KS, Plenter RJ, Kedl RM, Clambey ET, Gill RG. Disruption of Transplant Tolerance by an "Incognito" Form of CD8 T Cell-Dependent Memory. Am J Transplant. 2017 Jul; 17(7):1742-1753. PMID: 28066981.
      View in: PubMed
    15. Eberlein J, Davenport B, Nguyen T, Victorino F, Haist K, Jhun K, Karimpour-Fard A, Hunter L, Kedl R, Clambey ET, Homann D. Aging promotes acquisition of naive-like CD8+ memory T cell traits and enhanced functionalities. J Clin Invest. 2016 10 03; 126(10):3942-3960. PMID: 27617858.
      View in: PubMed
    16. Pritchard GH, Cross EW, Strobel M, Jameson SC, Kedl RM, Hogquist KA, Hunter CA. Spontaneous partial loss of the OT-I transgene. Nat Immunol. 2016 May; 17(5):471. PMID: 27092794.
      View in: PubMed
    17. White JT, Cross EW, Burchill MA, Danhorn T, McCarter MD, Rosen HR, O'Connor B, Kedl RM. Virtual memory T cells develop and mediate bystander protective immunity in an IL-15-dependent manner. Nat Commun. 2016 Apr 21; 7:11291. PMID: 27097762.
      View in: PubMed
    18. Pennock ND, Kedl JD, Kedl RM. T Cell Vaccinology: Beyond the Reflection of Infectious Responses. Trends Immunol. 2016 Mar; 37(3):170-180. PMID: 26830540; PMCID: PMC4775298 [Available on 03/01/17].
      View in: PubMed, PubMed Central
    19. Thompson EA, Liang F, Lindgren G, Sandgren KJ, Quinn KM, Darrah PA, Koup RA, Seder RA, Kedl RM, Loré K. Correction: Human Anti-CD40 Antibody and Poly IC:LC Adjuvant Combination Induces Potent T Cell Responses in the Lung of Nonhuman Primates. J Immunol. 2015 Oct 01; 195(7):3497-8. PMID: 26386039.
      View in: PubMed
    20. Kedl RM, Tamburini BA. Antigen archiving by lymph node stroma: A novel function for the lymphatic endothelium. Eur J Immunol. 2015 Oct; 45(10):2721-9. PMID: 26278423; PMCID: PMC4694630 [Available on 10/01/16].
      View in: PubMed, PubMed Central
    21. Burchill MA, Tamburini BA, Kedl RM. T cells compete by cleaving cell surface CD27 and blocking access to CD70-bearing APCs. Eur J Immunol. 2015 Nov; 45(11):3140-9. PMID: 26179759; PMCID: PMC4674305 [Available on 11/01/16].
      View in: PubMed, PubMed Central
    22. Thompson EA, Liang F, Lindgren G, Sandgren KJ, Quinn KM, Darrah PA, Koup RA, Seder RA, Kedl RM, Loré K. Human Anti-CD40 Antibody and Poly IC:LC Adjuvant Combination Induces Potent T Cell Responses in the Lung of Nonhuman Primates. J Immunol. 2015 Aug 01; 195(3):1015-24. PMID: 26123354.
      View in: PubMed
    23. Atif SM, Nelsen MK, Gibbings SL, Desch AN, Kedl RM, Gill RG, Marrack P, Murphy KM, Grazia TJ, Henson PM, Jakubzick CV. Cutting Edge: Roles for Batf3-Dependent APCs in the Rejection of Minor Histocompatibility Antigen-Mismatched Grafts. J Immunol. 2015 Jul 01; 195(1):46-50. PMID: 26034174; PMCID: PMC4632856.
      View in: PubMed, PubMed Central
    24. Kedl JD, Kedl RM. How squalene GLAdly helps generate antigen-specific T cells via antigen-carrying neutrophils and IL-18. Eur J Immunol. 2015 Feb; 45(2):376-9. PMID: 25641415; PMCID: PMC4591922.
      View in: PubMed, PubMed Central
    25. Zhang Y, Tian S, Liu Z, Zhang J, Zhang M, Bosenberg MW, Kedl RM, Waldmann TA, Storkus WJ, Falo LD, You Z. Dendritic cell-derived interleukin-15 is crucial for therapeutic cancer vaccine potency. Oncoimmunology. 2014 Nov; 3(10):e959321. PMID: 25941586.
