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Morkos Adel Ibrahim Henen

TitleResearch Instructor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-BioChem&Molecular Genetics

    Collapse Biography 
    Collapse education and training
    Vienna University, AustriaPhD with Honor degreeMolecular Biology, Drug Discovery
    CNRS, Lille 1 University, FranceDrug discovery, NMR, Molecular Biology
    Health Science Center, San Antonio, TX, USAMolecular Biology, Drug Discovery, Biochemistry
    University of Pittsburgh, PA, USAStructural Biology, NMR, Drug Discovery
    Faculty of Pharmacy, Mansoura University, EgyptMasterPharmaceutical Chemistry
    Faculty of Pharmacy, Mansoura University, EgyptBachelorPharmacy
    Collapse awards and honors
    2015Best Poster Award, Health Science Center, University of Texas, SA, USA
    2016Bursary Award, Drug Discovery Course, Douglas Connect GmbH Bärmeggenweg 14 Zeiningen, Aargau 4314 CH
    2013 - 2014Marie Curie Grant member, European Union
    2009 - 2012Ku mit Agypten, Austrian Ministry of High Education, Vienna, Austria

    Collapse Overview 

    Collapse Research 
    Collapse research activities and funding
         Oct 1, 2009
    Austrian Ministry of High Education, Vienna Austria
    Chemistry and NMR studies of Beta Catenin
    Role: PhD fellow
         (Christian Ottmann and Isabelle Landrieu)Jan 1, 2013 - Dec 31, 2014
    European Union - Marie Curie Project
    14-3-3 Stabilizers
    Role: Senior PostDoctoral Fellow
         (Richard Johnson, Michael Wimpe, Beat Vogeli)Jan 1, 2019 - Dec 31, 2020
    ALSAM Foundation
    Developing AMP deaminase inhibitors for alcoholism
    Role Description: Collaborative effort to develop small drug inhibitors using a combination of methods, including computer modeling based on a previously published AMPD crystal, stepwise derivation of a published pan AMPD inhibitor (Astra Zeneca), and NMR-based studies to aid the design and synthesis of optimized ligands for inhibitory activity (using saturation-transfer difference NMR).
    Role: Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Celestino R, Henen MA, Gama JB, Carvalho C, McCabe M, Barbosa DJ, Born A, Nichols PJ, Carvalho AX, Gassmann R, Vögeli B. A transient helix in the disordered region of dynein light intermediate chain links the motor to structurally diverse adaptors for cargo transport. PLoS Biol. 2019 Jan; 17(1):e3000100. PMID: 30615611.
      View in: PubMed
    2. Henen MA, Mahlawat P, Zwieb C, Kodali RB, Hinck CS, Hanna RD, Krzysiak TC, Ilangovan U, Cano KE, Hinck G, Vonberg M, McCabe M, Hinck AP. TGF-ß2 uses the concave surface of its extended finger region to bind betaglycan's ZP domain via three residues specific to TGF-ß and inhibin-a. J Biol Chem. 2019 Mar 01; 294(9):3065-3080. PMID: 30598510.
      View in: PubMed
    3. Born A, Nichols PJ, Henen MA, Chi CN, Strotz D, Bayer P, Tate SI, Peng JW, Vögeli B. Backbone and side-chain chemical shift assignments of full-length, apo, human Pin1, a phosphoprotein regulator with interdomain allostery. Biomol NMR Assign. 2018 Oct 23. PMID: 30353504.
      View in: PubMed
    4. Nichols PJ, Born A, Henen MA, Strotz D, Celestine CN, Güntert P, Vögeli B. Extending the Applicability of Exact Nuclear Overhauser Enhancements to Large Proteins and RNA. Chembiochem. 2018 Jun 08. PMID: 29883016.
      View in: PubMed
    5. Nichols PJ, Henen MA, Born A, Strotz D, Güntert P, Vögeli B. High-resolution small RNA structures from exact nuclear Overhauser enhancement measurements without additional restraints. Commun Biol. 2018; 1:61. PMID: 30271943.
      View in: PubMed
    6. Alexandra Born , Morkos A. Henen, Parker Nichols, Jing Wang, David N. Jones and Beat Vögeli. Efficient Stereospecific Hß2/3 NMR Assignment Strategy for Mid-Size Proteins. Magnetochemistry. 2018; 2(4):25.
