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Brian M Freed

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED
Phone303/724-0535

    Collapse Research 
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    R03HL060538     (FREED, BRIAN M)Sep 30, 1997 - Sep 29, 1999
    NIH
    OXIDATION OF PHENOLIC COMPONENTS OF CIGARETTE TAR
    Role: Principal Investigator
    R01ES005673     (FREED, BRIAN M)Apr 1, 1993 - Nov 30, 2008
    NIH
    Immunotoxicology of Cigarette Smoke
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Laskowitz DT, Troy J, Poehlein E, Bennett ER, Shpall EJ, Wingard JR, Freed B, Belagaje SR, Khanna A, Jones W, Volpi JJ, Marrotte E, Kurtzberg J. A Randomized, Placebo-Controlled, Phase II Trial of Intravenous Allogeneic Non-HLA Matched, Unrelated Donor, Cord Blood Infusion for Ischemic Stroke. Stem Cells Transl Med. 2024 Feb 14; 13(2):125-136. PMID: 38071749.
      View in: PubMed
    2. Bai X, Verma D, Garcia C, Musheyev A, Kim K, Fornis L, Griffith DE, Li L, Whittel N, Gadwa J, Ohanjanyan T, Eggleston MJ, Galvan M, Freed BM, Ordway D, Chan ED. Ex vivo and in vivo evidence that cigarette smoke-exposed T regulatory cells impair host immunity against Mycobacterium tuberculosis. Front Cell Infect Microbiol. 2023; 13:1216492. PMID: 37965256.
      View in: PubMed
    3. Lang J, Leal AD, Mar?n-Jim?nez JA, Hartman SJ, Shulman J, Navarro NM, Lewis MS, Capasso A, Bagby SM, Yacob BW, MacBeth M, Freed BM, Eckhardt SG, Jordan K, Blatchford PJ, Pelanda R, Lieu CH, Messersmith WA, Pitts TM. Cabozantinib sensitizes microsatellite stable colorectal cancer to immune checkpoint blockade by immune modulation in human immune system mouse models. Front Oncol. 2022; 12:877635. PMID: 36419897.
      View in: PubMed
    4. Roark CL, Ho BE, Aubrey MT, Anobile C, Israeli S, Phang TL, Braxton D, Ho AP, Freed BM. HLA homozygosity is associated with Non-Hodgkin lymphoma. Hum Immunol. 2022 Oct; 83(10):730-735. PMID: 35953408.
      View in: PubMed
    5. Solomon SR, Aubrey MT, Zhang X, Jackson KC, Roark CL, Freed BM, Morris LE, Holland HK, Solh MM, Bashey A. Lineage-Specific Relapse Prediction After Haploidentical Transplantation With Post-Transplant Cyclophosphamide Based on Recipient HLA-B-Leader Genotype and HLA-C-Group KIR Ligand. Transplant Cell Ther. 2022 09; 28(9):601.e1-601.e8. PMID: 35788088.
      View in: PubMed
    6. Bai X, Buckle AM, Vladar EK, Janoff EN, Khare R, Ordway D, Beckham D, Fornis LB, Majluf-Cruz A, Fugit RV, Freed BM, Kim S, Sandhaus RA, Chan ED. Author Correction: Enoxaparin augments alpha-1-antitrypsin inhibition of TMPRSS2, a promising drug combination against COVID-19. Sci Rep. 2022 Apr 19; 12(1):6466. PMID: 35440617.
      View in: PubMed
    7. Bai X, Buckle AM, Vladar EK, Janoff EN, Khare R, Ordway D, Beckham D, Fornis LB, Majluf-Cruz A, Fugit RV, Freed BM, Kim S, Sandhaus RA, Chan ED. Enoxaparin augments alpha-1-antitrypsin inhibition of TMPRSS2, a promising drug combination against COVID-19. Sci Rep. 2022 03 25; 12(1):5207. PMID: 35338216.
      View in: PubMed
    8. Alves da Costa T, Peterson JN, Lang J, Shulman J, Liang X, Freed BM, Boackle SA, Lauzurica P, Torres RM, Pelanda R. Central human B cell tolerance manifests with a distinctive cell phenotype and is enforced via CXCR4 signaling in hu-mice. Proc Natl Acad Sci U S A. 2021 04 20; 118(16). PMID: 33850015.
