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Morkos Adel Ibrahim Henen

TitleAssistant Research Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-BioChem&Molecular Genetics
ORCID ORCID Icon0000-0003-4835-5583 Additional info

    Collapse Biography 
    Collapse education and training
    Vienna University, AustriaPhD with Honor degreeMolecular Biology, Drug Discovery
    CNRS, Lille 1 University, FranceDrug discovery, NMR, Molecular Biology
    Health Science Center, San Antonio, TX, USAMolecular Biology, Drug Discovery, Biochemistry
    University of Pittsburgh, PA, USAStructural Biology, NMR, Drug Discovery
    Faculty of Pharmacy, Mansoura University, EgyptMasterPharmaceutical Chemistry
    Faculty of Pharmacy, Mansoura University, EgyptBachelorPharmacy
    Collapse awards and honors
    2016Bursary Award, Drug Discovery Course, Douglas Connect GmbH Bärmeggenweg 14 Zeiningen, Aargau 4314 CH
    2013 - 2014Marie Curie Grant member, European Union
    2009 - 2012Ku mit Agypten, Austrian Ministry of High Education, Vienna, Austria
    2022 - 2024R21- NIH (role: PI), NIAID, USA

    Collapse Overview 

    Collapse Research 
    Collapse research activities and funding
         (Morkos Henen)Jul 1, 2022 - Jun 30, 2024
    NIH
    Small molecule inhibitors targeting the SARS-CoV-2 pathogenicity factor Nsp1
    Role: PI
         (Richard Johnson, Michael Wimpe, Beat Vogeli)Jan 1, 2019 - Dec 31, 2020
    ALSAM Foundation
    Developing AMP deaminase inhibitors for alcoholism
    Role Description: Collaborative effort to develop small drug inhibitors using a combination of methods, including computer modeling based on a previously published AMPD crystal, stepwise derivation of a published pan AMPD inhibitor (Astra Zeneca), and NMR-based studies to aid the design and synthesis of optimized ligands for inhibitory activity (using saturation-transfer difference NMR).
    Role: Investigator
         (Christian Ottmann and Isabelle Landrieu)Jan 1, 2013 - Dec 31, 2014
    European Union - Marie Curie Project
    14-3-3 Stabilizers
    Role: Senior PostDoctoral Fellow
         Oct 1, 2009
    Austrian Ministry of High Education, Vienna Austria
    Chemistry and NMR studies of Beta Catenin
    Role: PhD fellow

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Henen MA, McCall D, Jones D, Ahn NG, V?geli B. Protocol for converting assigned nuclear Overhauser enhancement spectroscopy series peaks into exact distance restraints using MATLAB- or CYANA-eNORA. STAR Protoc. 2025 Mar 21; 6(1):103653. PMID: 40022737.
      View in: PubMed
    2. Beck LG, Krall JB, Nichols PJ, Vicens Q, Henen MA, V?geli B. Solution NMR backbone assignment of the N-terminal tandem Za1-Za2 domains of Z-DNA binding protein 1. Biomol NMR Assign. 2024 Dec; 18(2):245-252. PMID: 39215796.
      View in: PubMed
    3. Romero MF, Krall JB, Nichols PJ, Vantreeck J, Henen MA, Dejardin E, Schulz F, Vicens Q, V?geli B, Diallo MA. Novel Z-DNA binding domains in giant viruses. J Biol Chem. 2024 Aug; 300(8):107504. PMID: 38944123.
      View in: PubMed
    4. Lambert KA, Clements CM, Mukherjee N, Pacheco TR, Shellman SX, Henen MA, V?geli B, Goldstein NB, Birlea S, Hintzsche J, Caryotakis G, Tan AC, Zhao R, Norris DA, Robinson WA, Wang Y, VanTreeck JG, Shellman YG. SASH1 S519N Variant Links Skin Hyperpigmentation and Premature Hair Graying to Dysfunction of Melanocyte Lineage. J Invest Dermatol. 2025 Jan; 145(1):144-154.e3. PMID: 38848986.
