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Christopher D Link

TitleAssociate Professor
InstitutionUniversity of Colorado Boulder
DepartmentIntegrative Physiology
Phone303/735-5112

    Collapse Research 
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    R29HD026087     (LINK, CHRISTOPHER D)Jul 1, 1989 - Jun 30, 1995
    NIH/NICHD
    GENETIC ANALYSIS OF BURSAL MORPHOGENESIS IN C ELEGANS
    Role: Principal Investigator

    R01AG012423     (LINK, CHRISTOPHER D.)Sep 1, 1996 - Mar 31, 2013
    NIH/NIA
    Transgenic C. elegans as Amyloid Disease Model
    Role: Principal Investigator

    R01AG021037     (LINK, CHRISTOPHER D.)Jun 1, 2003 - May 31, 2008
    NIH/NIA
    Comparative Modeling of Neurodegenerative Diseases
    Role: Principal Investigator

    R01NS063964     (LINK, CHRISTOPHER D.)Apr 1, 2009 - May 31, 2020
    NIH/NINDS
    TDP-43, RNA Metabolism, and ALS/FTD Pathology
    Role: Principal Investigator

    R21AG049693     (LINK, CHRISTOPHER D.)Sep 1, 2015 - Apr 30, 2017
    NIH/NIA
    Abeta Oligomers and Mechanisms of Neuronal Cell Death in Alzheimer's Disease
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Prudencio M, Gonzales PK, Cook CN, Gendron TF, Daughrity LM, Song Y, Ebbert MTW, van Blitterswijk M, Zhang YJ, Jansen-West K, Baker MC, DeTure M, Rademakers R, Boylan KB, Dickson DW, Petrucelli L, Link CD. Repetitive element transcripts are elevated in the brain of C9orf72 ALS/FTLD patients. Hum Mol Genet. 2017 Sep 01; 26(17):3421-3431. PMID: 28637276.
      View in: PubMed
    2. Kim SA, D'Acunto VF, Kokona B, Hofmann J, Cunningham NR, Bistline EM, Garcia FJ, Akhtar NM, Hoffman SH, Doshi SH, Ulrich KM, Jones NM, Bonini NM, Roberts CM, Link CD, Laue TM, Fairman R. Sedimentation Velocity Analysis with Fluorescence Detection of Mutant Huntingtin Exon 1 Aggregation in Drosophila melanogaster and Caenorhabditis elegans. Biochemistry. 2017 Sep 05; 56(35):4676-4688. PMID: 28786671.
      View in: PubMed
    3. Henze A, Homann T, Rohn I, Aschner M, Link CD, Kleuser B, Schweigert FJ, Schwerdtle T, Bornhorst J. Caenorhabditis elegans as a model system to study post-translational modifications of human transthyretin. Sci Rep. 2016 Nov 21; 6:37346. PMID: 27869126.
      View in: PubMed
    4. Kramer NJ, Carlomagno Y, Zhang YJ, Almeida S, Cook CN, Gendron TF, Prudencio M, Van Blitterswijk M, Belzil V, Couthouis J, Paul JW, Goodman LD, Daughrity L, Chew J, Garrett A, Pregent L, Jansen-West K, Tabassian LJ, Rademakers R, Boylan K, Graff-Radford NR, Josephs KA, Parisi JE, Knopman DS, Petersen RC, Boeve BF, Deng N, Feng Y, Cheng TH, Dickson DW, Cohen SN, Bonini NM, Link CD, Gao FB, Petrucelli L, Gitler AD. Spt4 selectively regulates the expression of C9orf72 sense and antisense mutant transcripts. Science. 2016 Aug 12; 353(6300):708-12. PMID: 27516603.
      View in: PubMed
    5. Munkácsy E, Khan MH, Lane RK, Borror MB, Park JH, Bokov AF, Fisher AL, Link CD, Rea SL. DLK-1, SEK-3 and PMK-3 Are Required for the Life Extension Induced by Mitochondrial Bioenergetic Disruption in C. elegans. PLoS Genet. 2016 07; 12(7):e1006133. PMID: 27420916; PMCID: PMC4946786.