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    9. Mar?n-Jim?nez JA, Capasso A, Lewis MS, Bagby SM, Hartman SJ, Shulman J, Navarro NM, Yu H, Rivard CJ, Wang X, Barkow JC, Geng D, Kar A, Yingst A, Tufa DM, Dolan JT, Blatchford PJ, Freed BM, Torres RM, Davila E, Slansky JE, Pelanda R, Eckhardt SG, Messersmith WA, Diamond JR, Lieu CH, Verneris MR, Wang JH, Kiseljak-Vassiliades K, Pitts TM, Lang J. Testing Cancer Immunotherapy in a Human Immune System Mouse Model: Correlating Treatment Responses to Human Chimerism, Therapeutic Variables and Immune Cell Phenotypes. Front Immunol. 2021; 12:607282. PMID: 33854497.
      View in: PubMed
    10. Bai X, Hippensteel J, Leavitt A, Maloney JP, Beckham D, Garcia C, Li Q, Freed BM, Ordway D, Sandhaus RA, Chan ED. Hypothesis: Alpha-1-antitrypsin is a promising treatment option for COVID-19. Med Hypotheses. 2021 Jan; 146:110394. PMID: 33239231.
      View in: PubMed
    11. Zhang Y, Anderson KM, Freed BM, Dai S, Pacheco KA. HLA-DR53 (DRB4*01) associates with nickel sensitization. Ann Allergy Asthma Immunol. 2020 11; 125(5):614-616. PMID: 32693207.
      View in: PubMed
    12. Lang J, Capasso A, Jordan KR, French JD, Kar A, Bagby SM, Barbee J, Yacob BW, Head LS, Tompkins KD, Freed BM, Somerset H, Clark TJ, Pitts TM, Messersmith WA, Eckhardt SG, Wierman ME, Leong S, Kiseljak-Vassiliades K. Development of an Adrenocortical Cancer Humanized Mouse Model to Characterize Anti-PD1 Effects on Tumor Microenvironment. J Clin Endocrinol Metab. 2020 01 01; 105(1). PMID: 31513709.
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    13. Stites E, Renner B, Laskowski J, Le Quintrec M, You Z, Freed B, Cooper J, Jalal D, Thurman JM. Complement fragments are biomarkers of antibody-mediated endothelial injury. Mol Immunol. 2020 02; 118:142-152. PMID: 31884386.
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    14. Anderson K, Carey B, Martin A, Roark C, Chalk C, Nowell-Bostic M, Freed B, Aubrey M, Trapnell B, Fontenot A. Pulmonary alveolar proteinosis: An autoimmune disease lacking an HLA association. PLoS One. 2019; 14(3):e0213179. PMID: 30845238.
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    15. Capasso A, Lang J, Pitts TM, Jordan KR, Lieu CH, Davis SL, Diamond JR, Kopetz S, Barbee J, Peterson J, Freed BM, Yacob BW, Bagby SM, Messersmith WA, Slansky JE, Pelanda R, Eckhardt SG. Characterization of immune responses to anti-PD-1 mono and combination immunotherapy in hematopoietic humanized mice implanted with tumor xenografts. J Immunother Cancer. 2019 02 08; 7(1):37. PMID: 30736857.
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    16. Coleman CB, Lang J, Sweet LA, Smith NA, Freed BM, Pan Z, Haverkos B, Pelanda R, Rochford R. Epstein-Barr Virus Type 2 Infects T Cells and Induces B Cell Lymphomagenesis in Humanized Mice. J Virol. 2018 11 01; 92(21). PMID: 30089703.
      View in: PubMed
    17. Solomon SR, Aubrey MT, Zhang X, Piluso A, Freed BM, Brown S, Jackson KC, Morris LE, Holland HK, Solh MM, Bashey A. Selecting the Best Donor for Haploidentical Transplant: Impact of HLA, Killer Cell Immunoglobulin-Like Receptor Genotyping, and Other Clinical Variables. Biol Blood Marrow Transplant. 2018 04; 24(4):789-798. PMID: 29355721.
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    18. Lang J, Zhang B, Kelly M, Peterson JN, Barbee J, Freed BM, Di Santo JP, Matsuda JL, Torres RM, Pelanda R. Replacing mouse BAFF with human BAFF does not improve B-cell maturation in hematopoietic humanized mice. Blood Adv. 2017 Dec 26; 1(27):2729-2741. PMID: 29296925.
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    19. Davis S, Gralla J, Klem P, Tong S, Wedermyer G, Freed B, Wiseman A, Cooper JE. Lower tacrolimus exposure and time in therapeutic range increase the risk of de novo donor-specific antibodies in the first year of kidney transplantation. Am J Transplant. 2018 04; 18(4):907-915. PMID: 28925597.