      View in: PubMed
    26. Kedl RM, Wysocki LJ, Janssen WJ, Born WK, Rosenbaum MD, Granowski J, Kench JA, Fong DL, Switzer LA, Cruse M, Huang H, Jakubzick CV, Kosmider B, Takeda K, Stranova TJ, Klumm RC, Delgado C, Tummala S, De Langhe S, Cambier J, Haskins K, Lenz LL, Curran-Everett D. General parity between trio and pairwise breeding of laboratory mice in static caging. J Immunol. 2014 Nov 15; 193(10):4757-60. PMID: 25381356; PMCID: PMC4440340.
      View in: PubMed, PubMed Central
    27. Pennock ND, Gapin L, Kedl RM. IL-27 is required for shaping the magnitude, affinity distribution, and memory of T cells responding to subunit immunization. Proc Natl Acad Sci U S A. 2014 Nov 18; 111(46):16472-7. PMID: 25267651.
      View in: PubMed
    28. Desch AN, Gibbings SL, Clambey ET, Janssen WJ, Slansky JE, Kedl RM, Henson PM, Jakubzick C. Dendritic cell subsets require cis-activation for cytotoxic CD8 T-cell induction. Nat Commun. 2014 Aug 19; 5:4674. PMID: 25135627; PMCID: PMC4153365.
      View in: PubMed, PubMed Central
    29. Tamburini BA, Burchill MA, Kedl RM. Antigen capture and archiving by lymphatic endothelial cells following vaccination or viral infection. Nat Commun. 2014 Jun 06; 5:3989. PMID: 24905362; PMCID: PMC4073648.
      View in: PubMed, PubMed Central
    30. Pennock ND, White JT, Cross EW, Cheney EE, Tamburini BA, Kedl RM. T cell responses: naive to memory and everything in between. Adv Physiol Educ. 2013 Dec; 37(4):273-83. PMID: 24292902.
      View in: PubMed
    31. Christie M, Torres RM, Kedl RM, Randolph TW, Carpenter JF. Recombinant murine growth hormone particles are more immunogenic with intravenous than subcutaneous administration. J Pharm Sci. 2014 Jan; 103(1):128-39. PMID: 25133276; PMCID: PMC4137484.
      View in: PubMed, PubMed Central
    32. Bahr TM, Hughes GJ, Armstrong M, Reisdorph R, Coldren CD, Edwards MG, Schnell C, Kedl R, LaFlamme DJ, Reisdorph N, Kechris KJ, Bowler RP. Peripheral blood mononuclear cell gene expression in chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol. 2013 Aug; 49(2):316-23. PMID: 23590301; PMCID: PMC3824029.
      View in: PubMed, PubMed Central
    33. Edwards LE, Haluszczak C, Kedl RM. Phenotype and function of protective, CD4-independent CD8 T cell memory. Immunol Res. 2013 Mar; 55(1-3):135-45. PMID: 22948808; PMCID: PMC3922058.
      View in: PubMed, PubMed Central
    34. Friend SF, Peterson LK, Kedl RM, Dragone LL. SLAP deficiency increases TCR avidity leading to altered repertoire and negative selection of cognate antigen-specific CD8+ T cells. Immunol Res. 2013 Mar; 55(1-3):116-24. PMID: 22956467; PMCID: PMC3912270.
      View in: PubMed, PubMed Central
    35. Sosinowski T, White JT, Cross EW, Haluszczak C, Marrack P, Gapin L, Kedl RM. CD8a+ dendritic cell trans presentation of IL-15 to naive CD8+ T cells produces antigen-inexperienced T cells in the periphery with memory phenotype and function. J Immunol. 2013 Mar 01; 190(5):1936-47. PMID: 23355737; PMCID: PMC3578102.
      View in: PubMed, PubMed Central
    36. Lang J, Kelly M, Freed BM, McCarter MD, Kedl RM, Torres RM, Pelanda R. Studies of lymphocyte reconstitution in a humanized mouse model reveal a requirement of T cells for human B cell maturation. J Immunol. 2013 Mar 01; 190(5):2090-101. PMID: 23335750; PMCID: PMC3578183.
      View in: PubMed, PubMed Central
    37. Huang Y, Aydintug MK, Loomis J, Macleod MK, McKee AS, Kirchenbaum G, Jakubzick CV, Kedl RM, Sun D, Jacobelli J, O'Brien RL, Born WK. Antigen-specific regulation of IgE antibodies by non-antigen-specific ?d T cells. J Immunol. 2013 Feb 01; 190(3):913-21. PMID: 23275606; PMCID: PMC3552125.
