Apoptosomes
"Apoptosomes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Multimeric protein complexes formed in the CYTOSOL that play a role in the activation of APOPTOSIS. They can occur when MITOCHONDRIA become damaged due to cell stress and release CYTOCHROME C. Cytosolic cytochrome C associates with APOPTOTIC PROTEASE-ACTIVATING FACTOR 1 to form the apoptosomal protein complex. The apoptosome signals apoptosis by binding to and activating specific INITIATOR CASPASES such as CASPASE 9.
| Descriptor ID |
D053478
|
| MeSH Number(s) |
D05.500.099
|
| Concept/Terms |
Apoptosomes- Apoptosomes
- Apoptosome
- Apoptosomal Protein Complex
- Complex, Apoptosomal Protein
- Protein Complex, Apoptosomal
|
Below are MeSH descriptors whose meaning is more general than "Apoptosomes".
Below are MeSH descriptors whose meaning is more specific than "Apoptosomes".
This graph shows the total number of publications written about "Apoptosomes" by people in this website by year, and whether "Apoptosomes" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 0 | 1 | 1 |
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Below are the most recent publications written about "Apoptosomes" by people in Profiles.
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Mallikarjun V, Clarke DJ, Campbell CJ. Cellular redox potential and the biomolecular electrochemical series: a systems hypothesis. Free Radic Biol Med. 2012 Jul 15; 53(2):280-8.
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Albeck JG, Burke JM, Spencer SL, Lauffenburger DA, Sorger PK. Modeling a snap-action, variable-delay switch controlling extrinsic cell death. PLoS Biol. 2008 Dec 02; 6(12):2831-52.