Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
Keywords
Last Name
Institution

Contact Us
If you have any questions or feedback please contact us.

Xuedong Liu

TitleProfessor
InstitutionUniversity of Colorado Boulder
DepartmentBiochemistry
Phone303/735-6161

    Collapse Research 
    Collapse research activities and funding
    R21GM135668     (GOODWIN, ANDREW P)Jan 1, 2020 - Dec 31, 2021
    NIH
    Affinity-Mediated Covalent Conjugation: A Method for Direct Modification of Specific Receptors on Cell Membranes
    Role: Co-Principal Investigator

    S10OD025072     (LIU, XUEDONG)Jul 15, 2018 - Jul 14, 2019
    NIH
    Opera Phenix High Throughput and High Content Confocal Microscope
    Role: Principal Investigator

    S10OD021601     (LIU, XUEDONG)Apr 1, 2016 - Mar 31, 2017
    NIH
    FACSAria Fusion Cell Sorter
    Role: Principal Investigator

    R01AR068254     (LIU, XUEDONG)Sep 14, 2015 - Aug 31, 2021
    NIH
    Quantitative Analysis of Mechanochemical Signaling in Wound Response
    Role: Principal Investigator

    R03NS093607     (LIU, XUEDONG)Aug 15, 2015 - Jul 31, 2018
    NIH
    Development of Analog Sensitive PINK1 Animal Model and iPS Cells
    Role: Principal Investigator

    R01GM113141     (LIU, XUEDONG)Aug 1, 2015 - Jul 31, 2019
    NIH
    High Throughput Screening to Discover Chemical Probes and Pharmacological Agents for Modulating Parkin Activity
    Role: Principal Investigator

    S10RR026680     (LIU, XUEDONG)Sep 26, 2011 - Sep 25, 2013
    NIH
    ImageXpress Micro Cellular Imagining and Analysis System
    Role: Principal Investigator

    F33GM093670     (LIU, XUEDONG)May 21, 2010 - Nov 20, 2010
    NIH
    A Systems Biology Analysis of Spindle Checkpoint Signaling
    Role: Principal Investigator

    R01GM083172     (LIU, XUEDONG)Apr 1, 2008 - Mar 31, 2013
    NIH
    Quantitative Analysis of TGF-b/Smad Signaling Dynamics
    Role: Principal Investigator

    R01CA107098     (LIU, XUEDONG)Apr 1, 2004 - Apr 30, 2014
    NIH
    Mechanisms of p27Kipl Proteolysis in Cancer Cells
    Role: Principal Investigator

    R01CA095527     (LIU, XUEDONG)Apr 1, 2002 - Mar 31, 2008
    NIH
    Regulation of Ski-SnoN by Cell Cycle and TGF-beta
    Role: Principal Investigator