      View in: PubMed, PubMed Central
    38. Burchill MA, Tamburini BA, Pennock ND, White JT, Kurche JS, Kedl RM. T cell vaccinology: exploring the known unknowns. Vaccine. 2013 Jan 02; 31(2):297-305. PMID: 23137843; PMCID: PMC3529748.
      View in: PubMed, PubMed Central
    39. Nakagawa P, Liu Y, Liao TD, Chen X, González GE, Bobbitt KR, Smolarek D, Peterson EL, Kedl R, Yang XP, Rhaleb NE, Carretero OA. Treatment with N-acetyl-seryl-aspartyl-lysyl-proline prevents experimental autoimmune myocarditis in rats. Am J Physiol Heart Circ Physiol. 2012 Nov 01; 303(9):H1114-27. PMID: 22923621; PMCID: PMC3517643.
      View in: PubMed, PubMed Central
    40. Lu L, Faubel S, He Z, Andres Hernando A, Jani A, Kedl R, Edelstein CL. Depletion of macrophages and dendritic cells in ischemic acute kidney injury. Am J Nephrol. 2012; 35(2):181-90. PMID: 22286667; PMCID: PMC3326279.
      View in: PubMed, PubMed Central
    41. Tamburini BA, Kedl RM, Bellgrau D. IL-6-inducing whole yeast-based immunotherapy directly controls IL-12-dependent CD8 T-cell responses. J Immunother. 2012 Jan; 35(1):14-22. PMID: 22130158; PMCID: PMC3241875.
      View in: PubMed, PubMed Central
    42. Sanchez PJ, Kedl RM. An alternative signal 3: CD8? T cell memory independent of IL-12 and type I IFN is dependent on CD27/OX40 signaling. Vaccine. 2012 Feb 01; 30(6):1154-61. PMID: 22178730; PMCID: PMC3269501.
      View in: PubMed, PubMed Central
    43. Kurche JS, Haluszczak C, McWilliams JA, Sanchez PJ, Kedl RM. Type I IFN-dependent T cell activation is mediated by IFN-dependent dendritic cell OX40 ligand expression and is independent of T cell IFNR expression. J Immunol. 2012 Jan 15; 188(2):585-93. PMID: 22156349; PMCID: PMC3253193.
      View in: PubMed, PubMed Central
    44. Kemmler CB, Clambey ET, Kedl RM, Slansky JE. Elevated tumor-associated antigen expression suppresses variant peptide vaccine responses. J Immunol. 2011 Nov 01; 187(9):4431-9. PMID: 21940675; PMCID: PMC3334317.
      View in: PubMed, PubMed Central
    45. Desch AN, Randolph GJ, Murphy K, Gautier EL, Kedl RM, Lahoud MH, Caminschi I, Shortman K, Henson PM, Jakubzick CV. CD103+ pulmonary dendritic cells preferentially acquire and present apoptotic cell-associated antigen. J Exp Med. 2011 Aug 29; 208(9):1789-97. PMID: 21859845; PMCID: PMC3171085.
      View in: PubMed, PubMed Central
    46. Oh JZ, Kurche JS, Burchill MA, Kedl RM. TLR7 enables cross-presentation by multiple dendritic cell subsets through a type I IFN-dependent pathway. Blood. 2011 Sep 15; 118(11):3028-38. PMID: 21813451; PMCID: PMC3175780.
      View in: PubMed, PubMed Central
    47. Henderson A, Propst K, Kedl R, Dow S. Mucosal immunization with liposome-nucleic acid adjuvants generates effective humoral and cellular immunity. Vaccine. 2011 Jul 18; 29(32):5304-12. PMID: 21600950; PMCID: PMC3539814.
      View in: PubMed, PubMed Central
    48. Oh JZ, Kedl RM. The capacity to induce cross-presentation dictates the success of a TLR7 agonist-conjugate vaccine for eliciting cellular immunity. J Immunol. 2010 Oct 15; 185(8):4602-8. PMID: 20844205; PMCID: PMC3905619.
      View in: PubMed, PubMed Central
    49. Kurche JS, Burchill MA, Sanchez PJ, Haluszczak C, Kedl RM. Comparison of OX40 ligand and CD70 in the promotion of CD4+ T cell responses. J Immunol. 2010 Aug 15; 185(4):2106-15. PMID: 20639485; PMCID: PMC3863553.