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    20. Brady C, Armitage S, Freed B, Duffy M, Gass A, Spellman S, Kurtzberg J, Regan D. How transplant centers deal with the dextran shortage: recommendations for comparing alternatives. Transfusion. 2016 11; 56(11):2657-2661. PMID: 27596242.
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    21. Schade H, Sen S, Neff CP, Freed BM, Gao D, Gutman JA, Palmer BE. Programmed Death 1 Expression on CD4+ T Cells Predicts Mortality after Allogeneic Stem Cell Transplantation. Biol Blood Marrow Transplant. 2016 12; 22(12):2172-2179. PMID: 27519280.
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    22. Anderson KM, Stastny TH, Freed BM. Reply. Arthritis Rheumatol. 2016 08; 68(8):2051-2. PMID: 27110851.
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    23. Anderson KM, Roark CL, Portas M, Aubrey MT, Rosloniec EF, Freed BM. A Molecular Analysis of the Shared Epitope Hypothesis: Binding of Arthritogenic Peptides to DRB1*04 Alleles. Arthritis Rheumatol. 2016 07; 68(7):1627-36. PMID: 26866513.
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    24. Adebiyi OO, Gralla J, Klem P, Freed B, Davis S, Wiseman AC, Cooper JE. Clinical Significance of Pretransplant Donor-Specific Antibodies in the Setting of Negative Cell-Based Flow Cytometry Crossmatching in Kidney Transplant Recipients. Am J Transplant. 2016 12; 16(12):3458-3467. PMID: 27140940.
      View in: PubMed
    25. Fingerlin TE, Zhang W, Yang IV, Ainsworth HC, Russell PH, Blumhagen RZ, Schwarz MI, Brown KK, Steele MP, Loyd JE, Cosgrove GP, Lynch DA, Groshong S, Collard HR, Wolters PJ, Bradford WZ, Kossen K, Seiwert SD, du Bois RM, Garcia CK, Devine MS, Gudmundsson G, Isaksson HJ, Kaminski N, Zhang Y, Gibson KF, Lancaster LH, Maher TM, Molyneaux PL, Wells AU, Moffatt MF, Selman M, Pardo A, Kim DS, Crapo JD, Make BJ, Regan EA, Walek DS, Daniel JJ, Kamatani Y, Zelenika D, Murphy E, Smith K, McKean D, Pedersen BS, Talbert J, Powers J, Markin CR, Beckman KB, Lathrop M, Freed B, Langefeld CD, Schwartz DA. Genome-wide imputation study identifies novel HLA locus for pulmonary fibrosis and potential role for auto-immunity in fibrotic idiopathic interstitial pneumonia. BMC Genet. 2016 06 07; 17(1):74. PMID: 27266705.
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    26. Roark CL, Anderson KM, Aubrey MT, Rosloniec EF, Freed BM. Arthritogenic peptide binding to DRB1*01 alleles correlates with susceptibility to rheumatoid arthritis. J Autoimmun. 2016 08; 72:25-32. PMID: 27143337.
      View in: PubMed
    27. Lang J, Ota T, Kelly M, Strauch P, Freed BM, Torres RM, Nemazee D, Pelanda R. Receptor editing and genetic variability in human autoreactive B cells. J Exp Med. 2016 Jan 11; 213(1):93-108. PMID: 26694971.
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    28. Roark CL, Anderson KM, Simon LJ, Schuyler RP, Aubrey MT, Freed BM. Multiple HLA epitopes contribute to type 1 diabetes susceptibility. Diabetes. 2014 Jan; 63(1):323-31. PMID: 24357703.
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    29. Andersen NJ, Mondal TK, Preissler MT, Freed BM, Stockinger S, Bell E, Druschel C, Louis GM, Lawrence DA. Detection of immunoglobulin isotypes from dried blood spots. J Immunol Methods. 2014 Feb; 404:24-32. PMID: 24333851.
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    30. Choudhary R, Baturin D, Fosmire S, Freed B, Porter CC. Knockdown of HPRT for selection of genetically modified human hematopoietic progenitor cells. PLoS One. 2013; 8(3):e59594. PMID: 23555045.
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    31. Mack CL, Anderson KM, Aubrey MT, Rosenthal P, Sokol RJ, Freed BM. Lack of HLA predominance and HLA shared epitopes in biliary Atresia. Springerplus. 2013 Dec; 2(1):42. PMID: 23505615.
