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Xuedong Liu

TitleProfessor
InstitutionUniversity of Colorado Boulder
DepartmentChemistry & Biochemistry
Phone303/735-6161
ORCID ORCID Icon0000-0001-7209-4964 Additional info

    Collapse Research 
    Collapse research activities and funding
    F32CA067460     (LIU, XUEDONG)Nov 11, 1995
    NIH/NCI
    TGF B SIGNAL TRANSDUCTION PATHWAY(S)
    Role: Principal Investigator

    R01CA095527     (LIU, XUEDONG)Apr 1, 2002 - Mar 31, 2008
    NIH/NCI
    Regulation of Ski-SnoN by Cell Cycle and TGF-beta
    Role: Principal Investigator

    R01CA107098     (LIU, XUEDONG)Apr 1, 2004 - Apr 30, 2014
    NIH/NCI
    Mechanisms of p27Kipl Proteolysis in Cancer Cells
    Role: Principal Investigator

    R01GM083172     (LIU, XUEDONG)Apr 1, 2008 - Mar 31, 2013
    NIH/NIGMS
    Quantitative Analysis of TGF-b/Smad Signaling Dynamics
    Role: Principal Investigator

    F33GM093670     (LIU, XUEDONG)May 21, 2010 - Nov 20, 2010
    NIH/NIGMS
    A Systems Biology Analysis of Spindle Checkpoint Signaling
    Role: Principal Investigator

    S10RR026680     (LIU, XUEDONG)Sep 26, 2011 - Sep 25, 2013
    NIH/NCRR
    ImageXpress Micro Cellular Imagining and Analysis System
    Role: Principal Investigator

    R01GM113141     (LIU, XUEDONG)Aug 1, 2015 - Jul 31, 2018
    NIH/NIGMS
    High Throughput Screening to Discover Chemical Probes and Pharmacological Agents for Modulating Parkin Activity
    Role: Principal Investigator

    R03NS093607     (LIU, XUEDONG)Aug 15, 2015 - Jul 31, 2017
    NIH/NINDS
    Development of Analog Sensitive PINK1 Animal Model and iPS Cells
    Role: Principal Investigator

    R01AR068254     (LIU, XUEDONG)Sep 14, 2015 - Aug 31, 2020
    NIH/NIAMS
    Quantitative Analysis of Mechanochemical Signaling in Wound Response
    Role: Principal Investigator

