 Morkos Adel Ibrahim Henen
| Title | Research Instructor |
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| Institution | University of Colorado Denver - Anschutz Medical Campus |
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| Department | SOM-BioChem&Molecular Genetics |
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 Biography | Vienna University, Austria | PhD with Honor degree | | Molecular Biology, Drug Discovery | | CNRS, Lille 1 University, France | | | Drug discovery, NMR, Molecular Biology | | Health Science Center, San Antonio, TX, USA | | | Molecular Biology, Drug Discovery, Biochemistry | | University of Pittsburgh, PA, USA | | | Structural Biology, NMR, Drug Discovery | | Faculty of Pharmacy, Mansoura University, Egypt | Master | | Pharmaceutical Chemistry | | Faculty of Pharmacy, Mansoura University, Egypt | Bachelor | | Pharmacy |
| 2016 | Bursary Award, Drug Discovery Course, Douglas Connect GmbH Bärmeggenweg 14 Zeiningen, Aargau 4314 CH | | 2013 - 2014 | Marie Curie Grant member, European Union | | 2009 - 2012 | Ku mit Agypten, Austrian Ministry of High Education, Vienna, Austria |
Overview Research Oct 1, 2009 Austrian Ministry of High Education, Vienna Austria
Chemistry and NMR studies of Beta Catenin
Role: PhD fellow |
| (Christian Ottmann and Isabelle Landrieu)Jan 1, 2013 - Dec 31, 2014 European Union - Marie Curie Project
14-3-3 Stabilizers
Role: Senior PostDoctoral Fellow |
| (Richard Johnson, Michael Wimpe, Beat Vogeli)Jan 1, 2019 - Dec 31, 2020 ALSAM Foundation
Developing AMP deaminase inhibitors for alcoholism
Role Description: Collaborative effort to develop small drug inhibitors using a combination of methods, including computer modeling based on a previously published AMPD crystal, stepwise derivation of a published pan AMPD inhibitor (Astra Zeneca), and NMR-based studies to aid the design and synthesis of optimized ligands for inhibitory activity (using saturation-transfer difference NMR).
Role: Investigator |
Bibliographic
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Nichols PJ, Bevers S, Henen M, Kieft JS, Vicens Q, Vögeli B. Recognition of non-CpG repeats in Alu and ribosomal RNAs by the Z-RNA binding domain of ADAR1 induces A-Z junctions. Nat Commun. 2021 02 04; 12(1):793. PMID: 33542240.
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Henen MA, Myers W, Schmitt LR, Wade KJ, Born A, Nichols PJ, Vögeli B. The Disordered Spindly C-terminus Interacts with RZZ Subunits ROD-1 and ZWL-1 in the Kinetochore through the Same Sites in C. Elegans. J Mol Biol. 2021 Feb 19; 433(4):166812. PMID: 33450249.
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El-Khouly OA, Henen MA, El-Sayed MA, Shabaan MI, El-Messery SM. Synthesis, anticancer and antimicrobial evaluation of new benzofuran based derivatives: PI3K inhibition, quorum sensing and molecular modeling study. Bioorg Med Chem. 2021 Feb 01; 31:115976. PMID: 33388654.
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Nichols PJ, Born A, Henen MA, Strotz D, Jones DN, Delaglio F, Vögeli B. Reducing the measurement time of exact NOEs by non-uniform sampling. J Biomol NMR. 2020 Dec; 74(12):717-739. PMID: 32880802.
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Nashaat S, Henen MA, El-Messery SM, Eisa H. Synthesis, state-of-the-art NMR-binding and molecular modeling study of new benzimidazole core derivatives as Pin1 inhibitors: Targeting breast cancer. Bioorg Med Chem. 2020 06 01; 28(11):115495. PMID: 32307260.
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Born A, Henen MA, Vögeli B. Activity and Affinity of Pin1 Variants. Molecules. 2019 Dec 20; 25(1). PMID: 31861908.
