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Rui Zhao

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-BioChem&Molecular Genetics
Phone303/724-3269

    Collapse Research 
    Collapse research activities and funding
    R01GM080334     (ZHAO, RUI)Sep 1, 2008 - Aug 31, 2014
    NIH/NIGMS
    Understanding the structure and function of splicing factor Prp8
    Role: Principal Investigator

    R03DA030559     (ZHAO, RUI)Jun 1, 2010 - May 31, 2012
    NIH/NIDA
    Identify inhibitors of the Eya phosphatase activity using high throughput screeni
    Role: Principal Investigator

    R03DA033174     (ZHAO, RUI)Jul 15, 2011 - Jun 30, 2014
    NIH/NIDA
    Identify inhibitors of the Six1/Eya interaction using high throughput screening
    Role: Principal Investigator

    R03DA033982     (ZHAO, RUI)Feb 1, 2012 - Jan 31, 2014
    NIH/NIDA
    Identify Inhibitors of the Transcriptional Co-Repressor CtBP Using HTS for Cancer
    Role: Principal Investigator

    R41CA180347     (FORD, HEIDE L.)Jul 17, 2013 - Jun 30, 2014
    NIH/NCI
    The anti-tumorigenic and anti-metastatic potential of Eya phosphatase inhibitors
    Role: Co-Principal Investigator

    R21NS085514     (ZHAO, RUI)Jul 1, 2014 - May 31, 2016
    NIH/NINDS
    Spinal muscular atrophy therapy using recombinant SMN proteins
    Role: Principal Investigator

    R21CA185752     (FORD, HEIDE L.)Dec 18, 2014 - Nov 30, 2016
    NIH/NCI
    Developing cancer therapies through targeting the Six1/Eya transcriptional complex
    Role: Co-Principal Investigator

    R01GM114178     (ZHAO, RUI)Apr 1, 2015 - Mar 31, 2019
    NIH/NIGMS
    Structure and function of U5 snRNP
    Role: Principal Investigator

