MAP Kinase Signaling System
"MAP Kinase Signaling System" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An intracellular signaling system involving the MAP kinase cascades (three-membered protein kinase cascades). Various upstream activators, which act in response to extracellular stimuli, trigger the cascades by activating the first member of a cascade, MAP KINASE KINASE KINASES; (MAPKKKs). Activated MAPKKKs phosphorylate MITOGEN-ACTIVATED PROTEIN KINASE KINASES which in turn phosphorylate the MITOGEN-ACTIVATED PROTEIN KINASES; (MAPKs). The MAPKs then act on various downstream targets to affect gene expression. In mammals, there are several distinct MAP kinase pathways including the ERK (extracellular signal-regulated kinase) pathway, the SAPK/JNK (stress-activated protein kinase/c-jun kinase) pathway, and the p38 kinase pathway. There is some sharing of components among the pathways depending on which stimulus originates activation of the cascade.
Descriptor ID |
D020935
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MeSH Number(s) |
G02.111.820.560 G03.493.560 G04.835.560
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Concept/Terms |
ERK1-2 Pathway- ERK1-2 Pathway
- ERK1 2 Pathway
- ERK1-2 Pathways
- Pathway, ERK1-2
- Pathways, ERK1-2
- ERK1 and ERK2 Pathway
p38 Kinase Pathway- p38 Kinase Pathway
- Kinase Pathway, p38
- Kinase Pathways, p38
- Pathway, p38 Kinase
- Pathways, p38 Kinase
- p38 Kinase Pathways
- p38 Kinase Signaling Pathway
MAP Kinase Cascade- MAP Kinase Cascade
- Cascade, MAP Kinase
- Kinase Cascade, MAP
- MAP Kinase Cascades
- MAP Kinase Modules
- MAP Kinase Module
- Module, MAP Kinase
- MAP Kinase Signaling Cascades
MEK-ERK Pathway- MEK-ERK Pathway
- MEK ERK Pathway
- MEK-ERK Pathways
- Pathway, MEK-ERK
- Pathways, MEK-ERK
JNK Pathway- JNK Pathway
- JNK Pathways
- Pathway, JNK
- Pathways, JNK
- JNK Signaling Pathway
- JNK Signaling Pathways
- Pathway, JNK Signaling
- Pathways, JNK Signaling
- Signaling Pathway, JNK
- Signaling Pathways, JNK
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Below are MeSH descriptors whose meaning is more general than "MAP Kinase Signaling System".
Below are MeSH descriptors whose meaning is more specific than "MAP Kinase Signaling System".
This graph shows the total number of publications written about "MAP Kinase Signaling System" by people in this website by year, and whether "MAP Kinase Signaling System" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
Year | Major Topic | Minor Topic | Total |
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1999 | 2 | 1 | 3 | 2000 | 7 | 2 | 9 | 2001 | 7 | 3 | 10 | 2002 | 6 | 6 | 12 | 2003 | 3 | 3 | 6 | 2004 | 5 | 7 | 12 | 2005 | 1 | 3 | 4 | 2006 | 9 | 8 | 17 | 2007 | 5 | 2 | 7 | 2008 | 2 | 9 | 11 | 2009 | 4 | 2 | 6 | 2010 | 1 | 1 | 2 | 2011 | 5 | 9 | 14 | 2012 | 5 | 5 | 10 | 2013 | 4 | 11 | 15 | 2014 | 2 | 11 | 13 | 2015 | 7 | 9 | 16 | 2016 | 5 | 1 | 6 | 2017 | 1 | 4 | 5 | 2018 | 7 | 1 | 8 | 2019 | 2 | 7 | 9 | 2020 | 0 | 1 | 1 | 2021 | 4 | 7 | 11 | 2022 | 0 | 1 | 1 | 2023 | 1 | 2 | 3 | 2024 | 1 | 1 | 2 | 2025 | 3 | 2 | 5 |
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Below are the most recent publications written about "MAP Kinase Signaling System" by people in Profiles.
