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Corrella Scott Detweiler

TitleAssociate Professor
InstitutionUniversity of Colorado Boulder
DepartmentBiology-MCD Instruction
ORCID ORCID Icon0000-0002-7783-0876 Additional info

    Collapse Research 
    Collapse research activities and funding
    R56AI063116     (DETWEILER, CORRELLA)Sep 1, 2005 - Aug 31, 2007
    The Salmonella RcsC Phosphorelay System and Virulence
    Role: Principal Investigator

    R01AI072492     (DETWEILER, CORRELLA)Jun 1, 2007 - Dec 31, 2013
    Persistent Systemic Infection of Mice by Salmonella Enterica
    Role: Principal Investigator

    R21AI076682     (DETWEILER, CORRELLA)Dec 15, 2007 - Nov 30, 2010
    A Mammalian Cellular Niche for Chronic Bacteria
    Role: Principal Investigator

    R56AI095395     (DETWEILER, CORRELLA)Sep 1, 2011 - Feb 29, 2012
    Hemophagocytic Macrophages and Systemic Salmonella Infection
    Role: Principal Investigator

    R21AI099593     (DETWEILER, CORRELLA)Feb 15, 2012 - Jan 31, 2015
    Host Pathways that Enable /Salmonella/ Replication Within Hemophagocytic Macropha
    Role: Principal Investigator

    R01AI095395     (DETWEILER, CORRELLA)Mar 1, 2012 - Feb 28, 2017
    Hemophagocytic Macrophages and Systemic Salmonella Infection
    Role: Principal Investigator

    R21AI121365     (DETWEILER, CORRELLA)Dec 1, 2015 - Nov 30, 2017
    A Novel Screen for Antibacterials that Are Non-Toxic to Mammals
    Role: Principal Investigator

    R21AI121474     (DETWEILER, CORRELLA)Jun 1, 2016 - May 31, 2018
    Macrophages, Granulomas, and Bacterial Persistence
    Role: Principal Investigator

