 CRISPR-Cas Systems
"CRISPR-Cas Systems" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Adaptive antiviral defense mechanisms, in archaea and bacteria, based on DNA repeat arrays called CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS (CRISPR elements) that function in conjunction with CRISPR-ASSOCIATED PROTEINS (Cas proteins). Several types have been distinguished, including Type I, Type II, and Type III, based on signature motifs of CRISPR-ASSOCIATED PROTEINS.
| Descriptor ID |
D064113
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| MeSH Number(s) |
G05.308.203.374.394
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| Concept/Terms |
CRISPR-Cas Systems- CRISPR-Cas Systems
- CRISPR Cas Systems
- CRISPR-Cas System
- System, CRISPR-Cas
- Systems, CRISPR-Cas
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Below are MeSH descriptors whose meaning is more general than "CRISPR-Cas Systems".
Below are MeSH descriptors whose meaning is more specific than "CRISPR-Cas Systems".
This graph shows the total number of publications written about "CRISPR-Cas Systems" by people in this website by year, and whether "CRISPR-Cas Systems" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2014 | 0 | 1 | 1 | | 2015 | 4 | 1 | 5 | | 2016 | 4 | 5 | 9 | | 2017 | 3 | 6 | 9 | | 2018 | 4 | 3 | 7 | | 2019 | 5 | 5 | 10 | | 2020 | 4 | 7 | 11 | | 2021 | 5 | 7 | 12 | | 2022 | 1 | 4 | 5 | | 2023 | 3 | 1 | 4 | | 2024 | 1 | 8 | 9 | | 2025 | 13 | 13 | 26 | | 2026 | 0 | 4 | 4 |
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Below are the most recent publications written about "CRISPR-Cas Systems" by people in Profiles.
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Carturan A, Angelos MG, Guruprasad P, Patel RP, Pajarillo R, Lee A, Espie D, Zhang Y, Chiang YH, Xie W, Rodriguez JL, Harris J, Devi P, Afolayan-Oloye OI, Xu J, Sussman JH, Elghawy O, Yang A, Barsouk A, Cho JH, Shaw CE, Singh E, Ugwuanyi O, Paruzzo L, Stella F, Liu S, Nason S, Imparato A, Rotolo A, Lemoine J, Barrett DM, Posey A, Rook AH, Pillai V, Bagg A, Pileri SA, Liu D, Tan K, Schuster SJ, Teachey DT, Porazzi P, Ruella M. Harnessing the CD2 axis to broaden and enhance the efficacy of CAR T-cell therapies. Blood. 2026 Apr 16; 147(16):1842-1856.
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Purvis IJ, Ochoa Olmos OE, Park KU, Kaufman ML, Henry CM, Schaaf C, Clise OJ, Tesdahl CD, Haas A, Brzezinski JA. A robust cis-regulatory network ensures Otx2 expression during retinal development. Development. 2026 Mar 15; 153(6).
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Nebenfuehr B, Sanford L, Taylor ER, Ball K, Woods-Killam CE, Ghasemi HI, Proctor B, Ortega R, Sempeck C, Dowell RD, Arnoult N. Uncovering genetic interactions in the DNA repair network in response to endogenous damage and ionizing radiation. Cell Rep. 2026 Jan 27; 45(1):116850.
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Arena KA, Kearns CA, Ahmed M, O'Rourke R, Sagerström CG, Franco SJ, Appel B. Gsx2 regulates oligodendrocyte precursor formation in the zebrafish spinal cord. Dev Biol. 2026 Mar; 531:30-44.
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Wang D, Ritz C, Luo Y, Suresh A, Pierce A, Veo B, Brunt B, Dahl N, Serkova N, Venkataraman S, Danis E, Kus K, Mazan M, Rzymski T, Vibhakar R. Transcriptional regulation of protein synthesis by mediator kinase represents a therapeutic vulnerability in MYC-driven medulloblastoma. Nat Commun. 2025 Dec 16; 16(1):11152.
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Cheng KW, Bhave M, Markhard AL, Peng D, Bhatt KD, Travisano KA, Medicielo JV, Anaya A, Lembirik S, Njoya L, Anantpadma M, Kuhn JH, Puschnik AS, Kistler AL. Replicon-based genome-wide CRISPR knockout screening for the identification of host factors involved in viral replication. Nat Commun. 2025 Dec 10; 16(1):11028.
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Savage N, Danis E, Chokshi CR, Custers S, Shaikh MV, Miletic P, Venugopal C, Brown KR, Vibhakar R, Moffat J, Singh SK. CRISPR screen reveals SOX2 as a critical regulator of CD133 and cellular stress response in glioblastoma. Sci Rep. 2025 Oct 16; 15(1):36228.
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Marchenko N, Nesbitt NM, Alexandrova E, Reisz JA, D'Alessandro A, Suh J, Uryasev S, Pennacchia L, Bahou WF. Biliverdin reductase B as a new target in breast cancer. Breast Cancer Res. 2025 Oct 16; 27(1):179.
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Conery M, Pippin JA, Wagley Y, Trang K, Pahl MC, Villani DA, Favazzo LJ, Ackert-Bicknell CL, Zuscik MJ, Katsevich E, Wells AD, Zemel BS, Voight BF, Hankenson KD, Chesi A, Grant SFA. GWAS-informed data integration and non-coding CRISPRi screen illuminate genetic etiology of bone mineral density. Genome Biol. 2025 Oct 03; 26(1):331.
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Sobral LM, Walker FM, Madhavan K, Janko E, Donthula S, Danis E, Bompada P, Balakrishnan I, Wang D, Pierce A, Haag MM, Carstens BJ, Serkova NJ, Foreman NK, Venkataraman S, Veo B, Vibhakar R, Dahl NA. Targeting processive transcription for Myc-driven circuitry in medulloblastoma. Neuro Oncol. 2025 Oct 01; 27(10):2697-2710.
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