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Campa?a MB, Perkins MR, McCabe MC, Neumann A, Larson ED, Fantauzzo KA. PDGFRa/? heterodimer activation negatively affects downstream ERK1/2 signaling and cellular proliferation. Nat Commun. 2025 May 22; 16(1):4754.
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Li C, Syed MU, Nimbalkar A, Shen Y, Vieira MD, Fraser C, Inde Z, Qin X, Ouyang J, Kreuzer J, Clark SE, Kelley G, Hensley EM, Morris R, Lazaro R, Belmonte B, Oh A, Walcott M, Nabel CS, Caenepeel S, Saiki AY, Rex K, Lipford JR, Heist RS, Lin JJ, Haas W, Sarosiek K, Hughes PE, Hata AN. LKB1 regulates JNK-dependent stress signaling and apoptotic dependency of KRAS-mutant lung cancers. Nat Commun. 2025 May 02; 16(1):4112.
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Voss DM, Kral AJ, Sim G, Utama R, Lin KT, Cizmeciyan C, Schafer B, Cunniff PJ, Vakoc CR, Caruthers MH, Mishra L, Krainer AR. PKM splice-switching ASOs induce upregulation of dual-specificity phosphatases and dephosphorylation of ERK1/2 in hepatocellular carcinoma. J Biol Chem. 2025 Apr; 301(4):108345.
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Zent KH, Dell'Acqua ML. Synapse-to-Nucleus ERK?CREB Transcriptional Signaling Requires Dendrite-to-Soma Ca2+ Propagation Mediated by L-Type Voltage-Gated Ca2+ Channels. J Neurosci. 2025 Jan 22; 45(4).
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Hoffman TE, Tian C, Nangia V, Yang C, Regot S, Gerosa L, Spencer SL. CDK2 activity crosstalk on the ERK kinase translocation reporter can be resolved computationally. Cell Syst. 2025 Jan 15; 16(1):101162.
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Apps JR, Gonzalez-Meljem JM, Guiho R, Pickles JC, Prince E, Schwalbe E, Joshi N, Stone TJ, Ogunbiyi O, Chalker J, Bassey A, Otto G, Davies R, Hughes D, Brandner S, Tan E, Lee V, Hayhurst C, Kline C, Castellano S, Hankinson T, Deutschbein T, Jacques TS, Martinez-Barbera JP. Recurrent adamantinomatous craniopharyngiomas show MAPK pathway activation, clonal evolution and rare TP53-loss-mediated malignant progression. Acta Neuropathol Commun. 2024 Aug 10; 12(1):127.
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Hicks HM, Nassar VL, Lund J, Rose MM, Schweppe RE. The effects of Aurora Kinase inhibition on thyroid cancer growth and sensitivity to MAPK-directed therapies. Cancer Biol Ther. 2024 Dec 31; 25(1):2332000.
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Hicks HM, Pozdeyev N, Sams SB, Pugazhenthi U, Bales ES, Hofmann MC, McKenna LR, Schweppe RE. Fibronectin Contributes to a BRAF Inhibitor-driven Invasive Phenotype in Thyroid Cancer through EGR1, Which Can Be Blocked by Inhibition of ERK1/2. Mol Cancer Res. 2023 09 01; 21(9):867-880.
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Hoffman TE, Nangia V, Ill CR, Passanisi VJ, Armstrong C, Yang C, Spencer SL. Multiple cancers escape from multiple MAPK pathway inhibitors and use DNA replication stress signaling to tolerate aberrant cell cycles. Sci Signal. 2023 08; 16(796):eade8744.
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Kandhari K, Mishra JPN, Agarwal R, Singh RP. Acacetin induces sustained ERK1/2 activation and RIP1-dependent necroptotic death in breast cancer cells. Toxicol Appl Pharmacol. 2023 03 01; 462:116409.
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