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Arina Marijke Keestra-Gounder

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-IMM MICRO GENERAL OPER

    Collapse Research 
    Collapse research activities and funding
    R21AI188344     (KEESTRA-GOUNDER, ARINA MARIJKE)Dec 5, 2024 - Nov 30, 2026
    NIH
    Intestinal NOD2 and the microbiota enhance Coxsackievirus B3 pathogenesis
    Role: Principal Investigator
    R01AI173121     (KEESTRA-GOUNDER, ARINA MARIJKE)Sep 20, 2022 - Jul 31, 2027
    NIH
    The impact of ER stress on Salmonella Typhimurium infections
    Role: Principal Investigator
    R21AI164154     (KEESTRA-GOUNDER, ARINA MARIJKE)May 18, 2021 - Apr 30, 2024
    NIH
    NOD2 promotes coxsackievirus entry and pathogenesis
    Role: Principal Investigator
    R21AI154043     (KEESTRA-GOUNDER, ARINA MARIJKE)Jun 1, 2020 - May 31, 2022
    NIH
    Activation of the NOD1 and NOD2 signaling pathways
    Role: Principal Investigator
    R21AI122092     (KEESTRA-GOUNDER, ARINA MARIJKE)Jul 1, 2016 - Jun 30, 2019
    NIH
    Targeting ER Stress in Inflammatory Bowel Disease
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Nagao PE, Santos L, Keestra-Gounder AM. Editorial: Inflammasomes in infectious diseases, cell death and ROS generation: stimulation by microorganisms and membrane-derived microvesicles. Front Immunol. 2024; 15:1378506. PMID: 38476228.
      View in: PubMed
    2. Sweet LA, Kuss-Duerkop SK, Byndloss MX, Keestra-Gounder AM. Nitrate-mediated luminal expansion of Salmonella Typhimurium is dependent on the ER stress protein CHOP. bioRxiv. 2023 Nov 03. PMID: 37961401.
      View in: PubMed
    3. Jang KK, Heaney T, London M, Ding Y, Putzel G, Yeung F, Ercelen D, Chen YH, Axelrad J, Gurunathan S, Zhou C, Podkowik M, Arguelles N, Srivastava A, Shopsin B, Torres VJ, Keestra-Gounder AM, Pironti A, Griffin ME, Hang HC, Cadwell K. Antimicrobial overproduction sustains intestinal inflammation by inhibiting Enterococcus colonization. Cell Host Microbe. 2023 09 13; 31(9):1450-1468.e8. PMID: 37652008.
      View in: PubMed
    4. Keestra-Gounder AM, Nagao PE. Inflammasome activation by Gram-positive bacteria: Mechanisms of activation and regulation. Front Immunol. 2023; 14:1075834. PMID: 36761775.
      View in: PubMed
    5. Sweet LA, Kuss-Duerkop SK, Keestra-Gounder AM. IRE1a-Driven Inflammation Promotes Clearance of Citrobacter rodentium Infection. Infect Immun. 2022 01 25; 90(1):e0048121. PMID: 34748367.
      View in: PubMed
    6. Villarreal R, Manzer HS, Keestra-Gounder AM, Doran KS. Vimentin Regulates Chemokine Expression and NOD2 Activation in Brain Endothelium during Group B Streptococcal Infection. Infect Immun. 2021 11 16; 89(12):e0034021. PMID: 34491787.
      View in: PubMed
    7. Kuss-Duerkop SK, Keestra-Gounder AM. NOD1 and NOD2 Activation by Diverse Stimuli: a Possible Role for Sensing Pathogen-Induced Endoplasmic Reticulum Stress. Infect Immun. 2020 06 22; 88(7). PMID: 32229616.
      View in: PubMed
    8. Pham OH, Lee B, Labuda J, Keestra-Gounder AM, Byndloss MX, Tsolis RM, McSorley SJ. NOD1/NOD2 and RIP2 Regulate Endoplasmic Reticulum Stress-Induced Inflammation during Chlamydia Infection. mBio. 2020 06 02; 11(3). PMID: 32487756.
      View in: PubMed
    9. Mendez JM, Keestra-Gounder AM. NF-?B-dependent Luciferase Activation and Quantification of Gene Expression in Salmonella Infected Tissue Culture Cells. J Vis Exp. 2020 01 12; (155). PMID: 31984953.
      View in: PubMed
    10. Mendez JM, Kolora LD, Lemon JS, Dupree SL, Keestra-Gounder AM. Activation of the Endoplasmic Reticulum Stress Response Impacts the NOD1 Signaling Pathway. Infect Immun. 2019 08; 87(8). PMID: 31109951.
      View in: PubMed
    11. Keestra-Gounder AM, Tsolis RM. NOD1 and NOD2: Beyond Peptidoglycan Sensing. Trends Immunol. 2017 10; 38(10):758-767. PMID: 28823510.