      View in: PubMed
    5. Nichols PJ, Welty R, Krall JB, Henen MA, Vicens Q, V?geli B. Za Domain of ADAR1 Binds to an A-Form-like Nucleic Acid Duplex with Low Micromolar Affinity. Biochemistry. 2024 03 19; 63(6):777-787. PMID: 38437710.
      View in: PubMed
    6. Nichols PJ, Krall JB, Henen MA, Welty R, Macfadden A, Vicens Q, V?geli B. Z-Form Adoption of Nucleic Acid is a Multi-Step Process Which Proceeds through a Melted Intermediate. J Am Chem Soc. 2024 01 10; 146(1):677-694. PMID: 38131335.
      View in: PubMed
    7. Lambert KA, Clements CM, Mukherjee N, Pacheco TR, Shellman SX, Henen MA, V?geli B, Goldstein NB, Birlea S, Hintzsche J, Tan AC, Zhao R, Norris DA, Robinson WA, Wang Y, VanTreeck JG, Shellman YG. SASH1 interacts with TNKS2 and promotes human melanocyte stem cell maintenance. bioRxiv. 2023 Sep 27. PMID: 37808724.
      View in: PubMed
    8. Maurina SF, O'Sullivan JP, Sharma G, Pineda Rodriguez DC, MacFadden A, Cendali F, Henen MA, V?geli B, Kieft JS, Glasgow A, Steckelberg AL. An Evolutionarily Conserved Strategy for Ribosome Binding and Host Translation Inhibition by ?-coronavirus Non-structural Protein 1. J Mol Biol. 2023 10 15; 435(20):168259. PMID: 37660941.
      View in: PubMed
    9. Henen MA, Paukovich N, Prekeris R, V?geli B. Solution NMR Backbone Assignment of the C-Terminal Region of Human Dynein Light Intermediate Chain 2 (LIC2-C) Unveils Structural Resemblance with Its Homologue LIC1-C. Magnetochemistry. 2023 Jul; 9(7). PMID: 37476506.
      View in: PubMed
    10. Maurina SF, O'Sullivan JP, Sharma G, Pineda Rodriguez DC, MacFadden A, Cendali F, Henen MA, Kieft JS, Glasgow A, Steckelberg AL. An evolutionarily conserved strategy for ribosome binding and inhibition by ?-coronavirus non-structural protein 1. bioRxiv. 2023 Jun 08. PMID: 37333070.
      View in: PubMed
    11. Clements CM, Henen MA, V?geli B, Shellman YG. The Structural Dynamics, Complexity of Interactions, and Functions in Cancer of Multi-SAM Containing Proteins. Cancers (Basel). 2023 Jun 01; 15(11). PMID: 37296980.
      View in: PubMed
    12. Clements CM, V?geli B, Shellman YG, Henen MA. Solution NMR backbone assignment of the SASH1 SLy proteins associated disordered region (SPIDER). Biomol NMR Assign. 2023 06; 17(1):151-157. PMID: 37155029.
      View in: PubMed
    13. De Silva SM, Dhiman A, Sood S, Mercedes KF, Simmons WJ, Henen MA, V?geli B, Dykhuizen EC, Musselman CA. PBRM1 bromodomains associate with RNA to facilitate chromatin association. Nucleic Acids Res. 2023 05 08; 51(8):3631-3649. PMID: 36808431.
      View in: PubMed
    14. Langeberg CJ, Nichols PJ, Henen MA, Vicens Q, V?geli B. Differential Structural Features of Two Mutant ADAR1p150 Za Domains Associated with Aicardi-Gouti?res Syndrome. J Mol Biol. 2023 04 15; 435(8):168040. PMID: 36889460.
