 Allosteric Site
"Allosteric Site" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A site on an enzyme which upon binding of a modulator, causes the enzyme to undergo a conformational change that may alter its catalytic or binding properties.
| Descriptor ID |
D000495
|
| MeSH Number(s) |
G02.111.570.120.147
|
| Concept/Terms |
Allosteric Site- Allosteric Site
- Allosteric Sites
- Site, Allosteric
- Sites, Allosteric
|
Below are MeSH descriptors whose meaning is more general than "Allosteric Site".
Below are MeSH descriptors whose meaning is more specific than "Allosteric Site".
This graph shows the total number of publications written about "Allosteric Site" by people in this website by year, and whether "Allosteric Site" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 | | 2006 | 1 | 3 | 4 | | 2007 | 2 | 0 | 2 | | 2008 | 0 | 1 | 1 | | 2010 | 0 | 1 | 1 | | 2014 | 0 | 1 | 1 | | 2017 | 1 | 2 | 3 | | 2018 | 1 | 5 | 6 | | 2019 | 1 | 1 | 2 | | 2020 | 0 | 1 | 1 | | 2021 | 0 | 1 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Allosteric Site" by people in Profiles.
-
Sarkar A, Kim EY, Jang T, Hongdusit A, Kim H, Choi JM, Fox JM. Microbially Guided Discovery and Biosynthesis of Biologically Active Natural Products. ACS Synth Biol. 2021 06 18; 10(6):1505-1519.
-
Liu X, Lu S, Song K, Shen Q, Ni D, Li Q, He X, Zhang H, Wang Q, Chen Y, Li X, Wu J, Sheng C, Chen G, Liu Y, Lu X, Zhang J. Unraveling allosteric landscapes of allosterome with ASD. Nucleic Acids Res. 2020 01 08; 48(D1):D394-D401.
-
Song K, Li Q, Gao W, Lu S, Shen Q, Liu X, Wu Y, Wang B, Lin H, Chen G, Zhang J. AlloDriver: a method for the identification and analysis of cancer driver targets. Nucleic Acids Res. 2019 07 02; 47(W1):W315-W321.
-
Song K, Zhang J, Lu S. Progress in Allosteric Database. Adv Exp Med Biol. 2019; 1163:65-87.
-
An X, Lu S, Song K, Shen Q, Huang M, Yao X, Liu H, Zhang J. Are the Apo Proteins Suitable for the Rational Discovery of Allosteric Drugs? J Chem Inf Model. 2019 01 28; 59(1):597-604.
-
Huang Z, Zhao J, Deng W, Chen Y, Shang J, Song K, Zhang L, Wang C, Lu S, Yang X, He B, Min J, Hu H, Tan M, Xu J, Zhang Q, Zhong J, Sun X, Mao Z, Lin H, Xiao M, Chin YE, Jiang H, Xu Y, Chen G, Zhang J. Identification of a cellularly active SIRT6 allosteric activator. Nat Chem Biol. 2018 12; 14(12):1118-1126.
-
Hjortness MK, Riccardi L, Hongdusit A, Zwart PH, Sankaran B, De Vivo M, Fox JM. Evolutionarily Conserved Allosteric Communication in Protein Tyrosine Phosphatases. Biochemistry. 2018 11 13; 57(45):6443-6451.
-
Huang M, Song K, Liu X, Lu S, Shen Q, Wang R, Gao J, Hong Y, Li Q, Ni D, Xu J, Chen G, Zhang J. AlloFinder: a strategy for allosteric modulator discovery and allosterome analyses. Nucleic Acids Res. 2018 07 02; 46(W1):W451-W458.
-
Ho JD, Chau B, Rodgers L, Lu F, Wilbur KL, Otto KA, Chen Y, Song M, Riley JP, Yang HC, Reynolds NA, Kahl SD, Lewis AP, Groshong C, Madsen RE, Conners K, Lineswala JP, Gheyi T, Saflor MD, Lee MR, Benach J, Baker KA, Montrose-Rafizadeh C, Genin MJ, Miller AR, Hamdouchi C. Structural basis for GPR40 allosteric agonism and incretin stimulation. Nat Commun. 2018 04 25; 9(1):1645.
-
Song K, Zhang J. Single Binding Pockets Versus Allosteric Binding. Methods Mol Biol. 2018; 1825:295-326.
|
People  People who have written about this concept. _
Similar Concepts
People who have written about this concept.
_
Top Journals
Top journals in which articles about this concept have been published.
|