Alternative Splicing
"Alternative Splicing" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A process whereby multiple RNA transcripts are generated from a single gene. Alternative splicing involves the splicing together of other possible sets of EXONS during the processing of some, but not all, transcripts of the gene. Thus a particular exon may be connected to any one of several alternative exons to form a mature RNA. The alternative forms of mature MESSENGER RNA produce PROTEIN ISOFORMS in which one part of the isoforms is common while the other parts are different.
Descriptor ID |
D017398
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MeSH Number(s) |
G02.111.760.700.100 G03.839.700.100 G05.308.700.700.100
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Concept/Terms |
Alternative Splicing- Alternative Splicing
- Alternative Splicings
- Splicings, Alternative
- Alternate Splicing
- Alternate Splicings
- Splicing, Alternate
- Splicings, Alternate
- RNA Splicing, Alternative
- Alternative RNA Splicing
- Alternative RNA Splicings
- RNA Splicings, Alternative
- Splicing, Alternative RNA
- Splicings, Alternative RNA
- Splicing, Alternative
Nested Transcripts- Nested Transcripts
- Nested Transcript
- Transcript, Nested
- Transcripts, Nested
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Below are MeSH descriptors whose meaning is more general than "Alternative Splicing".
Below are MeSH descriptors whose meaning is more specific than "Alternative Splicing".
This graph shows the total number of publications written about "Alternative Splicing" by people in this website by year, and whether "Alternative Splicing" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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1992 | 0 | 1 | 1 | 1993 | 0 | 1 | 1 | 1994 | 0 | 1 | 1 | 1995 | 1 | 1 | 2 | 1996 | 0 | 2 | 2 | 1997 | 0 | 1 | 1 | 1998 | 3 | 2 | 5 | 1999 | 2 | 1 | 3 | 2000 | 3 | 2 | 5 | 2001 | 1 | 2 | 3 | 2002 | 2 | 5 | 7 | 2003 | 3 | 1 | 4 | 2004 | 2 | 5 | 7 | 2005 | 1 | 3 | 4 | 2006 | 2 | 2 | 4 | 2007 | 2 | 2 | 4 | 2008 | 1 | 1 | 2 | 2009 | 4 | 0 | 4 | 2010 | 2 | 3 | 5 | 2011 | 1 | 1 | 2 | 2013 | 3 | 3 | 6 | 2014 | 2 | 3 | 5 | 2015 | 4 | 1 | 5 | 2016 | 3 | 1 | 4 | 2017 | 1 | 4 | 5 | 2018 | 2 | 3 | 5 | 2019 | 4 | 3 | 7 | 2020 | 0 | 4 | 4 | 2021 | 3 | 0 | 3 | 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Alternative Splicing" by people in Profiles.
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Henrich M, Ha P, Wang Y, Ting K, Stodieck L, Soo C, Adams JS, Chun R. Alternative splicing diversifies the skeletal muscle transcriptome during prolonged spaceflight. Skelet Muscle. 2022 May 31; 12(1):11.
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Kim SP, Srivatsan SN, Chavez M, Shirai CL, White BS, Ahmed T, Alberti MO, Shao J, Nunley R, White LS, Bednarski J, Pehrson JR, Walter MJ. Mutant U2AF1-induced alternative splicing of H2afy (macroH2A1) regulates B-lymphopoiesis in mice. Cell Rep. 2021 08 31; 36(9):109626.
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Saldi T, Riemondy K, Erickson B, Bentley DL. Alternative RNA structures formed during transcription depend on elongation rate and modify RNA processing. Mol Cell. 2021 04 15; 81(8):1789-1801.e5.
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Biayna J, Mazuelas H, Gel B, Terribas E, Dumbovic G, Rosas I, Fernández-Rodriguez J, Blanco I, Castellanos E, Carrió M, Lazaro C, Serra E. Using antisense oligonucleotides for the physiological modulation of the alternative splicing of NF1 exon 23a during PC12 neuronal differentiation. Sci Rep. 2021 02 11; 11(1):3661.
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Han Y, Wood SD, Wright JM, Dostal V, Lau E, Lam MPY. Computation-assisted targeted proteomics of alternative splicing protein isoforms in the human heart. J Mol Cell Cardiol. 2021 05; 154:92-96.
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Weskamp K, Olwin BB, Parker R. Post-Transcriptional Regulation in Skeletal Muscle Development, Repair, and Disease. Trends Mol Med. 2021 05; 27(5):469-481.
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Thompson B, Davidson EA, Liu W, Nebert DW, Bruford EA, Zhao H, Dermitzakis ET, Thompson DC, Vasiliou V. Overview of PAX gene family: analysis of human tissue-specific variant expression and involvement in human disease. Hum Genet. 2021 Mar; 140(3):381-400.
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Lee S, Sears MJ, Zhang Z, Li H, Salhab I, Krebs P, Xing Y, Nah HD, Williams T, Carstens RP. Cleft lip and cleft palate in Esrp1 knockout mice is associated with alterations in epithelial-mesenchymal crosstalk. Development. 2020 04 30; 147(21).
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Lee FF, Davidson K, Harris C, McClendon J, Janssen WJ, Alper S. NF-?B mediates lipopolysaccharide-induced alternative pre-mRNA splicing of MyD88 in mouse macrophages. J Biol Chem. 2020 05 01; 295(18):6236-6248.
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Lau E, Han Y, Williams DR, Thomas CT, Shrestha R, Wu JC, Lam MPY. Splice-Junction-Based Mapping of Alternative Isoforms in the Human Proteome. Cell Rep. 2019 12 10; 29(11):3751-3765.e5.
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