      View in: PubMed
    15. Krall JB, Nichols PJ, Henen MA, Vicens Q, V?geli B. Structure and Formation of Z-DNA and Z-RNA. Molecules. 2023 Jan 14; 28(2). PMID: 36677900.
      View in: PubMed
    16. Nichols PJ, Krall JB, Henen MA, V?geli B, Vicens Q. Z-RNA biology: a central role in the innate immune response? RNA. 2023 03; 29(3):273-281. PMID: 36596670.
      View in: PubMed
    17. Nichols PJ, Bevers S, Henen MA, Kieft JS, Vicens Q, V?geli B. Adoption of A-Z Junctions in RNAs by Binding of Za Domains. Methods Mol Biol. 2023; 2651:251-275. PMID: 36892773.
      View in: PubMed
    18. Pacheco A, Issaian A, Davis J, Anderson N, Nemkov T, Paukovich N, Henen MA, V?geli B, Sikela JM, Hansen K. Proteolytic activation of human-specific Olduvai domains by the furin protease. Int J Biol Macromol. 2023 Apr 15; 234:123041. PMID: 36581038.
      View in: PubMed
    19. Clements CM, V?geli B, Shellman YG, Henen MA. SAM1 domain of SASH1 harbors distinctive structural heterogeneity. J Struct Biol. 2022 12; 214(4):107914. PMID: 36341956.
      View in: PubMed
    20. Kim JS, Born A, Till JKA, Liu L, Kant S, Henen MA, V?geli B, V?zquez-Torres A. Promiscuity of response regulators for thioredoxin steers bacterial virulence. Nat Commun. 2022 10 20; 13(1):6210. PMID: 36266276.
      View in: PubMed
    21. El-Khouly OA, Henen MA, El-Sayed MA, El-Messery SM. Design, synthesis and computational study of new benzofuran hybrids as dual PI3K/VEGFR2 inhibitors targeting cancer. Sci Rep. 2022 10 12; 12(1):17104. PMID: 36224254.
      View in: PubMed
    22. Hussain A, Paukovich N, Henen MA, V?geli B. Advances in the exact nuclear Overhauser effect 2018-2022. Methods. 2022 10; 206:87-98. PMID: 35985641.
      View in: PubMed
    23. Nashaat S, Henen MA, El-Messery SM, Eisa H. New Benzimidazoles Targeting Breast Cancer: Synthesis, Pin1 Inhibition, 2D NMR Binding, and Computational Studies. Molecules. 2022 Aug 17; 27(16). PMID: 36014485.
      View in: PubMed
    24. Born A, Soetbeer J, Henen MA, Breitgoff F, Polyhach Y, Jeschke G, V?geli B. Ligand-specific conformational change drives interdomain allostery in Pin1. Nat Commun. 2022 08 04; 13(1):4546. PMID: 35927276.
      View in: PubMed
    25. Paukovich N, Henen MA, Hussain A, Issaian A, Sikela JM, Hansen KC, V?geli B. Solution NMR backbone assignments of disordered Olduvai protein domain CON1 employing Ha-detected experiments. Biomol NMR Assign. 2022 04; 16(1):113-119. PMID: 35098449.
      View in: PubMed
    26. Born A, Henen MA, Nichols PJ, V?geli B. On the use of residual dipolar couplings in multi-state structure calculation of two-domain proteins. Magn Reson Lett. 2022 May; 2(2):61-68. PMID: 35734611.
      View in: PubMed
    27. Born A, Soetbeer J, Breitgoff F, Henen MA, Sgourakis N, Polyhach Y, Nichols PJ, Strotz D, Jeschke G, V?geli B. Reconstruction of Coupled Intra- and Interdomain Protein Motion from Nuclear and Electron Magnetic Resonance. J Am Chem Soc. 2021 10 06; 143(39):16055-16067. PMID: 34579531.