    R01CA221282     (FORD, HEIDE L.)Aug 1, 2017 - Jul 31, 2022
    NIH/NCI
    Role of Eya3 in regulating the immune microenvironment to promote breast tumor progression
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Zhou H, Zhang L, Vartuli RL, Ford HL, Zhao R. The Eya phosphatase: Its unique role in cancer. Int J Biochem Cell Biol. 2017 Sep 05. PMID: 28887153.
      View in: PubMed
    2. Blevins MA, Huang M, Zhao R. The Role of CtBP1 in Oncogenic Processes and Its Potential as a Therapeutic Target. Mol Cancer Ther. 2017 Jun; 16(6):981-990. PMID: 28576945.
      View in: PubMed
    3. Espinosa S, Zhang L, Li X, Zhao R. Understanding pre-mRNA splicing through crystallography. Methods. 2017 Aug 01; 125:55-62. PMID: 28506657.
      View in: PubMed
    4. Gavett BE, Zhao R, John SE, Bussell CA, Roberts JR, Yue C. Phishing suspiciousness in older and younger adults: The role of executive functioning. PLoS One. 2017; 12(2):e0171620. PMID: 28158316.
      View in: PubMed
    5. Zhang L, Li X, Hill RC, Qiu Y, Zhang W, Hansen KC, Zhao R. Brr2 plays a role in spliceosomal activation in addition to U4/U6 unwinding. Nucleic Acids Res. 2015 Mar 31; 43(6):3286-97. PMID: 25670679; PMCID: PMC4381053.
    6. Blevins MA, Towers CG, Patrick AN, Zhao R, Ford HL. The SIX1-EYA transcriptional complex as a therapeutic target in cancer. Expert Opin Ther Targets. 2015 Feb; 19(2):213-25. PMID: 25555392; PMCID: PMC4336540.
    7. Blevins MA, Kouznetsova J, Krueger AB, King R, Griner LM, Hu X, Southall N, Marugan JJ, Zhang Q, Ferrer M, Zhao R. Small Molecule, NSC95397, Inhibits the CtBP1-Protein Partner Interaction and CtBP1-Mediated Transcriptional Repression. J Biomol Screen. 2015 Jun; 20(5):663-72. PMID: 25477201; PMCID: PMC4486263.
    8. Wang C, Chen Z, Hong X, Ning F, Liu H, Zang J, Yan X, Kemp J, Musselman CA, Kutateladze TG, Zhao R, Jiang C, Zhang G. The structural basis of urea-induced protein unfolding in ß-catenin. Acta Crystallogr D Biol Crystallogr. 2014 Nov; 70(Pt 11):2840-7. PMID: 25372676; PMCID: PMC4220971.
    9. Garrey SM, Katolik A, Prekeris M, Li X, York K, Bernards S, Fields S, Zhao R, Damha MJ, Hesselberth JR. A homolog of lariat-debranching enzyme modulates turnover of branched RNA. RNA. 2014 Aug; 20(8):1337-48. PMID: 24919400; PMCID: PMC4105757.
    10. Krueger AB, Drasin DJ, Lea WA, Patrick AN, Patnaik S, Backos DS, Matheson CJ, Hu X, Barnaeva E, Holliday MJ, Blevins MA, Robin TP, Eisenmesser EZ, Ferrer M, Simeonov A, Southall N, Reigan P, Marugan J, Ford HL, Zhao R. Allosteric inhibitors of the Eya2 phosphatase are selective and inhibit Eya2-mediated cell migration. J Biol Chem. 2014 Jun 06; 289(23):16349-61. PMID: 24755226; PMCID: PMC4047403.
    11. Zhang L, Li X, Zhao R. Structural analyses of the pre-mRNA splicing machinery. Protein Sci. 2013 Jun; 22(6):677-92. PMID: 23592432; PMCID: PMC3690710.
    12. Han G, Bian L, Li F, Cotrim A, Wang D, Lu J, Deng Y, Bird G, Sowers A, Mitchell JB, Gutkind JS, Zhao R, Raben D, ten Dijke P, Refaeli Y, Zhang Q, Wang XJ. Preventive and therapeutic effects of Smad7 on radiation-induced oral mucositis. Nat Med. 2013 Apr; 19(4):421-8. PMID: 23475202; PMCID: PMC3780964.
    13. Li X, Zhang W, Xu T, Ramsey J, Zhang L, Hill R, Hansen KC, Hesselberth JR, Zhao R. Comprehensive in vivo RNA-binding site analyses reveal a role of Prp8 in spliceosomal assembly. Nucleic Acids Res. 2013 Apr 01; 41(6):3805-18. PMID: 23393194; PMCID: PMC3616732.
    14. Liu W, Jankowska-Anyszka M, Piecyk K, Dickson L, Wallace A, Niedzwiecka A, Stepinski J, Stolarski R, Darzynkiewicz E, Kieft J, Zhao R, Jones DN, Davis RE. Structural basis for nematode eIF4E binding an m(2,2,7)G-Cap and its implications for translation initiation. Nucleic Acids Res. 2011 Nov 01; 39(20):8820-32. PMID: 21965542; PMCID: PMC3203607.
    15. Deng Y, Deng H, Liu J, Han G, Malkoski S, Liu B, Zhao R, Wang XJ, Zhang Q. Transcriptional down-regulation of Brca1 and E-cadherin by CtBP1 in breast cancer. Mol Carcinog. 2012 Jun; 51(6):500-7. PMID: 21681822; PMCID: PMC3177013.
    16. Guarnieri MT, Blagg BS, Zhao R. A high-throughput TNP-ATP displacement assay for screening inhibitors of ATP-binding in bacterial histidine kinases. Assay Drug Dev Technol. 2011 Apr; 9(2):174-83. PMID: 21050069; PMCID: PMC3065726.
    17. Hong X, Zang J, White J, Wang C, Pan CH, Zhao R, Murphy RC, Dai S, Henson P, Kappler JW, Hagman J, Zhang G. Interaction of JMJD6 with single-stranded RNA. Proc Natl Acad Sci U S A. 2010 Aug 17; 107(33):14568-72. PMID: 20679243; PMCID: PMC2930430.
    18. Liu W, Zhao R, McFarland C, Kieft J, Niedzwiecka A, Jankowska-Anyszka M, Stepinski J, Darzynkiewicz E, Jones DN, Davis RE. Structural insights into parasite eIF4E binding specificity for m7G and m2,2,7G mRNA caps. J Biol Chem. 2009 Nov 06; 284(45):31336-49. PMID: 19710013; PMCID: PMC2781531.
    19. Zhang L, Xu T, Maeder C, Bud LO, Shanks J, Nix J, Guthrie C, Pleiss JA, Zhao R. Structural evidence for consecutive Hel308-like modules in the spliceosomal ATPase Brr2. Nat Struct Mol Biol. 2009 Jul; 16(7):731-9. PMID: 19525970; PMCID: PMC2743687.
    20. Patrick AN, Schiemann BJ, Yang K, Zhao R, Ford HL. Biochemical and functional characterization of six SIX1 Branchio-oto-renal syndrome mutations. J Biol Chem. 2009 Jul 31; 284(31):20781-90. PMID: 19497856; PMCID: PMC2742842.
    21. Yang K, Zhang L, Xu T, Heroux A, Zhao R. Crystal structure of the beta-finger domain of Prp8 reveals analogy to ribosomal proteins. Proc Natl Acad Sci U S A. 2008 Sep 16; 105(37):13817-22. PMID: 18779563; PMCID: PMC2544537.
    22. Guarnieri MT, Zhang L, Shen J, Zhao R. The Hsp90 inhibitor radicicol interacts with the ATP-binding pocket of bacterial sensor kinase PhoQ. J Mol Biol. 2008 May 23; 379(1):82-93. PMID: 18440021.
      View in: PubMed
    23. Shen J, Zhang L, Zhao R. Biochemical characterization of the ATPase and helicase activity of UAP56, an essential pre-mRNA splicing and mRNA export factor. J Biol Chem. 2007 Aug 03; 282(31):22544-50. PMID: 17562711.
      View in: PubMed
    24. Zhang L, Shen J, Guarnieri MT, Heroux A, Yang K, Zhao R. Crystal structure of the C-terminal domain of splicing factor Prp8 carrying retinitis pigmentosa mutants. Protein Sci. 2007 Jun; 16(6):1024-31. PMID: 17473007; PMCID: PMC2206663.
    25. Gai D, Zhao R, Li D, Finkielstein CV, Chen XS. Mechanisms of conformational change for a replicative hexameric helicase of SV40 large tumor antigen. Cell. 2004 Oct 01; 119(1):47-60. PMID: 15454080.
      View in: PubMed
    26. Kruse SW, Zhao R, Smith DP, Jones DN. Structure of a specific alcohol-binding site defined by the odorant binding protein LUSH from Drosophila melanogaster. Nat Struct Biol. 2003 Sep; 10(9):694-700. PMID: 12881720; PMCID: PMC4397894.
    27. Li D, Zhao R, Lilyestrom W, Gai D, Zhang R, DeCaprio JA, Fanning E, Jochimiak A, Szakonyi G, Chen XS. Structure of the replicative helicase of the oncoprotein SV40 large tumour antigen. Nature. 2003 May 29; 423(6939):512-8. PMID: 12774115.
      View in: PubMed
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