 Macrophage Activation
"Macrophage Activation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The process of altering the morphology and functional activity of macrophages so that they become avidly phagocytic. It is initiated by lymphokines, such as the macrophage activation factor (MAF) and the macrophage migration-inhibitory factor (MMIF), immune complexes, C3b, and various peptides, polysaccharides, and immunologic adjuvants.
| Descriptor ID |
D008262
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| MeSH Number(s) |
G12.287.500
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| Concept/Terms |
Macrophage Activation- Macrophage Activation
- Activation, Macrophage
- Activations, Macrophage
- Macrophage Activations
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Below are MeSH descriptors whose meaning is more general than "Macrophage Activation".
Below are MeSH descriptors whose meaning is more specific than "Macrophage Activation".
This graph shows the total number of publications written about "Macrophage Activation" by people in this website by year, and whether "Macrophage Activation" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 4 | 4 | | 1996 | 1 | 0 | 1 | | 1997 | 2 | 0 | 2 | | 1998 | 2 | 0 | 2 | | 2000 | 0 | 2 | 2 | | 2001 | 0 | 2 | 2 | | 2002 | 0 | 1 | 1 | | 2004 | 1 | 0 | 1 | | 2005 | 3 | 2 | 5 | | 2006 | 1 | 2 | 3 | | 2007 | 3 | 3 | 6 | | 2008 | 3 | 4 | 7 | | 2009 | 2 | 1 | 3 | | 2010 | 4 | 0 | 4 | | 2011 | 3 | 2 | 5 | | 2012 | 3 | 3 | 6 | | 2013 | 2 | 3 | 5 | | 2014 | 2 | 5 | 7 | | 2015 | 1 | 3 | 4 | | 2016 | 0 | 4 | 4 | | 2017 | 4 | 4 | 8 | | 2018 | 5 | 1 | 6 | | 2019 | 2 | 4 | 6 | | 2020 | 2 | 3 | 5 | | 2021 | 4 | 4 | 8 | | 2022 | 1 | 1 | 2 | | 2023 | 0 | 2 | 2 | | 2025 | 1 | 0 | 1 |
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Below are the most recent publications written about "Macrophage Activation" by people in Profiles.
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Matsuzaki H, Kai K, Komohara Y, Yano H, Pan C, Fujiwara Y, Yamada R, Iwauchi A, Fukasawa N, Tanaka T, Shimoda M, Watanabe H, Maruyama T, Takeo T, Mikami Y, Mukasa A. Abnormal Vessels Potentially Accelerate Glioblastoma Proliferation by Inducing the Protumor Activation of Macrophages. Cancer Sci. 2025 Apr; 116(4):897-909.
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Kaneko S, Shimizu M, Miyaoka F, Shimbo A, Irabu H, Mizuta M, Nakagishi Y, Iwata N, Fujimura J, Mori M, Morio T. The dynamics of laboratory markers reflecting cytokine overproduction in macrophage activation syndrome complicated with systemic juvenile idiopathic arthritis. Clin Immunol. 2023 03; 248:109270.
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Shearn CT, Anderson AL, Miller CG, Noyd RC, Devereaux MW, Balasubramaniyan N, Orlicky DJ, Schmidt EE, Sokol RJ. Thioredoxin reductase 1 regulates hepatic inflammation and macrophage activation during acute cholestatic liver injury. Hepatol Commun. 2023 01 01; 7(1):e0020.
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Kawaguchi S, Kawahara K, Fujiwara Y, Ohnishi K, Pan C, Yano H, Hirosue A, Nagata M, Hirayama M, Sakata J, Nakashima H, Arita H, Yamana K, Gohara S, Nagao Y, Maeshiro M, Iwamoto A, Hirayama M, Yoshida R, Komohara Y, Nakayama H. Naringenin potentiates anti-tumor immunity against oral cancer by inducing lymph node CD169-positive macrophage activation and cytotoxic T cell infiltration. Cancer Immunol Immunother. 2022 Sep; 71(9):2127-2139.
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Saleh LS, Amer LD, Thompson BJ, Danhorn T, Knapp JR, Gibbings SL, Thomas S, Barthel L, O'Connor BP, Janssen WJ, Alper S, Bryant SJ. Mapping Macrophage Polarization and Origin during the Progression of the Foreign Body Response to a Poly(ethylene glycol) Hydrogel Implant. Adv Healthc Mater. 2022 05; 11(9):e2102209.
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El Kasmi KC, Ghosh S, Anderson AL, Devereaux MW, Balasubramaniyan N, D'Alessandro A, Orlicky DJ, Suchy FJ, Shearn CT, Sokol RJ. Pharmacologic activation of hepatic farnesoid X receptor prevents parenteral nutrition-associated cholestasis in mice. Hepatology. 2022 02; 75(2):252-265.
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Pan C, Fujiwara Y, Horlad H, Iriki T, Shiraishi D, Komohara Y. Cyclic sulfur compounds targeting macrophage polarization into M2/protumor phenotype and their anti-tumor effects. Cancer Immunol Immunother. 2022 Jun; 71(6):1331-1343.
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Santeford A, Lee AY, Sene A, Hassman LM, Sergushichev AA, Loginicheva E, Artyomov MN, Ruzycki PA, Apte RS. Loss of Mir146b with aging contributes to inflammation and mitochondrial dysfunction in thioglycollate-elicited peritoneal macrophages. Elife. 2021 08 23; 10.
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Hobby ARH, Berretta RM, Eaton DM, Kubo H, Feldsott E, Yang Y, Headrick AL, Koch KA, Rubino M, Kurian J, Khan M, Tan Y, Mohsin S, Gallucci S, McKinsey TA, Houser SR. Cortical bone stem cells modify cardiac inflammation after myocardial infarction by inducing a novel macrophage phenotype. Am J Physiol Heart Circ Physiol. 2021 10 01; 321(4):H684-H701.
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Wong NR, Mohan J, Kopecky BJ, Guo S, Du L, Leid J, Feng G, Lokshina I, Dmytrenko O, Luehmann H, Bajpai G, Ewald L, Bell L, Patel N, Bredemeyer A, Weinheimer CJ, Nigro JM, Kovacs A, Morimoto S, Bayguinov PO, Fisher MR, Stump WT, Greenberg M, Fitzpatrick JAJ, Epelman S, Kreisel D, Sah R, Liu Y, Hu H, Lavine KJ. Resident cardiac macrophages mediate adaptive myocardial remodeling. Immunity. 2021 09 14; 54(9):2072-2088.e7.
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