    F32CA067460     (LIU, XUEDONG)Sep 1, 1996
    NIH
    TGF B SIGNAL TRANSDUCTION PATHWAY(S)
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Xu Q, Zhang X, Sanchez GJ, Ramirez AT, Liu X. Cell type-specific intercellular gene transfer in mammalian cells via transient cell entrapment. Cell Discov. 2022 Mar 01; 8(1):20. PMID: 35228545.
      View in: PubMed
    2. Liu Z, Ramirez A, Liu X. Live Cell Imaging of Spatiotemporal Ca2+ Fluctuation Responses to Anticancer Drugs. Methods Mol Biol. 2022; 2488:227-236. PMID: 35347692.
      View in: PubMed
    3. Wheeler GE, Purkayastha A, Bunker EN, Bortz DM, Liu X. Protocol for Analysis and Consolidation of TrackMate Outputs for Measuring Two-Dimensional Cell Motility using Nuclear Tracking. J Vis Exp. 2021 12 18; (178). PMID: 34978296.
      View in: PubMed
    4. Ramirez A, Old W, Selwood DL, Liu X. Cannabidiol activates PINK1-Parkin-dependent mitophagy and mitochondrial-derived vesicles. Eur J Cell Biol. 2022 Jan; 101(1):151185. PMID: 34915361.
      View in: PubMed
    5. Roy S, Curry SD, Bibbey MG, Chapnick DA, Liu X, Goodwin AP, Cha JN. Effect of covalent photoconjugation of affibodies to epidermal growth factor receptor (EGFR) on cellular quiescence. Biotechnol Bioeng. 2022 01; 119(1):187-198. PMID: 34676884.
      View in: PubMed
    6. Clarke DC, Brown ML, Erickson RA, Shi Y, Liu X. Correction for Clarke et al., "Transforming Growth Factor ß Depletion Is the Primary Determinant of Smad Signaling Kinetics". Mol Cell Biol. 2021 Jul 23; 41(8):e0025521. PMID: 34296951.
      View in: PubMed
    7. Bunker EN, Wheeler GE, Chapnick DA, Liu X. Suppression of a-catenin and adherens junctions enhances epithelial cell proliferation and motility via TACE-mediated TGF-a autocrine/paracrine signaling. Mol Biol Cell. 2021 02 15; 32(4):348-361. PMID: 33378218.
      View in: PubMed
    8. Zhang X, Xu Q, Zi Z, Liu Z, Wan C, Crisman L, Shen J, Liu X. Programmable Extracellular Vesicles for Macromolecule Delivery and Genome Modifications. Dev Cell. 2020 12 21; 55(6):784-801.e9. PMID: 33296682.
      View in: PubMed
    9. Zhang C, Wang R, Liu Z, Bunker E, Lee S, Giuntini M, Chapnick D, Liu X. The plant triterpenoid celastrol blocks PINK1-dependent mitophagy by disrupting PINK1's association with the mitochondrial protein TOM20. J Biol Chem. 2019 05 03; 294(18):7472-7487. PMID: 30885942.
      View in: PubMed
    10. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 31119673.
      View in: PubMed
    11. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 27105673.
      View in: PubMed
    12. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 30062120.
      View in: PubMed
    13. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 35753663.
      View in: PubMed
    14. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 23401343.
      View in: PubMed
    15. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 22482908.
      View in: PubMed
    16. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 18042455.
      View in: PubMed
    17. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 22204556.
      View in: PubMed
    18. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 18706811.
      View in: PubMed
    19. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 22279528.
      View in: PubMed
    20. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 16631162.
      View in: PubMed
    21. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 22274912.
      View in: PubMed
    22. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 18923149.
      View in: PubMed
    23. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 14676846.
      View in: PubMed
    24. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 18478108.
      View in: PubMed
    25. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 21778823.
      View in: PubMed
    26. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 20694662.
      View in: PubMed
    27. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 12813041.
      View in: PubMed
    28. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 19144825.
      View in: PubMed
    29. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 25088558.
      View in: PubMed
    30. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 25714465.
      View in: PubMed
    31. Sanchez GJ, Richmond PA, Bunker EN, Karman SS, Azofeifa J, Garnett AT, Xu Q, Wheeler GE, Toomey CM, Zhang Q, Dowell RD, Liu X. Genome-wide dose-dependent inhibition of histone deacetylases studies reveal their roles in enhancer remodeling and suppression of oncogenic super-enhancers. Nucleic Acids Res. 2018 02 28; 46(4):1756-1776. PMID: 29240919.
      View in: PubMed
    32. Zhang C, Liu Z, Bunker E, Ramirez A, Lee S, Peng Y, Tan AC, Eckhardt SG, Chapnick DA, Liu X. Sorafenib targets the mitochondrial electron transport chain complexes and ATP synthase to activate the PINK1-Parkin pathway and modulate cellular drug response. J Biol Chem. 2017 09 08; 292(36):15105-15120. PMID: 28673964.
      View in: PubMed
    33. McQuate SE, Young AM, Silva-Herzog E, Bunker E, Hernandez M, de Chaumont F, Liu X, Detweiler CS, Palmer AE. Long-term live-cell imaging reveals new roles for Salmonella effector proteins SseG and SteA. Cell Microbiol. 2017 01; 19(1). PMID: 27376507.
      View in: PubMed
    34. Bennett CG, Riemondy K, Chapnick DA, Bunker E, Liu X, Kuersten S, Yi R. Genome-wide analysis of Musashi-2 targets reveals novel functions in governing epithelial cell migration. Nucleic Acids Res. 2016 05 05; 44(8):3788-800. PMID: 27034466.