    S10OD021601     (LIU, XUEDONG)Apr 1, 2016 - Mar 31, 2017
    NIH
    FACSAria Fusion Cell Sorter
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Zhang C, Liu Z, Bunker E, Ramirez A, Lee S, Peng Y, Tan AC, Eckhardt SG, Chapnick DA, Liu X. Sorafenib targets the mitochondrial electron transport chain complexes and ATP synthase to activate the PINK1-Parkin pathway and modulate cellular drug response. J Biol Chem. 2017 Sep 08; 292(36):15105-15120. PMID: 28673964.
      View in: PubMed
    2. Bennett CG, Riemondy K, Chapnick DA, Bunker E, Liu X, Kuersten S, Yi R. Genome-wide analysis of Musashi-2 targets reveals novel functions in governing epithelial cell migration. Nucleic Acids Res. 2016 May 05; 44(8):3788-800. PMID: 27034466; PMCID: PMC4857000.
    3. Feng Z, Zi Z, Liu X. Measuring TGF-ß Ligand Dynamics in Culture Medium. Methods Mol Biol. 2016; 1344:379-89. PMID: 26520139.
      View in: PubMed
    4. Davis EM, Kim J, Menasche BL, Sheppard J, Liu X, Tan AC, Shen J. Comparative Haploid Genetic Screens Reveal Divergent Pathways in the Biogenesis and Trafficking of Glycophosphatidylinositol-Anchored Proteins. Cell Rep. 2015 Jun 23; 11(11):1727-36. PMID: 26074080; PMCID: PMC4481156.
    5. Chapnick DA, Bunker E, Liu X. A biosensor for the activity of the "sheddase" TACE (ADAM17) reveals novel and cell type-specific mechanisms of TACE activation. Sci Signal. 2015 Feb 24; 8(365):rs1. PMID: 25714465; PMCID: PMC5012641.
    6. Zhang C, Lee S, Peng Y, Bunker E, Shen C, Giaime E, Shen J, Shen J, Zhou Z, Liu X. A chemical genetic approach to probe the function of PINK1 in regulating mitochondrial dynamics. Cell Res. 2015 Mar; 25(3):394-7. PMID: 25475060; PMCID: PMC4349247.
    7. Lee S, Zhang C, Liu X. Role of glucose metabolism and ATP in maintaining PINK1 levels during Parkin-mediated mitochondrial damage responses. J Biol Chem. 2015 Jan 09; 290(2):904-17. PMID: 25404737; PMCID: PMC4294517.
    8. Zhang C, Lee S, Peng Y, Bunker E, Giaime E, Shen J, Zhou Z, Liu X. PINK1 triggers autocatalytic activation of Parkin to specify cell fate decisions. Curr Biol. 2014 Aug 18; 24(16):1854-65. PMID: 25088558; PMCID: PMC4143385.
    9. Chapnick DA, Liu X. Leader cell positioning drives wound-directed collective migration in TGFß-stimulated epithelial sheets. Mol Biol Cell. 2014 May; 25(10):1586-93. PMID: 24623725; PMCID: PMC4019490.
    10. Chapnick DA, Jacobsen J, Liu X. The development of a novel high throughput computational tool for studying individual and collective cellular migration. PLoS One. 2013; 8(12):e82444. PMID: 24386097; PMCID: PMC3873918.
    11. Ungermannova D, Lee J, Zhang G, Dallmann HG, McHenry CS, Liu X. High-throughput screening AlphaScreen assay for identification of small-molecule inhibitors of ubiquitin E3 ligase SCFSkp2-Cks1. J Biomol Screen. 2013 Sep; 18(8):910-20. PMID: 23589337; PMCID: PMC4168015.
    12. Lee J, Sammond DW, Fiorini Z, Saludes JP, Resch MG, Hao B, Wang W, Yin H, Liu X. Computationally designed peptide inhibitors of the ubiquitin E3 ligase SCF(Fbx4). Chembiochem. 2013 Mar 04; 14(4):445-51. PMID: 23401343; PMCID: PMC4028150.
    13. Liu X, Winey M. The MPS1 family of protein kinases. Annu Rev Biochem. 2012; 81:561-85. PMID: 22482908; PMCID: PMC4026297.
    14. Ungermannova D, Parker SJ, Nasveschuk CG, Chapnick DA, Phillips AJ, Kuchta RD, Liu X. Identification and mechanistic studies of a novel ubiquitin E1 inhibitor. J Biomol Screen. 2012 Apr; 17(4):421-34. PMID: 22274912; PMCID: PMC3339042.
    15. Ungermannova D, Parker SJ, Nasveschuk CG, Wang W, Quade B, Zhang G, Kuchta RD, Phillips AJ, Liu X. Largazole and its derivatives selectively inhibit ubiquitin activating enzyme (e1). PLoS One. 2012; 7(1):e29208. PMID: 22279528; PMCID: PMC3261141.
    16. Chapnick DA, Warner L, Bernet J, Rao T, Liu X. Partners in crime: the TGFß and MAPK pathways in cancer progression. Cell Biosci. 2011 Dec 28; 1:42. PMID: 22204556; PMCID: PMC3275500.
    17. Zhang X, Yin Q, Ling Y, Zhang Y, Ma R, Ma Q, Cao C, Zhong H, Liu X, Xu Q. Two LXXLL motifs in the N terminus of Mps1 are required for Mps1 nuclear import during G(2)/M transition and sustained spindle checkpoint responses. Cell Cycle. 2011 Aug 15; 10(16):2742-50. PMID: 21778823; PMCID: PMC3219542.
    18. Sun T, Yang X, Wang W, Zhang X, Xu Q, Zhu S, Kuchta R, Chen G, Liu X. Cellular abundance of Mps1 and the role of its carboxyl terminal tail in substrate recruitment. J Biol Chem. 2010 Dec 03; 285(49):38730-9. PMID: 20884615; PMCID: PMC2992306.
    19. Clarke DC, Liu X. Measuring the absolute abundance of the Smad transcription factors using quantitative immunoblotting. Methods Mol Biol. 2010; 647:357-76. PMID: 20694679; PMCID: PMC4168016.
    20. Chapnick DA, Liu X. Analysis of ligand-dependent nuclear accumulation of Smads in TGF-beta signaling. Methods Mol Biol. 2010; 647:95-111. PMID: 20694662; PMCID: PMC4083701.