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Kim SK, Henen MA, Hinck AP. Structural biology of betaglycan and endoglin, membrane-bound co-receptors of the TGF-beta family. Exp Biol Med (Maywood). 2019 12; 244(17):1547-1558. PMID: 31601110.
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Issaian A, Schmitt L, Born A, Nichols PJ, Sikela J, Hansen K, Vögeli B, Henen MA. Solution NMR backbone assignment reveals interaction-free tumbling of human lineage-specific Olduvai protein domains. Biomol NMR Assign. 2019 10; 13(2):339-343. PMID: 31264103.
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Celestino R, Henen MA, Gama JB, Carvalho C, McCabe M, Barbosa DJ, Born A, Nichols PJ, Carvalho AX, Gassmann R, Vögeli B. A transient helix in the disordered region of dynein light intermediate chain links the motor to structurally diverse adaptors for cargo transport. PLoS Biol. 2019 01; 17(1):e3000100. PMID: 30615611.
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Henen MA, Mahlawat P, Zwieb C, Kodali RB, Hinck CS, Hanna RD, Krzysiak TC, Ilangovan U, Cano KE, Hinck G, Vonberg M, McCabe M, Hinck AP. TGF-ß2 uses the concave surface of its extended finger region to bind betaglycan's ZP domain via three residues specific to TGF-ß and inhibin-a. J Biol Chem. 2019 03 01; 294(9):3065-3080. PMID: 30598510.
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Born A, Nichols PJ, Henen MA, Chi CN, Strotz D, Bayer P, Tate SI, Peng JW, Vögeli B. Backbone and side-chain chemical shift assignments of full-length, apo, human Pin1, a phosphoprotein regulator with interdomain allostery. Biomol NMR Assign. 2019 04; 13(1):85-89. PMID: 30353504.
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Nichols PJ, Born A, Henen MA, Strotz D, Celestine CN, Güntert P, Vögeli B. Extending the Applicability of Exact Nuclear Overhauser Enhancements to Large Proteins and RNA. Chembiochem. 2018 Jun 08. PMID: 29883016.
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Nichols PJ, Henen MA, Born A, Strotz D, Güntert P, Vögeli B. High-resolution small RNA structures from exact nuclear Overhauser enhancement measurements without additional restraints. Commun Biol. 2018; 1:61. PMID: 30271943.
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Alexandra Born , Morkos A. Henen, Parker Nichols, Jing Wang, David N. Jones and Beat Vögeli. Efficient Stereospecific Hß2/3 NMR Assignment Strategy for Mid-Size Proteins. Magnetochemistry. 2018; 2(4):25.
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Born A, Henen MA, Nichols P, Wang J, Jones DN, Vögeli B. Efficient Stereospecific Hß2/3 NMR Assignment Strategy for Mid-Size Proteins. Magnetochemistry. 2018 Jun; 4(2). PMID: 31093488.
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Morkos A. Henen et al. Understanding Chemistry and Unique NMR Characters of Novel Amide and Ester Leflunomide Analogues. Magnetochemistry. 2017; 4(3):41.
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Nichols PJ, Born A, Henen MA, Strotz D, Orts J, Olsson S, Güntert P, Chi CN, Vögeli B. The Exact Nuclear Overhauser Enhancement: Recent Advances. Molecules. 2017 Jul 14; 22(7). PMID: 28708092.
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Villarreal MM, Kim SK, Barron L, Kodali R, Baardsnes J, Hinck CS, Krzysiak TC, Henen MA, Pakhomova O, Mendoza V, O'Connor-McCourt MD, Lafer EM, López-Casillas F, Hinck AP. Correction to Binding Properties of the Transforming Growth Factor-ß Coreceptor Betaglycan: Proposed Mechanism for Potentiation of Receptor Complex Assembly and Signaling. Biochemistry. 2017 07 18; 56(28):3689. PMID: 28677957.