    6. Kokona B, May CA, Cunningham NR, Richmond L, Jay Garcia F, Durante JC, Ulrich KM, Roberts CM, Link CD, Stafford WF, Laue TM, Fairman R. Studying polyglutamine aggregation in Caenorhabditis elegans using an analytical ultracentrifuge equipped with fluorescence detection. Protein Sci. 2016 Mar; 25(3):605-17. PMID: 26647351; PMCID: PMC4815402 [Available on 03/01/17].
    7. Prudencio M, Belzil VV, Batra R, Ross CA, Gendron TF, Pregent LJ, Murray ME, Overstreet KK, Piazza-Johnston AE, Desaro P, Bieniek KF, DeTure M, Lee WC, Biendarra SM, Davis MD, Baker MC, Perkerson RB, van Blitterswijk M, Stetler CT, Rademakers R, Link CD, Dickson DW, Boylan KB, Li H, Petrucelli L. Distinct brain transcriptome profiles in C9orf72-associated and sporadic ALS. Nat Neurosci. 2015 Aug; 18(8):1175-82. PMID: 26192745; PMCID: PMC4830686.
    8. Saldi TK, Ash PE, Wilson G, Gonzales P, Garrido-Lecca A, Roberts CM, Dostal V, Gendron TF, Stein LD, Blumenthal T, Petrucelli L, Link CD. TDP-1, the Caenorhabditis elegans ortholog of TDP-43, limits the accumulation of double-stranded RNA. EMBO J. 2014 Dec 17; 33(24):2947-66. PMID: 25391662; PMCID: PMC4282642.
    9. Hassan WM, Dostal V, Huemann BN, Yerg JE, Link CD. Identifying Aß-specific pathogenic mechanisms using a nematode model of Alzheimer's disease. Neurobiol Aging. 2015 Feb; 36(2):857-66. PMID: 25457027; PMCID: PMC4315719.
    10. Machino K, Link CD, Wang S, Murakami H, Murakami S. A semi-automated motion-tracking analysis of locomotion speed in the C. elegans transgenics overexpressing beta-amyloid in neurons. Front Genet. 2014; 5:202. PMID: 25071831; PMCID: PMC4082091.
    11. McColl G, Roberts BR, Pukala TL, Kenche VB, Roberts CM, Link CD, Ryan TM, Masters CL, Barnham KJ, Bush AI, Cherny RA. Utility of an improved model of amyloid-beta (Aß1?42) toxicity in Caenorhabditis elegans for drug screening for Alzheimer's disease. Mol Neurodegener. 2012 Nov 21; 7:57. PMID: 23171715; PMCID: PMC3519830.
    12. Gass J, Lee WC, Cook C, Finch N, Stetler C, Jansen-West K, Lewis J, Link CD, Rademakers R, Nykjær A, Petrucelli L. Progranulin regulates neuronal outgrowth independent of sortilin. Mol Neurodegener. 2012 Jul 10; 7:33. PMID: 22781549; PMCID: PMC3508877.
    13. Cotella D, Hernandez-Enriquez B, Wu X, Li R, Pan Z, Leveille J, Link CD, Oddo S, Sesti F. Toxic role of K+ channel oxidation in mammalian brain. J Neurosci. 2012 Mar 21; 32(12):4133-44. PMID: 22442077.
      View in: PubMed
    14. Link CD, Saldi TK. Development. Cell death by glutamine repeats? Science. 2012 Feb 24; 335(6071):926-7. PMID: 22362996.
      View in: PubMed
    15. Fonte V, Dostal V, Roberts CM, Gonzales P, Lacor PN, Lacor P, Velasco PT, Magrane J, Dingwell N, Fan EY, Silverman MA, Stein GH, Link CD. A glycine zipper motif mediates the formation of toxic ß-amyloid oligomers in vitro and in vivo. Mol Neurodegener. 2011 Aug 23; 6(1):61. PMID: 21861874; PMCID: PMC3178497.
    16. Mendenhall AR, Wu D, Park SK, Cypser JR, Tedesco PM, Link CD, Phillips PC, Johnson TE. Genetic dissection of late-life fertility in Caenorhabditis elegans. J Gerontol A Biol Sci Med Sci. 2011 Aug; 66(8):842-54. PMID: 21622982; PMCID: PMC3148761.