      View Publication
    7. Morkos A. Henen et al. Understanding Chemistry and Unique NMR Characters of Novel Amide and Ester Leflunomide Analogues. Magnetochemistry. 2017; 4(3):41.
    8. Nichols PJ, Born A, Henen MA, Strotz D, Orts J, Olsson S, Güntert P, Chi CN, Vögeli B. The Exact Nuclear Overhauser Enhancement: Recent Advances. Molecules. 2017 Jul 14; 22(7). PMID: 28708092.
      View in: PubMed
    9. Villarreal MM, Kim SK, Barron L, Kodali R, Baardsnes J, Hinck CS, Krzysiak TC, Henen MA, Pakhomova O, Mendoza V, O'Connor-McCourt MD, Lafer EM, López-Casillas F, Hinck AP. Correction to Binding Properties of the Transforming Growth Factor-ß Coreceptor Betaglycan: Proposed Mechanism for Potentiation of Receptor Complex Assembly and Signaling. Biochemistry. 2017 07 18; 56(28):3689. PMID: 28677957.
      View in: PubMed
    10. Hinck, Andrew Henen, Morkos A. Zwieb, Christian Kodali, Ravindra Hinck, Cynthia S. Methyl-Labeling Assisted NMR Structure Determination of a 66 KDA Growth Factor-Receptor Complex. Biophysical Journal. 2017; 112(3):487a-488a.
    11. Villarreal MM, Kim SK, Barron L, Kodali R, Baardsnes J, Hinck CS, Krzysiak TC, Henen MA, Pakhomova O, Mendoza V, O'Connor-McCourt MD, Lafer EM, López-Casillas F, Hinck AP. Binding Properties of the Transforming Growth Factor-ß Coreceptor Betaglycan: Proposed Mechanism for Potentiation of Receptor Complex Assembly and Signaling. Biochemistry. 2016 12 13; 55(49):6880-6896. PMID: 27951653.
      View in: PubMed
    12. Byrne C, Henen MA, Belnou M, Cantrelle FX, Kamah A, Qi H, Giustiniani J, Chambraud B, Baulieu EE, Lippens G, Landrieu I, Jacquot Y. A ß-Turn Motif in the Steroid Hormone Receptor's Ligand-Binding Domains Interacts with the Peptidyl-prolyl Isomerase (PPIase) Catalytic Site of the Immunophilin FKBP52. Biochemistry. 2016 09 27; 55(38):5366-76. PMID: 27641460.
      View in: PubMed
    13. Milroy LG, Bartel M, Henen MA, Leysen S, Adriaans JM, Brunsveld L, Landrieu I, Ottmann C. Stabilizer-Guided Inhibition of Protein-Protein Interactions. Angew Chem Int Ed Engl. 2015 Dec 21; 54(52):15720-4. PMID: 26537010.
      View in: PubMed
    14. Geist L, Henen MA, Haiderer S, Schwarz TC, Kurzbach D, Zawadzka-Kazimierczuk A, Saxena S, Zerko S, Kozminski W, Hinderberger D, Konrat R. Protonation-dependent conformational variability of intrinsically disordered proteins. Protein Sci. 2013 Sep; 22(9):1196-205. PMID: 23821606.
      View in: PubMed
    15. Kurzbach D, Platzer G, Schwarz TC, Henen MA, Konrat R, Hinderberger D. Cooperative unfolding of compact conformations of the intrinsically disordered protein osteopontin. Biochemistry. 2013 Aug 06; 52(31):5167-75. PMID: 23848319; PMCID: PMC3737600.
      View in: PubMed, PubMed Central
    16. Dennis Kurzbach, Gerald Platzer, Thomas Schwarz, Morkos Henen, Robert Konrat, Dariush Hinderberger . Cooperatively Folded Conformational Sub-States in Intrinsically Disordered Proteins as Revealed by EPR Spectroscopy. Biophysical Journal. 2013; 104(2):P190a.
      View Publication
    17. Orbán-Németh Z, Henen MA, Geist L, Zerko S, Saxena S, Stanek J, Kozminski W, Propst F, Konrat R. Backbone and partial side chain assignment of the microtubule binding domain of the MAP1B light chain. Biomol NMR Assign. 2014 Apr; 8(1):123-7. PMID: 23339032; PMCID: PMC3955483.
      View in: PubMed, PubMed Central
    18. Henen MA, Coudevylle N, Geist L, Konrat R. Toward rational fragment-based lead design without 3D structures. J Med Chem. 2012 Sep 13; 55(17):7909-19. PMID: 22889313.
      View in: PubMed
    19. Henen, Morkos A. El Bialy, Serry A A Goda, Fatma E. Nasr, Magda N A Eisa, Hassan M. [1,2,4]Triazolo[4,3-a]quinoxaline: Synthesis, antiviral, and antimicrobial activities. Medicinal Chemistry Research. 2012; 21(9):2368-2378.
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