      View in: PubMed
    12. Vaezirad MM, Keestra-Gounder AM, de Zoete MR, Koene MG, Wagenaar JA, van Putten JPM. Invasive behavior of Campylobacter jejuni in immunosuppressed chicken. Virulence. 2017 04 03; 8(3):248-260. PMID: 27574876.
      View in: PubMed
    13. Byndloss MX, Keestra-Gounder AM, B?umler AJ, Tsolis RM. NOD1 and NOD2: New Functions Linking Endoplasmic Reticulum Stress and Inflammation. DNA Cell Biol. 2016 Jul; 35(7):311-3. PMID: 27341284.
      View in: PubMed
    14. Keestra-Gounder AM, Byndloss MX, Seyffert N, Young BM, Ch?vez-Arroyo A, Tsai AY, Cevallos SA, Winter MG, Pham OH, Tiffany CR, de Jong MF, Kerrinnes T, Ravindran R, Luciw PA, McSorley SJ, B?umler AJ, Tsolis RM. NOD1 and NOD2 signalling links ER stress with inflammation. Nature. 2016 Apr 21; 532(7599):394-7. PMID: 27007849.
      View in: PubMed
    15. Keestra-Gounder AM, Tsolis RM, B?umler AJ. Now you see me, now you don't: the interaction of Salmonella with innate immune receptors. Nat Rev Microbiol. 2015 Apr; 13(4):206-16. PMID: 25749454.
      View in: PubMed
    16. Winter SE, Winter MG, Poon V, Keestra AM, Sterzenbach T, Faber F, Costa LF, Cassou F, Costa EA, Alves GE, Paix?o TA, Santos RL, B?umler AJ. Salmonella enterica Serovar Typhi conceals the invasion-associated type three secretion system from the innate immune system by gene regulation. PLoS Pathog. 2014 Jul; 10(7):e1004207. PMID: 24992093.
      View in: PubMed
    17. Keestra AM, B?umler AJ. Detection of enteric pathogens by the nodosome. Trends Immunol. 2014 Mar; 35(3):123-30. PMID: 24268520.
      View in: PubMed
    18. Xavier MN, Winter MG, Spees AM, den Hartigh AB, Nguyen K, Roux CM, Silva TM, Atluri VL, Kerrinnes T, Keestra AM, Monack DM, Luciw PA, Eigenheer RA, B?umler AJ, Santos RL, Tsolis RM. PPAR?-mediated increase in glucose availability sustains chronic Brucella abortus infection in alternatively activated macrophages. Cell Host Microbe. 2013 Aug 14; 14(2):159-70. PMID: 23954155.
      View in: PubMed
    19. Keestra AM, de Zoete MR, Bouwman LI, Vaezirad MM, van Putten JP. Unique features of chicken Toll-like receptors. Dev Comp Immunol. 2013 Nov; 41(3):316-23. PMID: 23628643.
      View in: PubMed
    20. Keestra AM, Winter MG, Auburger JJ, Fr?ssle SP, Xavier MN, Winter SE, Kim A, Poon V, Ravesloot MM, Waldenmaier JF, Tsolis RM, Eigenheer RA, B?umler AJ. Manipulation of small Rho GTPases is a pathogen-induced process detected by NOD1. Nature. 2013 Apr 11; 496(7444):233-7. PMID: 23542589.
      View in: PubMed
    21. Winter SE, Winter MG, Xavier MN, Thiennimitr P, Poon V, Keestra AM, Laughlin RC, Gomez G, Wu J, Lawhon SD, Popova IE, Parikh SJ, Adams LG, Tsolis RM, Stewart VJ, B?umler AJ. Host-derived nitrate boosts growth of E. coli in the inflamed gut. Science. 2013 Feb 08; 339(6120):708-11. PMID: 23393266.
      View in: PubMed
    22. Crawford RW, Keestra AM, Winter SE, Xavier MN, Tsolis RM, Tolstikov V, B?umler AJ. Very long O-antigen chains enhance fitness during Salmonella-induced colitis by increasing bile resistance. PLoS Pathog. 2012 Sep; 8(9):e1002918. PMID: 23028318.
      View in: PubMed
    23. Keestra AM, Winter MG, Klein-Douwel D, Xavier MN, Winter SE, Kim A, Tsolis RM, B?umler AJ. A Salmonella virulence factor activates the NOD1/NOD2 signaling pathway. mBio. 2011; 2(6). PMID: 22186610.
      View in: PubMed
    24. Godinez I, Keestra AM, Spees A, B?umler AJ. The IL-23 axis in Salmonella gastroenteritis. Cell Microbiol. 2011 Nov; 13(11):1639-47. PMID: 21740501.
      View in: PubMed
    25. Keestra AM, Godinez I, Xavier MN, Winter MG, Winter SE, Tsolis RM, B?umler AJ. Early MyD88-dependent induction of interleukin-17A expression during Salmonella colitis. Infect Immun. 2011 Aug; 79(8):3131-40. PMID: 21576324.
