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Search Results to Joseph Falke

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Falke, Joseph

One or more keywords matched the following items that are connected to Falke, Joseph

Item Type	Name
Academic Article	Lock on/off disulfides identify the transmembrane signaling helix of the aspartate receptor.
Academic Article	Molecular mechanism of transmembrane signaling by the aspartate receptor: a model.
Academic Article	Intermolecular tuning of calmodulin by target peptides and proteins: differential effects on Ca2+ binding and implications for kinase activation.
Academic Article	The two-component signaling pathway of bacterial chemotaxis: a molecular view of signal transduction by receptors, kinases, and adaptation enzymes.
Academic Article	Identification of a site critical for kinase regulation on the central processing unit (CPU) helix of the aspartate receptor.
Academic Article	Detection of a conserved alpha-helix in the kinase-docking region of the aspartate receptor by cysteine and disulfide scanning.
Academic Article	Signaling domain of the aspartate receptor is a helical hairpin with a localized kinase docking surface: cysteine and disulfide scanning studies.
Academic Article	Attractant regulation of the aspartate receptor-kinase complex: limited cooperative interactions between receptors and effects of the receptor modification state.
Academic Article	C2 domains from different Ca2+ signaling pathways display functional and mechanistic diversity.
Academic Article	The C2 domain calcium-binding motif: structural and functional diversity.
Academic Article	C2 domains of protein kinase C isoforms alpha, beta, and gamma: activation parameters and calcium stoichiometries of the membrane-bound state.
Academic Article	C2 domain of protein kinase C alpha: elucidation of the membrane docking surface by site-directed fluorescence and spin labeling.
Academic Article	Quantitative analysis of aspartate receptor signaling complex reveals that the homogeneous two-state model is inadequate: development of a heterogeneous two-state model.
Academic Article	Adaptation mechanism of the aspartate receptor: electrostatics of the adaptation subdomain play a key role in modulating kinase activity.
Academic Article	Specific translocation of protein kinase Calpha to the plasma membrane requires both Ca2+ and PIP2 recognition by its C2 domain.
Academic Article	Conserved glycine residues in the cytoplasmic domain of the aspartate receptor play essential roles in kinase coupling and on-off switching.
Academic Article	Evidence that the adaptation region of the aspartate receptor is a dynamic four-helix bundle: cysteine and disulfide scanning studies.
Academic Article	Ca2+ influx is an essential component of the positive-feedback loop that maintains leading-edge structure and activity in macrophages.
Academic Article	Effect of PIP2 binding on the membrane docking geometry of PKC alpha C2 domain: an EPR site-directed spin-labeling and relaxation study.
Academic Article	Thermal domain motions of CheA kinase in solution: Disulfide trapping reveals the motional constraints leading to trans-autophosphorylation.
Academic Article	Structure of a conserved receptor domain that regulates kinase activity: the cytoplasmic domain of bacterial taxis receptors.
Academic Article	Evidence that both ligand binding and covalent adaptation drive a two-state equilibrium in the aspartate receptor signaling complex.
Academic Article	Assembly of membrane-bound protein complexes: detection and analysis by single molecule diffusion.
Academic Article	CheA Kinase of bacterial chemotaxis: chemical mapping of four essential docking sites.
Academic Article	Mapping out regions on the surface of the aspartate receptor that are essential for kinase activation.
Academic Article	Mechanism of specific membrane targeting by C2 domains: localized pools of target lipids enhance Ca2+ affinity.
Academic Article	Engineered socket study of signaling through a four-helix bundle: evidence for a yin-yang mechanism in the kinase control module of the aspartate receptor.
Academic Article	Membrane docking geometry and target lipid stoichiometry of membrane-bound PKCa C2 domain: a combined molecular dynamics and experimental study.
Academic Article	Isolated bacterial chemosensory array possesses quasi- and ultrastable components: functional links between array stability, cooperativity, and order.
Academic Article	Defining a key receptor-CheA kinase contact and elucidating its function in the membrane-bound bacterial chemosensory array: a disulfide mapping and TAM-IDS Study.
Academic Article	The 3.2 ? resolution structure of a receptor: CheA:CheW signaling complex defines overlapping binding sites and key residue interactions within bacterial chemosensory arrays.
Concept	Protein Kinase C
Concept	Aspartate Kinase
Concept	Myosin-Light-Chain Kinase
Concept	Protein Kinase C-alpha
Concept	Protein Kinases
Concept	Phosphotransferases
Concept	Phosphatidylinositol 3-Kinases
Academic Article	Lateral diffusion of peripheral membrane proteins on supported lipid bilayers is controlled by the additive frictional drags of (1) bound lipids and (2) protein domains penetrating into the bilayer hydrocarbon core.
Academic Article	Structure, function, and on-off switching of a core unit contact between CheA kinase and CheW adaptor protein in the bacterial chemosensory array: A disulfide mapping and mutagenesis study.
Academic Article	The PH domain of phosphoinositide-dependent kinase-1 exhibits a novel, phospho-regulated monomer-dimer equilibrium with important implications for kinase domain activation: single-molecule and ensemble studies.
Academic Article	Single-molecule studies reveal a hidden key step in the activation mechanism of membrane-bound protein kinase C-a.
Academic Article	New insights into bacterial chemoreceptor array structure and assembly from electron cryotomography.
Academic Article	Interactions of protein kinase C-a C1A and C1B domains with membranes: a combined computational and experimental study.
Academic Article	Piston versus scissors: chemotaxis receptors versus sensor His-kinase receptors in two-component signaling pathways.
Academic Article	Increasing and decreasing the ultrastability of bacterial chemotaxis core signaling complexes by modifying protein-protein contacts.
Academic Article	Signaling and sensory adaptation in Escherichia coli chemoreceptors: 2015 update.
Academic Article	Regulation of PI3K by PKC and MARCKS: Single-Molecule Analysis of a Reconstituted Signaling Pathway.
Academic Article	Regulation of a Coupled MARCKS-PI3K Lipid Kinase Circuit by Calmodulin: Single-Molecule Analysis of a Membrane-Bound Signaling Module.
Grant	Activation and Dynamics of Receptors and Kinases
Grant	Acquisition of a Continuous Wave X-band EPR Spectrometer
Grant	Mechanisms of Signaling on Membrane Surfaces
Academic Article	Single-Molecule Study Reveals How Receptor and Ras Synergistically Activate PI3Ka and PIP3 Signaling.
Academic Article	A PKC-MARCKS-PI3K regulatory module links Ca2+ and PIP3 signals at the leading edge of polarized macrophages.
Concept	Myristoylated Alanine-Rich C Kinase Substrate
Concept	Class III Phosphatidylinositol 3-Kinases
Concept	Protein Kinase C beta
Concept	Histidine Kinase
Concept	Phosphatidylinositol 3-Kinase
Concept	3-Phosphoinositide-Dependent Protein Kinases
Academic Article	The G-Protein Rab5A Activates VPS34 Complex II, a Class III PI3K, by a Dual Regulatory Mechanism.
Academic Article	Single-molecule studies reveal regulatory interactions between master kinases PDK1, AKT1, and PKC.
Academic Article	Binding of active Ras and its mutants to the Ras binding domain of PI-3-kinase: A quantitative approach to KD measurements.
Academic Article	PDK1:PKCa heterodimer association-dissociation dynamics in single-molecule diffusion tracks on a target membrane.

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Phosphotransferases