      View in: PubMed
    28. Redzic JS, Lee E, Born A, Issaian A, Henen MA, Nichols PJ, Blue A, Hansen KC, D'Alessandro A, V?geli B, Eisenmesser EZ. The Inherent Dynamics and Interaction Sites of the SARS-CoV-2 Nucleocapsid N-Terminal Region. J Mol Biol. 2021 07 23; 433(15):167108. PMID: 34161778.
      View in: PubMed
    29. Alexeev EE, Dowdell AS, Henen MA, Lanis JM, Lee JS, Cartwright IM, Schaefer REM, Ornelas A, Onyiah JC, V?geli B, Colgan SP. Microbial-derived indoles inhibit neutrophil myeloperoxidase to diminish bystander tissue damage. FASEB J. 2021 05; 35(5):e21552. PMID: 33826788.
      View in: PubMed
    30. Nichols PJ, Henen MA, Vicens Q, V?geli B. Solution NMR backbone assignments of the N-terminal Za-linker-Z? segment from Homo sapiens ADAR1p150. Biomol NMR Assign. 2021 Oct; 15(2):273-279. PMID: 33742389.
      View in: PubMed
    31. Tengesdal IW, Menon DR, Osborne DG, Neff CP, Powers NE, Gamboni F, Mauro AG, D'Alessandro A, Stefanoni D, Henen MA, Mills TS, De Graaf DM, Azam T, Vogeli B, Palmer BE, Pietras EM, DeGregori J, Tan AC, Joosten LAB, Fujita M, Dinarello CA, Marchetti C. Targeting tumor-derived NLRP3 reduces melanoma progression by limiting MDSCs expansion. Proc Natl Acad Sci U S A. 2021 03 09; 118(10). PMID: 33649199.
      View in: PubMed
    32. Nichols PJ, Bevers S, Henen M, Kieft JS, Vicens Q, V?geli B. Recognition of non-CpG repeats in Alu and ribosomal RNAs by the Z-RNA binding domain of ADAR1 induces A-Z junctions. Nat Commun. 2021 02 04; 12(1):793. PMID: 33542240.
      View in: PubMed
    33. Henen MA, Myers W, Schmitt LR, Wade KJ, Born A, Nichols PJ, V?geli B. The Disordered Spindly C-terminus Interacts with RZZ Subunits ROD-1 and ZWL-1 in the Kinetochore through the Same Sites in C. Elegans. J Mol Biol. 2021 02 19; 433(4):166812. PMID: 33450249.
      View in: PubMed
    34. Wang RX, Henen MA, Lee JS, V?geli B, Colgan SP. Microbiota-derived butyrate is an endogenous HIF prolyl hydroxylase inhibitor. Gut Microbes. 2021 Jan-Dec; 13(1):1938380. PMID: 34190032.
      View in: PubMed
    35. El-Khouly OA, Henen MA, El-Sayed MA, Shabaan MI, El-Messery SM. Synthesis, anticancer and antimicrobial evaluation of new benzofuran based derivatives: PI3K inhibition, quorum sensing and molecular modeling study. Bioorg Med Chem. 2021 02 01; 31:115976. PMID: 33388654.
      View in: PubMed
    36. Nichols PJ, Born A, Henen MA, Strotz D, Jones DN, Delaglio F, V?geli B. Reducing the measurement time of exact NOEs by non-uniform sampling. J Biomol NMR. 2020 Dec; 74(12):717-739. PMID: 32880802.
      View in: PubMed
    37. Nashaat S, Henen MA, El-Messery SM, Eisa H. Synthesis, state-of-the-art NMR-binding and molecular modeling study of new benzimidazole core derivatives as Pin1 inhibitors: Targeting breast cancer. Bioorg Med Chem. 2020 06 01; 28(11):115495. PMID: 32307260.
      View in: PubMed
    38. Born A, Henen MA, V?geli B. Activity and Affinity of Pin1 Variants. Molecules. 2019 Dec 20; 25(1). PMID: 31861908.
      View in: PubMed
    39. Kim SK, Henen MA, Hinck AP. Structural biology of betaglycan and endoglin, membrane-bound co-receptors of the TGF-beta family. Exp Biol Med (Maywood). 2019 12; 244(17):1547-1558. PMID: 31601110.