      View in: PubMed
    35. Feng Z, Zi Z, Liu X. Measuring TGF-ß Ligand Dynamics in Culture Medium. Methods Mol Biol. 2016; 1344:379-89. PMID: 26520139.
      View in: PubMed
    36. Davis EM, Kim J, Menasche BL, Sheppard J, Liu X, Tan AC, Shen J. Comparative Haploid Genetic Screens Reveal Divergent Pathways in the Biogenesis and Trafficking of Glycophosphatidylinositol-Anchored Proteins. Cell Rep. 2015 Jun 23; 11(11):1727-36. PMID: 26074080.
      View in: PubMed
    37. Zhang C, Lee S, Peng Y, Bunker E, Shen C, Giaime E, Shen J, Shen J, Zhou Z, Liu X. A chemical genetic approach to probe the function of PINK1 in regulating mitochondrial dynamics. Cell Res. 2015 Mar; 25(3):394-7. PMID: 25475060.
      View in: PubMed
    38. Lee S, Zhang C, Liu X. Role of glucose metabolism and ATP in maintaining PINK1 levels during Parkin-mediated mitochondrial damage responses. J Biol Chem. 2015 Jan 09; 290(2):904-17. PMID: 25404737.
      View in: PubMed
    39. Chapnick DA, Liu X. Leader cell positioning drives wound-directed collective migration in TGFß-stimulated epithelial sheets. Mol Biol Cell. 2014 May; 25(10):1586-93. PMID: 24623725.
      View in: PubMed
    40. Chapnick DA, Jacobsen J, Liu X. The development of a novel high throughput computational tool for studying individual and collective cellular migration. PLoS One. 2013; 8(12):e82444. PMID: 24386097.
      View in: PubMed
    41. Ungermannova D, Lee J, Zhang G, Dallmann HG, McHenry CS, Liu X. High-throughput screening AlphaScreen assay for identification of small-molecule inhibitors of ubiquitin E3 ligase SCFSkp2-Cks1. J Biomol Screen. 2013 Sep; 18(8):910-20. PMID: 23589337.
      View in: PubMed
    42. Sun T, Yang X, Wang W, Zhang X, Xu Q, Zhu S, Kuchta R, Chen G, Liu X. Cellular abundance of Mps1 and the role of its carboxyl terminal tail in substrate recruitment. J Biol Chem. 2010 Dec 03; 285(49):38730-9. PMID: 20884615.
      View in: PubMed
    43. Clarke DC, Liu X. Measuring the absolute abundance of the Smad transcription factors using quantitative immunoblotting. Methods Mol Biol. 2010; 647:357-76. PMID: 20694679.
      View in: PubMed
    44. Wang W, Yang Y, Gao Y, Xu Q, Wang F, Zhu S, Old W, Resing K, Ahn N, Lei M, Liu X. Structural and mechanistic insights into Mps1 kinase activation. J Cell Mol Med. 2009 Aug; 13(8B):1679-1694. PMID: 19120698.
      View in: PubMed
    45. Clarke DC, Brown ML, Erickson RA, Shi Y, Liu X. Transforming growth factor beta depletion is the primary determinant of Smad signaling kinetics. Mol Cell Biol. 2009 May; 29(9):2443-55. PMID: 19223462.
      View in: PubMed
    46. Nasveschuk CG, Ungermannova D, Liu X, Phillips AJ. A concise total synthesis of largazole, solution structure, and some preliminary structure activity relationships. Org Lett. 2008 Aug 21; 10(16):3595-8. PMID: 18616341.
      View in: PubMed
    47. Cheung TH, Barthel KK, Kwan YL, Liu X. Identifying pattern-defined regulatory islands in mammalian genomes. Proc Natl Acad Sci U S A. 2007 Jun 12; 104(24):10116-21. PMID: 17535887.
      View in: PubMed
    48. Zhu S, Wang W, Clarke DC, Liu X. Activation of Mps1 promotes transforming growth factor-beta-independent Smad signaling. J Biol Chem. 2007 Jun 22; 282(25):18327-18338. PMID: 17452325.
      View in: PubMed
    49. Cheung TH, Kwan YL, Hamady M, Liu X. Unraveling transcriptional control and cis-regulatory codes using the software suite GeneACT. Genome Biol. 2006; 7(10):R97. PMID: 17064417.
      View in: PubMed
    50. Riquelme C, Barthel KK, Liu X. SUMO-1 modification of MEF2A regulates its transcriptional activity. J Cell Mol Med. 2006 Jan-Mar; 10(1):132-44. PMID: 16563226.
      View in: PubMed
    51. Wang W, Nacusi L, Sheaff RJ, Liu X. Ubiquitination of p21Cip1/WAF1 by SCFSkp2: substrate requirement and ubiquitination site selection. Biochemistry. 2005 Nov 08; 44(44):14553-64. PMID: 16262255.
      View in: PubMed
    52. Knuesel M, Cheung HT, Hamady M, Barthel KK, Liu X. A method of mapping protein sumoylation sites by mass spectrometry using a modified small ubiquitin-like modifier 1 (SUMO-1) and a computational program. Mol Cell Proteomics. 2005 Oct; 4(10):1626-36. PMID: 16020427.
      View in: PubMed
    53. Ungermannova D, Gao Y, Liu X. Ubiquitination of p27Kip1 requires physical interaction with cyclin E and probable phosphate recognition by SKP2. J Biol Chem. 2005 Aug 26; 280(34):30301-9. PMID: 15980415.
      View in: PubMed
    54. Wang W, Ungermannova D, Chen L, Liu X. Molecular and biochemical characterization of the Skp2-Cks1 binding interface. J Biol Chem. 2004 Dec 03; 279(49):51362-9. PMID: 15452136.
      View in: PubMed
    55. Macdonald M, Wan Y, Wang W, Roberts E, Cheung TH, Erickson R, Knuesel MT, Liu X. Control of cell cycle-dependent degradation of c-Ski proto-oncoprotein by Cdc34. Oncogene. 2004 Jul 22; 23(33):5643-53. PMID: 15122324.
      View in: PubMed
    56. Knuesel M, Wan Y, Xiao Z, Holinger E, Lowe N, Wang W, Liu X. Identification of novel protein-protein interactions using a versatile mammalian tandem affinity purification expression system. Mol Cell Proteomics. 2003 Nov; 2(11):1225-33. PMID: 12963786.
      View in: PubMed
    Liu's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    _
    Co-Authors Expand Description
    _
    Similar People Expand Description
    _
    Same Department Expand Description

    Copyright © 2022 The Regents of the University of Colorado, a body corporate. All rights reserved. (Harvard PROFILES RNS software version: 2.11.1)