Alternative Splicing
"Alternative Splicing" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A process whereby multiple RNA transcripts are generated from a single gene. Alternative splicing involves the splicing together of other possible sets of EXONS during the processing of some, but not all, transcripts of the gene. Thus a particular exon may be connected to any one of several alternative exons to form a mature RNA. The alternative forms of mature MESSENGER RNA produce PROTEIN ISOFORMS in which one part of the isoforms is common while the other parts are different.
Descriptor ID |
D017398
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MeSH Number(s) |
G02.111.760.700.100 G03.839.700.100 G05.308.700.700.100
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Concept/Terms |
Alternative Splicing- Alternative Splicing
- Alternative Splicings
- Splicings, Alternative
- Alternate Splicing
- Alternate Splicings
- Splicing, Alternate
- Splicings, Alternate
- RNA Splicing, Alternative
- Alternative RNA Splicing
- Alternative RNA Splicings
- RNA Splicings, Alternative
- Splicing, Alternative RNA
- Splicings, Alternative RNA
- Splicing, Alternative
Nested Transcripts- Nested Transcripts
- Nested Transcript
- Transcript, Nested
- Transcripts, Nested
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Below are MeSH descriptors whose meaning is more general than "Alternative Splicing".
Below are MeSH descriptors whose meaning is more specific than "Alternative Splicing".
This graph shows the total number of publications written about "Alternative Splicing" by people in this website by year, and whether "Alternative Splicing" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
Year | Major Topic | Minor Topic | Total |
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1992 | 0 | 1 | 1 | 1993 | 0 | 1 | 1 | 1994 | 1 | 2 | 3 | 1995 | 1 | 1 | 2 | 1996 | 0 | 5 | 5 | 1997 | 0 | 1 | 1 | 1998 | 4 | 2 | 6 | 1999 | 2 | 2 | 4 | 2000 | 3 | 2 | 5 | 2001 | 1 | 5 | 6 | 2002 | 2 | 7 | 9 | 2003 | 4 | 2 | 6 | 2004 | 2 | 6 | 8 | 2005 | 1 | 4 | 5 | 2006 | 8 | 4 | 12 | 2007 | 1 | 3 | 4 | 2008 | 1 | 2 | 3 | 2009 | 4 | 1 | 5 | 2010 | 2 | 4 | 6 | 2011 | 1 | 1 | 2 | 2012 | 0 | 1 | 1 | 2013 | 5 | 5 | 10 | 2014 | 2 | 3 | 5 | 2015 | 4 | 2 | 6 | 2016 | 3 | 1 | 4 | 2017 | 3 | 6 | 9 | 2018 | 5 | 3 | 8 | 2019 | 5 | 5 | 10 | 2020 | 3 | 2 | 5 |
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Below are the most recent publications written about "Alternative Splicing" by people in Profiles.
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Shenasa H, Movassat M, Forouzmand E, Hertel KJ. Allosteric regulation of U1 snRNP by splicing regulatory proteins controls spliceosomal assembly. RNA. 2020 10; 26(10):1389-1399.
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Hu Q, Greene CS, Heller EA. Specific histone modifications associate with alternative exon selection during mammalian development. Nucleic Acids Res. 2020 05 21; 48(9):4709-4724.
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Lee S, Sears MJ, Zhang Z, Li H, Salhab I, Krebs P, Xing Y, Nah HD, Williams T, Carstens RP. Cleft lip and cleft palate in Esrp1 knockout mice is associated with alterations in epithelial-mesenchymal crosstalk. Development. 2020 04 30; 147(21).
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Lee FF, Davidson K, Harris C, McClendon J, Janssen WJ, Alper S. NF-?B mediates lipopolysaccharide-induced alternative pre-mRNA splicing of MyD88 in mouse macrophages. J Biol Chem. 2020 05 01; 295(18):6236-6248.
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Haltenhof T, Kotte A, De Bortoli F, Schiefer S, Meinke S, Emmerichs AK, Petermann KK, Timmermann B, Imhof P, Franz A, Loll B, Wahl MC, Preußner M, Heyd F. A Conserved Kinase-Based Body-Temperature Sensor Globally Controls Alternative Splicing and Gene Expression. Mol Cell. 2020 04 02; 78(1):57-69.e4.
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Lau E, Han Y, Williams DR, Thomas CT, Shrestha R, Wu JC, Lam MPY. Splice-Junction-Based Mapping of Alternative Isoforms in the Human Proteome. Cell Rep. 2019 12 10; 29(11):3751-3765.e5.
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Suzuki H, Kumar SA, Shuai S, Diaz-Navarro A, Gutierrez-Fernandez A, De Antonellis P, Cavalli FMG, Juraschka K, Farooq H, Shibahara I, Vladoiu MC, Zhang J, Abeysundara N, Przelicki D, Skowron P, Gauer N, Luu B, Daniels C, Wu X, Forget A, Momin A, Wang J, Dong W, Kim SK, Grajkowska WA, Jouvet A, Fèvre-Montange M, Garrè ML, Nageswara Rao AA, Giannini C, Kros JM, French PJ, Jabado N, Ng HK, Poon WS, Eberhart CG, Pollack IF, Olson JM, Weiss WA, Kumabe T, López-Aguilar E, Lach B, Massimino M, Van Meir EG, Rubin JB, Vibhakar R, Chambless LB, Kijima N, Klekner A, Bognár L, Chan JA, Faria CC, Ragoussis J, Pfister SM, Goldenberg A, Wechsler-Reya RJ, Bailey SD, Garzia L, Morrissy AS, Marra MA, Huang X, Malkin D, Ayrault O, Ramaswamy V, Puente XS, Calarco JA, Stein L, Taylor MD. Recurrent noncoding U1 snRNA mutations drive cryptic splicing in SHH medulloblastoma. Nature. 2019 10; 574(7780):707-711.
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Hood VL, Berger R, Freedman R, Law AJ. Transcription of PIK3CD in human brain and schizophrenia: regulation by proinflammatory cytokines. Hum Mol Genet. 2019 10 01; 28(19):3188-3198.
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Pacheco A, Berger R, Freedman R, Law AJ. A VNTR Regulates miR-137 Expression Through Novel Alternative Splicing and Contributes to Risk for Schizophrenia. Sci Rep. 2019 08 13; 9(1):11793.
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Johnson V, Junge HJ, Chen Z. Temporal regulation of axonal repulsion by alternative splicing of a conserved microexon in mammalian Robo1 and Robo2. Elife. 2019 08 08; 8.
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