      View in: PubMed
    40. Issaian A, Schmitt L, Born A, Nichols PJ, Sikela J, Hansen K, V?geli B, Henen MA. Solution NMR backbone assignment reveals interaction-free tumbling of human lineage-specific Olduvai protein domains. Biomol NMR Assign. 2019 10; 13(2):339-343. PMID: 31264103.
      View in: PubMed
    41. Celestino R, Henen MA, Gama JB, Carvalho C, McCabe M, Barbosa DJ, Born A, Nichols PJ, Carvalho AX, Gassmann R, V?geli B. A transient helix in the disordered region of dynein light intermediate chain links the motor to structurally diverse adaptors for cargo transport. PLoS Biol. 2019 01; 17(1):e3000100. PMID: 30615611.
      View in: PubMed
    42. Henen MA, Mahlawat P, Zwieb C, Kodali RB, Hinck CS, Hanna RD, Krzysiak TC, Ilangovan U, Cano KE, Hinck G, Vonberg M, McCabe M, Hinck AP. TGF-?2 uses the concave surface of its extended finger region to bind betaglycan's ZP domain via three residues specific to TGF-? and inhibin-a. J Biol Chem. 2019 03 01; 294(9):3065-3080. PMID: 30598510.
      View in: PubMed
    43. Born A, Nichols PJ, Henen MA, Chi CN, Strotz D, Bayer P, Tate SI, Peng JW, V?geli B. Backbone and side-chain chemical shift assignments of full-length, apo, human Pin1, a phosphoprotein regulator with interdomain allostery. Biomol NMR Assign. 2019 04; 13(1):85-89. PMID: 30353504.
      View in: PubMed
    44. Nichols PJ, Born A, Henen MA, Strotz D, Celestine CN, G?ntert P, V?geli B. Extending the Applicability of Exact Nuclear Overhauser Enhancements to Large Proteins and RNA. Chembiochem. 2018 Jun 08. PMID: 29883016.
      View in: PubMed
    45. Nichols PJ, Henen MA, Born A, Strotz D, G?ntert P, V?geli B. High-resolution small RNA structures from exact nuclear Overhauser enhancement measurements without additional restraints. Commun Biol. 2018; 1:61. PMID: 30271943.
      View in: PubMed
    46. Alexandra Born , Morkos A. Henen, Parker Nichols, Jing Wang, David N. Jones and Beat Vögeli. Efficient Stereospecific Hß2/3 NMR Assignment Strategy for Mid-Size Proteins. Magnetochemistry. 2018; 2(4):25.
      View Publication
    47. Born A, Henen MA, Nichols P, Wang J, Jones DN, V?geli B. Efficient Stereospecific H?2/3 NMR Assignment Strategy for Mid-Size Proteins. Magnetochemistry. 2018 Jun; 4(2). PMID: 31093488.
      View in: PubMed
    48. Morkos A. Henen et al. Understanding Chemistry and Unique NMR Characters of Novel Amide and Ester Leflunomide Analogues. Magnetochemistry. 2017; 4(3):41.
    49. Nichols PJ, Born A, Henen MA, Strotz D, Orts J, Olsson S, G?ntert P, Chi CN, V?geli B. The Exact Nuclear Overhauser Enhancement: Recent Advances. Molecules. 2017 Jul 14; 22(7). PMID: 28708092.
      View in: PubMed
    50. Villarreal MM, Kim SK, Barron L, Kodali R, Baardsnes J, Hinck CS, Krzysiak TC, Henen MA, Pakhomova O, Mendoza V, O'Connor-McCourt MD, Lafer EM, L?pez-Casillas F, Hinck AP. Correction to Binding Properties of the Transforming Growth Factor-? Coreceptor Betaglycan: Proposed Mechanism for Potentiation of Receptor Complex Assembly and Signaling. Biochemistry. 2017 07 18; 56(28):3689. PMID: 28677957.