      View in: PubMed
    26. Keestra AM, B?umler AJ. Host defenses trigger salmonella's arsenal. Cell Host Microbe. 2011 Mar 17; 9(3):167-168. PMID: 21402352.
      View in: PubMed
    27. de Zoete MR, Bouwman LI, Keestra AM, van Putten JP. Cleavage and activation of a Toll-like receptor by microbial proteases. Proc Natl Acad Sci U S A. 2011 Mar 22; 108(12):4968-73. PMID: 21383168.
      View in: PubMed
    28. T?kel C, Nishimori JH, Wilson RP, Winter MG, Keestra AM, van Putten JP, B?umler AJ. Toll-like receptors 1 and 2 cooperatively mediate immune responses to curli, a common amyloid from enterobacterial biofilms. Cell Microbiol. 2010 Oct; 12(10):1495-505. PMID: 20497180.
      View in: PubMed
    29. Winter SE, Keestra AM, Tsolis RM, B?umler AJ. The blessings and curses of intestinal inflammation. Cell Host Microbe. 2010 Jul 22; 8(1):36-43. PMID: 20638640.
      View in: PubMed
    30. Keestra AM, de Zoete MR, Bouwman LI, van Putten JP. Chicken TLR21 is an innate CpG DNA receptor distinct from mammalian TLR9. J Immunol. 2010 Jul 01; 185(1):460-7. PMID: 20498358.
      View in: PubMed
    31. de Zoete MR, Keestra AM, Wagenaar JA, van Putten JP. Reconstitution of a functional Toll-like receptor 5 binding site in Campylobacter jejuni flagellin. J Biol Chem. 2010 Apr 16; 285(16):12149-58. PMID: 20164175.
      View in: PubMed
    32. de Zoete MR, Keestra AM, Roszczenko P, van Putten JP. Activation of human and chicken toll-like receptors by Campylobacter spp. Infect Immun. 2010 Mar; 78(3):1229-38. PMID: 20038539.
      View in: PubMed
    33. Keestra AM, van Putten JP. Unique properties of the chicken TLR4/MD-2 complex: selective lipopolysaccharide activation of the MyD88-dependent pathway. J Immunol. 2008 Sep 15; 181(6):4354-62. PMID: 18768894.
      View in: PubMed
    34. Steeghs L, Keestra AM, van Mourik A, Uronen-Hansson H, van der Ley P, Callard R, Klein N, van Putten JP. Differential activation of human and mouse Toll-like receptor 4 by the adjuvant candidate LpxL1 of Neisseria meningitidis. Infect Immun. 2008 Aug; 76(8):3801-7. PMID: 18490457.
      View in: PubMed
    35. Keestra AM, de Zoete MR, van Aubel RA, van Putten JP. Functional characterization of chicken TLR5 reveals species-specific recognition of flagellin. Mol Immunol. 2008 Mar; 45(5):1298-307. PMID: 17964652.
      View in: PubMed
    36. Keestra AM, de Zoete MR, van Aubel RA, van Putten JP. The central leucine-rich repeat region of chicken TLR16 dictates unique ligand specificity and species-specific interaction with TLR2. J Immunol. 2007 Jun 01; 178(11):7110-9. PMID: 17513760.
      View in: PubMed
    37. van Aubel RA, Keestra AM, Krooshoop DJ, van Eden W, van Putten JP. Ligand-induced differential cross-regulation of Toll-like receptors 2, 4 and 5 in intestinal epithelial cells. Mol Immunol. 2007 Jul; 44(15):3702-14. PMID: 17493681.
      View in: PubMed
    38. Kingsley RA, Abi Ghanem D, Puebla-Osorio N, Keestra AM, Berghman L, B?umler AJ. Fibronectin binding to the Salmonella enterica serotype Typhimurium ShdA autotransporter protein is inhibited by a monoclonal antibody recognizing the A3 repeat. J Bacteriol. 2004 Aug; 186(15):4931-9. PMID: 15262930.
      View in: PubMed
    39. Kingsley RA, Keestra AM, de Zoete MR, B?umler AJ. The ShdA adhesin binds to the cationic cradle of the fibronectin 13FnIII repeat module: evidence for molecular mimicry of heparin binding. Mol Microbiol. 2004 Apr; 52(2):345-55. PMID: 15066025.
      View in: PubMed
    40. Kingsley RA, Weening EH, Keestra AM, B?umler AJ. Population heterogeneity of Salmonella enterica serotype Typhimurium resulting from phase variation of the lpf operon in vitro and in vivo. J Bacteriol. 2002 May; 184(9):2352-9. PMID: 11948147.
      View in: PubMed
    41. Kingsley RA, Santos RL, Keestra AM, Adams LG, B?umler AJ. Salmonella enterica serotype Typhimurium ShdA is an outer membrane fibronectin-binding protein that is expressed in the intestine. Mol Microbiol. 2002 Feb; 43(4):895-905. PMID: 11929540.
      View in: PubMed
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