    17. Dostal V, Link CD. Assaying ß-amyloid toxicity using a transgenic C. elegans model. J Vis Exp. 2010 Oct 09; (44). PMID: 20972410; PMCID: PMC3185644.
    18. McColl G, Rogers AN, Alavez S, Hubbard AE, Melov S, Link CD, Bush AI, Kapahi P, Lithgow GJ. Insulin-like signaling determines survival during stress via posttranscriptional mechanisms in C. elegans. Cell Metab. 2010 Sep 08; 12(3):260-72. PMID: 20816092; PMCID: PMC2945254.
    19. Dostal V, Roberts CM, Link CD. Genetic mechanisms of coffee extract protection in a Caenorhabditis elegans model of ß-amyloid peptide toxicity. Genetics. 2010 Nov; 186(3):857-66. PMID: 20805557; PMCID: PMC2975290.
    20. Ash PE, Zhang YJ, Roberts CM, Saldi T, Hutter H, Buratti E, Petrucelli L, Link CD. Neurotoxic effects of TDP-43 overexpression in C. elegans. Hum Mol Genet. 2010 Aug 15; 19(16):3206-18. PMID: 20530643; PMCID: PMC2908471.
    21. Dosanjh LE, Brown MK, Rao G, Link CD, Luo Y. Behavioral phenotyping of a transgenic Caenorhabditis elegans expressing neuronal amyloid-beta. J Alzheimers Dis. 2010; 19(2):681-90. PMID: 20110612.
      View in: PubMed
    22. Teschendorf D, Link CD. What have worm models told us about the mechanisms of neuronal dysfunction in human neurodegenerative diseases? Mol Neurodegener. 2009 Sep 28; 4:38. PMID: 19785750; PMCID: PMC2762972.
    23. Park SK, Link CD, Johnson TE. Life-span extension by dietary restriction is mediated by NLP-7 signaling and coelomocyte endocytosis in C. elegans. FASEB J. 2010 Feb; 24(2):383-92. PMID: 19783783; PMCID: PMC2812037.
    24. Hassan WM, Merin DA, Fonte V, Link CD. AIP-1 ameliorates beta-amyloid peptide toxicity in a Caenorhabditis elegans Alzheimer's disease model. Hum Mol Genet. 2009 Aug 01; 18(15):2739-47. PMID: 19414486; PMCID: PMC2706681.
    25. Zhang YJ, Xu YF, Cook C, Gendron TF, Roettges P, Link CD, Lin WL, Tong J, Castanedes-Casey M, Ash P, Gass J, Rangachari V, Buratti E, Baralle F, Golde TE, Dickson DW, Petrucelli L. Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity. Proc Natl Acad Sci U S A. 2009 May 05; 106(18):7607-12. PMID: 19383787; PMCID: PMC2671323.
    26. Link CD, Fonte V, Roberts CM, Hiester B, Silverman MA, Stein GH. The beta amyloid peptide can act as a modular aggregation domain. Neurobiol Dis. 2008 Dec; 32(3):420-5. PMID: 18778773; PMCID: PMC2646107.
    27. Fonte V, Kipp DR, Yerg J, Merin D, Forrestal M, Wagner E, Roberts CM, Link CD. Suppression of in vivo beta-amyloid peptide toxicity by overexpression of the HSP-16.2 small chaperone protein. J Biol Chem. 2008 Jan 11; 283(2):784-91. PMID: 17993648.
      View in: PubMed
    28. Florez-McClure ML, Hohsfield LA, Fonte G, Bealor MT, Link CD. Decreased insulin-receptor signaling promotes the autophagic degradation of beta-amyloid peptide in C. elegans. Autophagy. 2007 Nov-Dec; 3(6):569-80. PMID: 17675890.
      View in: PubMed
    29. Stas S, Whaley-Connell A, Habibi J, Appesh L, Hayden MR, Karuparthi PR, Qazi M, Morris EM, Cooper SA, Link CD, Stump C, Hay M, Ferrario C, Sowers JR. Mineralocorticoid receptor blockade attenuates chronic overexpression of the renin-angiotensin-aldosterone system stimulation of reduced nicotinamide adenine dinucleotide phosphate oxidase and cardiac remodeling. Endocrinology. 2007 Aug; 148(8):3773-80. PMID: 17494996.