    R21AI126453     (DETWEILER, CORRELLA)Jun 15, 2016 - May 31, 2018
    Chemical Probes for Bacteria-Macrophage Interactions
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Courtney CM, Goodman SM, Nagy TA, Levy M, Bhusal P, Madinger NE, Detweiler CS, Nagpal P, Chatterjee A. Potentiating antibiotics in drug-resistant clinical isolates via stimuli-activated superoxide generation. Sci Adv. 2017 Oct; 3(10):e1701776. PMID: 28983513.
      View in: PubMed
    2. Detweiler CS. A New Way to Beat Intestinal Pathogens. Trends Microbiol. 2017 Mar; 25(3):169-170. PMID: 28139374.
      View in: PubMed
    3. Bauler TJ, Starr T, Nagy TA, Sridhar S, Scott D, Winkler CW, Steele-Mortimer O, Detweiler CS, Peterson KE. Salmonella Meningitis Associated with Monocyte Infiltration in Mice. Am J Pathol. 2017 Jan; 187(1):187-199. PMID: 27955815.
      View in: PubMed
    4. Silva-Herzog E, McDonald EM, Crooks AL, Detweiler CS. Physiologic Stresses Reveal a Salmonella Persister State and TA Family Toxins Modulate Tolerance to These Stresses. PLoS One. 2015; 10(12):e0141343. PMID: 26633172; PMCID: PMC4669091.
    5. McDonald EM, Pilonieta MC, Nick HJ, Detweiler CS. Bacterial Stimulation of Toll-Like Receptor 4 Drives Macrophages To Hemophagocytose. Infect Immun. 2015 Oct 12; 84(1):47-55. PMID: 26459510; PMCID: PMC4693988.
    6. Brown DE, Nick HJ, McCoy MW, Moreland SM, Stepanek AM, Benik R, O'Connell KE, Pilonieta MC, Nagy TA, Detweiler CS. Increased ferroportin-1 expression and rapid splenic iron loss occur with anemia caused by Salmonella enterica Serovar Typhimurium infection in mice. Infect Immun. 2015 Jun; 83(6):2290-9. PMID: 25824831; PMCID: PMC4432749.
    7. Teske SS, Detweiler CS. The biomechanisms of metal and metal-oxide nanoparticles' interactions with cells. Int J Environ Res Public Health. 2015 Jan 22; 12(2):1112-34. PMID: 25648173; PMCID: PMC4344658.
    8. Pilonieta MC, Moreland SM, English CN, Detweiler CS. Salmonella enterica infection stimulates macrophages to hemophagocytose. MBio. 2014 Dec 09; 5(6):e02211. PMID: 25491357; PMCID: PMC4324247.
    9. Nagy TA, Moreland SM, Detweiler CS. Salmonella acquires ferrous iron from haemophagocytic macrophages. Mol Microbiol. 2014 Sep; 93(6):1314-26. PMID: 25081030; PMCID: PMC4160465.
    10. Nagy TA, Moreland SM, Andrews-Polymenis H, Detweiler CS. The ferric enterobactin transporter Fep is required for persistent Salmonella enterica serovar typhimurium infection. Infect Immun. 2013 Nov; 81(11):4063-70. PMID: 23959718; PMCID: PMC3811836.
    11. Brown DE, Libby SJ, Moreland SM, McCoy MW, Brabb T, Stepanek A, Fang FC, Detweiler CS. Salmonella enterica causes more severe inflammatory disease in C57/BL6 Nramp1G169 mice than Sv129S6 mice. Vet Pathol. 2013 Sep; 50(5):867-76. PMID: 23446432; PMCID: PMC3769438.
    12. McCoy MW, Moreland SM, Detweiler CS. Hemophagocytic macrophages in murine typhoid fever have an anti-inflammatory phenotype. Infect Immun. 2012 Oct; 80(10):3642-9. PMID: 22868497; PMCID: PMC3457584.
    13. Pilonieta MC, Nagy TA, Jorgensen DR, Detweiler CS. A glycine betaine importer limits Salmonella stress resistance and tissue colonization by reducing trehalose production. Mol Microbiol. 2012 Apr; 84(2):296-309. PMID: 22375627; PMCID: PMC3323685.
    14. Silva-Herzog E, Detweiler CS. Salmonella enterica replication in hemophagocytic macrophages requires two type three secretion systems. Infect Immun. 2010 Aug; 78(8):3369-77. PMID: 20515933; PMCID: PMC2916269.
    15. Brown DE, McCoy MW, Pilonieta MC, Nix RN, Detweiler CS. Chronic murine typhoid fever is a natural model of secondary hemophagocytic lymphohistiocytosis. PLoS One. 2010 Feb 26; 5(2):e9441. PMID: 20195482; PMCID: PMC2829187.
    16. Pilonieta MC, Erickson KD, Ernst RK, Detweiler CS. A protein important for antimicrobial peptide resistance, YdeI/OmdA, is in the periplasm and interacts with OmpD/NmpC. J Bacteriol. 2009 Dec; 191(23):7243-52. PMID: 19767429; PMCID: PMC2786563.
    17. Silva-Herzog E, Detweiler CS. Intracellular microbes and haemophagocytosis. Cell Microbiol. 2008 Nov; 10(11):2151-8. PMID: 18616693; PMCID: PMC2758559.
    18. Nix RN, Altschuler SE, Henson PM, Detweiler CS. Hemophagocytic macrophages harbor Salmonella enterica during persistent infection. PLoS Pathog. 2007 Dec; 3(12):e193. PMID: 18085823; PMCID: PMC2134957.
    19. Karimpour-Fard A, Detweiler CS, Erickson KD, Hunter L, Gill RT. Cross-species cluster co-conservation: a new method for generating protein interaction networks. Genome Biol. 2007; 8(9):R185. PMID: 17803817; PMCID: PMC2375023.
    20. Erickson KD, Detweiler CS. The Rcs phosphorelay system is specific to enteric pathogens/commensals and activates ydeI, a gene important for persistent Salmonella infection of mice. Mol Microbiol. 2006 Nov; 62(3):883-94. PMID: 17010160; PMCID: PMC2895427.
    21. De Keersmaecker SC, Marchal K, Verhoeven TL, Engelen K, Vanderleyden J, Detweiler CS. Microarray analysis and motif detection reveal new targets of the Salmonella enterica serovar Typhimurium HilA regulatory protein, including hilA itself. J Bacteriol. 2005 Jul; 187(13):4381-91. PMID: 15968047; PMCID: PMC1151768.
    22. Detweiler CS, Monack DM, Brodsky IE, Mathew H, Falkow S. virK, somA and rcsC are important for systemic Salmonella enterica serovar Typhimurium infection and cationic peptide resistance. Mol Microbiol. 2003 Apr; 48(2):385-400. PMID: 12675799.
      View in: PubMed
    23. Chan K, Baker S, Kim CC, Detweiler CS, Dougan G, Falkow S. Genomic comparison of Salmonella enterica serovars and Salmonella bongori by use of an S. enterica serovar typhimurium DNA microarray. J Bacteriol. 2003 Jan; 185(2):553-63. PMID: 12511502; PMCID: PMC145314.
    24. Monack DM, Detweiler CS, Falkow S. Salmonella pathogenicity island 2-dependent macrophage death is mediated in part by the host cysteine protease caspase-1. Cell Microbiol. 2001 Dec; 3(12):825-37. PMID: 11736994.
      View in: PubMed
    25. Detweiler CS, Cunanan DB, Falkow S. Host microarray analysis reveals a role for the Salmonella response regulator phoP in human macrophage cell death. Proc Natl Acad Sci U S A. 2001 May 08; 98(10):5850-5. PMID: 11320214; PMCID: PMC33302.
    26. Lee AK, Detweiler CS, Falkow S. OmpR regulates the two-component system SsrA-ssrB in Salmonella pathogenicity island 2. J Bacteriol. 2000 Feb; 182(3):771-81. PMID: 10633113; PMCID: PMC94342.
    27. Owens JC, Detweiler CS, Li JJ. CDC45 is required in conjunction with CDC7/DBF4 to trigger the initiation of DNA replication. Proc Natl Acad Sci U S A. 1997 Nov 11; 94(23):12521-6. PMID: 9356482; PMCID: PMC25024.
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