    21. Wang W, Yang Y, Gao Y, Xu Q, Wang F, Zhu S, Old W, Resing K, Ahn N, Lei M, Liu X. Structural and mechanistic insights into Mps1 kinase activation. J Cell Mol Med. 2009 Aug; 13(8B):1679-94. PMID: 19120698; PMCID: PMC2829362.
    22. Clarke DC, Brown ML, Erickson RA, Shi Y, Liu X. Transforming growth factor beta depletion is the primary determinant of Smad signaling kinetics. Mol Cell Biol. 2009 May; 29(9):2443-55. PMID: 19223462; PMCID: PMC2668365.
    23. Erickson RA, Liu X. Association of v-ErbA with Smad4 disrupts TGF-beta signaling. Mol Biol Cell. 2009 Mar; 20(5):1509-19. PMID: 19144825; PMCID: PMC2649266.
    24. Xu Q, Zhu S, Wang W, Zhang X, Old W, Ahn N, Liu X. Regulation of kinetochore recruitment of two essential mitotic spindle checkpoint proteins by Mps1 phosphorylation. Mol Biol Cell. 2009 Jan; 20(1):10-20. PMID: 18923149; PMCID: PMC2613107.
    25. Clarke DC, Liu X. Decoding the quantitative nature of TGF-beta/Smad signaling. Trends Cell Biol. 2008 Sep; 18(9):430-42. PMID: 18706811; PMCID: PMC2774497.
    26. Nasveschuk CG, Ungermannova D, Liu X, Phillips AJ. A concise total synthesis of largazole, solution structure, and some preliminary structure activity relationships. Org Lett. 2008 Aug 21; 10(16):3595-8. PMID: 18616341; PMCID: PMC2664405.
    27. Barthel KK, Liu X. A transcriptional enhancer from the coding region of ADAMTS5. PLoS One. 2008 May 14; 3(5):e2184. PMID: 18478108; PMCID: PMC2364661.
    28. Zhang L, Ding L, Cheung TH, Dong MQ, Chen J, Sewell AK, Liu X, Yates JR, Han M. Systematic identification of C. elegans miRISC proteins, miRNAs, and mRNA targets by their interactions with GW182 proteins AIN-1 and AIN-2. Mol Cell. 2007 Nov 30; 28(4):598-613. PMID: 18042455; PMCID: PMC2186060.
    29. Cheung TH, Barthel KK, Kwan YL, Liu X. Identifying pattern-defined regulatory islands in mammalian genomes. Proc Natl Acad Sci U S A. 2007 Jun 12; 104(24):10116-21. PMID: 17535887; PMCID: PMC1891267.
    30. Zhu S, Wang W, Clarke DC, Liu X. Activation of Mps1 promotes transforming growth factor-beta-independent Smad signaling. J Biol Chem. 2007 Jun 22; 282(25):18327-38. PMID: 17452325.
      View in: PubMed
    31. Cheung TH, Kwan YL, Hamady M, Liu X. Unraveling transcriptional control and cis-regulatory codes using the software suite GeneACT. Genome Biol. 2006; 7(10):R97. PMID: 17064417; PMCID: PMC1794569.
    32. Riquelme C, Barthel KK, Qin XF, Liu X. Ubc9 expression is essential for myotube formation in C2C12. Exp Cell Res. 2006 Jul 01; 312(11):2132-41. PMID: 16631162.
      View in: PubMed
    33. Riquelme C, Barthel KK, Liu X. SUMO-1 modification of MEF2A regulates its transcriptional activity. J Cell Mol Med. 2006 Jan-Mar; 10(1):132-44. PMID: 16563226; PMCID: PMC3933106.
    34. Wang W, Nacusi L, Sheaff RJ, Liu X. Ubiquitination of p21Cip1/WAF1 by SCFSkp2: substrate requirement and ubiquitination site selection. Biochemistry. 2005 Nov 08; 44(44):14553-64. PMID: 16262255.
      View in: PubMed
    35. Knuesel M, Cheung HT, Hamady M, Barthel KK, Liu X. A method of mapping protein sumoylation sites by mass spectrometry using a modified small ubiquitin-like modifier 1 (SUMO-1) and a computational program. Mol Cell Proteomics. 2005 Oct; 4(10):1626-36. PMID: 16020427.
      View in: PubMed
    36. Ungermannova D, Gao Y, Liu X. Ubiquitination of p27Kip1 requires physical interaction with cyclin E and probable phosphate recognition by SKP2. J Biol Chem. 2005 Aug 26; 280(34):30301-9. PMID: 15980415.
      View in: PubMed
    37. Wang W, Ungermannova D, Chen L, Liu X. Molecular and biochemical characterization of the Skp2-Cks1 binding interface. J Biol Chem. 2004 Dec 03; 279(49):51362-9. PMID: 15452136.
      View in: PubMed
    38. Macdonald M, Wan Y, Wang W, Roberts E, Cheung TH, Erickson R, Knuesel MT, Liu X. Control of cell cycle-dependent degradation of c-Ski proto-oncoprotein by Cdc34. Oncogene. 2004 Jul 22; 23(33):5643-53. PMID: 15122324.
      View in: PubMed
    39. Wang W, Ungermannova D, Jin J, Harper JW, Liu X. Negative regulation of SCFSkp2 ubiquitin ligase by TGF-beta signaling. Oncogene. 2004 Feb 05; 23(5):1064-75. PMID: 14676846.
      View in: PubMed
    40. Knuesel M, Wan Y, Xiao Z, Holinger E, Lowe N, Wang W, Liu X. Identification of novel protein-protein interactions using a versatile mammalian tandem affinity purification expression system. Mol Cell Proteomics. 2003 Nov; 2(11):1225-33. PMID: 12963786.
      View in: PubMed
    41. Wang W, Ungermannova D, Chen L, Liu X. A negatively charged amino acid in Skp2 is required for Skp2-Cks1 interaction and ubiquitination of p27Kip1. J Biol Chem. 2003 Aug 22; 278(34):32390-6. PMID: 12813041.
      View in: PubMed
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