      View in: PubMed
    51. Hinck, Andrew Henen, Morkos A. Zwieb, Christian Kodali, Ravindra Hinck, Cynthia S. Methyl-Labeling Assisted NMR Structure Determination of a 66 KDA Growth Factor-Receptor Complex. Biophysical Journal. 2017; 112(3):487a-488a.
    52. Villarreal MM, Kim SK, Barron L, Kodali R, Baardsnes J, Hinck CS, Krzysiak TC, Henen MA, Pakhomova O, Mendoza V, O'Connor-McCourt MD, Lafer EM, L?pez-Casillas F, Hinck AP. Binding Properties of the Transforming Growth Factor-? Coreceptor Betaglycan: Proposed Mechanism for Potentiation of Receptor Complex Assembly and Signaling. Biochemistry. 2016 12 13; 55(49):6880-6896. PMID: 27951653.
      View in: PubMed
    53. Byrne C, Henen MA, Belnou M, Cantrelle FX, Kamah A, Qi H, Giustiniani J, Chambraud B, Baulieu EE, Lippens G, Landrieu I, Jacquot Y. A ?-Turn Motif in the Steroid Hormone Receptor's Ligand-Binding Domains Interacts with the Peptidyl-prolyl Isomerase (PPIase) Catalytic Site of the Immunophilin FKBP52. Biochemistry. 2016 09 27; 55(38):5366-76. PMID: 27641460.
      View in: PubMed
    54. Milroy LG, Bartel M, Henen MA, Leysen S, Adriaans JM, Brunsveld L, Landrieu I, Ottmann C. Stabilizer-Guided Inhibition of Protein-Protein Interactions. Angew Chem Int Ed Engl. 2015 Dec 21; 54(52):15720-4. PMID: 26537010.
      View in: PubMed
    55. Geist L, Henen MA, Haiderer S, Schwarz TC, Kurzbach D, Zawadzka-Kazimierczuk A, Saxena S, Zerko S, Kozminski W, Hinderberger D, Konrat R. Protonation-dependent conformational variability of intrinsically disordered proteins. Protein Sci. 2013 Sep; 22(9):1196-205. PMID: 23821606.
      View in: PubMed
    56. Kurzbach D, Platzer G, Schwarz TC, Henen MA, Konrat R, Hinderberger D. Cooperative unfolding of compact conformations of the intrinsically disordered protein osteopontin. Biochemistry. 2013 Aug 06; 52(31):5167-75. PMID: 23848319.
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    57. Dennis Kurzbach, Gerald Platzer, Thomas Schwarz, Morkos Henen, Robert Konrat, Dariush Hinderberger . Cooperatively Folded Conformational Sub-States in Intrinsically Disordered Proteins as Revealed by EPR Spectroscopy. Biophysical Journal. 2013; 104(2):P190a.
      View Publication
    58. Orb?n-N?meth Z, Henen MA, Geist L, Zerko S, Saxena S, Stanek J, Kozminski W, Propst F, Konrat R. Backbone and partial side chain assignment of the microtubule binding domain of the MAP1B light chain. Biomol NMR Assign. 2014 Apr; 8(1):123-7. PMID: 23339032.
      View in: PubMed
    59. Henen MA, Coudevylle N, Geist L, Konrat R. Toward rational fragment-based lead design without 3D structures. J Med Chem. 2012 Sep 13; 55(17):7909-19. PMID: 22889313.
      View in: PubMed
    60. Henen, Morkos A. El Bialy, Serry A A Goda, Fatma E. Nasr, Magda N A Eisa, Hassan M. [1,2,4]Triazolo[4,3-a]quinoxaline: Synthesis, antiviral, and antimicrobial activities. Medicinal Chemistry Research. 2012; 21(9):2368-2378.
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