Activation loop dynamics determine the different catalytic efficiencies of B cell- and T cell-specific tec kinases.
Joseph RE, Kleino I, Wales TE, Xie Q, Fulton DB, Engen JR, Berg LJ, Andreotti AH. Activation loop dynamics determine the different catalytic efficiencies of B cell- and T cell-specific tec kinases. Sci Signal. 2013 Aug 27; 6(290):ra76.
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Amino Acid Sequence
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Animals
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Binding Sites
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Biocatalysis
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Blotting, Western
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Deuterium Exchange Measurement
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Kinetics
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Mice
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Mice, Inbred C57BL
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Mice, Knockout
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Models, Molecular
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Molecular Sequence Data
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Mutation
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Phosphorylation
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Protein Structure, Tertiary
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Protein-Tyrosine Kinases
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Receptors, Antigen, B-Cell
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Receptors, Antigen, T-Cell
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Sequence Homology, Amino Acid
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Sf9 Cells
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Signal Transduction
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T-Lymphocytes
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Tyrosine