      View in: PubMed, PubMed Central
    50. McWilliams JA, Sanchez PJ, Haluszczak C, Gapin L, Kedl RM. Multiple innate signaling pathways cooperate with CD40 to induce potent, CD70-dependent cellular immunity. Vaccine. 2010 Feb 10; 28(6):1468-76. PMID: 19995538; PMCID: PMC2822033.
      View in: PubMed, PubMed Central
    51. Cubillos-Ruiz JR, Engle X, Scarlett UK, Martinez D, Barber A, Elgueta R, Wang L, Nesbeth Y, Durant Y, Gewirtz AT, Sentman CL, Kedl R, Conejo-Garcia JR. Polyethylenimine-based siRNA nanocomplexes reprogram tumor-associated dendritic cells via TLR5 to elicit therapeutic antitumor immunity. J Clin Invest. 2009 Aug; 119(8):2231-44. PMID: 19620771; PMCID: PMC2719935.
      View in: PubMed, PubMed Central
    52. Takeda K, Dow SW, Miyahara N, Kodama T, Koya T, Taube C, Joetham A, Park JW, Dakhama A, Kedl RM, Gelfand EW. Vaccine-induced CD8+ T cell-dependent suppression of airway hyperresponsiveness and inflammation. J Immunol. 2009 Jul 01; 183(1):181-90. PMID: 19542429.
      View in: PubMed
    53. Kedl RM. Revolving doors: from academia to industry and back again. Nat Immunol. 2009 Mar; 10(3):227-9. PMID: 19221549.
      View in: PubMed
    54. Haluszczak C, Akue AD, Hamilton SE, Johnson LD, Pujanauski L, Teodorovic L, Jameson SC, Kedl RM. The antigen-specific CD8+ T cell repertoire in unimmunized mice includes memory phenotype cells bearing markers of homeostatic expansion. J Exp Med. 2009 02 16; 206(2):435-48. PMID: 19188498.
      View in: PubMed
    55. Zhang X, Kedl RM, Xiang J. CD40 ligation converts TGF-beta-secreting tolerogenic CD4-8- dendritic cells into IL-12-secreting immunogenic ones. Biochem Biophys Res Commun. 2009 Feb 20; 379(4):954-8. PMID: 19135981.
      View in: PubMed
    56. You Q, Cheng L, Kedl RM, Ju C. Mechanism of T cell tolerance induction by murine hepatic Kupffer cells. Hepatology. 2008 Sep; 48(3):978-90. PMID: 18712788; PMCID: PMC2600585.
      View in: PubMed, PubMed Central
    57. Ahonen CL, Wasiuk A, Fuse S, Turk MJ, Ernstoff MS, Suriawinata AA, Gorham JD, Kedl RM, Usherwood EJ, Noelle RJ. Enhanced efficacy and reduced toxicity of multifactorial adjuvants compared with unitary adjuvants as cancer vaccines. Blood. 2008 Mar 15; 111(6):3116-25. PMID: 18202224; PMCID: PMC2265452.
      View in: PubMed, PubMed Central
    58. Jordan KR, McMahan RH, Oh JZ, Pipeling MR, Pardoll DM, Kedl RM, Kappler JW, Slansky JE. Baculovirus-infected insect cells expressing peptide-MHC complexes elicit protective antitumor immunity. J Immunol. 2008 Jan 01; 180(1):188-97. PMID: 18097019; PMCID: PMC3111388.
      View in: PubMed, PubMed Central
    59. Moon JJ, Chu HH, Pepper M, McSorley SJ, Jameson SC, Kedl RM, Jenkins MK. Naive CD4(+) T cell frequency varies for different epitopes and predicts repertoire diversity and response magnitude. Immunity. 2007 Aug; 27(2):203-13. PMID: 17707129; PMCID: PMC2200089.
      View in: PubMed, PubMed Central
    60. Sanchez PJ, McWilliams JA, Haluszczak C, Yagita H, Kedl RM. Combined TLR/CD40 stimulation mediates potent cellular immunity by regulating dendritic cell expression of CD70 in vivo. J Immunol. 2007 Feb 01; 178(3):1564-72. PMID: 17237405.
      View in: PubMed
    61. U'Ren L, Kedl R, Dow S. Vaccination with liposome--DNA complexes elicits enhanced antitumor immunity. Cancer Gene Ther. 2006 Nov; 13(11):1033-44. PMID: 16841080.