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    32. Lang J, Kelly M, Freed BM, McCarter MD, Kedl RM, Torres RM, Pelanda R. Studies of lymphocyte reconstitution in a humanized mouse model reveal a requirement of T cells for human B cell maturation. J Immunol. 2013 Mar 01; 190(5):2090-101. PMID: 23335750.
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    33. Menezes CA, Sullivan AK, Falta MT, Mack DG, Freed BM, Rocha MO, Gollob KJ, Fontenot AP, Dutra WO. Highly conserved CDR3 region in circulating CD4(+)V?5(+) T cells may be associated with cytotoxic activity in Chagas disease. Clin Exp Immunol. 2012 Aug; 169(2):109-18. PMID: 22774985.
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    34. Rocha V, Spellman S, Zhang MJ, Ruggeri A, Purtill D, Brady C, Baxter-Lowe LA, Baudoux E, Bergamaschi P, Chow R, Freed B, Koegler G, Kurtzberg J, Larghero J, Lecchi L, Nagler A, Navarrette C, Prasad V, Pouthier F, Price T, Ratanatharathorn V, van Rood JJ, Horowitz MM, Gluckman E, Eapen M. Effect of HLA-matching recipients to donor noninherited maternal antigens on outcomes after mismatched umbilical cord blood transplantation for hematologic malignancy. Biol Blood Marrow Transplant. 2012 Dec; 18(12):1890-6. PMID: 22814031.
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    35. Kamani NR, Walters MC, Carter S, Aquino V, Brochstein JA, Chaudhury S, Eapen M, Freed BM, Grimley M, Levine JE, Logan B, Moore T, Panepinto J, Parikh S, Pulsipher MA, Sande J, Schultz KR, Spellman S, Shenoy S. Unrelated donor cord blood transplantation for children with severe sickle cell disease: results of one cohort from the phase II study from the Blood and Marrow Transplant Clinical Trials Network (BMT CTN). Biol Blood Marrow Transplant. 2012 Aug; 18(8):1265-72. PMID: 22343376.
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    36. Lyu DM, Grazia TJ, Benson AB, Cagle LR, Freed BM, Zamora MR. Pre-transplant presence of antibodies to MICA and HLA class I or II are associated with an earlier onset of bronchiolitis obliterans syndrome in lung transplant recipients. Clin Transpl. 2012; 237-46. PMID: 23721028.
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    37. Freed BM, Schuyler RP, Aubrey MT. Association of the HLA-DRB1 epitope LA(67, 74) with rheumatoid arthritis and citrullinated vimentin binding. Arthritis Rheum. 2011 Dec; 63(12):3733-9. PMID: 22094856.
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    38. Gutman JA, Miller S, Kuenne S, Oppenheim J, Quinones R, Freed BM, Stark C, Zarlengo G. Cord blood collection after cesarean section improves banking efficiency. Transfusion. 2011 Sep; 51(9):2050-1. PMID: 21896038.
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    39. Lang J, Weiss N, Freed BM, Torres RM, Pelanda R. Generation of hematopoietic humanized mice in the newborn BALB/c-Rag2null Il2r?null mouse model: a multivariable optimization approach. Clin Immunol. 2011 Jul; 140(1):102-16. PMID: 21536497.
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    40. Shang S, Ordway D, Henao-Tamayo M, Bai X, Oberley-Deegan R, Shanley C, Orme IM, Case S, Minor M, Ackart D, Hascall-Dove L, Ovrutsky AR, Kandasamy P, Voelker DR, Lambert C, Freed BM, Iseman MD, Basaraba RJ, Chan ED. Cigarette smoke increases susceptibility to tuberculosis--evidence from in vivo and in vitro models. J Infect Dis. 2011 May 01; 203(9):1240-8. PMID: 21357942.
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    41. Dreskin SC, Tripputi MT, Aubrey MT, Mustafa SS, Atkins D, Leo HL, Song B, Schlichting D, Talwar H, Wang Q, Freed BM. Peanut-allergic subjects and their peanut-tolerant siblings have large differences in peanut-specific IgG that are independent of HLA class II. Clin Immunol. 2010 Dec; 137(3):366-73. PMID: 20850383.
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    42. Lambert C, Li J, Jonscher K, Yang TC, Reigan P, Quintana M, Harvey J, Freed BM. Acrolein inhibits cytokine gene expression by alkylating cysteine and arginine residues in the NF-kappaB1 DNA binding domain. J Biol Chem. 2007 Jul 06; 282(27):19666-75. PMID: 17491020.