      View in: PubMed
    30. Wu Y, Wu Z, Butko P, Christen Y, Lambert MP, Klein WL, Link CD, Luo Y. Amyloid-beta-induced pathological behaviors are suppressed by Ginkgo biloba extract EGb 761 and ginkgolides in transgenic Caenorhabditis elegans. J Neurosci. 2006 Dec 13; 26(50):13102-13. PMID: 17167099.
      View in: PubMed
    31. Link CD. C. elegans models of age-associated neurodegenerative diseases: lessons from transgenic worm models of Alzheimer's disease. Exp Gerontol. 2006 Oct; 41(10):1007-13. PMID: 16930903.
      View in: PubMed
    32. Whaley-Connell AT, Chowdhury NA, Hayden MR, Stump CS, Habibi J, Wiedmeyer CE, Gallagher PE, Tallant EA, Cooper SA, Link CD, Ferrario C, Sowers JR. Oxidative stress and glomerular filtration barrier injury: role of the renin-angiotensin system in the Ren2 transgenic rat. Am J Physiol Renal Physiol. 2006 Dec; 291(6):F1308-14. PMID: 16788142.
      View in: PubMed
    33. Link CD, Fonte V, Hiester B, Yerg J, Ferguson J, Csontos S, Silverman MA, Stein GH. Conversion of green fluorescent protein into a toxic, aggregation-prone protein by C-terminal addition of a short peptide. J Biol Chem. 2006 Jan 20; 281(3):1808-16. PMID: 16239215.
      View in: PubMed
    34. Gutierrez-Zepeda A, Santell R, Wu Z, Brown M, Wu Y, Khan I, Link CD, Zhao B, Luo Y. Soy isoflavone glycitein protects against beta amyloid-induced toxicity and oxidative stress in transgenic Caenorhabditis elegans. BMC Neurosci. 2005 Aug 25; 6:54. PMID: 16122394; PMCID: PMC1215487.
    35. Boyd-Kimball D, Poon HF, Lynn BC, Cai J, Pierce WM, Klein JB, Ferguson J, Link CD, Butterfield DA. Proteomic identification of proteins specifically oxidized in Caenorhabditis elegans expressing human Abeta(1-42): implications for Alzheimer's disease. Neurobiol Aging. 2006 Sep; 27(9):1239-49. PMID: 16099075.
      View in: PubMed
    36. Cottrell BA, Galvan V, Banwait S, Gorostiza O, Lombardo CR, Williams T, Schilling B, Peel A, Gibson B, Koo EH, Link CD, Bredesen DE. A pilot proteomic study of amyloid precursor interactors in Alzheimer's disease. Ann Neurol. 2005 Aug; 58(2):277-89. PMID: 16049941; PMCID: PMC1847583.
    37. Kapulkin WJ, Kapulkin V, Hiester BG, Link CD. Compensatory regulation among ER chaperones in C. elegans. FEBS Lett. 2005 Jun 06; 579(14):3063-8. PMID: 15907843.
      View in: PubMed
    38. Link CD. Invertebrate models of Alzheimer's disease. Genes Brain Behav. 2005 Apr; 4(3):147-56. PMID: 15810903.
      View in: PubMed
    39. Strayer A, Wu Z, Christen Y, Link CD, Luo Y. Expression of the small heat-shock protein Hsp16-2 in Caenorhabditis elegans is suppressed by Ginkgo biloba extract EGb 761. FASEB J. 2003 Dec; 17(15):2305-7. PMID: 14525938.
      View in: PubMed
    40. Leiers B, Kampkötter A, Grevelding CG, Link CD, Johnson TE, Henkle-Dührsen K. A stress-responsive glutathione S-transferase confers resistance to oxidative stress in Caenorhabditis elegans. Free Radic Biol Med. 2003 Jun 01; 34(11):1405-15. PMID: 12757851.
      View in: PubMed
    41. Drake J, Link CD, Butterfield DA. Oxidative stress precedes fibrillar deposition of Alzheimer's disease amyloid beta-peptide (1-42) in a transgenic Caenorhabditis elegans model. Neurobiol Aging. 2003 May-Jun; 24(3):415-20. PMID: 12600717.