      View in: PubMed
    62. McWilliams JA, McGurran SM, Dow SW, Slansky JE, Kedl RM. A modified tyrosinase-related protein 2 epitope generates high-affinity tumor-specific T cells but does not mediate therapeutic efficacy in an intradermal tumor model. J Immunol. 2006 Jul 01; 177(1):155-61. PMID: 16785510.
      View in: PubMed
    63. Zaks K, Jordan M, Guth A, Sellins K, Kedl R, Izzo A, Bosio C, Dow S. Efficient immunization and cross-priming by vaccine adjuvants containing TLR3 or TLR9 agonists complexed to cationic liposomes. J Immunol. 2006 Jun 15; 176(12):7335-45. PMID: 16751377.
      View in: PubMed
    64. Wille-Reece U, Flynn BJ, Loré K, Koup RA, Miles AP, Saul A, Kedl RM, Mattapallil JJ, Weiss WR, Roederer M, Seder RA. Toll-like receptor agonists influence the magnitude and quality of memory T cell responses after prime-boost immunization in nonhuman primates. J Exp Med. 2006 May 15; 203(5):1249-58. PMID: 16636134; PMCID: PMC2121207.
      View in: PubMed, PubMed Central
    65. Wille-Reece U, Flynn BJ, Loré K, Koup RA, Kedl RM, Mattapallil JJ, Weiss WR, Roederer M, Seder RA. HIV Gag protein conjugated to a Toll-like receptor 7/8 agonist improves the magnitude and quality of Th1 and CD8+ T cell responses in nonhuman primates. Proc Natl Acad Sci U S A. 2005 Oct 18; 102(42):15190-4. PMID: 16219698; PMCID: PMC1257732.
      View in: PubMed, PubMed Central
    66. Wille-Reece U, Wu CY, Flynn BJ, Kedl RM, Seder RA. Immunization with HIV-1 Gag protein conjugated to a TLR7/8 agonist results in the generation of HIV-1 Gag-specific Th1 and CD8+ T cell responses. J Immunol. 2005 Jun 15; 174(12):7676-83. PMID: 15944268.
      View in: PubMed
    67. Gorden KB, Gorski KS, Gibson SJ, Kedl RM, Kieper WC, Qiu X, Tomai MA, Alkan SS, Vasilakos JP. Synthetic TLR agonists reveal functional differences between human TLR7 and TLR8. J Immunol. 2005 Feb 01; 174(3):1259-68. PMID: 15661881.
      View in: PubMed
    68. Ahonen CL, Doxsee CL, McGurran SM, Riter TR, Wade WF, Barth RJ, Vasilakos JP, Noelle RJ, Kedl RM. Combined TLR and CD40 triggering induces potent CD8+ T cell expansion with variable dependence on type I IFN. J Exp Med. 2004 Mar 15; 199(6):775-84. PMID: 15007094; PMCID: PMC2212721.
      View in: PubMed, PubMed Central
    69. Doxsee CL, Riter TR, Reiter MJ, Gibson SJ, Vasilakos JP, Kedl RM. The immune response modifier and Toll-like receptor 7 agonist S-27609 selectively induces IL-12 and TNF-alpha production in CD11c+CD11b+CD8- dendritic cells. J Immunol. 2003 Aug 01; 171(3):1156-63. PMID: 12874201.
      View in: PubMed
    70. Kedl RM, Kappler JW, Marrack P. Epitope dominance, competition and T cell affinity maturation. Curr Opin Immunol. 2003 Feb; 15(1):120-7. PMID: 12495743.
      View in: PubMed
    71. Mitchell TC, Teague TK, Hildeman DA, Bender J, Rees WA, Kedl RM, Swanson B, Kappler JW, Marrack P. Stronger correlation of bcl-3 than bcl-2, bcl-xL, costimulation, or antioxidants with adjuvant-induced T cell survival. Ann N Y Acad Sci. 2002 Dec; 975:114-31. PMID: 12538159.
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    72. Gibson SJ, Lindh JM, Riter TR, Gleason RM, Rogers LM, Fuller AE, Oesterich JL, Gorden KB, Qiu X, McKane SW, Noelle RJ, Miller RL, Kedl RM, Fitzgerald-Bocarsly P, Tomai MA, Vasilakos JP. Plasmacytoid dendritic cells produce cytokines and mature in response to the TLR7 agonists, imiquimod and resiquimod. Cell Immunol. 2002 Jul-Aug; 218(1-2):74-86. PMID: 12470615.