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    43. Mack CL, Falta MT, Sullivan AK, Karrer F, Sokol RJ, Freed BM, Fontenot AP. Oligoclonal expansions of CD4+ and CD8+ T-cells in the target organ of patients with biliary atresia. Gastroenterology. 2007 Jul; 133(1):278-87. PMID: 17631149.
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    44. Gibney EM, Cagle LR, Freed B, Warnell SE, Chan L, Wiseman AC. Detection of donor-specific antibodies using HLA-coated microspheres: another tool for kidney transplant risk stratification. Nephrol Dial Transplant. 2006 Sep; 21(9):2625-9. PMID: 16644776.
      View in: PubMed
    45. Frazer-Abel AA, McCue JM, Lazis S, Portas M, Lambert C, Freed BM. Cigarette tar phenols impede T cell cycle progression by inhibiting cyclin-dependent kinases. Mol Immunol. 2007 Jan; 44(4):488-93. PMID: 16584776.
      View in: PubMed
    46. Yang Y, Aubrey MT, Zhang G, Ji Y, Freed BM. HLA-B*1586 is a novel, hybrid HLA-B15/B22 allele with unique serology and haplotypic association. Tissue Antigens. 2006 Feb; 67(2):176-7. PMID: 16441499.
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    47. Meyer AM, Dwyer-Nield LD, Hurteau G, Keith RL, Ouyang Y, Freed BM, Kisley LR, Geraci MW, Bonventre JV, Nemenoff RA, Malkinson AM. Attenuation of the pulmonary inflammatory response following butylated hydroxytoluene treatment of cytosolic phospholipase A2 null mice. Am J Physiol Lung Cell Mol Physiol. 2006 Jun; 290(6):L1260-6. PMID: 16443645.
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    48. Bill JR, Mack DG, Falta MT, Maier LA, Sullivan AK, Joslin FG, Martin AK, Freed BM, Kotzin BL, Fontenot AP. Beryllium presentation to CD4+ T cells is dependent on a single amino acid residue of the MHC class II beta-chain. J Immunol. 2005 Nov 15; 175(10):7029-37. PMID: 16272364.
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    49. Lambert C, McCue J, Portas M, Ouyang Y, Li J, Rosano TG, Lazis A, Freed BM. Acrolein in cigarette smoke inhibits T-cell responses. J Allergy Clin Immunol. 2005 Oct; 116(4):916-22. PMID: 16210070.
      View in: PubMed
    50. Dunn JS, Freed BM, Gustafson DL, Stringer KA. Inhibition of human neutrophil reactive oxygen species production and p67phox translocation by cigarette smoke extract. Atherosclerosis. 2005 Apr; 179(2):261-7. PMID: 15777540.
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    51. McCue J, Freed B. Measuring lymphocyte transcription factor activity by ELISA. Curr Protoc Toxicol. 2005; Chapter 18:Unit18.5. PMID: 23045117.
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    52. Stringer KA, Freed BM, Dunn JS, Sayers S, Gustafson DL, Flores SC. Particulate phase cigarette smoke increases MnSOD, NQO1, and CINC-1 in rat lungs. Free Radic Biol Med. 2004 Nov 15; 37(10):1527-33. PMID: 15477004.
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    53. McCue JM, Lazis S, John Cohen J, Modiano JF, Freed BM. Hydroquinone and catechol interfere with T cell cycle entry and progression through the G1 phase. Mol Immunol. 2003 Jun; 39(16):995-1001. PMID: 12749906.
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    54. Shpall EJ, Quinones R, Giller R, Zeng C, Baron AE, Jones RB, Bearman SI, Nieto Y, Freed B, Madinger N, Hogan CJ, Slat-Vasquez V, Russell P, Blunk B, Schissel D, Hild E, Malcolm J, Ward W, McNiece IK. Transplantation of ex vivo expanded cord blood. Biol Blood Marrow Transplant. 2002; 8(7):368-76. PMID: 12171483.
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    55. Supon P, Constantino D, Hao P, Cagle L, Hahn A, Conti DJ, Freed BM. Prevalence of donor-specific anti-HLA antibodies during episodes of renal allograft rejection. Transplantation. 2001 Feb 27; 71(4):577-80. PMID: 11258441.