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Hinck, Andrew
Henen, Morkos A.
Zwieb, Christian
Kodali, Ravindra
Hinck, Cynthia S. Methyl-Labeling Assisted NMR Structure Determination of a 66 KDA Growth Factor-Receptor Complex. Biophysical Journal. 2017; 112(3):487a-488a.
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Villarreal MM, Kim SK, Barron L, Kodali R, Baardsnes J, Hinck CS, Krzysiak TC, Henen MA, Pakhomova O, Mendoza V, O'Connor-McCourt MD, Lafer EM, López-Casillas F, Hinck AP. Binding Properties of the Transforming Growth Factor-ß Coreceptor Betaglycan: Proposed Mechanism for Potentiation of Receptor Complex Assembly and Signaling. Biochemistry. 2016 12 13; 55(49):6880-6896. PMID: 27951653.
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Byrne C, Henen MA, Belnou M, Cantrelle FX, Kamah A, Qi H, Giustiniani J, Chambraud B, Baulieu EE, Lippens G, Landrieu I, Jacquot Y. A ß-Turn Motif in the Steroid Hormone Receptor's Ligand-Binding Domains Interacts with the Peptidyl-prolyl Isomerase (PPIase) Catalytic Site of the Immunophilin FKBP52. Biochemistry. 2016 09 27; 55(38):5366-76. PMID: 27641460.
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Milroy LG, Bartel M, Henen MA, Leysen S, Adriaans JM, Brunsveld L, Landrieu I, Ottmann C. Stabilizer-Guided Inhibition of Protein-Protein Interactions. Angew Chem Int Ed Engl. 2015 Dec 21; 54(52):15720-4. PMID: 26537010.
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Geist L, Henen MA, Haiderer S, Schwarz TC, Kurzbach D, Zawadzka-Kazimierczuk A, Saxena S, Zerko S, Kozminski W, Hinderberger D, Konrat R. Protonation-dependent conformational variability of intrinsically disordered proteins. Protein Sci. 2013 Sep; 22(9):1196-205. PMID: 23821606.
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Kurzbach D, Platzer G, Schwarz TC, Henen MA, Konrat R, Hinderberger D. Cooperative unfolding of compact conformations of the intrinsically disordered protein osteopontin. Biochemistry. 2013 Aug 06; 52(31):5167-75. PMID: 23848319.
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Dennis Kurzbach, Gerald Platzer, Thomas Schwarz, Morkos Henen, Robert Konrat, Dariush Hinderberger
. Cooperatively Folded Conformational Sub-States in Intrinsically Disordered Proteins as Revealed by EPR Spectroscopy. Biophysical Journal. 2013; 104(2):P190a.
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Orbán-Németh Z, Henen MA, Geist L, Zerko S, Saxena S, Stanek J, Kozminski W, Propst F, Konrat R. Backbone and partial side chain assignment of the microtubule binding domain of the MAP1B light chain. Biomol NMR Assign. 2014 Apr; 8(1):123-7. PMID: 23339032.
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Henen MA, Coudevylle N, Geist L, Konrat R. Toward rational fragment-based lead design without 3D structures. J Med Chem. 2012 Sep 13; 55(17):7909-19. PMID: 22889313.
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Henen, Morkos A.
El Bialy, Serry A A
Goda, Fatma E.
Nasr, Magda N A
Eisa, Hassan M. [1,2,4]Triazolo[4,3-a]quinoxaline: Synthesis, antiviral, and antimicrobial activities. Medicinal Chemistry Research. 2012; 21(9):2368-2378.
This graph shows the total number of publications by year, by first, middle/unknown, or last author.
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| Year | Publications |
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| 2012 | 2 | | 2013 | 4 | | 2015 | 1 | | 2016 | 2 | | 2017 | 4 | | 2018 | 6 | | 2019 | 4 | | 2020 | 3 | | 2021 | 2 |
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