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    73. Schaefer BC, Schaefer ML, Kappler JW, Marrack P, Kedl RM. Observation of antigen-dependent CD8+ T-cell/ dendritic cell interactions in vivo. Cell Immunol. 2001 Dec 15; 214(2):110-22. PMID: 12088410.
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    74. Kedl RM, Schaefer BC, Kappler JW, Marrack P. T cells down-modulate peptide-MHC complexes on APCs in vivo. Nat Immunol. 2002 Jan; 3(1):27-32. PMID: 11731800.
      View in: PubMed
    75. Kedl RM, Jordan M, Potter T, Kappler J, Marrack P, Dow S. CD40 stimulation accelerates deletion of tumor-specific CD8(+) T cells in the absence of tumor-antigen vaccination. Proc Natl Acad Sci U S A. 2001 Sep 11; 98(19):10811-6. PMID: 11526222; PMCID: PMC58556.
      View in: PubMed, PubMed Central
    76. Mitchell TC, Hildeman D, Kedl RM, Teague TK, Schaefer BC, White J, Zhu Y, Kappler J, Marrack P. Immunological adjuvants promote activated T cell survival via induction of Bcl-3. Nat Immunol. 2001 May; 2(5):397-402. PMID: 11323692.
      View in: PubMed
    77. Kedl RM, Rees WA, Hildeman DA, Schaefer B, Mitchell T, Kappler J, Marrack P. T cells compete for access to antigen-bearing antigen-presenting cells. J Exp Med. 2000 Oct 16; 192(8):1105-13. PMID: 11034600; PMCID: PMC2195874.
      View in: PubMed, PubMed Central
    78. Marrack P, Mitchell T, Hildeman D, Kedl R, Teague TK, Bender J, Rees W, Schaefer BC, Kappler J. Genomic-scale analysis of gene expression in resting and activated T cells. Curr Opin Immunol. 2000 Apr; 12(2):206-9. PMID: 10712937.
      View in: PubMed
    79. Teague TK, Hildeman D, Kedl RM, Mitchell T, Rees W, Schaefer BC, Bender J, Kappler J, Marrack P. Activation changes the spectrum but not the diversity of genes expressed by T cells. Proc Natl Acad Sci U S A. 1999 Oct 26; 96(22):12691-6. PMID: 10535984; PMCID: PMC23052.
      View in: PubMed, PubMed Central
    80. Rees W, Bender J, Teague TK, Kedl RM, Crawford F, Marrack P, Kappler J. An inverse relationship between T cell receptor affinity and antigen dose during CD4(+) T cell responses in vivo and in vitro. Proc Natl Acad Sci U S A. 1999 Aug 17; 96(17):9781-6. PMID: 10449771; PMCID: PMC22287.
      View in: PubMed, PubMed Central
    81. Deeths MJ, Kedl RM, Mescher MF. CD8+ T cells become nonresponsive (anergic) following activation in the presence of costimulation. J Immunol. 1999 Jul 01; 163(1):102-10. PMID: 10384105.
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    82. Curtsinger JM, Schmidt CS, Mondino A, Lins DC, Kedl RM, Jenkins MK, Mescher MF. Inflammatory cytokines provide a third signal for activation of naive CD4+ and CD8+ T cells. J Immunol. 1999 Mar 15; 162(6):3256-62. PMID: 10092777.
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    83. Marrack P, Mitchell T, Bender J, Hildeman D, Kedl R, Teague K, Kappler J. T-cell survival. Immunol Rev. 1998 Oct; 165:279-85. PMID: 9850867.
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    84. Kedl RM, Mescher MF. Qualitative differences between naive and memory T cells make a major contribution to the more rapid and efficient memory CD8+ T cell response. J Immunol. 1998 Jul 15; 161(2):674-83. PMID: 9670942.
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    85. Kedl RM, Mescher MF. Migration and activation of antigen-specific CD8+ T cells upon in vivo stimulation with allogeneic tumor. J Immunol. 1997 Jul 15; 159(2):650-63. PMID: 9218580.
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    86. Kedl R, Schmechel S, Schiff L. Comparative sequence analysis of the reovirus S4 genes from 13 serotype 1 and serotype 3 field isolates. J Virol. 1995 Jan; 69(1):552-9. PMID: 7527088; PMCID: PMC188609.
      View in: PubMed, PubMed Central
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