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    56. Freed BM, Ouyang Y, McCue JM. Mechanisms of altered transcription by cigarette smoke. Toxicol Sci. 2001 Jan; 59(1):1-2. PMID: 11134538.
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    57. McCue JM, Link KL, Eaton SS, Freed BM. Exposure to cigarette tar inhibits ribonucleotide reductase and blocks lymphocyte proliferation. J Immunol. 2000 Dec 15; 165(12):6771-5. PMID: 11120797.
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    58. Redondo MJ, Kawasaki E, Mulgrew CL, Noble JA, Erlich HA, Freed BM, Lie BA, Thorsby E, Eisenbarth GS, Undlien DE, Ronningen KS. DR- and DQ-associated protection from type 1A diabetes: comparison of DRB1*1401 and DQA1*0102-DQB1*0602*. J Clin Endocrinol Metab. 2000 Oct; 85(10):3793-7. PMID: 11061540.
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    59. Ouyang Y, Virasch N, Hao P, Aubrey MT, Mukerjee N, Bierer BE, Freed BM. Suppression of human IL-1beta, IL-2, IFN-gamma, and TNF-alpha production by cigarette smoke extracts. J Allergy Clin Immunol. 2000 Aug; 106(2):280-7. PMID: 10932071.
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    60. Fontenot AP, Falta MT, Freed BM, Newman LS, Kotzin BL. Identification of pathogenic T cells in patients with beryllium-induced lung disease. J Immunol. 1999 Jul 15; 163(2):1019-26. PMID: 10395700.
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    61. Cohen MD, Schook LB, Oppenheim JJ, Freed BM, Rodgers KE. Symposium overview: alterations in cytokine receptors by xenobiotics. Toxicol Sci. 1999 Apr; 48(2):163-9. PMID: 10353307.
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    62. Yu L, Brewer KW, Gates S, Wu A, Wang T, Babu SR, Gottlieb PA, Freed BM, Noble J, Erlich HA, Rewers MJ, Eisenbarth GS. DRB1*04 and DQ alleles: expression of 21-hydroxylase autoantibodies and risk of progression to Addison's disease. J Clin Endocrinol Metab. 1999 Jan; 84(1):328-35. PMID: 9920103.
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    63. Isenberg A, Singh TP, Shen GK, Freed BM, Conti DJ. Selective CellCept therapy in high-risk renal transplant recipients. Transplant Proc. 1998 Jun; 30(4):1188-9. PMID: 9636480.
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    64. Li Q, Kasten-Jolly J, Yen Y, Freed BM. Reversal of hydroquinone-mediated suppression of T cell proliferation by transfection of the M2 subunit of ribonucleotide reductase. Toxicol Appl Pharmacol. 1998 May; 150(1):154-7. PMID: 9630464.
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    65. Li Q, Aubrey MT, Christian T, Freed BM. Differential inhibition of DNA synthesis in human T cells by the cigarette tar components hydroquinone and catechol. Fundam Appl Toxicol. 1997 Aug; 38(2):158-65. PMID: 9299189.
      View in: PubMed
    66. Kasten-Jolly J, Aubrey MT, Conti DJ, Rosano TG, Ross JS, Freed BM. Reversal of hyperglycemia in diabetic NOD mice by human proinsulin gene therapy. Transplant Proc. 1997 Jun; 29(4):2216-8. PMID: 9193599.
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    67. Geiselhart LA, Christian T, Minnear F, Freed BM. The cigarette tar component p-benzoquinone blocks T-lymphocyte activation by inhibiting interleukin-2 production, but not CD25, ICAM-1, or LFA-1 expression. Toxicol Appl Pharmacol. 1997 Mar; 143(1):30-6. PMID: 9073589.
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    68. Conti DJ, Shen G, Singh T, Isenberg A, Freed BM. Ganciclovir prophylaxis of cytomegalovirus disease. Transplant Proc. 1997 Feb-Mar; 29(1-2):804-6. PMID: 9123534.
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    69. Hughes SE, Xiao S, Perera S, Fluno C, Hasselbarth J, Jayasankar V, Singh J, Del Rosario A, Freed BM, Singh TP, Lempert N, Conti DJ, Gruber SA. Local immunosuppression of canine renal allografts with 15-deoxyspergualin. Transplant Proc. 1996 Aug; 28(4):2054-5. PMID: 8769153.
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    70. Li Q, Geiselhart L, Mittler JN, Mudzinski SP, Lawrence DA, Freed BM. Inhibition of human T lymphoblast proliferation by hydroquinone. Toxicol Appl Pharmacol. 1996 Aug; 139(2):317-23. PMID: 8806848.