      View in: PubMed
    42. Link CD, Taft A, Kapulkin V, Duke K, Kim S, Fei Q, Wood DE, Sahagan BG. Gene expression analysis in a transgenic Caenorhabditis elegans Alzheimer's disease model. Neurobiol Aging. 2003 May-Jun; 24(3):397-413. PMID: 12600716.
      View in: PubMed
    43. Kampkötter A, Volkmann TE, de Castro SH, Leiers B, Klotz LO, Johnson TE, Link CD, Henkle-Dührsen K. Functional analysis of the glutathione S-transferase 3 from Onchocerca volvulus (Ov-GST-3): a parasite GST confers increased resistance to oxidative stress in Caenorhabditis elegans. J Mol Biol. 2003 Jan 03; 325(1):25-37. PMID: 12473450.
      View in: PubMed
    44. Fonte V, Kapulkin WJ, Kapulkin V, Taft A, Fluet A, Friedman D, Link CD. Interaction of intracellular beta amyloid peptide with chaperone proteins. Proc Natl Acad Sci U S A. 2002 Jul 09; 99(14):9439-44. PMID: 12089340; PMCID: PMC123159.
    45. Blumenthal T, Evans D, Link CD, Guffanti A, Lawson D, Thierry-Mieg J, Thierry-Mieg D, Chiu WL, Duke K, Kiraly M, Kim SK. A global analysis of Caenorhabditis elegans operons. Nature. 2002 Jun 20; 417(6891):851-4. PMID: 12075352.
      View in: PubMed
    46. Johnson TE, Henderson S, Murakami S, de Castro E, de Castro SH, Cypser J, Rikke B, Tedesco P, Link C. Longevity genes in the nematode Caenorhabditis elegans also mediate increased resistance to stress and prevent disease. J Inherit Metab Dis. 2002 May; 25(3):197-206. PMID: 12137228.
      View in: PubMed
    47. GuhaThakurta D, Palomar L, Stormo GD, Tedesco P, Johnson TE, Walker DW, Lithgow G, Kim S, Link CD. Identification of a novel cis-regulatory element involved in the heat shock response in Caenorhabditis elegans using microarray gene expression and computational methods. Genome Res. 2002 May; 12(5):701-12. PMID: 11997337; PMCID: PMC186591.
    48. Link CD, Johnson CJ. Reporter transgenes for study of oxidant stress in Caenorhabditis elegans. Methods Enzymol. 2002; 353:497-505. PMID: 12078522.
      View in: PubMed
    49. Link CD. Transgenic invertebrate models of age-associated neurodegenerative diseases. Mech Ageing Dev. 2001 Sep 30; 122(14):1639-49. PMID: 11511401.
      View in: PubMed
    50. Link CD, Johnson CJ, Fonte V, Paupard M, Hall DH, Styren S, Mathis CA, Klunk WE. Visualization of fibrillar amyloid deposits in living, transgenic Caenorhabditis elegans animals using the sensitive amyloid dye, X-34. Neurobiol Aging. 2001 Mar-Apr; 22(2):217-26. PMID: 11182471.
      View in: PubMed
    51. Johnson TE, Cypser J, de Castro E, de Castro S, Henderson S, Murakami S, Rikke B, Tedesco P, Link C. Gerontogenes mediate health and longevity in nematodes through increasing resistance to environmental toxins and stressors. Exp Gerontol. 2000 Sep; 35(6-7):687-94. PMID: 11053658.
      View in: PubMed
    52. Link CD, Cypser JR, Johnson CJ, Johnson TE. Direct observation of stress response in Caenorhabditis elegans using a reporter transgene. Cell Stress Chaperones. 1999 Dec; 4(4):235-42. PMID: 10590837; PMCID: PMC312938.
    53. Fay DS, Fluet A, Johnson CJ, Link CD. In vivo aggregation of beta-amyloid peptide variants. J Neurochem. 1998 Oct; 71(4):1616-25. PMID: 9751195.
      View in: PubMed
    54. Link CD, Ehrenfels CW, Wood WB. Mutant expression of male copulatory bursa surface markers in Caenorhabditis elegans. Development. 1988 Jul; 103(3):485-95. PMID: 3246219.
      View in: PubMed
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