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    71. Geiselhart L, Conti DJ, Freed BM. RO 31-8220, a novel protein kinase C inhibitor, inhibits early and late T cell activation events. Transplantation. 1996 Jun 15; 61(11):1637-42. PMID: 8669110.
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    72. Gruber SA, Gallichio M, Rosano TG, Hughes SE, Singh TP, Lempert N, Conti DJ, Hasselbarth J, Freed BM, Stein D, Drusano G. Comparative pharmacokinetics of cyclosporine A and cyclosporine G in renal allograft recipients. Transplant Proc. 1996 Apr; 28(2):892. PMID: 8623449.
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    73. Conti DJ, Freed BM, Singh TP, Gallichio M, Gruber SA, Lempert N. Preemptive ganciclovir therapy in cytomegalovirus-seropositive renal transplants recipients. Arch Surg. 1995 Nov; 130(11):1217-21; discussion 1221-2. PMID: 7487465.
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    74. Singh TP, Gruber SA, Lempert N, Freed B, Conti DJ. Efficacy of cytomegalovirus prophylaxis in renal retransplantation. Transplant Proc. 1995 Feb; 27(1):964-5. PMID: 7879247.
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    75. Conti DJ, Freed BM, Gruber SA, Singh TP, Gallichio M, Lempert N. Impact of retransplant status on delayed graft function: an analysis of paired cadaver kidneys. Transplant Proc. 1995 Feb; 27(1):1070-1. PMID: 7878809.
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    76. Gallichio MH, Conti DJ, Lempert N, Gruber SA, Geiselhart L, Freed BM. Calcium-mediated induction of anergy in the Jurkat T-cell line. Transplant Proc. 1994 Dec; 26(6):3458-9. PMID: 7998221.
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    77. Aubrey M, Gallichio M, Amjad I, Dasika U, Conti D, Lempert N, Gruber S, Freed B. Fibroblasts diminish the insulin secretory response of HIT-T15 beta cells to glucose. Transplant Proc. 1994 Dec; 26(6):3447. PMID: 7998214.
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    78. Conti DJ, Freed BM, Gruber SA, Lempert N. Prophylaxis of primary cytomegalovirus disease in renal transplant recipients. A trial of ganciclovir vs immunoglobulin. Arch Surg. 1994 Apr; 129(4):443-7. PMID: 8154971.
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    79. Conti DJ, Freed BM, Lempert N. Prophylactic immunoglobulin therapy improves the outcome of renal transplantation in recipients at risk for primary cytomegalovirus disease. Transplant Proc. 1993 Feb; 25(1 Pt 2):1421-2. PMID: 8382867.
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    80. Conti DJ, Aubrey MT, Lempert N, Freed BM. Human fibroblasts inhibit production of insulin by the HIT-T15 cell line. Transplant Proc. 1992 Dec; 24(6):2913-4. PMID: 1465996.
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    81. Aubrey MT, Conti DJ, Lempert N, Freed BM. Rapid assessment of islet cell growth and function in vitro by enzyme-linked immunosorbent assay. Transplant Proc. 1992 Dec; 24(6):2792-3. PMID: 1465942.
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    82. Freed BM, Bennett JA, Rosano TG, Brooks CA, Cramer SM, Lempert N. Assessment of the in vivo immunosuppressive activity of the major cyclosporine metabolite by leukemia allograft rejection. Transplantation. 1992 Feb; 53(2):456-60. PMID: 1738941.
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    83. Stevens C, Lempert N, Freed BM. The effects of immunosuppressive agents on in vitro production of human immunoglobulins. Transplantation. 1991 Jun; 51(6):1240-4. PMID: 1710843.
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    84. Freed BM, Stevens C, Brooks C, Cramer S, Lempert N, Rosano TG. Assessment of the biological activity of cyclosporine metabolites using the human JURKAT cell line. Transplant Proc. 1991 Feb; 23(1 Pt 2):980-1. PMID: 1989352.
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    85. Freed BM, Lempert N, Lawrence DA. Inhibition of interleukin-2 production in the human T cell line JURKAT by nonpolar maleimides. Toxicol Appl Pharmacol. 1991 Jan; 107(1):173-82. PMID: 1987656.
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    86. Rosano TG, Brooks CA, Dybas MT, Cramer SM, Stevens C, Freed BM. Selection of an optimal assay method for monitoring cyclosporine therapy. Transplant Proc. 1990 Jun; 22(3):1125-8. PMID: 2349672.
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    87. Freed BM, Lempert N, Lawrence DA. The inhibitory effects of N-ethylmaleimide, colchicine and cytochalasins on human T-cell functions. Int J Immunopharmacol. 1989; 11(5):459-65. PMID: 2807624.
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    88. Rosano TG, Pell MA, Freed BM, Dybas MT, Lempert N. Cyclosporine and metabolites in blood from renal allograft recipients with nephrotoxicity, rejection, or good renal function: comparative high-performance liquid chromatography and monoclonal radioimmunoassay studies. Transplant Proc. 1988 Apr; 20(2 Suppl 2):330-8. PMID: 3284076.
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    89. Pell MA, Rosano TG, Brayman KL, Freed BM, Shaw LM, Lempert N. Predominance of native cyclosporine over metabolites in rat blood and tissue. Transplant Proc. 1988 Apr; 20(2 Suppl 2):674-9. PMID: 3363664.
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    90. Freed BM, Stevens C, Zhang G, Rosano TG, Lempert N. A comparison of the effects of cyclosporine and steroids on human T lymphocyte responses. Transplant Proc. 1988 Apr; 20(2 Suppl 2):233-9. PMID: 3284070.
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    91. Patterson DA, Rapoport R, Patterson MA, Freed BM, Lempert N. Hydrogen peroxide-mediated inhibition of T-cell response to mitogens is a result of direct action on T cells. Arch Surg. 1988 Mar; 123(3):300-4. PMID: 3257684.
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    92. Freed BM, Patterson DA, Rapoport R, Lawrence DA, Lempert N. Inhibition of human T cell responses by hydrogen peroxide. Pharmacol Ther. 1988; 39(1-3):267-8. PMID: 3264407.
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    93. Lempert N, Laffin RJ, Fitzgerald K, Freed BM. Elevation of serum C-reactive protein levels during graft rejection. Transplant Proc. 1987 Feb; 19(1 Pt 2):1683-5. PMID: 3274404.
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    94. Freed BM, Rosano TG, Quick C, Lempert N. Effects of cyclosporine metabolites M17 and M18 on proliferation and interleukin 2 production in the mixed lymphocyte culture. Transplant Proc. 1987 Feb; 19(1 Pt 2):1223-6. PMID: 2950629.
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    95. Rosano TG, Freed BM, Pell MA, Dybas MT, Lempert N. Involvement of cyclosporine metabolites in therapeutic monitoring and immunosuppression. Transplant Proc. 1987 Feb; 19(1 Pt 2):1699-703. PMID: 2950633.
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    96. Freed BM, Rapoport R, Lempert N. Inhibition of early events in the human T-lymphocyte response to mitogens and alloantigens by hydrogen peroxide. Arch Surg. 1987 Jan; 122(1):99-104. PMID: 2948481.
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    97. Freed BM, Rosano TG, Lempert N. In vitro immunosuppressive properties of cyclosporine metabolites. Transplantation. 1987 Jan; 43(1):123-7. PMID: 2948307.
      View in: PubMed
    98. Rosano TG, Freed BM, Pell MA, Lempert N. Cyclosporine metabolites in human blood and renal tissue. Transplant Proc. 1986 Dec; 18(6 Suppl 5):35-40. PMID: 3538572.
      View in: PubMed
    99. Rosano TG, Freed BM, Cerilli J, Lempert N. Immunosuppressive metabolites of cyclosporine in the blood of renal allograft recipients. Transplantation. 1986 Sep; 42(3):262-7. PMID: 2944258.
      View in: PubMed
    100. Freed BM, Mozayeni B, Lawrence DA, Wallach FR, Lempert N. Differential inhibition of human T-lymphocyte activation by maleimide probes. Cell Immunol. 1986 Aug; 101(1):181-94. PMID: 2943414.
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    101. Freed B, Walsh A, Pietrocola D, MacDowell R, Laffin R, Lempert N. Early detection of renal allograft rejection by serial monitoring of serum C-reactive protein. Transplantation. 1984 Feb; 37(2):215-18. PMID: 6364503.
      View in: PubMed
    102. Simon JD, Freed BM, Davignon D, Albala MM. Identification and characterization of a soluble suppressor factor(s) in the serum of AKR mice bearing lymphocytic leukemia. Cell Immunol. 1983 Nov; 82(1):163-73. PMID: 6605807.
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